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The map label for this gene is yhdG [H]

Identifier: 146283992

GI number: 146283992

Start: 3977872

End: 3979320

Strand: Direct

Name: yhdG [H]

Synonym: PST_3680

Alternate gene names: 146283992

Gene position: 3977872-3979320 (Clockwise)

Preceding gene: 146283991

Following gene: 146283993

Centisome position: 87.09

GC content: 65.22

Gene sequence:

>1449_bases
ATGGCTCTCGAACACAGCAGTTCAACGCCACCGCACCACGCAATCGATTTCGAAACCGTTGGCAGTAGCTATTTCCAGGA
ACGCGAACTGAAGAAAGGCGCCGCCGGCTGGGTGCTGCTGGTCGGCCTTGGCGTCGCCTACGTGATTTCCGGCGACTACG
CCGGCTGGAACTTCGGCCTCGCCCAGGGCGGCTGGGGCGGGCTGTTCATCGCCACGCTGCTGATGGCGACCATGTACCTG
TGCATGTGCTTCTCGCTGGCCGAGCTGTCGTCGATGGTCCCGACCGCGGGCGGCGGCTATGGTTTTGCCCGCACCGCCTT
CGGCCCATTGGGCGGCTTTCTCACCGGCACGGCGATCCTCATCGAATACGCCATCGCGCCGGCGGCGATCGCCGTGTTCA
TCGGCGCCTATTGCGAGTCACTGTTCGGCATCGGCGGCTGGATGATCTATCTGGCCTTCTACATCGTCTTCATCGGCATC
CATATCTTCGGCGTCGGCGAGGCGCTGAAGCTGATGTTCATCATCACCGCGGTCGCCGCCCTTGCCCTGGCGGTGTTCAT
CGTCGCCATGGTGCCGCACTTCTCGGTGGACAAGCTGCTCGATATCGCGCCGACCACCGCTGCCGGTGCCAGCAACTTCC
TGCCCTACGGCTACGTCGGCATCTGGGCGGCGATTCCCTACGCGATCTGGTTCTTCCTCGCCGTCGAAGGCGTGCCGCTG
GCCGCCGAGGAAACCAAGAACCCGCAGCGCGACATGCCCCGCGGGCTGATCGGCGCCATGCTGATACTGGTCGCCTTTGC
CGGCCTGATCTTGCTGGTCGGCCCGGGCGGCGCCGGTTCCAGCACCCTGGTGGCATCCGGCAACCCGCTGGTGGAAGCGC
TGACCACGGCCTACGGCTCGTCCACCTGGATGAGCGGCTTCGTCAACCTGGTTGGCCTGGCCGGGCTGATCGCCAGCTTC
TTCTCGATCATCTTCGCCTACTCGCGGCAGATCTTTGCCCTGTCGCGGGCCGGCTACCTGCCGCGCAACCTCTCGCTGAC
CAACAAGAACAAGGCGCCGGTGCTGGCCCTGGTGATCCCCGGTGTGATCGGCTTCCTGCTCTCGCTGACCGGCCAGGGCG
ACCTGCTGATCCTCGTCGCGGTGTTCGGCGCGACCATCTCCTACGTGTTGATGATGGCTTCGCACATCGTGCTGCGCCTG
CGCCGGCCGGATCTGCATCGCCCGTACAGGACACCTGGCGGCATCGTCACCTCGGGCGTGGCGCTGGTACTGGCCTGCAT
CGCGGTCATCGCGGGCTTCCTGGTCGACCCGCGGGTGGTGATCGGCGCCGCGATCATCTACGGGATCTTCATCGCCTATT
TCGCGATCTACAGTCGACACCATCTGGTGGCCGGCACGCCGGAAGGGGAATTCGCGGCGATCGAGCAGGCCGAGGCGACA
CTCAAGTAG

Upstream 100 bases:

