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The map label for this gene is czcC [H]

Identifier: 146283740

GI number: 146283740

Start: 3697189

End: 3698430

Strand: Direct

Name: czcC [H]

Synonym: PST_3423

Alternate gene names: 146283740

Gene position: 3697189-3698430 (Clockwise)

Preceding gene: 146283736

Following gene: 146283741

Centisome position: 80.95

GC content: 62.16

Gene sequence:

>1242_bases
ATGTATCAAAAGAAACGCTTGTATCTGCTTGCTAGCGGGCTGCTTGGGCTCGGGCTGGCACTAATGTCGCTCGAGGTGGG
CGCGCAAGACGGTCTGACACTGGAGCGGGCCGTGTCCCTTGCGTATGAACGCAACCCAGAATTTTCCGCTGCGCGGTCGG
AGATCGGCATCGCAAGCGGTCTGCGCCGCCAAGCTGGGGTTATCCCGAACCCGGAATTAGGGTTCGAGGTGGAAGACACT
CAGTCCGACCGCCAGACCCGCTCAATTACAATCACCCAGTCGATCGAGTTGGGCGGCAAGCGCGGCGCTCGAATCGGCGT
GGCGGATGCTAATCGCTCGATGGTGGATGCCGATCTCGACCTTCGACGCCAAGGATTACGTGCAGATGTGATCCAGGCAT
TCTTCGCCGCCCTGCGCGCCCAAGAAGGCATGCGACTGGCCGAGGCCTCTCTGTCATTGGCCGAACGGGCTGCTAAGGTC
GCCGATGCACAGGTCGATGCCGGAAAAGTTTCGCCAGTGGAGGCGACGCGCGCCGATATGCAACTGGCGACCGTACAACT
GGACCTGCGGCGAGCACGCCAGGAATGGGACAACGCTCGACAGATGCTAGCGCGCCTGCTCGGGACCGACGCACCGGAGT
TTGGCAGTTTGCTGGGCAGTTTCGAACACCTGCCAGATGTGCCTAGCGAATCTGCATTATTGGCGCGCGTGCGTGAGAGT
GCCGATATGCGTAGGGCTCTGCGCCAAGTGGCCTTGAGTGAAGCCGAGCTGGGGCTTCAGCGAAGCCAGCGCTACCCGGA
CATAAGCGTCAGTATCGGTAGCCAGTACGACGAAATCGAGCGTGAGCGCGTCAACCTCGTCGGCCTCTCTGTTCCGCTGC
CTTTGTTTGATCGTAACCAAGGCAATGTTCTGGCGGCCGCACGGCGGGCGGAACAGGCGCGTGATCTTCGCAATGCGGCC
GAGCTGCGTGTGCGTGCGGAGATCCAACAGGCCCTGCGCGACTGGCGCACCGCACGTGCGGACGTCGAGGAGATACGCAA
CCGGATTCTGCCGGCGGGACAGCGAACCGTGGAAGCGGCAACGCGTGGCTTCGGTCTGGGCCGCTTCGCATTCCTCGACG
TGCTCGACGCACAGCGTGCGCTGATCGATGCACGCACGCGCTATCTGCAGTCATTGCAAGCCGTGGTCGACGCCTGGGCG
CGTATCGAGCGGCTGTACGGACCTACCACTACCTTCGAATGA

Upstream 100 bases:

>100_bases
TTATCTAAAGTCACGCCGCTTAGCCATCAGCTATCTGGCCGGTTTAGTGCGGCTGAGGAAACGCTATCGACGAAGGGGGC
ACTGCACTGCAGTGTTGCGT

Downstream 100 bases:

>100_bases
CCGAAACGCCGCCATTACGTATTGGCGGTGGGGGAGCTTGCATGAAAAAACAGACGGGAATCGCTCTGGCGGTCGCTTTG
GTACTGCTGACCGGCGTTGG

Product: cobalt-zinc-cadmium resistance protein CzcC, putative

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MYQKKRLYLLASGLLGLGLALMSLEVGAQDGLTLERAVSLAYERNPEFSAARSEIGIASGLRRQAGVIPNPELGFEVEDT
QSDRQTRSITITQSIELGGKRGARIGVADANRSMVDADLDLRRQGLRADVIQAFFAALRAQEGMRLAEASLSLAERAAKV
ADAQVDAGKVSPVEATRADMQLATVQLDLRRARQEWDNARQMLARLLGTDAPEFGSLLGSFEHLPDVPSESALLARVRES
ADMRRALRQVALSEAELGLQRSQRYPDISVSIGSQYDEIERERVNLVGLSVPLPLFDRNQGNVLAAARRAEQARDLRNAA
ELRVRAEIQQALRDWRTARADVEEIRNRILPAGQRTVEAATRGFGLGRFAFLDVLDAQRALIDARTRYLQSLQAVVDAWA
RIERLYGPTTTFE

