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The map label for this gene is stc [H]

Identifier: 146283550

GI number: 146283550

Start: 3481874

End: 3483373

Strand: Direct

Name: stc [H]

Synonym: PST_3225

Alternate gene names: 146283550

Gene position: 3481874-3483373 (Clockwise)

Preceding gene: 146283549

Following gene: 146283551

Centisome position: 76.23

GC content: 69.67

Gene sequence:

>1500_bases
ATGAGCATTGCCCGCGACGCACTCGACAACCACGGCCTGATCGTCGGCGTATCCCCGGAACGTTTCCGTGCCGTGGCCAT
GCCTCTGTTGTTCGATCACCTCAACGCGCAGTGTGAGGGCACCATCGCGGTCAACCGTCAGGCGCGCATCGTCTGGATCA
ACGACAAGTACGCCGAGAAAGTCGGCATTCGCGATCCGTCCAGCGTGCTCGGCAAGGAGATCGAGGAAGTGCTGCCGGCC
AGCCGCCTGCGCGAGGTGGTGGAAAGCGGCCAGCCGAGCATGCTCGACCTGATGGCCTTCGGCGACGAGCACTTCGTGGT
CACCCGCATTCCGCTGCGCGACGAGGACGGCACCCTGGTCGGCGCGCTGGGCTTCGTGCTGTTCGACCGAGCCCGCCACC
TCAAGCCGCTGATGTCCAAGTACACCAGCCTGCAGACCCAGCTGGTCGCCACCCAGAACGAACTGGCCAAGGCACGCCGG
GCGCGTTACACCATCGCCGGTTTCATCGGCAACAGCCCGGCTGCCAGCGAAATCAAGCGTCAGGCCCGGCGCGCCGCGCA
GCTCGATGCCACGGTGCTGCTGCGTGGCGAGACCGGCACCGGCAAGGAGCTGCTGGCCCAGGGCATCCATAACCTCTCGC
CGCGGGCGCGCGGGCCCTTCGTCGCGGTCAACGTCGCGGCGATTCCGGAAAGCCTGGTGGAGGCCGAGCTGTTCGGCACC
GCCCCCGGCGCCTTTACCGGTGCCGACCGCAAGGCGCGCATCGGCAAGTTCGAGGTGGCCAACGGCGGCACGCTGTTCCT
CGACGAGATCGGCGACCTGCCGCTGCCGCTGCAGGCCAAGCTGCTGCGCGTGCTGCAGGAGCAGGAGGTCGAGCCGCTGG
GCTCCAACCAGGTCAAGGCGCTCAACGTACGGGTGATCGCCGCGACCCATATCGACCTGGAAGCCAAGGTTGCCGCCGGC
CAGTTTCGCGACGACCTCTACTACCGCCTCAACGTCCTGGCCCTGCGCGTGCCGCCGTTGCGCGAGCGCGCCAGCGACAT
CCCCGCCGTGGTCGAGCACCTGCTGGACGACATCGCCAACCGCTCCGGGCAGCCGCCGATGGAGCTGAGCCCCGAGGCAC
TGGCGCTGCTCTGCGCGCAACCCTGGCGCGGCAACGTGCGCGAGCTGGGCAACCTGCTGGAGCGCGCGCAGCTGTCCGCC
GATGGCCCGCAGCTGCAGGCTGCGCACCTGCTGCCGCTGCTGGGCGAGCAGGCGCGCTCGGCCGACGCGCCGGCCTATGC
GTCAAGCGCGCCAAGCGCTGTCCTGCCGACCGAGGCTGCGCCGAGCGAAGAACTGCCGCTGCAACCGCTGGCGCAGACCC
TCGCCCAGGCCGAGCGGCGCGCCCTGCAGAGCGCACTGGCCGCCTGCAAGGGCAACCGACGGCGCGCCGCCATGGAGCTC
GGCATCTCCCGCGCCAGCCTCTACAGCAAGCTGCAGCAGCATGGCCTGAGCCAGCGCTGA

Upstream 100 bases:

>100_bases
AACGAAGTGTACTCCCAGCCCTGAGCATGTCCCGGTTGCCTTGCCCGTGGCAGCCGGGGCCAACCATAATCGGCCGCTCC
AGAACGGACCCTGACTGCCC

Downstream 100 bases:

>100_bases
GCGGCCTAACGCGCGGGTTGGCGCCAACCGCGACGCGGCAATGTCGCAGCGGCTGATCTACATTGGAGTCAGGGCCGCCG
ACTCCCGGCGCCGCAACTGG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MSIARDALDNHGLIVGVSPERFRAVAMPLLFDHLNAQCEGTIAVNRQARIVWINDKYAEKVGIRDPSSVLGKEIEEVLPA
SRLREVVESGQPSMLDLMAFGDEHFVVTRIPLRDEDGTLVGALGFVLFDRARHLKPLMSKYTSLQTQLVATQNELAKARR
ARYTIAGFIGNSPAASEIKRQARRAAQLDATVLLRGETGTGKELLAQGIHNLSPRARGPFVAVNVAAIPESLVEAELFGT
APGAFTGADRKARIGKFEVANGGTLFLDEIGDLPLPLQAKLLRVLQEQEVEPLGSNQVKALNVRVIAATHIDLEAKVAAG
QFRDDLYYRLNVLALRVPPLRERASDIPAVVEHLLDDIANRSGQPPMELSPEALALLCAQPWRGNVRELGNLLERAQLSA
DGPQLQAAHLLPLLGEQARSADAPAYASSAPSAVLPTEAAPSEELPLQPLAQTLAQAERRALQSALAACKGNRRRAAMEL
GISRASLYSKLQQHGLSQR

Sequences:

>Translated_499_residues
MSIARDALDNHGLIVGVSPERFRAVAMPLLFDHLNAQCEGTIAVNRQARIVWINDKYAEKVGIRDPSSVLGKEIEEVLPA
SRLREVVESGQPSMLDLMAFGDEHFVVTRIPLRDEDGTLVGALGFVLFDRARHLKPLMSKYTSLQTQLVATQNELAKARR
ARYTIAGFIGNSPAASEIKRQARRAAQLDATVLLRGETGTGKELLAQGIHNLSPRARGPFVAVNVAAIPESLVEAELFGT
APGAFTGADRKARIGKFEVANGGTLFLDEIGDLPLPLQAKLLRVLQEQEVEPLGSNQVKALNVRVIAATHIDLEAKVAAG
QFRDDLYYRLNVLALRVPPLRERASDIPAVVEHLLDDIANRSGQPPMELSPEALALLCAQPWRGNVRELGNLLERAQLSA
DGPQLQAAHLLPLLGEQARSADAPAYASSAPSAVLPTEAAPSEELPLQPLAQTLAQAERRALQSALAACKGNRRRAAMEL
GISRASLYSKLQQHGLSQR
>Mature_498_residues
SIARDALDNHGLIVGVSPERFRAVAMPLLFDHLNAQCEGTIAVNRQARIVWINDKYAEKVGIRDPSSVLGKEIEEVLPAS
RLREVVESGQPSMLDLMAFGDEHFVVTRIPLRDEDGTLVGALGFVLFDRARHLKPLMSKYTSLQTQLVATQNELAKARRA
RYTIAGFIGNSPAASEIKRQARRAAQLDATVLLRGETGTGKELLAQGIHNLSPRARGPFVAVNVAAIPESLVEAELFGTA
PGAFTGADRKARIGKFEVANGGTLFLDEIGDLPLPLQAKLLRVLQEQEVEPLGSNQVKALNVRVIAATHIDLEAKVAAGQ
FRDDLYYRLNVLALRVPPLRERASDIPAVVEHLLDDIANRSGQPPMELSPEALALLCAQPWRGNVRELGNLLERAQLSAD
GPQLQAAHLLPLLGEQARSADAPAYASSAPSAVLPTEAAPSEELPLQPLAQTLAQAERRALQSALAACKGNRRRAAMELG
ISRASLYSKLQQHGLSQR

