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The map label for this gene is czcD [H]

Identifier: 146283745

GI number: 146283745

Start: 3703822

End: 3704742

Strand: Direct

Name: czcD [H]

Synonym: PST_3428

Alternate gene names: 146283745

Gene position: 3703822-3704742 (Clockwise)

Preceding gene: 146283742

Following gene: 146283749

Centisome position: 81.09

GC content: 49.95

Gene sequence:

>921_bases
ATGGGCCACGAACATAACCATAACACCGAAGCTATAGGCGATAAGCGTCTAATTGCTGCTATAGGCGTTAACGCCGCATT
AACACTGGCACAAATAGTCGGTGGAATACTCTCTGGTAGCTTATCACTCATTGCTGACGCGCTACATAATTTGAGCGATG
CCGCATCACTGGTTATTGCGCTGATCGCACGTAAGATCGGTCGCAGACCGCCAGATGCATTTAAAACCTTTGGCTATCGA
CGCAGTGAAACCATAGCGGCTTTGATCAACTTGGTCACCCTGATCATCGTCGGTCTCTATCTTATTTACGAGGCCATAGG
CCGGTTGTTTTCCCCGCAGCCCATTGAAGGTTGGACAGTGGTCGTGGTCGCGGGAATAGCCTTGGTTGTAGATATCGTCA
CGGCCTTTCTCACCTACACAATGTCCAAGAACAGCATGAATATAAAGGCGGCATTCTTGCACAATGTGTCGGATGCGCTG
GCCTCCGTCGGCGTTGTTATCGCCGGGACATTGATACTTCTGTATGGGTGGTACTGGGCGGATACTGTACTGACACTGAT
GATTGCTGGCTACGTGCTCTGGCAAGGCTTTAGCATGCTGCCTAAAACCATCCATCTGTTAATGGAGGGCGCGCCAGAAG
GCGTTTCCGTCGCTGATATAATCAATGTCATGGAACAAGTAAACGACGTCGAGGGCGTTCACCACGTGCATGTTTGGGAA
ATCGCTGAGCATACAATTGCACTGGAAGCACATGTTGTCATCAAGAAGGCGAGTCTGCCTGGGATCGAACGAGTGAAGAC
TGATTTGAAACGTGTACTCCATGAGCAATTCAAAATCAGCCACTCGACACTCGAGATGGAGCTAGACGGCAGTGTTTGTC
TCGACACCAAGCAGACCGACAATCACTGCAGCGAAGCATAA

Upstream 100 bases:

>100_bases
ACGGTACAAAGGCACTAGTATATTTATTTGTTGCTATAGACGACCGTTTGGCTTCCTGTGCTTAGTCTTTTTTTAGATTT
TTAAGGGTGGTTAAAAACCA

Downstream 100 bases:

>100_bases
GCTTACTATGCGCTACAATTAAAACAAGGTATTAACAGAGCGAATAGCCGAATATCACTTATTGGCGCTATGCCCTCGAC
CTGCGACATATTTCAGGTAT

Product: cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MGHEHNHNTEAIGDKRLIAAIGVNAALTLAQIVGGILSGSLSLIADALHNLSDAASLVIALIARKIGRRPPDAFKTFGYR
RSETIAALINLVTLIIVGLYLIYEAIGRLFSPQPIEGWTVVVVAGIALVVDIVTAFLTYTMSKNSMNIKAAFLHNVSDAL
ASVGVVIAGTLILLYGWYWADTVLTLMIAGYVLWQGFSMLPKTIHLLMEGAPEGVSVADIINVMEQVNDVEGVHHVHVWE
IAEHTIALEAHVVIKKASLPGIERVKTDLKRVLHEQFKISHSTLEMELDGSVCLDTKQTDNHCSEA

Sequences:

>Translated_306_residues
MGHEHNHNTEAIGDKRLIAAIGVNAALTLAQIVGGILSGSLSLIADALHNLSDAASLVIALIARKIGRRPPDAFKTFGYR
RSETIAALINLVTLIIVGLYLIYEAIGRLFSPQPIEGWTVVVVAGIALVVDIVTAFLTYTMSKNSMNIKAAFLHNVSDAL
ASVGVVIAGTLILLYGWYWADTVLTLMIAGYVLWQGFSMLPKTIHLLMEGAPEGVSVADIINVMEQVNDVEGVHHVHVWE
IAEHTIALEAHVVIKKASLPGIERVKTDLKRVLHEQFKISHSTLEMELDGSVCLDTKQTDNHCSEA
>Mature_305_residues
GHEHNHNTEAIGDKRLIAAIGVNAALTLAQIVGGILSGSLSLIADALHNLSDAASLVIALIARKIGRRPPDAFKTFGYRR
SETIAALINLVTLIIVGLYLIYEAIGRLFSPQPIEGWTVVVVAGIALVVDIVTAFLTYTMSKNSMNIKAAFLHNVSDALA
SVGVVIAGTLILLYGWYWADTVLTLMIAGYVLWQGFSMLPKTIHLLMEGAPEGVSVADIINVMEQVNDVEGVHHVHVWEI
AEHTIALEAHVVIKKASLPGIERVKTDLKRVLHEQFKISHSTLEMELDGSVCLDTKQTDNHCSEA

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=265, Percent_Identity=27.5471698113208, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI289803013, Length=294, Percent_Identity=26.8707482993197, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI289803009, Length=294, Percent_Identity=26.8707482993197, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI289803007, Length=294, Percent_Identity=26.8707482993197, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI289803003, Length=294, Percent_Identity=26.8707482993197, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI64762489, Length=294, Percent_Identity=26.8707482993197, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI21361112, Length=316, Percent_Identity=27.8481012658228, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI21359890, Length=313, Percent_Identity=23.6421725239617, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI20070323, Length=286, Percent_Identity=22.7272727272727, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI14210520, Length=187, Percent_Identity=26.7379679144385, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI52351208, Length=120, Percent_Identity=35.8333333333333, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1786966, Length=275, Percent_Identity=35.6363636363636, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1790349, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193210990, Length=293, Percent_Identity=27.6450511945392, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17555794, Length=309, Percent_Identity=24.9190938511327, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17555796, Length=301, Percent_Identity=24.9169435215947, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32564488, Length=302, Percent_Identity=25.4966887417219, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323899, Length=134, Percent_Identity=37.3134328358209, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=109, Percent_Identity=42.2018348623853, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=177, Percent_Identity=28.8135593220339, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583858, Length=330, Percent_Identity=25.1515151515152, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24585900, Length=123, Percent_Identity=34.9593495934959, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585898, Length=123, Percent_Identity=34.9593495934959, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585896, Length=123, Percent_Identity=34.9593495934959, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921672, Length=123, Percent_Identity=34.9593495934959, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574430, Length=144, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24584409, Length=144, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33166; Mature: 33035

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHEHNHNTEAIGDKRLIAAIGVNAALTLAQIVGGILSGSLSLIADALHNLSDAASLVIA
CCCCCCCCCHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIARKIGRRPPDAFKTFGYRRSETIAALINLVTLIIVGLYLIYEAIGRLFSPQPIEGWTV
HHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
VVVAGIALVVDIVTAFLTYTMSKNSMNIKAAFLHNVSDALASVGVVIAGTLILLYGWYWA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTVLTLMIAGYVLWQGFSMLPKTIHLLMEGAPEGVSVADIINVMEQVNDVEGVHHVHVWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHH
IAEHTIALEAHVVIKKASLPGIERVKTDLKRVLHEQFKISHSTLEMELDGSVCLDTKQTD
HHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECCCCCC
NHCSEA
CCCCCC
>Mature Secondary Structure 
GHEHNHNTEAIGDKRLIAAIGVNAALTLAQIVGGILSGSLSLIADALHNLSDAASLVIA
CCCCCCCCHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIARKIGRRPPDAFKTFGYRRSETIAALINLVTLIIVGLYLIYEAIGRLFSPQPIEGWTV
HHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
VVVAGIALVVDIVTAFLTYTMSKNSMNIKAAFLHNVSDALASVGVVIAGTLILLYGWYWA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTVLTLMIAGYVLWQGFSMLPKTIHLLMEGAPEGVSVADIINVMEQVNDVEGVHHVHVWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHH
IAEHTIALEAHVVIKKASLPGIERVKTDLKRVLHEQFKISHSTLEMELDGSVCLDTKQTD
HHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECCCCCC
NHCSEA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]