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The map label for this gene is phhA [H]

Identifier: 146283879

GI number: 146283879

Start: 3855468

End: 3856253

Strand: Direct

Name: phhA [H]

Synonym: PST_3562

Alternate gene names: 146283879

Gene position: 3855468-3856253 (Clockwise)

Preceding gene: 146283877

Following gene: 146283880

Centisome position: 84.41

GC content: 65.52

Gene sequence:

>786_bases
ATGAAGACCACCCACTACGTAGCCCGCGAACCGGACGCGCAGGGGCATATTCATTACCCCGACGCCGAGCACGCGGTGTG
GCAGACGCTGGTCGAGCGTCAGCTGAAACTGCTCGACGGGCGCGCCTGCCAGGAATACCTCGACGGCCTCGACCAGCTCG
CCCTGCCCCACGAGCGCATCCCGCAGCTCGGCGAGATCAACCGCGTGCTGGCCACCACCACGGGATGGCAAGTGGAGCGC
GTACCGGCGCTGATCCCCTTCCAGCGCTTTTTCGAACTGCTGGCGAGCAAGCGTTTTCCCGTCGCGACCTTTATCCGCAC
CCCGGAAGAGCTGGACTACCTGCAGGAGCCGGACATCTTCCACGAGATCTTCGGTCACTGCCCGCTGCTGACCAACCCCT
GGTTCGCCGAATTCACCCACACCTACGGCCAGCTCGGCCTCGAGGCCAGCAAGGAGGAGCGGGTGTTCCTTGCCCGCCTG
TACTGGATGACCGTCGAGTTCGGCCTGGTGGATACGCCCGCCGGCCGGCGCATCTATGGCGGCGGCATCCTTTCCTCGCC
GAAGGAAACGCTCTACAGCCTGTCCGCCGAACCCGAGCACCAGCCGTTCGACCCGCTGGAGGCGATGCGCACGCCCTATC
GCATCGACATCCTGCAGCCGCTGTACTTCGTCCTGCCGGACCTCAAGCAGCTGTTCGACCTGGCCCAGCAGGACATCATG
GCGATGGTGCGCGAGGCCATGCGCATGGGCCTGCACCAGCCGAAGTTTCCGCCGAAGGCGGCATGA

Upstream 100 bases:

>100_bases
GCGCACATGCGACATTGCGCCACAGCGCCTCTCCCCTGCGGCACGCCTTCGCGTTCGAATGAGGGCAACAACAAGATGCC
CAAGCGGCCCAGGAGAAGCG

Downstream 100 bases:

>100_bases
TTCGGCCCTGAGTGATGCTCGTGGTGGGCTAAAGCCCACCCTACGGGCGCCATCTGTTCTGTAGGGTGGGCTTCAGCCCA
CCACTTGCCTAAGCTTCAAC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MKTTHYVAREPDAQGHIHYPDAEHAVWQTLVERQLKLLDGRACQEYLDGLDQLALPHERIPQLGEINRVLATTTGWQVER
VPALIPFQRFFELLASKRFPVATFIRTPEELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGQLGLEASKEERVFLARL
YWMTVEFGLVDTPAGRRIYGGGILSSPKETLYSLSAEPEHQPFDPLEAMRTPYRIDILQPLYFVLPDLKQLFDLAQQDIM
AMVREAMRMGLHQPKFPPKAA

Sequences:

>Translated_261_residues
MKTTHYVAREPDAQGHIHYPDAEHAVWQTLVERQLKLLDGRACQEYLDGLDQLALPHERIPQLGEINRVLATTTGWQVER
VPALIPFQRFFELLASKRFPVATFIRTPEELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGQLGLEASKEERVFLARL
YWMTVEFGLVDTPAGRRIYGGGILSSPKETLYSLSAEPEHQPFDPLEAMRTPYRIDILQPLYFVLPDLKQLFDLAQQDIM
AMVREAMRMGLHQPKFPPKAA
>Mature_261_residues
MKTTHYVAREPDAQGHIHYPDAEHAVWQTLVERQLKLLDGRACQEYLDGLDQLALPHERIPQLGEINRVLATTTGWQVER
VPALIPFQRFFELLASKRFPVATFIRTPEELDYLQEPDIFHEIFGHCPLLTNPWFAEFTHTYGQLGLEASKEERVFLARL
YWMTVEFGLVDTPAGRRIYGGGILSSPKETLYSLSAEPEHQPFDPLEAMRTPYRIDILQPLYFVLPDLKQLFDLAQQDIM
AMVREAMRMGLHQPKFPPKAA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=220, Percent_Identity=36.3636363636364, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI88900501, Length=220, Percent_Identity=36.3636363636364, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI88900505, Length=220, Percent_Identity=36.3636363636364, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4759248, Length=212, Percent_Identity=33.9622641509434, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4557819, Length=212, Percent_Identity=34.9056603773585, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI31795563, Length=236, Percent_Identity=30.9322033898305, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71980736, Length=217, Percent_Identity=32.7188940092166, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17531391, Length=212, Percent_Identity=36.7924528301887, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI115532103, Length=247, Percent_Identity=28.7449392712551, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI115533973, Length=247, Percent_Identity=28.7449392712551, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71980731, Length=155, Percent_Identity=29.6774193548387, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136774, Length=232, Percent_Identity=32.7586206896552, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136776, Length=232, Percent_Identity=32.7586206896552, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24660393, Length=213, Percent_Identity=32.8638497652582, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI62472054, Length=213, Percent_Identity=32.8638497652582, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24654994, Length=212, Percent_Identity=32.0754716981132, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 30143; Mature: 30143

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTHYVAREPDAQGHIHYPDAEHAVWQTLVERQLKLLDGRACQEYLDGLDQLALPHERI
CCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHC
PQLGEINRVLATTTGWQVERVPALIPFQRFFELLASKRFPVATFIRTPEELDYLQEPDIF
CCHHHHHHHHHHCCCCCHHHCCHHCCHHHHHHHHHCCCCCHHHHHCCHHHHHHCCCCHHH
HEIFGHCPLLTNPWFAEFTHTYGQLGLEASKEERVFLARLYWMTVEFGLVDTPAGRRIYG
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCEEEC
GGILSSPKETLYSLSAEPEHQPFDPLEAMRTPYRIDILQPLYFVLPDLKQLFDLAQQDIM
CCCCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AMVREAMRMGLHQPKFPPKAA
HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKTTHYVAREPDAQGHIHYPDAEHAVWQTLVERQLKLLDGRACQEYLDGLDQLALPHERI
CCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHC
PQLGEINRVLATTTGWQVERVPALIPFQRFFELLASKRFPVATFIRTPEELDYLQEPDIF
CCHHHHHHHHHHCCCCCHHHCCHHCCHHHHHHHHHCCCCCHHHHHCCHHHHHHCCCCHHH
HEIFGHCPLLTNPWFAEFTHTYGQLGLEASKEERVFLARLYWMTVEFGLVDTPAGRRIYG
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCEEEC
GGILSSPKETLYSLSAEPEHQPFDPLEAMRTPYRIDILQPLYFVLPDLKQLFDLAQQDIM
CCCCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AMVREAMRMGLHQPKFPPKAA
HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]