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The map label for this gene is yeiR [C]

Identifier: 146283921

GI number: 146283921

Start: 3890626

End: 3891828

Strand: Direct

Name: yeiR [C]

Synonym: PST_3604

Alternate gene names: 146283921

Gene position: 3890626-3891828 (Clockwise)

Preceding gene: 146283920

Following gene: 146283922

Centisome position: 85.18

GC content: 64.75

Gene sequence:

>1203_bases
ATGAACCGCCTCCCTGTAACCGTCCTGTCCGGCTTCCTCGGCGCCGGCAAGAGCACCCTGCTCAACCACATCCTGAAGAA
CCGCGACGGCCGCCGCGTGGCTGTGATCGTCAACGACATGAGCGAGATCAACATCGACGGCAACGAGGTGCAGCGCGGCG
TCAGCCTCAATCGCGCCGAAGAGAAGCTGGTGGAGATGAGCAATGGCTGTATCTGCTGCACCCTGCGCGAAGACCTGCTC
GAAGAAGTCGGCAAGCTCGCCCGCGAAGGCTGTTTCGACTACCTGTTGATCGAGTCCACCGGTATTTCCGAACCGCTGCC
GGTGGCCGAGACCTTCACCTTCCGCGATGAACAGGGCCAGAGCCTGGCCGATCTGGCTCGCCTGGACACCATGGTCACGG
TAGTCGACGGGGTGAACTTCCTGCGTGACTTCCACGAGGCCGAGAGCCTGGCCAGCCACGGCGAAACCCTTGGCGAGGAC
GACGAACGCTCGGTCACCGAGCTTCTGATCGAACAGGTGGAGTTTGCCGACGTCATCCTGATCAGCAAGATCGACCTGAT
CTCCGCGGCCGACCGCGAAGAGCTGACCGCCATCCTCGGCCGGCTCAACACCCACGCCGAGATCCTGCCGATGAGCATGG
GCCAGGTGCCGCTCGACCGAATCCTCGACACCGGCCGTTTCGATTTCGAACGCGCCGCCCAGGCGCCGGGCTGGCTCAAG
GAAATGCGCGGTGAGCATGTGCCGGAAACCGAGGAATATGGCATCGCCTCCACCGCCTACCTGGCGCGCCGGCCGTTTCA
TCCGCAGCGTTTCTACAACTTCCTCAACCGCGAGTGGAGCAATGGCCGCCTGCTACGCTCCAAGGGCTTCTTCTGGCTGG
CCAGCCGTCCGGAGGAAGCCGGCAGCTGGTCCCAGGCCGGTGGGCTGATGCGCTACGACTACGCCGGGCGCTGGTGGCAC
TTCACGCCGGAATCGGCCTGGCCGAGCGACAGCGAAAGCCGCACGGCGATCCTCGGCAAATCCCGCGGCGAGTTCGGCGA
CTGCCGCCAGGAACTGGTCTTCATCGGGCAGAACATCAACTTCGAACGGTTGCGCCGCGAACTGAACGCCTGCCTGCTGA
ACGATAGCGAATGGGCCGTGGGCGTCGACGGCTGGCTGCGCCTGCCGGACCCGTTCGGCCCCTGGCACGAGCAGGTCGCC
TGA

Upstream 100 bases:

>100_bases
GCAGCGCCTGCTGTTGCGTCCCACCACGACGCTGTCCATCGAGGCGAAGCAACGCCAGGAACAGCGCGAAAAACACCAAC
GTTCCGCCTGAGAGACCGCC

Downstream 100 bases:

>100_bases
TGCTGGCGCAGCGGATCATCCGTCCACAGCCACGCCAGCTGCTGGGCGATTCTCCGGCAATACTCGGCGAAACGCTGAAC
GACGGCGTCAACCTCAGCGT

Product: CobW/P47K family protein

Products: NA

Alternate protein names: P47K [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNRLPVTVLSGFLGAGKSTLLNHILKNRDGRRVAVIVNDMSEINIDGNEVQRGVSLNRAEEKLVEMSNGCICCTLREDLL
EEVGKLAREGCFDYLLIESTGISEPLPVAETFTFRDEQGQSLADLARLDTMVTVVDGVNFLRDFHEAESLASHGETLGED
DERSVTELLIEQVEFADVILISKIDLISAADREELTAILGRLNTHAEILPMSMGQVPLDRILDTGRFDFERAAQAPGWLK
EMRGEHVPETEEYGIASTAYLARRPFHPQRFYNFLNREWSNGRLLRSKGFFWLASRPEEAGSWSQAGGLMRYDYAGRWWH
FTPESAWPSDSESRTAILGKSRGEFGDCRQELVFIGQNINFERLRRELNACLLNDSEWAVGVDGWLRLPDPFGPWHEQVA

Sequences:

>Translated_400_residues
MNRLPVTVLSGFLGAGKSTLLNHILKNRDGRRVAVIVNDMSEINIDGNEVQRGVSLNRAEEKLVEMSNGCICCTLREDLL
EEVGKLAREGCFDYLLIESTGISEPLPVAETFTFRDEQGQSLADLARLDTMVTVVDGVNFLRDFHEAESLASHGETLGED
DERSVTELLIEQVEFADVILISKIDLISAADREELTAILGRLNTHAEILPMSMGQVPLDRILDTGRFDFERAAQAPGWLK
EMRGEHVPETEEYGIASTAYLARRPFHPQRFYNFLNREWSNGRLLRSKGFFWLASRPEEAGSWSQAGGLMRYDYAGRWWH
FTPESAWPSDSESRTAILGKSRGEFGDCRQELVFIGQNINFERLRRELNACLLNDSEWAVGVDGWLRLPDPFGPWHEQVA
>Mature_400_residues
MNRLPVTVLSGFLGAGKSTLLNHILKNRDGRRVAVIVNDMSEINIDGNEVQRGVSLNRAEEKLVEMSNGCICCTLREDLL
EEVGKLAREGCFDYLLIESTGISEPLPVAETFTFRDEQGQSLADLARLDTMVTVVDGVNFLRDFHEAESLASHGETLGED
DERSVTELLIEQVEFADVILISKIDLISAADREELTAILGRLNTHAEILPMSMGQVPLDRILDTGRFDFERAAQAPGWLK
EMRGEHVPETEEYGIASTAYLARRPFHPQRFYNFLNREWSNGRLLRSKGFFWLASRPEEAGSWSQAGGLMRYDYAGRWWH
FTPESAWPSDSESRTAILGKSRGEFGDCRQELVFIGQNINFERLRRELNACLLNDSEWAVGVDGWLRLPDPFGPWHEQVA

Specific function: The presence of P47K is critical for the expression of the nitrile hydratase genes. May stabilize or activate the nitrile hydratase proteins [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=255, Percent_Identity=31.7647058823529, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI126722884, Length=255, Percent_Identity=31.3725490196078, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI146231952, Length=255, Percent_Identity=31.3725490196078, Blast_Score=121, Evalue=9e-28,
Organism=Homo sapiens, GI148727351, Length=255, Percent_Identity=30.9803921568627, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI223941779, Length=255, Percent_Identity=30.5882352941176, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI223941776, Length=244, Percent_Identity=30.7377049180328, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI119120938, Length=148, Percent_Identity=34.4594594594595, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI87082430, Length=306, Percent_Identity=28.7581699346405, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788499, Length=109, Percent_Identity=33.9449541284404, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324356, Length=284, Percent_Identity=26.056338028169, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 45181; Mature: 45181

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLPVTVLSGFLGAGKSTLLNHILKNRDGRRVAVIVNDMSEINIDGNEVQRGVSLNRAE
CCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCHHHHHHCCCCCHHH
EKLVEMSNGCICCTLREDLLEEVGKLAREGCFDYLLIESTGISEPLPVAETFTFRDEQGQ
HHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHEEEECCCCCC
SLADLARLDTMVTVVDGVNFLRDFHEAESLASHGETLGEDDERSVTELLIEQVEFADVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ISKIDLISAADREELTAILGRLNTHAEILPMSMGQVPLDRILDTGRFDFERAAQAPGWLK
HHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCCCHHHHHCCCHHHH
EMRGEHVPETEEYGIASTAYLARRPFHPQRFYNFLNREWSNGRLLRSKGFFWLASRPEEA
HHCCCCCCCCHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCC
GSWSQAGGLMRYDYAGRWWHFTPESAWPSDSESRTAILGKSRGEFGDCRQELVFIGQNIN
CCHHHHCCEEEECCCCCEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC
FERLRRELNACLLNDSEWAVGVDGWLRLPDPFGPWHEQVA
HHHHHHHHHHHEECCCCEEEECCCEEECCCCCCCHHHCCC
>Mature Secondary Structure
MNRLPVTVLSGFLGAGKSTLLNHILKNRDGRRVAVIVNDMSEINIDGNEVQRGVSLNRAE
CCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHCCCCHHHHHHCCCCCHHH
EKLVEMSNGCICCTLREDLLEEVGKLAREGCFDYLLIESTGISEPLPVAETFTFRDEQGQ
HHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHEEEECCCCCC
SLADLARLDTMVTVVDGVNFLRDFHEAESLASHGETLGEDDERSVTELLIEQVEFADVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ISKIDLISAADREELTAILGRLNTHAEILPMSMGQVPLDRILDTGRFDFERAAQAPGWLK
HHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCCCHHHHHCCCHHHH
EMRGEHVPETEEYGIASTAYLARRPFHPQRFYNFLNREWSNGRLLRSKGFFWLASRPEEA
HHCCCCCCCCHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCC
GSWSQAGGLMRYDYAGRWWHFTPESAWPSDSESRTAILGKSRGEFGDCRQELVFIGQNIN
CCHHHHCCEEEECCCCCEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCC
FERLRRELNACLLNDSEWAVGVDGWLRLPDPFGPWHEQVA
HHHHHHHHHHHEECCCCEEEECCCEEECCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2013568 [H]