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The map label for this gene is msrA [H]

Identifier: 146284168

GI number: 146284168

Start: 4176771

End: 4177508

Strand: Direct

Name: msrA [H]

Synonym: PST_3856

Alternate gene names: 146284168

Gene position: 4176771-4177508 (Clockwise)

Preceding gene: 146284167

Following gene: 146284179

Centisome position: 91.45

GC content: 64.77

Gene sequence:

>738_bases
GTGGCGACGCACGGTCGCTGGTGCGCTTTCGCTGCCGGCCTGCCTTTTTGTAGCCTAGGGCTCAGCTACCGTCCCCCGAT
CGAGGCCCGCATGTCGCTACGCTCGCAGATACTGGTCAACAAACAAGCACTGCCCACGGCAGAACAGGCGCTGCCCGGCC
GCTCGACGGCGATGCCGGTCCCGCCGGCGCACCACGTGAACGGCAATCCGCTGCAGCCACCATTCCCGGCCGGCCTGCAA
CAGGCGGTCTTCGGCATGGGCTGTTTCTGGGGCGCGGAACGTCGCTTCTGGGAACAACCCGGAGTATGGACGACTGCGGT
GGGCTACGCCGGAGGGATTACGCCGAACCCGACCTACGACGAAGTGTGCTCCGGACTCACCGGTCACACCGAAGCGGTGC
TGGTGGTGTTCGACCCCAAGGTGATCGATTACGAAACCTTGCTGCGCATCTTCTGGGAGGCACACAACCCGACCCAGGGC
ATGCGTCAGGGCAACGATGTGGGCAGTCAGTACCGGTCGGCGATCTACTGCATGGACGCGCAGCAGCGCAGCGCGGCCGA
AGCCAGTCGGGAGCGCTTTCAGCAGCGCCTGAGCCAGGCGGGCTTTGCGCAGATCACTACCGAGATTGCCGACGCCCCGC
CTTTCTACTATGCGGAGGCGTACCACCAGCAGTATCTGGCGAAGAATCCAGGAGGTTATTGCGGACTCGGCGGGACCGGC
GTCTGCATGCCGGATTGA

Upstream 100 bases:

>100_bases
CGATATCGGCCAGGGCTATCTGTTCGACAAGCCGATCCCGGGCACCGGACTGACCGATGCCCTGCGCCGCTACCCTCACT
GGTGCTGATAGGCGGAAAGC

Downstream 100 bases:

>100_bases
TGCGGTGCAGTCGAGTTAATGCTGCCCTTCGCCAGGCGTCCCTGCTGCTTGGCAAACGGCGGACTTGGCAGAAAAGAAAA
ACCCCGCCGAAGCGGGGCTC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MATHGRWCAFAAGLPFCSLGLSYRPPIEARMSLRSQILVNKQALPTAEQALPGRSTAMPVPPAHHVNGNPLQPPFPAGLQ
QAVFGMGCFWGAERRFWEQPGVWTTAVGYAGGITPNPTYDEVCSGLTGHTEAVLVVFDPKVIDYETLLRIFWEAHNPTQG
MRQGNDVGSQYRSAIYCMDAQQRSAAEASRERFQQRLSQAGFAQITTEIADAPPFYYAEAYHQQYLAKNPGGYCGLGGTG
VCMPD

Sequences:

>Translated_245_residues
MATHGRWCAFAAGLPFCSLGLSYRPPIEARMSLRSQILVNKQALPTAEQALPGRSTAMPVPPAHHVNGNPLQPPFPAGLQ
QAVFGMGCFWGAERRFWEQPGVWTTAVGYAGGITPNPTYDEVCSGLTGHTEAVLVVFDPKVIDYETLLRIFWEAHNPTQG
MRQGNDVGSQYRSAIYCMDAQQRSAAEASRERFQQRLSQAGFAQITTEIADAPPFYYAEAYHQQYLAKNPGGYCGLGGTG
VCMPD
>Mature_244_residues
ATHGRWCAFAAGLPFCSLGLSYRPPIEARMSLRSQILVNKQALPTAEQALPGRSTAMPVPPAHHVNGNPLQPPFPAGLQQ
AVFGMGCFWGAERRFWEQPGVWTTAVGYAGGITPNPTYDEVCSGLTGHTEAVLVVFDPKVIDYETLLRIFWEAHNPTQGM
RQGNDVGSQYRSAIYCMDAQQRSAAEASRERFQQRLSQAGFAQITTEIADAPPFYYAEAYHQQYLAKNPGGYCGLGGTGV
CMPD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=197, Percent_Identity=62.4365482233503, Blast_Score=264, Evalue=5e-71,
Organism=Homo sapiens, GI208609995, Length=187, Percent_Identity=63.1016042780749, Blast_Score=252, Evalue=2e-67,
Organism=Homo sapiens, GI208609993, Length=197, Percent_Identity=47.7157360406091, Blast_Score=180, Evalue=1e-45,
Organism=Escherichia coli, GI1790665, Length=208, Percent_Identity=61.0576923076923, Blast_Score=239, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=39.5973154362416, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=35.9281437125749, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664627, Length=168, Percent_Identity=39.2857142857143, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664631, Length=168, Percent_Identity=39.2857142857143, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=42.1428571428571, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 26763; Mature: 26631

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHGRWCAFAAGLPFCSLGLSYRPPIEARMSLRSQILVNKQALPTAEQALPGRSTAMPV
CCCCCCHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
PPAHHVNGNPLQPPFPAGLQQAVFGMGCFWGAERRFWEQPGVWTTAVGYAGGITPNPTYD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCCCCCHH
EVCSGLTGHTEAVLVVFDPKVIDYETLLRIFWEAHNPTQGMRQGNDVGSQYRSAIYCMDA
HHHCCCCCCCCEEEEEECCCEECHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHEEEEECC
QQRSAAEASRERFQQRLSQAGFAQITTEIADAPPFYYAEAYHQQYLAKNPGGYCGLGGTG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEECCCCCC
VCMPD
CCCCC
>Mature Secondary Structure 
ATHGRWCAFAAGLPFCSLGLSYRPPIEARMSLRSQILVNKQALPTAEQALPGRSTAMPV
CCCCCHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
PPAHHVNGNPLQPPFPAGLQQAVFGMGCFWGAERRFWEQPGVWTTAVGYAGGITPNPTYD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCCCCCHH
EVCSGLTGHTEAVLVVFDPKVIDYETLLRIFWEAHNPTQGMRQGNDVGSQYRSAIYCMDA
HHHCCCCCCCCEEEEEECCCEECHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHEEEEECC
QQRSAAEASRERFQQRLSQAGFAQITTEIADAPPFYYAEAYHQQYLAKNPGGYCGLGGTG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEECCCCCC
VCMPD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA