Click here to switch to the map view.

The map label for this gene is gltT [H]

Identifier: 146283247

GI number: 146283247

Start: 3132840

End: 3134069

Strand: Direct

Name: gltT [H]

Synonym: PST_2912

Alternate gene names: 146283247

Gene position: 3132840-3134069 (Clockwise)

Preceding gene: 146283244

Following gene: 146283248

Centisome position: 68.59

GC content: 65.77

Gene sequence:

>1230_bases
TTGCCCAGCCTGAACCTGCAGATTCTCATCGCGGCCTGCCTGGGTGTGGCCATCGGCTGGCTGACCGGTACGCTGCCGGC
CGATGCGCCCGTGCGCGAAGGCGTGCTCTACGCCAGCACCCTGCTTGGCAGCATCTTCATCGGCCTGCTGAAAATGGTGC
TGATTCCGCTGATCTTCACCTCCATCGTGGTCGGTGTGGCCAACCTGCAGGCGCATCACCAGGTGCATCGGGTGTGGGGC
GGCGCGCTGGTCTACTTCACCCTCACCACCAGTGTGGCGATGCTGGTGGCGCTGATCGCGGCGAACCTGTTCAAGCCGGG
CGCGGGGCTGTCGCTGGACCTGTTCGCCGAGGCGATGAACGACTTCGAGGCGCGCCAGCTGACGCTACCCGAGTTCTTCC
TGCACTTCTTCGCCAACCTGTTCCAGAATCCCTTCGCCGCGCTGGCCAACGGCAGCATCCTGGCCGTCGTGGTGTTCGCC
ATGTTCATCGGCATCGCTCTGGTGGCCGGGGGCGACCGCTACCGCAATATCCTCGTTGTGCTGCAGGAATTTCTCGAGCT
GATGATGCGCATCATTGGCTGGATCATGCGCCTGGCGCCGCTGGGCATCCTCGCCCTGCTGATCAAGCTGGTGGCCGAGC
AGGATGTGGCGCTGCTCAGTGCGGTGGGCGGCTTTATCGTGCTGGTGTTCGCCACCACGCTGTTCCACGGCATCGTGGTG
CTGCCAGGCATTCTCTTTCTCACGACCGGCAGATCGCCGCTGTGGTTCTTCCGCGGCACCCGCGAGGCGCTGATCACGGC
GTTCGCCACCAGCTCCAGCGCGGCGACGTTGCCGATCTCCCTGCGCTGCGCGGAGGACAACCTCAAGGTGCGACCCGGCA
TCGCCGGCTTCGTGCTGCCGCTGGGCGCGACCATGAACATGGACGGCACCGCACTCTACGAAGCGGCGGCTGCGCTGTTC
GTCGCCAATCTGATGGGCATCGAGCTGAGCCTGGCGCAACAGGCGGTGGTGTTCTTCACCGCGATGATCGCGTCCACCGG
CGCACCGGGCATTCCCAGCGCCGGCATGGTGACCATGGTGATGGTGTTGCAGGCGGTCGGCCTGCCGGCCGAGGCGGTGG
CGATCCTGCTGCCGATCGACCGCTTGCTGGATACCGTGCGCACGGCGGTCAACGTCGAGGGCGACATCATTGGCAGCGTG
GTGGTGCAGCGTTTCGCCGACCGCGGCTAG

Upstream 100 bases:

>100_bases
GCTCGGCCTGTATGATGCTGCCGTGCTGCTGCGAACTTTCGCCACACCTTTCTATTCTCTTGCTTGACGTCACCGCCATC
GACCCGAGGAGCCGCCCGCC

Downstream 100 bases:

>100_bases
CCAGCGGCCAAGGTAGGCCCCCGGCGCAGCATCAGTTCGACGATTCCTTGCGGGTCTTGGCGATCAGCTCCGGGTCGATG
CCCCAGCATTCGTCCAGATA

Product: proton-glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MPSLNLQILIAACLGVAIGWLTGTLPADAPVREGVLYASTLLGSIFIGLLKMVLIPLIFTSIVVGVANLQAHHQVHRVWG
GALVYFTLTTSVAMLVALIAANLFKPGAGLSLDLFAEAMNDFEARQLTLPEFFLHFFANLFQNPFAALANGSILAVVVFA
MFIGIALVAGGDRYRNILVVLQEFLELMMRIIGWIMRLAPLGILALLIKLVAEQDVALLSAVGGFIVLVFATTLFHGIVV
LPGILFLTTGRSPLWFFRGTREALITAFATSSSAATLPISLRCAEDNLKVRPGIAGFVLPLGATMNMDGTALYEAAAALF
VANLMGIELSLAQQAVVFFTAMIASTGAPGIPSAGMVTMVMVLQAVGLPAEAVAILLPIDRLLDTVRTAVNVEGDIIGSV
VVQRFADRG

Sequences:

>Translated_409_residues
MPSLNLQILIAACLGVAIGWLTGTLPADAPVREGVLYASTLLGSIFIGLLKMVLIPLIFTSIVVGVANLQAHHQVHRVWG
GALVYFTLTTSVAMLVALIAANLFKPGAGLSLDLFAEAMNDFEARQLTLPEFFLHFFANLFQNPFAALANGSILAVVVFA
MFIGIALVAGGDRYRNILVVLQEFLELMMRIIGWIMRLAPLGILALLIKLVAEQDVALLSAVGGFIVLVFATTLFHGIVV
LPGILFLTTGRSPLWFFRGTREALITAFATSSSAATLPISLRCAEDNLKVRPGIAGFVLPLGATMNMDGTALYEAAAALF
VANLMGIELSLAQQAVVFFTAMIASTGAPGIPSAGMVTMVMVLQAVGLPAEAVAILLPIDRLLDTVRTAVNVEGDIIGSV
VVQRFADRG
>Mature_408_residues
PSLNLQILIAACLGVAIGWLTGTLPADAPVREGVLYASTLLGSIFIGLLKMVLIPLIFTSIVVGVANLQAHHQVHRVWGG
ALVYFTLTTSVAMLVALIAANLFKPGAGLSLDLFAEAMNDFEARQLTLPEFFLHFFANLFQNPFAALANGSILAVVVFAM
FIGIALVAGGDRYRNILVVLQEFLELMMRIIGWIMRLAPLGILALLIKLVAEQDVALLSAVGGFIVLVFATTLFHGIVVL
PGILFLTTGRSPLWFFRGTREALITAFATSSSAATLPISLRCAEDNLKVRPGIAGFVLPLGATMNMDGTALYEAAAALFV
ANLMGIELSLAQQAVVFFTAMIASTGAPGIPSAGMVTMVMVLQAVGLPAEAVAILLPIDRLLDTVRTAVNVEGDIIGSVV
VQRFADRG

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=438, Percent_Identity=35.3881278538813, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI40254478, Length=450, Percent_Identity=33.5555555555556, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI169790839, Length=420, Percent_Identity=33.8095238095238, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI66773030, Length=258, Percent_Identity=41.8604651162791, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI21314632, Length=404, Percent_Identity=33.4158415841584, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI223468564, Length=259, Percent_Identity=40.9266409266409, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI223468566, Length=259, Percent_Identity=40.9266409266409, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI5032093, Length=259, Percent_Identity=40.9266409266409, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI194239697, Length=246, Percent_Identity=41.869918699187, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI262359914, Length=347, Percent_Identity=31.700288184438, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI301601644, Length=161, Percent_Identity=36.0248447204969, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1790514, Length=413, Percent_Identity=31.7191283292978, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=29.951690821256, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1788024, Length=404, Percent_Identity=29.2079207920792, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789473, Length=374, Percent_Identity=25.668449197861, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71996953, Length=411, Percent_Identity=34.0632603406326, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71983106, Length=425, Percent_Identity=34.3529411764706, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71983099, Length=424, Percent_Identity=34.4339622641509, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17537407, Length=423, Percent_Identity=33.806146572104, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI193206505, Length=408, Percent_Identity=34.5588235294118, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17541374, Length=407, Percent_Identity=33.1695331695332, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI193206654, Length=438, Percent_Identity=29.9086757990868, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24583025, Length=443, Percent_Identity=30.2483069977427, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17137668, Length=443, Percent_Identity=30.2483069977427, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24583023, Length=443, Percent_Identity=30.2483069977427, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI281360483, Length=418, Percent_Identity=28.9473684210526, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17137666, Length=418, Percent_Identity=28.9473684210526, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI281360481, Length=418, Percent_Identity=28.9473684210526, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43304; Mature: 43173

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PSLNLQILIAACLGVAIGWLTGTLPADAPVREGVLYASTLLGSIFIGLLKMVLIPLIFT
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIVVGVANLQAHHQVHRVWGGALVYFTLTTSVAMLVALIAANLFKPGAGLSLDLFAEAMN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
DFEARQLTLPEFFLHFFANLFQNPFAALANGSILAVVVFAMFIGIALVAGGDRYRNILVV
HHHHHHCCHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LQEFLELMMRIIGWIMRLAPLGILALLIKLVAEQDVALLSAVGGFIVLVFATTLFHGIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGILFLTTGRSPLWFFRGTREALITAFATSSSAATLPISLRCAEDNLKVRPGIAGFVLP
HHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEEEEEEECCCCEECCCCHHHHHH
LGATMNMDGTALYEAAAALFVANLMGIELSLAQQAVVFFTAMIASTGAPGIPSAGMVTMV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
MVLQAVGLPAEAVAILLPIDRLLDTVRTAVNVEGDIIGSVVVQRFADRG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]