>100_bases
GCCGACATCCACCGACAAAACACCGGGAATCCCGTATTCCGTGCCGGGGCATGACGCTTGCTAGGGAGAGAGGTGCCAAC
CCGTCCAAGAGGATTCCCCC

Downstream 100 bases:

>100_bases
GGAGAGCAGCCATGACGTACTCGCACAGCGTGGGCGGCACCACCTGGCGCTTCGACGATCTGCGCGAGGTGATGGCCAAG
GCCAGCCCGGCGCGATCCGG

Product: ethanolamine transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MALEHSSSTPPHHAIDFETVGSSYFQERELKKGAAGWVLLVGLGVAYVISGDYAGWNFGLAQGGWGGLFIATLLMATMYL
CMCFSLAELSSMVPTAGGGYGFARTAFGPLGGFLTGTAILIEYAIAPAAIAVFIGAYCESLFGIGGWMIYLAFYIVFIGI
HIFGVGEALKLMFIITAVAALALAVFIVAMVPHFSVDKLLDIAPTTAAGASNFLPYGYVGIWAAIPYAIWFFLAVEGVPL
AAEETKNPQRDMPRGLIGAMLILVAFAGLILLVGPGGAGSSTLVASGNPLVEALTTAYGSSTWMSGFVNLVGLAGLIASF
FSIIFAYSRQIFALSRAGYLPRNLSLTNKNKAPVLALVIPGVIGFLLSLTGQGDLLILVAVFGATISYVLMMASHIVLRL
RRPDLHRPYRTPGGIVTSGVALVLACIAVIAGFLVDPRVVIGAAIIYGIFIAYFAIYSRHHLVAGTPEGEFAAIEQAEAT
LK

Sequences:

>Translated_482_residues
MALEHSSSTPPHHAIDFETVGSSYFQERELKKGAAGWVLLVGLGVAYVISGDYAGWNFGLAQGGWGGLFIATLLMATMYL
CMCFSLAELSSMVPTAGGGYGFARTAFGPLGGFLTGTAILIEYAIAPAAIAVFIGAYCESLFGIGGWMIYLAFYIVFIGI
HIFGVGEALKLMFIITAVAALALAVFIVAMVPHFSVDKLLDIAPTTAAGASNFLPYGYVGIWAAIPYAIWFFLAVEGVPL
AAEETKNPQRDMPRGLIGAMLILVAFAGLILLVGPGGAGSSTLVASGNPLVEALTTAYGSSTWMSGFVNLVGLAGLIASF
FSIIFAYSRQIFALSRAGYLPRNLSLTNKNKAPVLALVIPGVIGFLLSLTGQGDLLILVAVFGATISYVLMMASHIVLRL
RRPDLHRPYRTPGGIVTSGVALVLACIAVIAGFLVDPRVVIGAAIIYGIFIAYFAIYSRHHLVAGTPEGEFAAIEQAEAT
LK
>Mature_481_residues
ALEHSSSTPPHHAIDFETVGSSYFQERELKKGAAGWVLLVGLGVAYVISGDYAGWNFGLAQGGWGGLFIATLLMATMYLC
MCFSLAELSSMVPTAGGGYGFARTAFGPLGGFLTGTAILIEYAIAPAAIAVFIGAYCESLFGIGGWMIYLAFYIVFIGIH
IFGVGEALKLMFIITAVAALALAVFIVAMVPHFSVDKLLDIAPTTAAGASNFLPYGYVGIWAAIPYAIWFFLAVEGVPLA
AEETKNPQRDMPRGLIGAMLILVAFAGLILLVGPGGAGSSTLVASGNPLVEALTTAYGSSTWMSGFVNLVGLAGLIASFF
SIIFAYSRQIFALSRAGYLPRNLSLTNKNKAPVLALVIPGVIGFLLSLTGQGDLLILVAVFGATISYVLMMASHIVLRLR
RPDLHRPYRTPGGIVTSGVALVLACIAVIAGFLVDPRVVIGAAIIYGIFIAYFAIYSRHHLVAGTPEGEFAAIEQAEATL
K

