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The map label for this gene is accC [H]

Identifier: 146283594

GI number: 146283594

Start: 3540049

End: 3541398

Strand: Direct

Name: accC [H]

Synonym: PST_3274

Alternate gene names: 146283594

Gene position: 3540049-3541398 (Clockwise)

Preceding gene: 146283593

Following gene: 146283595

Centisome position: 77.51

GC content: 62.96

Gene sequence:

>1350_bases
ATGTTGGAAAAAGTACTGATCGCCAACCGCGGCGAGATCGCCCTTCGTGTCCTGCGCGCCTGCAAGGAACTGGGCATCAA
GACCGTGGCGGTGCACTCCACTGCCGACCGTGACCTGATGCATGTGTCGCTGGCCGACGAGTCCGTGTGCATCGGCCCGG
CCTCCTCCGCCCAGTCCTACCTGAGCATTCCGGCCATCATCGCCGCTGCCGAGGTCACTGGTGCCGACGGCATCCATCCC
GGTTACGGGTTCCTCGCCGAGAACGCCGACTTCGCCGAGCAGGTGGAAAAATCCGGTTTCACCTTCATCGGCCCGACTGC
CGACGTTATCCGCCTGATGGGCGATAAGGTGTCGGCCAAGGACGCCATGAAGCAGGCCGGCGTGCCGACTGTCCCGGGTT
CTGACGGTCCACTGCCGGAAGACGAAAAGGAAGCGCTGCGCATCGCTCGCGAAGTGGGCTACCCGGTGATCATCAAGGCC
GCCGGTGGCGGTGGTGGTCGCGGCATGCGTGTGGTGCACAAGGAAGAGGACCTGATCGCCTCGGCCAAGCTGACCCGCAA
CGAAGCCGGCGCCGCCTTCGGCAACCCGATGGTCTACCTCGAGAAGTTCCTCACCAATCCACGCCACGTGGAAATCCAGG
TGCTGGCCGACGGCCAGGGCAATGCGATTCACCTGGGCGATCGCGACTGCTCGCTGCAGCGCCGCCACCAGAAGGTAATC
GAGGAAGCCCCAGCCCCGCTGATCGATGAAGAAGCCCGCCGCAAGGTGCAGGCCCGCTGCGTCAAGGCGTGCATTGACAT
CGGCTACCGCGGCGCGGGTACCTTCGAGTTCCTCTATGAAGATGGCAACTTCTACTTCATCGAGATGAACACCCGTGTAC
AGGTGGAGCACCCGGTCACCGAGATGGTCACCGGCATCGACATCGTCAAGGAAATGCTGCTGATCGGTGGCGGCCAGAAG
CTGTCGATCAAGCAGGAAGACGTGGTCATCCGCGGCCATGCCGTCGAATGCCGCATCAACGCCGAAGACCCGCGTACCTT
CATGCCCAGCCCGGGCAAGGTGAAGCATTTCCATGCGCCCGGCGGCAACGGCGTGCGCGTCGACTCGCACCTGTACGACG
GCTACTCGGTACCGCCGCACTACGACTCGCTGATCGGCAAACTGATCACCTTCGGCGCGAACCGTGACGAGGCCATGGGC
CGGATGCGCAACGCGCTGGACGAACTGATCGTCGACGGCATCAAGACCAACGCCCCGCTGCATCGCGATCTCGTACGCGA
TCCAGGCTTCTGCAAGGGCGGCGTGAACATCCATTACCTGGAAAAGAAACTGGGTATGGACAAGCACTGA

Upstream 100 bases:

>100_bases
AGATCAGCGGCACCATCGAATCCATCCTGGTGGAGAATGGTCAGCCGGTCGAATACGACCAGCCGCTGTTCACCATCGTT
TGAACCGCGGAGAGCCAGCG

Downstream 100 bases:

