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The map label for this gene is polC [H]

Identifier: 146284212

GI number: 146284212

Start: 4229907

End: 4230614

Strand: Direct

Name: polC [H]

Synonym: PST_3900

Alternate gene names: 146284212

Gene position: 4229907-4230614 (Clockwise)

Preceding gene: 146284211

Following gene: 146284217

Centisome position: 92.61

GC content: 63.98

Gene sequence:

>708_bases
ATGAGCATGTTCTGGTTCAACCCACGCGGTCCGAAGTTGCCCCCGGAGCAGCAGCAACGCGTTGCCGAGCTGCCGCGCCC
GGAACTGCCGCAGCCCGTTCCGCTACGCCAGCAACGACTGGTGGTGCTGGATCTGGAAACGACCGGGCTGCACCTCAAGC
GCGACCTGGTCATCGCCATCGGCGCGGTGGTCATCGAGGACGGCGCGATCGATTATTCGCAGCAGTTCGAATGCACGCTG
TGCCGTCAGGTCAAGGTCAATGAAAGCGTGCTGATCCATGGCATCGCGCCTAGCGAACTGGCCAACGGACTGCCGCCGGC
CGAAGCGCTGCTCAGCTTCATGGAGTTTGCCGCGGGCAGCATCGTCCTGGCCTTTCACGCCCCCTTCGACCAACGCATGC
TGGGCCGCGCGCTGAAGAACGAGCTGGGCTATTCGCTGGAGAACAGTTTCCTTGACGTGGCCGACCTGGCCCCGATGCTG
TTCCCCGAAGCGATGATCCACCGCGGCAGCCTGGACCACTGGCTCGACTACTTCAACATCCATATCCCGCAGCGTCACAA
TGCGTCCGCCGACGCCATGGCGACAGCCGAGATCGCGCTGATCCTGCTCAATCGTGCCCAGCGCATCGGCCTGACCACCT
TCGACGAGCTGGCGCAGCGCCTCAGGTGCTGGCAGCGCGCCCGCAAGGCCGCATTCAATTCGATCTGA

Upstream 100 bases:

>100_bases
TGGATCCGGATACGCTCAATGTGTTGGATCGACGCATCCTGCGCGAGTCCTTTCGCCAGGCCCAGCGTCTCCAGGCCAGC
CTCGCGGTGCGCTATCAACT

Downstream 100 bases:

>100_bases
ACCTGACGACACGACCGCGGCCGTTCGGACAGCGATGACGGACACAGACGCAGCCATGCCCGAAAGGACAGGACGACCCA
AATCTCGGGCCGCCCACGCA

Product: exonuclease

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSMFWFNPRGPKLPPEQQQRVAELPRPELPQPVPLRQQRLVVLDLETTGLHLKRDLVIAIGAVVIEDGAIDYSQQFECTL
CRQVKVNESVLIHGIAPSELANGLPPAEALLSFMEFAAGSIVLAFHAPFDQRMLGRALKNELGYSLENSFLDVADLAPML
FPEAMIHRGSLDHWLDYFNIHIPQRHNASADAMATAEIALILLNRAQRIGLTTFDELAQRLRCWQRARKAAFNSI

Sequences:

>Translated_235_residues
MSMFWFNPRGPKLPPEQQQRVAELPRPELPQPVPLRQQRLVVLDLETTGLHLKRDLVIAIGAVVIEDGAIDYSQQFECTL
CRQVKVNESVLIHGIAPSELANGLPPAEALLSFMEFAAGSIVLAFHAPFDQRMLGRALKNELGYSLENSFLDVADLAPML
FPEAMIHRGSLDHWLDYFNIHIPQRHNASADAMATAEIALILLNRAQRIGLTTFDELAQRLRCWQRARKAAFNSI
>Mature_234_residues
SMFWFNPRGPKLPPEQQQRVAELPRPELPQPVPLRQQRLVVLDLETTGLHLKRDLVIAIGAVVIEDGAIDYSQQFECTLC
RQVKVNESVLIHGIAPSELANGLPPAEALLSFMEFAAGSIVLAFHAPFDQRMLGRALKNELGYSLENSFLDVADLAPMLF
PEAMIHRGSLDHWLDYFNIHIPQRHNASADAMATAEIALILLNRAQRIGLTTFDELAQRLRCWQRARKAAFNSI

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 26400; Mature: 26269

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMFWFNPRGPKLPPEQQQRVAELPRPELPQPVPLRQQRLVVLDLETTGLHLKRDLVIAI
CCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHH
GAVVIEDGAIDYSQQFECTLCRQVKVNESVLIHGIAPSELANGLPPAEALLSFMEFAAGS
HHHEEECCCCCCCCCCHHHHHHHEECCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCC
IVLAFHAPFDQRMLGRALKNELGYSLENSFLDVADLAPMLFPEAMIHRGSLDHWLDYFNI
EEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHE
HIPQRHNASADAMATAEIALILLNRAQRIGLTTFDELAQRLRCWQRARKAAFNSI
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SMFWFNPRGPKLPPEQQQRVAELPRPELPQPVPLRQQRLVVLDLETTGLHLKRDLVIAI
CEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHH
GAVVIEDGAIDYSQQFECTLCRQVKVNESVLIHGIAPSELANGLPPAEALLSFMEFAAGS
HHHEEECCCCCCCCCCHHHHHHHEECCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCC
IVLAFHAPFDQRMLGRALKNELGYSLENSFLDVADLAPMLFPEAMIHRGSLDHWLDYFNI
EEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHE
HIPQRHNASADAMATAEIALILLNRAQRIGLTTFDELAQRLRCWQRARKAAFNSI
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]