Specific function: Member Of The Two-Component Regulatory System Atos/Atoc Involved In The Transcriptional Regulation Of The Ato Genes For Acetoacetate Metabolism. Also An Inhibitor Of Polyamine Biosynthesis. [C]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=380, Percent_Identity=41.0526315789474, Blast_Score=269, Evalue=4e-73,
Organism=Escherichia coli, GI87082117, Length=364, Percent_Identity=44.5054945054945, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1790437, Length=327, Percent_Identity=43.7308868501529, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1788905, Length=330, Percent_Identity=44.5454545454545, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI1789087, Length=331, Percent_Identity=43.5045317220544, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1790299, Length=334, Percent_Identity=41.9161676646707, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1786524, Length=364, Percent_Identity=40.3846153846154, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1789233, Length=333, Percent_Identity=37.8378378378378, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI87082152, Length=335, Percent_Identity=40.8955223880597, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1787583, Length=335, Percent_Identity=36.4179104477612, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081872, Length=332, Percent_Identity=38.2530120481928, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI87081858, Length=484, Percent_Identity=30.3719008264463, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789828, Length=215, Percent_Identity=39.5348837209302, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR002078 [H]

Pfam domain/function: PF02954 HTH_8; PF00989 PAS; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54026; Mature: 53894

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIARDALDNHGLIVGVSPERFRAVAMPLLFDHLNAQCEGTIAVNRQARIVWINDKYAEK
CCCCHHHHCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCHHHHH
VGIRDPSSVLGKEIEEVLPASRLREVVESGQPSMLDLMAFGDEHFVVTRIPLRDEDGTLV
CCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEHEECCCCCEEEEEECCCCCCCCHH
GALGFVLFDRARHLKPLMSKYTSLQTQLVATQNELAKARRARYTIAGFIGNSPAASEIKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHH
QARRAAQLDATVLLRGETGTGKELLAQGIHNLSPRARGPFVAVNVAAIPESLVEAELFGT
HHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHCC
APGAFTGADRKARIGKFEVANGGTLFLDEIGDLPLPLQAKLLRVLQEQEVEPLGSNQVKA
CCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEE
LNVRVIAATHIDLEAKVAAGQFRDDLYYRLNVLALRVPPLRERASDIPAVVEHLLDDIAN
EEEEEEEEEEECCEEHHHHHHHHHHHHHEEEEEEEECCCHHHHHCCCHHHHHHHHHHHHC
RSGQPPMELSPEALALLCAQPWRGNVRELGNLLERAQLSADGPQLQAAHLLPLLGEQARS
CCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
ADAPAYASSAPSAVLPTEAAPSEELPLQPLAQTLAQAERRALQSALAACKGNRRRAAMEL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GISRASLYSKLQQHGLSQR
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIARDALDNHGLIVGVSPERFRAVAMPLLFDHLNAQCEGTIAVNRQARIVWINDKYAEK
CCCHHHHCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCHHHHH
VGIRDPSSVLGKEIEEVLPASRLREVVESGQPSMLDLMAFGDEHFVVTRIPLRDEDGTLV
CCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEHEECCCCCEEEEEECCCCCCCCHH
GALGFVLFDRARHLKPLMSKYTSLQTQLVATQNELAKARRARYTIAGFIGNSPAASEIKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHH
QARRAAQLDATVLLRGETGTGKELLAQGIHNLSPRARGPFVAVNVAAIPESLVEAELFGT
HHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHCC
APGAFTGADRKARIGKFEVANGGTLFLDEIGDLPLPLQAKLLRVLQEQEVEPLGSNQVKA
CCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEE
LNVRVIAATHIDLEAKVAAGQFRDDLYYRLNVLALRVPPLRERASDIPAVVEHLLDDIAN
EEEEEEEEEEECCEEHHHHHHHHHHHHHEEEEEEEECCCHHHHHCCCHHHHHHHHHHHHC
RSGQPPMELSPEALALLCAQPWRGNVRELGNLLERAQLSADGPQLQAAHLLPLLGEQARS
CCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
ADAPAYASSAPSAVLPTEAAPSEELPLQPLAQTLAQAERRALQSALAACKGNRRRAAMEL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GISRASLYSKLQQHGLSQR
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA