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The map label for this gene is arpR [H]

Identifier: 146283928

GI number: 146283928

Start: 3896698

End: 3897345

Strand: Direct

Name: arpR [H]

Synonym: PST_3611

Alternate gene names: 146283928

Gene position: 3896698-3897345 (Clockwise)

Preceding gene: 146283926

Following gene: 146283930

Centisome position: 85.32

GC content: 65.9

Gene sequence:

>648_bases
ATGCGCCGAACCAAAGAAGAAGCCGAGAAGACCCGCATCGCCATCCTCGCCTCCGCCGAGCGGCTGTTTCTGGACAAGGG
AGTAGCCCACACCAGTCTCGATCAGATCGCGCGCGACGCTGGCGTGACGCGCGGCGCCGTGTACTGGCACTTCCAGAACA
AGGCGCACCTGTTCCACGAGATGCTCAATCAGATCCGCCTGCCGCCTGAGCAGATGACCGAGCGTCTGTGCAGCTGCAAT
CAGCAGCAGCCGCTGCAGGCCCTGATCGCCCTGCGCAACCTGACGGTCGAGGCCATCAGCACCCTGGCCAGCAACGAGCA
GAAGCGCCGGATCTTCACCATCCTGCTGCACAAGTGCGAATTCACCGACGAGCTGCGCGAGGCCGAAGAGCGACATCACG
CCTTCATCAACCAGTTCATCGATCTGTGCGAGAACCTGCTGCGCAACGCCTCGGCCTGCCTGCGGCCCGGCGTCTCGCCG
CGCCTGGCGGCATTGTCGCTGCATGCCCTGGTGGTCGGGCTGTTCACCGACTGGACCCGCGACACCGGGCTGTTCGCGCC
GCTGGTCGACACCAAGGCGCTGATCGACCCGCTGTTCCGCGGCCTGGTCCGCGACTGGCCGGACGACCCCGACCAGCTCG
GTGCCTGA

Upstream 100 bases:

>100_bases
CCGCCGATTGTAAACATGCATCGCGACGAGATGCCTCGTTACACTGGTCGCCTCCACCGCTGCTGGATGCCTGAAGCAGC
CGCTACCGCCGAACCTGCCC

Downstream 100 bases:

>100_bases
GTGCCGGCATGATCACGCCACCTGATAGCCCTCCTCGCTGATCGCCTGGCGAATCGCCTGCTCGCTGGCGCTACTCTGCA
CCTCGACCGTCCCGCTCGCC

Product: transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MRRTKEEAEKTRIAILASAERLFLDKGVAHTSLDQIARDAGVTRGAVYWHFQNKAHLFHEMLNQIRLPPEQMTERLCSCN
QQQPLQALIALRNLTVEAISTLASNEQKRRIFTILLHKCEFTDELREAEERHHAFINQFIDLCENLLRNASACLRPGVSP
RLAALSLHALVVGLFTDWTRDTGLFAPLVDTKALIDPLFRGLVRDWPDDPDQLGA

Sequences:

>Translated_215_residues
MRRTKEEAEKTRIAILASAERLFLDKGVAHTSLDQIARDAGVTRGAVYWHFQNKAHLFHEMLNQIRLPPEQMTERLCSCN
QQQPLQALIALRNLTVEAISTLASNEQKRRIFTILLHKCEFTDELREAEERHHAFINQFIDLCENLLRNASACLRPGVSP
RLAALSLHALVVGLFTDWTRDTGLFAPLVDTKALIDPLFRGLVRDWPDDPDQLGA
>Mature_215_residues
MRRTKEEAEKTRIAILASAERLFLDKGVAHTSLDQIARDAGVTRGAVYWHFQNKAHLFHEMLNQIRLPPEQMTERLCSCN
QQQPLQALIALRNLTVEAISTLASNEQKRRIFTILLHKCEFTDELREAEERHHAFINQFIDLCENLLRNASACLRPGVSP
RLAALSLHALVVGLFTDWTRDTGLFAPLVDTKALIDPLFRGLVRDWPDDPDQLGA

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=191, Percent_Identity=34.0314136125654, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1789664, Length=210, Percent_Identity=29.0476190476191, Blast_Score=93, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24459; Mature: 24459

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTKEEAEKTRIAILASAERLFLDKGVAHTSLDQIARDAGVTRGAVYWHFQNKAHLFHE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHH
MLNQIRLPPEQMTERLCSCNQQQPLQALIALRNLTVEAISTLASNEQKRRIFTILLHKCE
HHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FTDELREAEERHHAFINQFIDLCENLLRNASACLRPGVSPRLAALSLHALVVGLFTDWTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
DTGLFAPLVDTKALIDPLFRGLVRDWPDDPDQLGA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MRRTKEEAEKTRIAILASAERLFLDKGVAHTSLDQIARDAGVTRGAVYWHFQNKAHLFHE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHH
MLNQIRLPPEQMTERLCSCNQQQPLQALIALRNLTVEAISTLASNEQKRRIFTILLHKCE
HHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FTDELREAEERHHAFINQFIDLCENLLRNASACLRPGVSPRLAALSLHALVVGLFTDWTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
DTGLFAPLVDTKALIDPLFRGLVRDWPDDPDQLGA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]