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The map label for this gene is accA1 [H]

Identifier: 146283541

GI number: 146283541

Start: 3471943

End: 3473853

Strand: Direct

Name: accA1 [H]

Synonym: PST_3216

Alternate gene names: 146283541

Gene position: 3471943-3473853 (Clockwise)

Preceding gene: 146283540

Following gene: 146283542

Centisome position: 76.02

GC content: 68.03

Gene sequence:

>1911_bases
ATGAATCGCCATATCGATACCCTGCTGGTCGCCAACCGCGGCGAGATCGCCTGCCGCGTGATGCGCACCGCCAAGGCCAT
GGGCCTGACCACCGTTGCGGTGCACAGCGCCATCGACGCCAGCGCGCGCCATGCCCGCGAGGCCGATATCCGCATCGACC
TGGGCGGCGCCAAGCCGGCCGAGAGCTACCTGCGCATCGACAAGCTGATCGAGGCGGCCAAGGCCAGCGGCGCCCAGGCG
ATCCACCCGGGCTACGGCTTTCTCTCGGAGAACGCCGAGTTCGCCCGCGCCATCGAACAGGCCGGGCTGATCTTCCTCGG
CCCACCCGCCTCCGCCATCGACGCCATGGGCAGCAAGTCCGCCGCCAAGGCGCTGATGGAAGAAGCCGGCGTGCCGCTGG
TACCGGGCTACCACGGCGAAGCGCAGGACGTGGAAACCTTCCGTGCTGCGGCGGAAAAGATCGGCTACCCGGTGCTGCTC
AAGGCCACCGCCGGTGGCGGCGGCAAGGGCATGAAGGTGGTCGAGCGCGAGGCGGACCTGGCCGAGGCGCTGGCGTCCGC
CCAGCGCGAGGCGCAGTCGTCGTTCGGCGATTCGCGCATGCTGGTCGAGAAATACGTGCTCAAGCCGCGCCATGTGGAAA
TCCAGGTCTTCGCCGACCAGCACGGCAACTGCCTGTACCTCAACGAGCGCGACTGCTCGATCCAGCGCCGCCATCAGAAG
GTGGTCGAAGAGGCCCCTGCCCCCGGCCTGTCCCCCGAGCTGCGCCGTGCCATGGGCGAAGCCGCGGTGAAGGCGGCCAA
GGCCATCGGCTACGTCGGCGCCGGCACCGTGGAATTCCTGCTGGATGCCCGTGGCGAATTCTTCTTCATGGAAATGAACA
CCCGTCTGCAGGTCGAGCACCCGGTCACGGAGGCCATCACCGGCCTCGATCTGGTCGCCTGGCAGATTCGCGTCGCCCGC
GGCGAGCCGCTGCCGATCAGCCAGGAGCAGGTGCCGCTGATCGGCCATGCCATCGAGGTACGGCTGTACGCCGAGGACCC
GGACAACGATTTCCTTCCCGCCACCGGCACCCTCGAGCTCTACCGTGAAGCCGCGGATGGTCCGGGCCGTCGCGTCGACA
GCGGCGTCGCCGAGGGCGATACGGTGTCGCCGTTCTACGATCCGATGCTCGGCAAGCTGATCGCCTGGGGCGAGAACCGC
GAGGAAGCGCGCCTGCGCCTCTTGGCCATGCTCGACGAGACCGCCGTCGGCGGCGTGCGCACCAACCTCGCGTTTCTGCG
CCGCGTCGTCGGCCATCGCGCCTTTGCCCAGGCCGAGCTGGATACCGGCTTTATCCCGCGCCACGAAAGCGAACTGCTGC
GTCCGGCCGGCGAGCTGTCCGATGCCTTCTGGCAGCAGGCTGCCGAGTGCTTCGTGCAGAGCGAACCGACCTCGGTTCGC
GACGACGATGCCCATTCGCCGTGGTCCAAGCGCAGCGGGCTGCGTTTCGGCATGCCGGCGCAGATCAGTCTGCATCTGCA
GTGCAATGGCGAGAGCCGCCGGCTGAAGGTCGACCCGGCAGCGCCGCGGCAGAACGTCCGCACGCCCAGGGCGATCCGCC
AGGGCGATGCACTGTACCTGCAGTGGAACGGCGAATGGCTGGCCGTGCGCGCGTTCGACCCCATCGCCGAAGCCGAGGCC
AGCCACCAGCATCACGGCGGCCTGACCGCGCCAATGAACGGCAGCATCGTGCGTGTACTGGTGGAGGCCGGTCAGCATGT
CGAGGCCGGCACCGCATTGATCGTGCTGGAAGCGATGAAGATGGAACACAGCATCCGCAGCGCCCAGGCTGGCGTGGTCA
AGAGCCTGTTCTGCAGCGAAGGCGAAATGGTCAGCGAAGGCGCGGTGCTGCTGGAGATGGAAGAGGCTTGA

Upstream 100 bases:

>100_bases
CCGAACAGGCCATCGCGCGCCTGCGCACCAGCCCGGAAGGTCAGGAAGGCCTGAGCGCCTTTCTGGAAAAACGCACGCCC
GCCTGGCAGGAGAAGAAGTG

Downstream 100 bases:

>100_bases
CGGATGCACAAGGTGGACAAGGCTTCGCCGTTGTCCACCCTATGCACGAACGCAAGGCCGTAGGGTGGAAAACGCCGCAG
GCTTTTCCACCGGTAGCCGG

Product: acetyl-CoA carboxylase, biotin carboxylase, putative

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MNRHIDTLLVANRGEIACRVMRTAKAMGLTTVAVHSAIDASARHAREADIRIDLGGAKPAESYLRIDKLIEAAKASGAQA
IHPGYGFLSENAEFARAIEQAGLIFLGPPASAIDAMGSKSAAKALMEEAGVPLVPGYHGEAQDVETFRAAAEKIGYPVLL
KATAGGGGKGMKVVEREADLAEALASAQREAQSSFGDSRMLVEKYVLKPRHVEIQVFADQHGNCLYLNERDCSIQRRHQK
VVEEAPAPGLSPELRRAMGEAAVKAAKAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVEHPVTEAITGLDLVAWQIRVAR
GEPLPISQEQVPLIGHAIEVRLYAEDPDNDFLPATGTLELYREAADGPGRRVDSGVAEGDTVSPFYDPMLGKLIAWGENR
EEARLRLLAMLDETAVGGVRTNLAFLRRVVGHRAFAQAELDTGFIPRHESELLRPAGELSDAFWQQAAECFVQSEPTSVR
DDDAHSPWSKRSGLRFGMPAQISLHLQCNGESRRLKVDPAAPRQNVRTPRAIRQGDALYLQWNGEWLAVRAFDPIAEAEA
SHQHHGGLTAPMNGSIVRVLVEAGQHVEAGTALIVLEAMKMEHSIRSAQAGVVKSLFCSEGEMVSEGAVLLEMEEA

Sequences:

>Translated_636_residues
MNRHIDTLLVANRGEIACRVMRTAKAMGLTTVAVHSAIDASARHAREADIRIDLGGAKPAESYLRIDKLIEAAKASGAQA
IHPGYGFLSENAEFARAIEQAGLIFLGPPASAIDAMGSKSAAKALMEEAGVPLVPGYHGEAQDVETFRAAAEKIGYPVLL
KATAGGGGKGMKVVEREADLAEALASAQREAQSSFGDSRMLVEKYVLKPRHVEIQVFADQHGNCLYLNERDCSIQRRHQK
VVEEAPAPGLSPELRRAMGEAAVKAAKAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVEHPVTEAITGLDLVAWQIRVAR
GEPLPISQEQVPLIGHAIEVRLYAEDPDNDFLPATGTLELYREAADGPGRRVDSGVAEGDTVSPFYDPMLGKLIAWGENR
EEARLRLLAMLDETAVGGVRTNLAFLRRVVGHRAFAQAELDTGFIPRHESELLRPAGELSDAFWQQAAECFVQSEPTSVR
DDDAHSPWSKRSGLRFGMPAQISLHLQCNGESRRLKVDPAAPRQNVRTPRAIRQGDALYLQWNGEWLAVRAFDPIAEAEA
SHQHHGGLTAPMNGSIVRVLVEAGQHVEAGTALIVLEAMKMEHSIRSAQAGVVKSLFCSEGEMVSEGAVLLEMEEA
>Mature_636_residues
MNRHIDTLLVANRGEIACRVMRTAKAMGLTTVAVHSAIDASARHAREADIRIDLGGAKPAESYLRIDKLIEAAKASGAQA
IHPGYGFLSENAEFARAIEQAGLIFLGPPASAIDAMGSKSAAKALMEEAGVPLVPGYHGEAQDVETFRAAAEKIGYPVLL
KATAGGGGKGMKVVEREADLAEALASAQREAQSSFGDSRMLVEKYVLKPRHVEIQVFADQHGNCLYLNERDCSIQRRHQK
VVEEAPAPGLSPELRRAMGEAAVKAAKAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVEHPVTEAITGLDLVAWQIRVAR
GEPLPISQEQVPLIGHAIEVRLYAEDPDNDFLPATGTLELYREAADGPGRRVDSGVAEGDTVSPFYDPMLGKLIAWGENR
EEARLRLLAMLDETAVGGVRTNLAFLRRVVGHRAFAQAELDTGFIPRHESELLRPAGELSDAFWQQAAECFVQSEPTSVR
DDDAHSPWSKRSGLRFGMPAQISLHLQCNGESRRLKVDPAAPRQNVRTPRAIRQGDALYLQWNGEWLAVRAFDPIAEAEA
SHQHHGGLTAPMNGSIVRVLVEAGQHVEAGTALIVLEAMKMEHSIRSAQAGVVKSLFCSEGEMVSEGAVLLEMEEA

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=670, Percent_Identity=45.9701492537313, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI189095269, Length=670, Percent_Identity=42.3880597014925, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI65506442, Length=670, Percent_Identity=42.3880597014925, Blast_Score=494, Evalue=1e-139,
Organism=Homo sapiens, GI295821183, Length=647, Percent_Identity=42.6584234930448, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI106049528, Length=489, Percent_Identity=43.3537832310838, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=489, Percent_Identity=43.3537832310838, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=489, Percent_Identity=43.3537832310838, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=32.8740157480315, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=32.8740157480315, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=32.8740157480315, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=32.8740157480315, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=32.8740157480315, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI134142062, Length=507, Percent_Identity=33.3333333333333, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI18105007, Length=267, Percent_Identity=26.9662921348315, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=50.9009009009009, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71987519, Length=670, Percent_Identity=45.2238805970149, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=52.1444695259594, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17562816, Length=486, Percent_Identity=41.9753086419753, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=710, Percent_Identity=26.4788732394366, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=522, Percent_Identity=28.1609195402299, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=522, Percent_Identity=28.1609195402299, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI193204318, Length=187, Percent_Identity=28.3422459893048, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=448, Percent_Identity=42.6339285714286, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=44.2953020134228, Blast_Score=350, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=44.7427293064877, Blast_Score=345, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6324343, Length=725, Percent_Identity=27.7241379310345, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323863, Length=472, Percent_Identity=31.5677966101695, Blast_Score=236, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24651757, Length=666, Percent_Identity=45.3453453453453, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24651759, Length=625, Percent_Identity=44.8, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI281363050, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=451, Percent_Identity=46.7849223946785, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=33.6, Blast_Score=269, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=33.6, Blast_Score=269, Evalue=4e-72,
Organism=Drosophila melanogaster, GI161076407, Length=501, Percent_Identity=33.5329341317365, Blast_Score=269, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24586460, Length=501, Percent_Identity=33.5329341317365, Blast_Score=269, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 68941; Mature: 68941

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRHIDTLLVANRGEIACRVMRTAKAMGLTTVAVHSAIDASARHAREADIRIDLGGAKPA
CCCCEEEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
ESYLRIDKLIEAAKASGAQAIHPGYGFLSENAEFARAIEQAGLIFLGPPASAIDAMGSKS
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHCCCHH
AAKALMEEAGVPLVPGYHGEAQDVETFRAAAEKIGYPVLLKATAGGGGKGMKVVEREADL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHH
AEALASAQREAQSSFGDSRMLVEKYVLKPRHVEIQVFADQHGNCLYLNERDCSIQRRHQK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHH
VVEEAPAPGLSPELRRAMGEAAVKAAKAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVEH
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCEEEECC
PVTEAITGLDLVAWQIRVARGEPLPISQEQVPLIGHAIEVRLYAEDPDNDFLPATGTLEL
CHHHHHHCHHEEEEEEEEECCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHH
YREAADGPGRRVDSGVAEGDTVSPFYDPMLGKLIAWGENREEARLRLLAMLDETAVGGVR
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHH
TNLAFLRRVVGHRAFAQAELDTGFIPRHESELLRPAGELSDAFWQQAAECFVQSEPTSVR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCC
DDDAHSPWSKRSGLRFGMPAQISLHLQCNGESRRLKVDPAAPRQNVRTPRAIRQGDALYL
CCCCCCCCHHCCCCEECCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
QWNGEWLAVRAFDPIAEAEASHQHHGGLTAPMNGSIVRVLVEAGQHVEAGTALIVLEAMK
EECCCEEEEEECCCHHHHHCCHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEHHHHH
MEHSIRSAQAGVVKSLFCSEGEMVSEGAVLLEMEEA
HHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEECC
>Mature Secondary Structure
MNRHIDTLLVANRGEIACRVMRTAKAMGLTTVAVHSAIDASARHAREADIRIDLGGAKPA
CCCCEEEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
ESYLRIDKLIEAAKASGAQAIHPGYGFLSENAEFARAIEQAGLIFLGPPASAIDAMGSKS
HHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHCCCHH
AAKALMEEAGVPLVPGYHGEAQDVETFRAAAEKIGYPVLLKATAGGGGKGMKVVEREADL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHH
AEALASAQREAQSSFGDSRMLVEKYVLKPRHVEIQVFADQHGNCLYLNERDCSIQRRHQK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHH
VVEEAPAPGLSPELRRAMGEAAVKAAKAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVEH
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCEEEECC
PVTEAITGLDLVAWQIRVARGEPLPISQEQVPLIGHAIEVRLYAEDPDNDFLPATGTLEL
CHHHHHHCHHEEEEEEEEECCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHH
YREAADGPGRRVDSGVAEGDTVSPFYDPMLGKLIAWGENREEARLRLLAMLDETAVGGVR
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHH
TNLAFLRRVVGHRAFAQAELDTGFIPRHESELLRPAGELSDAFWQQAAECFVQSEPTSVR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCC
DDDAHSPWSKRSGLRFGMPAQISLHLQCNGESRRLKVDPAAPRQNVRTPRAIRQGDALYL
CCCCCCCCHHCCCCEECCCCEEEEEEEECCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
QWNGEWLAVRAFDPIAEAEASHQHHGGLTAPMNGSIVRVLVEAGQHVEAGTALIVLEAMK
EECCCEEEEEECCCHHHHHCCHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEHHHHH
MEHSIRSAQAGVVKSLFCSEGEMVSEGAVLLEMEEA
HHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]