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The map label for this gene is panC

Identifier: 146283617

GI number: 146283617

Start: 3568867

End: 3569727

Strand: Direct

Name: panC

Synonym: PST_3297

Alternate gene names: 146283617

Gene position: 3568867-3569727 (Clockwise)

Preceding gene: 146283616

Following gene: 146283618

Centisome position: 78.14

GC content: 65.97

Gene sequence:

>861_bases
ATGAACGTCGTCAAGAACATCGCCGACCTGCGCGCCGCGGTCGCCCGCGCGCGCGGCGAAGGCAAACGCATCGGTTTCGT
GCCGACCATGGGCAACCTCCACGCCGGTCATATCGCGCTGGTTAAGAAAGCCGGCCAGCGCGCCGACTTCGTGGTCGCCA
GCATCTTCGTCAATCCGTTGCAGTTCGGTCCCAACGAGGACCTGGACAACTACCCGCGTACGCTCGCAGCGGACCAGGAA
AAGCTGTTCGACGCCGGCTGCCACCTGCTCTTCGCGCCCAGCGTGGAGGAGATGTACCCCCACGGCCAGGCCAACCAGAC
CATCGTGCGCGTACCCGGCGTATCCGAAGGCCTCTGCGGCGGCAGTCGCCCCGGTCATTTCGACGGTGTCTCCACGGTGG
TGAGCAAGCTGTTCAACATGGTCCTGCCGGACCTCGCCGTGTTCGGCCAGAAGGATTTCCAGCAGCTGGCGGTGATCCGC
ACCATGGTGCGCGACCTGAACATGCCGGTGCAGATCCTCTCCGAACCGACCGTACGGGCCGACGACGGCCTGGCACTGTC
CTCGCGCAACGGTTACCTGAGCGCCGACGAGCGCGCCACGGCGCCTGTCCTCTATCGCACGCTGAACCAGCTCAGGGATG
CGCTCCAGGGCGGTCGCCGGGACCTTCCCGCGCTGATCGACGAAGGTCTGGAAGCACTGCGCAACGCCGGCTTGCGTCCG
GACTACCTGGACATCCGCAATGCCATCGACCTGCAGCCGGTCACCGACGCCTCCAGCGAGTTGGTCATTCTCGCGGCGGC
CTACCTGGGCAAGACGCGGCTGATCGACAACCTGCTGGTCGACCTCCGCACATCGGCCTGA

Upstream 100 bases:

>100_bases
ACTTCATGCGCGAGCACGGCGACATCCCCGCGGCCATCGCCGGCTACGTCAAGGCGGTCAAGGCCGTCGAATTCCCCGCA
GCCGAACACGGTTTCTCCGC

Downstream 100 bases:

>100_bases
TCCCTGCCAATTGCCTGCAGCCTTGATCGCGTTCGAGGCTTCGGGCACACTCTGCGCCGCTTGCGCACCCGGAGGACCCC
GCCATGCACGCCATCATGCT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNVVKNIADLRAAVARARGEGKRIGFVPTMGNLHAGHIALVKKAGQRADFVVASIFVNPLQFGPNEDLDNYPRTLAADQE
KLFDAGCHLLFAPSVEEMYPHGQANQTIVRVPGVSEGLCGGSRPGHFDGVSTVVSKLFNMVLPDLAVFGQKDFQQLAVIR
TMVRDLNMPVQILSEPTVRADDGLALSSRNGYLSADERATAPVLYRTLNQLRDALQGGRRDLPALIDEGLEALRNAGLRP
DYLDIRNAIDLQPVTDASSELVILAAAYLGKTRLIDNLLVDLRTSA

Sequences:

>Translated_286_residues
MNVVKNIADLRAAVARARGEGKRIGFVPTMGNLHAGHIALVKKAGQRADFVVASIFVNPLQFGPNEDLDNYPRTLAADQE
KLFDAGCHLLFAPSVEEMYPHGQANQTIVRVPGVSEGLCGGSRPGHFDGVSTVVSKLFNMVLPDLAVFGQKDFQQLAVIR
TMVRDLNMPVQILSEPTVRADDGLALSSRNGYLSADERATAPVLYRTLNQLRDALQGGRRDLPALIDEGLEALRNAGLRP
DYLDIRNAIDLQPVTDASSELVILAAAYLGKTRLIDNLLVDLRTSA
>Mature_286_residues
MNVVKNIADLRAAVARARGEGKRIGFVPTMGNLHAGHIALVKKAGQRADFVVASIFVNPLQFGPNEDLDNYPRTLAADQE
KLFDAGCHLLFAPSVEEMYPHGQANQTIVRVPGVSEGLCGGSRPGHFDGVSTVVSKLFNMVLPDLAVFGQKDFQQLAVIR
TMVRDLNMPVQILSEPTVRADDGLALSSRNGYLSADERATAPVLYRTLNQLRDALQGGRRDLPALIDEGLEALRNAGLRP
DYLDIRNAIDLQPVTDASSELVILAAAYLGKTRLIDNLLVDLRTSA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=282, Percent_Identity=54.6099290780142, Blast_Score=303, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6322046, Length=306, Percent_Identity=38.562091503268, Blast_Score=192, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_PSEU5 (A4VPM7)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001173770.1
- ProteinModelPortal:   A4VPM7
- SMR:   A4VPM7
- STRING:   A4VPM7
- GeneID:   5096258
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_3297
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   A4VPM7
- ProtClustDB:   PRK00380
- BioCyc:   PSTU379731:PST_3297-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31008; Mature: 31008

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVVKNIADLRAAVARARGEGKRIGFVPTMGNLHAGHIALVKKAGQRADFVVASIFVNPL
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
QFGPNEDLDNYPRTLAADQEKLFDAGCHLLFAPSVEEMYPHGQANQTIVRVPGVSEGLCG
CCCCCCCCHHCCHHHHCCHHHHHHHCCCEEECCCHHHHCCCCCCCCEEEECCCCCCCCCC
GSRPGHFDGVSTVVSKLFNMVLPDLAVFGQKDFQQLAVIRTMVRDLNMPVQILSEPTVRA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
DDGLALSSRNGYLSADERATAPVLYRTLNQLRDALQGGRRDLPALIDEGLEALRNAGLRP
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
DYLDIRNAIDLQPVTDASSELVILAAAYLGKTRLIDNLLVDLRTSA
CHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVVKNIADLRAAVARARGEGKRIGFVPTMGNLHAGHIALVKKAGQRADFVVASIFVNPL
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
QFGPNEDLDNYPRTLAADQEKLFDAGCHLLFAPSVEEMYPHGQANQTIVRVPGVSEGLCG
CCCCCCCCHHCCHHHHCCHHHHHHHCCCEEECCCHHHHCCCCCCCCEEEECCCCCCCCCC
GSRPGHFDGVSTVVSKLFNMVLPDLAVFGQKDFQQLAVIRTMVRDLNMPVQILSEPTVRA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
DDGLALSSRNGYLSADERATAPVLYRTLNQLRDALQGGRRDLPALIDEGLEALRNAGLRP
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
DYLDIRNAIDLQPVTDASSELVILAAAYLGKTRLIDNLLVDLRTSA
CHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA