Click here to switch to the map view.

The map label for this gene is cpg2 [H]

Identifier: 146283270

GI number: 146283270

Start: 3160377

End: 3161678

Strand: Direct

Name: cpg2 [H]

Synonym: PST_2935

Alternate gene names: 146283270

Gene position: 3160377-3161678 (Clockwise)

Preceding gene: 146283265

Following gene: 146283271

Centisome position: 69.19

GC content: 64.9

Gene sequence:

>1302_bases
TTGTGCCAACGGCGAGGCTCTGAGCTTAACCACCCCCCGCGATCCGAGGTCTTCCCGATGCACGTCCGCGCCATCGCCCC
GCTTGCCGCCGCAGTCGCACTCTGCCTGTCGTCTGTGACCGCCGTGGCTGCCGAAATCGAACCCGCCGAATTGTTGAAAC
AGGCGAAAGCCGAACAGCCGGCCTATCTCGAAACCGTCGAGCAGCTGGTAGCCGTGGATACCGGCACCGGCCAGGAAAAG
GGTCTGGCCACGGTCAGCCAGATGCTGGTCGAGCGCCTGCAGGCACTGGGGGCCGAGGTGAGCACCCGACCGGCCACGCC
CTCGGTAGGGGACAATATCGTCGCCACCTTGCAGGGCAAGGGCAGCAAGAACTTCCTGCTGATGATCCACTACGACACCG
TGTTCGCCGAAGGCAGCGCCGCCGAACGCCCGTTCCGCATGGACGGGCAGCGCGCCTACGGGCCGGGTGTCGCCGATGCC
AAGGGCGGCGTGGCGATGATCCTGCATGCGCTCAAGCTGCTGCGCGACCAGCAGTTCGACGACTACGGCACGATCACTGT
GCTGTTCAATCCGGACGAGGAGATGGGCTCGGCGGGCTCGAAGGCACTGATCGCCGAACTCGCCCGCAAGCATGATTACG
TTTTCTCCTACGAACCGCCGGATCGCGACGCGGTAACCACCGCCACCAATGGCATCAACGCCGTGATGCTGGAGGTCAAG
GGCAAATCGTCCCACGCAGGCTCCGCACCGGAAGATGGACGCAACGCCATCCTGGAGCTGGCGCACCAGCTGGTGCAGCT
CAAGGATCTGGGAGATGCGGACAAGGGCACCACGGTCAGCTGGACCATGATCGACGGCGGCGAGAAGCGCAACATCATTC
CCAACAAGGCCAGCGCCGAGGCGGACATGCGTTACTCGGACCTCACTGAGACCGAGCGAGTGCTCGCCGACGGCCAGCGC
ATCATTCAGAACCGGCTGATCGATGACACCCAGGTCGAACTGCGCATCGACAAGGGTCGCCCGCCGCTGGCGGAAAATTC
CGCGTCCAAGCGCCTGGCCGAGACCGCCCAGCACCTGTACAGCGAGATCGACCAGCGCATCGAACCCATCGCCATGCGAT
TCGGCACCGATGCCGGCTATGCCTATGTGCCGGGCAGCGACAAGCCGGCCGTGCTGGAAACCATGGGCGTGGTCGGTGCC
GGGCTGCATTCGGAGGACGAGTACATCGAACTGGCCAGCATCGCGCCGCGACTCTACCTGACCACGGCGATGATCCGCGC
GCTGTCCACCGACGCGCCTTAG

Upstream 100 bases:

>100_bases
GTTCTGCGGATCGTAGGTCGTGGTCAGGGACACCGGGAGTTCTCCGACAAGTGGAAAAGGCAGACCTTAGCACTCTCCAG
GCGAGGTGAAACGCTGAACG

Downstream 100 bases:

>100_bases
CAGCCGGCGAGCGGCTGGCGGTTCCCCTTGCCGGGATGGCGCCACGAAGCGCGGGCCAGACGCCTTGCGCTGCGGCACAA
TCGGCGCTTCGCCAGCCGCC

Product: glutamate carboxypeptidase

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MCQRRGSELNHPPRSEVFPMHVRAIAPLAAAVALCLSSVTAVAAEIEPAELLKQAKAEQPAYLETVEQLVAVDTGTGQEK
GLATVSQMLVERLQALGAEVSTRPATPSVGDNIVATLQGKGSKNFLLMIHYDTVFAEGSAAERPFRMDGQRAYGPGVADA
KGGVAMILHALKLLRDQQFDDYGTITVLFNPDEEMGSAGSKALIAELARKHDYVFSYEPPDRDAVTTATNGINAVMLEVK
GKSSHAGSAPEDGRNAILELAHQLVQLKDLGDADKGTTVSWTMIDGGEKRNIIPNKASAEADMRYSDLTETERVLADGQR
IIQNRLIDDTQVELRIDKGRPPLAENSASKRLAETAQHLYSEIDQRIEPIAMRFGTDAGYAYVPGSDKPAVLETMGVVGA
GLHSEDEYIELASIAPRLYLTTAMIRALSTDAP

Sequences:

>Translated_433_residues
MCQRRGSELNHPPRSEVFPMHVRAIAPLAAAVALCLSSVTAVAAEIEPAELLKQAKAEQPAYLETVEQLVAVDTGTGQEK
GLATVSQMLVERLQALGAEVSTRPATPSVGDNIVATLQGKGSKNFLLMIHYDTVFAEGSAAERPFRMDGQRAYGPGVADA
KGGVAMILHALKLLRDQQFDDYGTITVLFNPDEEMGSAGSKALIAELARKHDYVFSYEPPDRDAVTTATNGINAVMLEVK
GKSSHAGSAPEDGRNAILELAHQLVQLKDLGDADKGTTVSWTMIDGGEKRNIIPNKASAEADMRYSDLTETERVLADGQR
IIQNRLIDDTQVELRIDKGRPPLAENSASKRLAETAQHLYSEIDQRIEPIAMRFGTDAGYAYVPGSDKPAVLETMGVVGA
GLHSEDEYIELASIAPRLYLTTAMIRALSTDAP
>Mature_433_residues
MCQRRGSELNHPPRSEVFPMHVRAIAPLAAAVALCLSSVTAVAAEIEPAELLKQAKAEQPAYLETVEQLVAVDTGTGQEK
GLATVSQMLVERLQALGAEVSTRPATPSVGDNIVATLQGKGSKNFLLMIHYDTVFAEGSAAERPFRMDGQRAYGPGVADA
KGGVAMILHALKLLRDQQFDDYGTITVLFNPDEEMGSAGSKALIAELARKHDYVFSYEPPDRDAVTTATNGINAVMLEVK
GKSSHAGSAPEDGRNAILELAHQLVQLKDLGDADKGTTVSWTMIDGGEKRNIIPNKASAEADMRYSDLTETERVLADGQR
IIQNRLIDDTQVELRIDKGRPPLAENSASKRLAETAQHLYSEIDQRIEPIAMRFGTDAGYAYVPGSDKPAVLETMGVVGA
GLHSEDEYIELASIAPRLYLTTAMIRALSTDAP

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 46623; Mature: 46623

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCQRRGSELNHPPRSEVFPMHVRAIAPLAAAVALCLSSVTAVAAEIEPAELLKQAKAEQP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
AYLETVEQLVAVDTGTGQEKGLATVSQMLVERLQALGAEVSTRPATPSVGDNIVATLQGK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC
GSKNFLLMIHYDTVFAEGSAAERPFRMDGQRAYGPGVADAKGGVAMILHALKLLRDQQFD
CCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DYGTITVLFNPDEEMGSAGSKALIAELARKHDYVFSYEPPDRDAVTTATNGINAVMLEVK
CCCEEEEEECCCHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCEEEEEEEE
GKSSHAGSAPEDGRNAILELAHQLVQLKDLGDADKGTTVSWTMIDGGEKRNIIPNKASAE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCC
ADMRYSDLTETERVLADGQRIIQNRLIDDTQVELRIDKGRPPLAENSASKRLAETAQHLY
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHH
SEIDQRIEPIAMRFGTDAGYAYVPGSDKPAVLETMGVVGAGLHSEDEYIELASIAPRLYL
HHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHEEHHHHCHHHHH
TTAMIRALSTDAP
HHHHHHHHHCCCC
>Mature Secondary Structure
MCQRRGSELNHPPRSEVFPMHVRAIAPLAAAVALCLSSVTAVAAEIEPAELLKQAKAEQP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
AYLETVEQLVAVDTGTGQEKGLATVSQMLVERLQALGAEVSTRPATPSVGDNIVATLQGK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC
GSKNFLLMIHYDTVFAEGSAAERPFRMDGQRAYGPGVADAKGGVAMILHALKLLRDQQFD
CCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DYGTITVLFNPDEEMGSAGSKALIAELARKHDYVFSYEPPDRDAVTTATNGINAVMLEVK
CCCEEEEEECCCHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCEEEEEEEE
GKSSHAGSAPEDGRNAILELAHQLVQLKDLGDADKGTTVSWTMIDGGEKRNIIPNKASAE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCC
ADMRYSDLTETERVLADGQRIIQNRLIDDTQVELRIDKGRPPLAENSASKRLAETAQHLY
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHH
SEIDQRIEPIAMRFGTDAGYAYVPGSDKPAVLETMGVVGAGLHSEDEYIELASIAPRLYL
HHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHEEHHHHCHHHHH
TTAMIRALSTDAP
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]