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of D-Alanine, D-Serine And Glycine. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=405, Percent_Identity=24.9382716049383, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI258614005, Length=406, Percent_Identity=24.384236453202, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI258614003, Length=406, Percent_Identity=24.384236453202, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI7657683, Length=343, Percent_Identity=26.2390670553936, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI33286428, Length=398, Percent_Identity=25.1256281407035, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790653, Length=359, Percent_Identity=23.9554317548747, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786602, Length=398, Percent_Identity=23.1155778894472, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786302, Length=391, Percent_Identity=24.2966751918159, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787768, Length=222, Percent_Identity=27.9279279279279, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=357, Percent_Identity=24.6498599439776, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=357, Percent_Identity=24.9299719887955, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24667468, Length=359, Percent_Identity=25.3481894150418, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668806, Length=363, Percent_Identity=22.3140495867769, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356285, Length=363, Percent_Identity=22.3140495867769, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24668802, Length=363, Percent_Identity=22.3140495867769, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161077963, Length=340, Percent_Identity=25.2941176470588, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI221512776, Length=381, Percent_Identity=24.1469816272966, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666159, Length=381, Percent_Identity=24.1469816272966, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004758
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50675; Mature: 50544

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEHSSSTPPHHAIDFETVGSSYFQERELKKGAAGWVLLVGLGVAYVISGDYAGWNFGL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCCC
AQGGWGGLFIATLLMATMYLCMCFSLAELSSMVPTAGGGYGFARTAFGPLGGFLTGTAIL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IEYAIAPAAIAVFIGAYCESLFGIGGWMIYLAFYIVFIGIHIFGVGEALKLMFIITAVAA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALAVFIVAMVPHFSVDKLLDIAPTTAAGASNFLPYGYVGIWAAIPYAIWFFLAVEGVPL
HHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
AAEETKNPQRDMPRGLIGAMLILVAFAGLILLVGPGGAGSSTLVASGNPLVEALTTAYGS
CHHHCCCCHHHCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEECCCHHHHHHHHHHCC
STWMSGFVNLVGLAGLIASFFSIIFAYSRQIFALSRAGYLPRNLSLTNKNKAPVLALVIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
GVIGFLLSLTGQGDLLILVAVFGATISYVLMMASHIVLRLRRPDLHRPYRTPGGIVTSGV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
ALVLACIAVIAGFLVDPRVVIGAAIIYGIFIAYFAIYSRHHLVAGTPEGEFAAIEQAEAT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHC
LK
CC
>Mature Secondary Structure 
ALEHSSSTPPHHAIDFETVGSSYFQERELKKGAAGWVLLVGLGVAYVISGDYAGWNFGL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCCC
AQGGWGGLFIATLLMATMYLCMCFSLAELSSMVPTAGGGYGFARTAFGPLGGFLTGTAIL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IEYAIAPAAIAVFIGAYCESLFGIGGWMIYLAFYIVFIGIHIFGVGEALKLMFIITAVAA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALAVFIVAMVPHFSVDKLLDIAPTTAAGASNFLPYGYVGIWAAIPYAIWFFLAVEGVPL
HHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
AAEETKNPQRDMPRGLIGAMLILVAFAGLILLVGPGGAGSSTLVASGNPLVEALTTAYGS
CHHHCCCCHHHCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEECCCHHHHHHHHHHCC
STWMSGFVNLVGLAGLIASFFSIIFAYSRQIFALSRAGYLPRNLSLTNKNKAPVLALVIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
GVIGFLLSLTGQGDLLILVAVFGATISYVLMMASHIVLRLRRPDLHRPYRTPGGIVTSGV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
ALVLACIAVIAGFLVDPRVVIGAAIIYGIFIAYFAIYSRHHLVAGTPEGEFAAIEQAEAT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHC
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]