Sequences:

>Translated_413_residues
MYQKKRLYLLASGLLGLGLALMSLEVGAQDGLTLERAVSLAYERNPEFSAARSEIGIASGLRRQAGVIPNPELGFEVEDT
QSDRQTRSITITQSIELGGKRGARIGVADANRSMVDADLDLRRQGLRADVIQAFFAALRAQEGMRLAEASLSLAERAAKV
ADAQVDAGKVSPVEATRADMQLATVQLDLRRARQEWDNARQMLARLLGTDAPEFGSLLGSFEHLPDVPSESALLARVRES
ADMRRALRQVALSEAELGLQRSQRYPDISVSIGSQYDEIERERVNLVGLSVPLPLFDRNQGNVLAAARRAEQARDLRNAA
ELRVRAEIQQALRDWRTARADVEEIRNRILPAGQRTVEAATRGFGLGRFAFLDVLDAQRALIDARTRYLQSLQAVVDAWA
RIERLYGPTTTFE
>Mature_413_residues
MYQKKRLYLLASGLLGLGLALMSLEVGAQDGLTLERAVSLAYERNPEFSAARSEIGIASGLRRQAGVIPNPELGFEVEDT
QSDRQTRSITITQSIELGGKRGARIGVADANRSMVDADLDLRRQGLRADVIQAFFAALRAQEGMRLAEASLSLAERAAKV
ADAQVDAGKVSPVEATRADMQLATVQLDLRRARQEWDNARQMLARLLGTDAPEFGSLLGSFEHLPDVPSESALLARVRES
ADMRRALRQVALSEAELGLQRSQRYPDISVSIGSQYDEIERERVNLVGLSVPLPLFDRNQGNVLAAARRAEQARDLRNAA
ELRVRAEIQQALRDWRTARADVEEIRNRILPAGQRTVEAATRGFGLGRFAFLDVLDAQRALIDARTRYLQSLQAVVDAWA
RIERLYGPTTTFE

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 45616; Mature: 45616

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQKKRLYLLASGLLGLGLALMSLEVGAQDGLTLERAVSLAYERNPEFSAARSEIGIASG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LRRQAGVIPNPELGFEVEDTQSDRQTRSITITQSIELGGKRGARIGVADANRSMVDADLD
HHHHCCCCCCCCCCEEECCCCCCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCCCHH
LRRQGLRADVIQAFFAALRAQEGMRLAEASLSLAERAAKVADAQVDAGKVSPVEATRADM
HHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
QLATVQLDLRRARQEWDNARQMLARLLGTDAPEFGSLLGSFEHLPDVPSESALLARVRES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ADMRRALRQVALSEAELGLQRSQRYPDISVSIGSQYDEIERERVNLVGLSVPLPLFDRNQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHEEEEECCCCCCCCCC
GNVLAAARRAEQARDLRNAAELRVRAEIQQALRDWRTARADVEEIRNRILPAGQRTVEAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
TRGFGLGRFAFLDVLDAQRALIDARTRYLQSLQAVVDAWARIERLYGPTTTFE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYQKKRLYLLASGLLGLGLALMSLEVGAQDGLTLERAVSLAYERNPEFSAARSEIGIASG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LRRQAGVIPNPELGFEVEDTQSDRQTRSITITQSIELGGKRGARIGVADANRSMVDADLD
HHHHCCCCCCCCCCEEECCCCCCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCCCHH
LRRQGLRADVIQAFFAALRAQEGMRLAEASLSLAERAAKVADAQVDAGKVSPVEATRADM
HHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
QLATVQLDLRRARQEWDNARQMLARLLGTDAPEFGSLLGSFEHLPDVPSESALLARVRES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ADMRRALRQVALSEAELGLQRSQRYPDISVSIGSQYDEIERERVNLVGLSVPLPLFDRNQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHEEEEECCCCCCCCCC
GNVLAAARRAEQARDLRNAAELRVRAEIQQALRDWRTARADVEEIRNRILPAGQRTVEAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
TRGFGLGRFAFLDVLDAQRALIDARTRYLQSLQAVVDAWARIERLYGPTTTFE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]