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The map label for this gene is tlpA [H]

Identifier: 146283932

GI number: 146283932

Start: 3900644

End: 3902638

Strand: Direct

Name: tlpA [H]

Synonym: PST_3615

Alternate gene names: 146283932

Gene position: 3900644-3902638 (Clockwise)

Preceding gene: 146283931

Following gene: 146283934

Centisome position: 85.4

GC content: 63.71

Gene sequence:

>1995_bases
GTGAGGCCGAAGACAGAAGCGGCCGCCCTGCGTACCCGCTCGCATCGACAATTCATCTTGATTTGGACTGCCATGAATAA
CTGGTTTGCAAATATCGGGGTCAGCAGGAAGCTCGCACTGGGCTTCGGCGTCGTCCTGGCCCTCACCTTCATCCTCGCCT
GGAACGGCTGGGGCAGCCTGGGCAGCGTGATCCAGCGCAGCGGCTGGATGACCGAGATCTCGCAGCTGAACAAGACCCTC
ACCGACCTGCGCATTGCCCGCCTGCAGTTCATGCTGGCCAACGGCGACGCCGAGTCCACCGAGCGGCTGGACAAGAACCT
CGGCATCTACCTCGCTCAGCAGACCAAGCTGCTGGACACCTTCAAGAACCCGATCAACGTCGCCCAGCTCAAGGAACAGG
CCGGCTACAACGCCCAGTACCAGAACTCGCTGAACGACATGCGCAAGGCCTACAACCAGGCCAACGGTTCACGGCAAGTC
ATCGACGGCGCCGCTACCCGTCTGAGCGAGCTGACTGCCAGCGTCTCCAATCATGTGATTCAGCTGCCGGAATACGATGA
AGATCGCTTCGCGCAGCTCCTGGCGATCAGCCTGATCAAGGAAGACGTGCAGCGTGCGCAGTACCTGCTGCGCGTCTATA
TGGCAGCACCCGGCAACGATGCCGCCAAAGCGATCTACACCCAGCTTGACGCCGCGCAGGCCACTCTGGGCCGACACGCT
GGCGCCCTCGACGATGACAGCGGCGCCGCGGTGCAGCAGATCCGCTCGGTGCTCGGCGAGTACCGCGGCGCCATCGAGTC
GCTGGAGACAGCCACCCAGGCGATCGCCAAGGCGCGCCAGGAAATGACCGACCAGCAGAAGGAGATCGTCCGTATCAGCG
ACTCGCTCTATCAGTTCCAGCTCGATCAGCTCGATGTGGAGAGCGCCGCCGCCCGCACGCGCCTGATCGTCAGCACCCTG
CTGGCACTGGTACTCGGAGCGCTGGCCGCCTGGCTGATCACCCGCCAGATCGTGCTACCGCTTCGTGCCACCATGGCCGA
TGTTGAGCGCATTGCTTCCGGTGATCTCAGCGCCACCGCACAGGTTCATCGTCGCGACGAACTGGGCGTGCTGCAGCGCG
GCATTCAGCAAATGGGCTCGACCTTGCGTGAGTTGATTGGTGGCATTCGCGATGGCGTCAGCCAGATCAGCGCAGCTGCC
GAAGAGCTGTCCGCCGTCACCAAACAAACCAGCGCCGGCGTGAATAGTCAGAAGGAAGAGACCGACCAGGTCGCCACCGC
CATGCACGAAATGTCGGCGACCGTTCAGGAAGTGGCACGCAACGCCGAACAGGCTGCTCTGGCCGCCACCGAAGCGGACA
GCGAAGCCCGTGAAGGTGATCGCGTTGTGACCGAGGTGGTGACGCAGATCGAGCGCATGGCCACCGCCGTGGTGCGTTCC
ACCGAGGCGATGACCGCGCTGCAAGGCGAAAGTGACAAGATCGGCAGCGTGATGAACGTGATTCGCGCCGTTGCCGAGCA
GACCAACTTGCTGGCACTCAACGCTGCCATCGAGGCTGCTCGCGCTGGCGAAGCCGGCCGCGGCTTTGCCGTAGTCGCAG
ACGAAGTGCGCGGCCTGGCGCAACGCACGCAGAAGTCCACCGAGGAAATCGAAGGGCTGGTCGCCGCGCTGCAGAACGGC
ACGCAGCAGGTCGCCTCGATCATGCACACCAGCCGCGACCTGACCGACAGTGGTGTCGAGCTGGCGCGCCGCGCCGGTGC
GTCGCTCGGCAACATCACCCGTACCGTTTCGAACATTCAGGCGATGAACCAGCAGATCGCCGCGGCGGCCGAAGAGCAAA
GCGCGGTGGCCGAGGAAATCAGCCGCAGTGTGGTGAATGTGCGTGATGTGTCGGAACAGACCGCTGCCGCCAGCGAGGAA
ACCGCTGCATCGAGCACCGAGCTCGCCCGCCTCGGCGGCCAGCTGCAGATGATGGTAAGTCGCTTCAGACTCTGA