>100_bases
GCCTCGGCTCGGCATGACAGGGGCTGCCTTCGGGCGGCCCTTGTCGTTTCTGCGCCCCGCCCGACCGTTTGGGGCAAGCC
GCGCTGGCCGCCGCACCCGC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLEKVLIANRGEIALRVLRACKELGIKTVAVHSTADRDLMHVSLADESVCIGPASSAQSYLSIPAIIAAAEVTGADGIHP
GYGFLAENADFAEQVEKSGFTFIGPTADVIRLMGDKVSAKDAMKQAGVPTVPGSDGPLPEDEKEALRIAREVGYPVIIKA
AGGGGGRGMRVVHKEEDLIASAKLTRNEAGAAFGNPMVYLEKFLTNPRHVEIQVLADGQGNAIHLGDRDCSLQRRHQKVI
EEAPAPLIDEEARRKVQARCVKACIDIGYRGAGTFEFLYEDGNFYFIEMNTRVQVEHPVTEMVTGIDIVKEMLLIGGGQK
LSIKQEDVVIRGHAVECRINAEDPRTFMPSPGKVKHFHAPGGNGVRVDSHLYDGYSVPPHYDSLIGKLITFGANRDEAMG
RMRNALDELIVDGIKTNAPLHRDLVRDPGFCKGGVNIHYLEKKLGMDKH

Sequences:

>Translated_449_residues
MLEKVLIANRGEIALRVLRACKELGIKTVAVHSTADRDLMHVSLADESVCIGPASSAQSYLSIPAIIAAAEVTGADGIHP
GYGFLAENADFAEQVEKSGFTFIGPTADVIRLMGDKVSAKDAMKQAGVPTVPGSDGPLPEDEKEALRIAREVGYPVIIKA
AGGGGGRGMRVVHKEEDLIASAKLTRNEAGAAFGNPMVYLEKFLTNPRHVEIQVLADGQGNAIHLGDRDCSLQRRHQKVI
EEAPAPLIDEEARRKVQARCVKACIDIGYRGAGTFEFLYEDGNFYFIEMNTRVQVEHPVTEMVTGIDIVKEMLLIGGGQK
LSIKQEDVVIRGHAVECRINAEDPRTFMPSPGKVKHFHAPGGNGVRVDSHLYDGYSVPPHYDSLIGKLITFGANRDEAMG
RMRNALDELIVDGIKTNAPLHRDLVRDPGFCKGGVNIHYLEKKLGMDKH
>Mature_449_residues
MLEKVLIANRGEIALRVLRACKELGIKTVAVHSTADRDLMHVSLADESVCIGPASSAQSYLSIPAIIAAAEVTGADGIHP
GYGFLAENADFAEQVEKSGFTFIGPTADVIRLMGDKVSAKDAMKQAGVPTVPGSDGPLPEDEKEALRIAREVGYPVIIKA
AGGGGGRGMRVVHKEEDLIASAKLTRNEAGAAFGNPMVYLEKFLTNPRHVEIQVLADGQGNAIHLGDRDCSLQRRHQKVI
EEAPAPLIDEEARRKVQARCVKACIDIGYRGAGTFEFLYEDGNFYFIEMNTRVQVEHPVTEMVTGIDIVKEMLLIGGGQK
LSIKQEDVVIRGHAVECRINAEDPRTFMPSPGKVKHFHAPGGNGVRVDSHLYDGYSVPPHYDSLIGKLITFGANRDEAMG
RMRNALDELIVDGIKTNAPLHRDLVRDPGFCKGGVNIHYLEKKLGMDKH

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.5327313769752, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.5327313769752, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.5327313769752, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=47.5225225225225, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=45.2115812917595, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=45.2115812917595, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=45.2115812917595, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=31.434184675835, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=31.434184675835, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=31.434184675835, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=31.434184675835, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=31.434184675835, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI134142062, Length=513, Percent_Identity=30.4093567251462, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=72.0982142857143, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=249, Percent_Identity=23.6947791164659, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=48.0812641083521, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=45.2702702702703, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=43.5267857142857, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71997168, Length=521, Percent_Identity=30.3262955854127, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=521, Percent_Identity=30.3262955854127, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=28.9795918367347, Blast_Score=207, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.413870246085, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=42.8893905191874, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=45.8612975391499, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=30.5882352941176, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=451, Percent_Identity=31.0421286031042, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=44.7427293064877, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=46.6517857142857, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=46.6517857142857, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=46.6517857142857, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=46.6517857142857, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=46.6517857142857, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=46.6517857142857, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=46.6517857142857, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=46.6517857142857, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=46.6517857142857, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=46.6517857142857, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=44.0097799511002, Blast_Score=354, Evalue=8e-98,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=29.5634920634921, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=29.5634920634921, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=29.5634920634921, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=29.5634920634921, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48773; Mature: 48773

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKVLIANRGEIALRVLRACKELGIKTVAVHSTADRDLMHVSLADESVCIGPASSAQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCHHH
LSIPAIIAAAEVTGADGIHPGYGFLAENADFAEQVEKSGFTFIGPTADVIRLMGDKVSAK
HHHHHHHEEHEECCCCCCCCCCCEEECCCHHHHHHHHCCCEEECCHHHHHHHHCCCCCHH
DAMKQAGVPTVPGSDGPLPEDEKEALRIAREVGYPVIIKAAGGGGGRGMRVVHKEEDLIA
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCHHHH
SAKLTRNEAGAAFGNPMVYLEKFLTNPRHVEIQVLADGQGNAIHLGDRDCSLQRRHQKVI
HHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPAPLIDEEARRKVQARCVKACIDIGYRGAGTFEFLYEDGNFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMVTGIDIVKEMLLIGGGQKLSIKQEDVVIRGHAVECRINAEDPRTFMPSPGKVKHFHAP
HHHHHHHHHHHHHHHCCCCEEEEECCCEEEECEEEEEEECCCCCCCCCCCCCCEEEEECC
GGNGVRVDSHLYDGYSVPPHYDSLIGKLITFGANRDEAMGRMRNALDELIVDGIKTNAPL
CCCCEEEECEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
HRDLVRDPGFCKGGVNIHYLEKKLGMDKH
HHHHHCCCCCCCCCCEEEEEHHHCCCCCC
>Mature Secondary Structure
MLEKVLIANRGEIALRVLRACKELGIKTVAVHSTADRDLMHVSLADESVCIGPASSAQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCHHH
LSIPAIIAAAEVTGADGIHPGYGFLAENADFAEQVEKSGFTFIGPTADVIRLMGDKVSAK
HHHHHHHEEHEECCCCCCCCCCCEEECCCHHHHHHHHCCCEEECCHHHHHHHHCCCCCHH
DAMKQAGVPTVPGSDGPLPEDEKEALRIAREVGYPVIIKAAGGGGGRGMRVVHKEEDLIA
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCHHHH
SAKLTRNEAGAAFGNPMVYLEKFLTNPRHVEIQVLADGQGNAIHLGDRDCSLQRRHQKVI
HHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPAPLIDEEARRKVQARCVKACIDIGYRGAGTFEFLYEDGNFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMVTGIDIVKEMLLIGGGQKLSIKQEDVVIRGHAVECRINAEDPRTFMPSPGKVKHFHAP
HHHHHHHHHHHHHHHCCCCEEEEECCCEEEECEEEEEEECCCCCCCCCCCCCCEEEEECC
GGNGVRVDSHLYDGYSVPPHYDSLIGKLITFGANRDEAMGRMRNALDELIVDGIKTNAPL
CCCCEEEECEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
HRDLVRDPGFCKGGVNIHYLEKKLGMDKH
HHHHHCCCCCCCCCCEEEEEHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]