Upstream 100 bases:

>100_bases
CGCGCGGGCGTTCACACGCCCGCCGATCGCTCGCTGCCGCGCAGGCAAGCGGGCAACCGTCCCTCGGCTGACATTCAAGT
TCGCATGCGCCAGGCCGACA

Downstream 100 bases:

>100_bases
CTAGGGCCTCGCAACACACCACGGGCAGCGTCCTGCCCGTGGTGCAAAACCGCTTCAGCCGGCTTGGGATTGCAGGTAGT
TCTGCAGGCCGATGCGGTCG

Product: methyl-accepting chemotaxis transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MRPKTEAAALRTRSHRQFILIWTAMNNWFANIGVSRKLALGFGVVLALTFILAWNGWGSLGSVIQRSGWMTEISQLNKTL
TDLRIARLQFMLANGDAESTERLDKNLGIYLAQQTKLLDTFKNPINVAQLKEQAGYNAQYQNSLNDMRKAYNQANGSRQV
IDGAATRLSELTASVSNHVIQLPEYDEDRFAQLLAISLIKEDVQRAQYLLRVYMAAPGNDAAKAIYTQLDAAQATLGRHA
GALDDDSGAAVQQIRSVLGEYRGAIESLETATQAIAKARQEMTDQQKEIVRISDSLYQFQLDQLDVESAAARTRLIVSTL
LALVLGALAAWLITRQIVLPLRATMADVERIASGDLSATAQVHRRDELGVLQRGIQQMGSTLRELIGGIRDGVSQISAAA
EELSAVTKQTSAGVNSQKEETDQVATAMHEMSATVQEVARNAEQAALAATEADSEAREGDRVVTEVVTQIERMATAVVRS
TEAMTALQGESDKIGSVMNVIRAVAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLAQRTQKSTEEIEGLVAALQNG
TQQVASIMHTSRDLTDSGVELARRAGASLGNITRTVSNIQAMNQQIAAAAEEQSAVAEEISRSVVNVRDVSEQTAAASEE
TAASSTELARLGGQLQMMVSRFRL

Sequences:

>Translated_664_residues
MRPKTEAAALRTRSHRQFILIWTAMNNWFANIGVSRKLALGFGVVLALTFILAWNGWGSLGSVIQRSGWMTEISQLNKTL
TDLRIARLQFMLANGDAESTERLDKNLGIYLAQQTKLLDTFKNPINVAQLKEQAGYNAQYQNSLNDMRKAYNQANGSRQV
IDGAATRLSELTASVSNHVIQLPEYDEDRFAQLLAISLIKEDVQRAQYLLRVYMAAPGNDAAKAIYTQLDAAQATLGRHA
GALDDDSGAAVQQIRSVLGEYRGAIESLETATQAIAKARQEMTDQQKEIVRISDSLYQFQLDQLDVESAAARTRLIVSTL
LALVLGALAAWLITRQIVLPLRATMADVERIASGDLSATAQVHRRDELGVLQRGIQQMGSTLRELIGGIRDGVSQISAAA
EELSAVTKQTSAGVNSQKEETDQVATAMHEMSATVQEVARNAEQAALAATEADSEAREGDRVVTEVVTQIERMATAVVRS
TEAMTALQGESDKIGSVMNVIRAVAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLAQRTQKSTEEIEGLVAALQNG
TQQVASIMHTSRDLTDSGVELARRAGASLGNITRTVSNIQAMNQQIAAAAEEQSAVAEEISRSVVNVRDVSEQTAAASEE
TAASSTELARLGGQLQMMVSRFRL
>Mature_664_residues
MRPKTEAAALRTRSHRQFILIWTAMNNWFANIGVSRKLALGFGVVLALTFILAWNGWGSLGSVIQRSGWMTEISQLNKTL
TDLRIARLQFMLANGDAESTERLDKNLGIYLAQQTKLLDTFKNPINVAQLKEQAGYNAQYQNSLNDMRKAYNQANGSRQV
IDGAATRLSELTASVSNHVIQLPEYDEDRFAQLLAISLIKEDVQRAQYLLRVYMAAPGNDAAKAIYTQLDAAQATLGRHA
GALDDDSGAAVQQIRSVLGEYRGAIESLETATQAIAKARQEMTDQQKEIVRISDSLYQFQLDQLDVESAAARTRLIVSTL
LALVLGALAAWLITRQIVLPLRATMADVERIASGDLSATAQVHRRDELGVLQRGIQQMGSTLRELIGGIRDGVSQISAAA
EELSAVTKQTSAGVNSQKEETDQVATAMHEMSATVQEVARNAEQAALAATEADSEAREGDRVVTEVVTQIERMATAVVRS
TEAMTALQGESDKIGSVMNVIRAVAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLAQRTQKSTEEIEGLVAALQNG
TQQVASIMHTSRDLTDSGVELARRAGASLGNITRTVSNIQAMNQQIAAAAEEQSAVAEEISRSVVNVRDVSEQTAAASEE
TAASSTELARLGGQLQMMVSRFRL

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=364, Percent_Identity=36.2637362637363, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1788195, Length=335, Percent_Identity=33.4328358208955, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788194, Length=377, Percent_Identity=30.7692307692308, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI2367378, Length=320, Percent_Identity=31.5625, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1789453, Length=334, Percent_Identity=29.0419161676647, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 71738; Mature: 71738

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPKTEAAALRTRSHRQFILIWTAMNNWFANIGVSRKLALGFGVVLALTFILAWNGWGSL
CCCCHHHHHHHHCCCCEEEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
GSVIQRSGWMTEISQLNKTLTDLRIARLQFMLANGDAESTERLDKNLGIYLAQQTKLLDT
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEHHHHHHHHH
FKNPINVAQLKEQAGYNAQYQNSLNDMRKAYNQANGSRQVIDGAATRLSELTASVSNHVI
HCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEE
QLPEYDEDRFAQLLAISLIKEDVQRAQYLLRVYMAAPGNDAAKAIYTQLDAAQATLGRHA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
GALDDDSGAAVQQIRSVLGEYRGAIESLETATQAIAKARQEMTDQQKEIVRISDSLYQFQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQLDVESAAARTRLIVSTLLALVLGALAAWLITRQIVLPLRATMADVERIASGDLSATA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
QVHRRDELGVLQRGIQQMGSTLRELIGGIRDGVSQISAAAEELSAVTKQTSAGVNSQKEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
TDQVATAMHEMSATVQEVARNAEQAALAATEADSEAREGDRVVTEVVTQIERMATAVVRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEAMTALQGESDKIGSVMNVIRAVAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLA
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QRTQKSTEEIEGLVAALQNGTQQVASIMHTSRDLTDSGVELARRAGASLGNITRTVSNIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
AMNQQIAAAAEEQSAVAEEISRSVVNVRDVSEQTAAASEETAASSTELARLGGQLQMMVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RFRL
HHCC
>Mature Secondary Structure
MRPKTEAAALRTRSHRQFILIWTAMNNWFANIGVSRKLALGFGVVLALTFILAWNGWGSL
CCCCHHHHHHHHCCCCEEEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
GSVIQRSGWMTEISQLNKTLTDLRIARLQFMLANGDAESTERLDKNLGIYLAQQTKLLDT
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEHHHHHHHHH
FKNPINVAQLKEQAGYNAQYQNSLNDMRKAYNQANGSRQVIDGAATRLSELTASVSNHVI
HCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEE
QLPEYDEDRFAQLLAISLIKEDVQRAQYLLRVYMAAPGNDAAKAIYTQLDAAQATLGRHA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
GALDDDSGAAVQQIRSVLGEYRGAIESLETATQAIAKARQEMTDQQKEIVRISDSLYQFQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQLDVESAAARTRLIVSTLLALVLGALAAWLITRQIVLPLRATMADVERIASGDLSATA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
QVHRRDELGVLQRGIQQMGSTLRELIGGIRDGVSQISAAAEELSAVTKQTSAGVNSQKEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
TDQVATAMHEMSATVQEVARNAEQAALAATEADSEAREGDRVVTEVVTQIERMATAVVRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEAMTALQGESDKIGSVMNVIRAVAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRGLA
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QRTQKSTEEIEGLVAALQNGTQQVASIMHTSRDLTDSGVELARRAGASLGNITRTVSNIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
AMNQQIAAAAEEQSAVAEEISRSVVNVRDVSEQTAAASEETAASSTELARLGGQLQMMVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RFRL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]