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The map label for this gene is ppiA [H]

Identifier: 146283024

GI number: 146283024

Start: 2910496

End: 2911110

Strand: Direct

Name: ppiA [H]

Synonym: PST_2685

Alternate gene names: 146283024

Gene position: 2910496-2911110 (Clockwise)

Preceding gene: 146283023

Following gene: 146283025

Centisome position: 63.72

GC content: 61.63

Gene sequence:

>615_bases
ATGCCGGACAGGCCAACTCGCTGGCCGGCTGACCGCTTTCCCCAACATCAGGAAACCATCATGTTGAAACGCATCGCCCT
CACCGCCTGTTCCGTACTGCTGGCCGGCAACCTGCTCGCTGCCGAAAACCCTCGCGTGCTGCTGACCACCAGCCTGGGTG
AGATCGAACTGGAGCTCGAGGCGGAAAAGGCACCGATCAGCGTCGAGAACTTCCTCGGCTACGTTGATAGCGGTTTCTAC
GACGGCACCGTGTTTCACCGCGTCATTCCCGGGTTCATGATCCAGGGTGGCGGCTTCGGCGAAGGGCTGAACCAGAAGCC
CACCAAGGCGCCGATCAAGAACGAGGCCGACAACGGCCTGCACAACGTTCGCGGCACCGTAGCCATGGCACGTACGCAGA
ACGTCAACTCGGCAACCAGCCAGTTCTTCATCAACCACCGCGACAACGACTTCCTCGACCACGGCAGCCGCGATTTCGGC
TACGCGGTGTTCGGCAAGGTGGTACGCGGCATGGAGGTCGTCGACCAGATCGCCCAGGTCCCCACCGGCAACCGCGCCAT
GATGCAGAACGTGCCGCTGACTCCGGTGAAGATCATCACCGCGAAGAAACTCTGA

Upstream 100 bases:

>100_bases
CAAGGCAGCATTCGCCGGCCGCTGTTCTATCTCTACACTAACCACGACAAACCGCTCGGGCCGGCTACCCGGATTCTCAT
CGAGCTGATCAAGACGTACG

Downstream 100 bases:

>100_bases
TCCCCGAAGGGCCGGTTCACCGGCCCTTCGCATTTACGGCGGCGCGTATCCCGCTGCCGCCATCGTGCGAAACCCTCAAC
CGACAGGAGATCGCGATATG

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MPDRPTRWPADRFPQHQETIMLKRIALTACSVLLAGNLLAAENPRVLLTTSLGEIELELEAEKAPISVENFLGYVDSGFY
DGTVFHRVIPGFMIQGGGFGEGLNQKPTKAPIKNEADNGLHNVRGTVAMARTQNVNSATSQFFINHRDNDFLDHGSRDFG
YAVFGKVVRGMEVVDQIAQVPTGNRAMMQNVPLTPVKIITAKKL

Sequences:

>Translated_204_residues
MPDRPTRWPADRFPQHQETIMLKRIALTACSVLLAGNLLAAENPRVLLTTSLGEIELELEAEKAPISVENFLGYVDSGFY
DGTVFHRVIPGFMIQGGGFGEGLNQKPTKAPIKNEADNGLHNVRGTVAMARTQNVNSATSQFFINHRDNDFLDHGSRDFG
YAVFGKVVRGMEVVDQIAQVPTGNRAMMQNVPLTPVKIITAKKL
>Mature_203_residues
PDRPTRWPADRFPQHQETIMLKRIALTACSVLLAGNLLAAENPRVLLTTSLGEIELELEAEKAPISVENFLGYVDSGFYD
GTVFHRVIPGFMIQGGGFGEGLNQKPTKAPIKNEADNGLHNVRGTVAMARTQNVNSATSQFFINHRDNDFLDHGSRDFGY
AVFGKVVRGMEVVDQIAQVPTGNRAMMQNVPLTPVKIITAKKL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=156, Percent_Identity=37.8205128205128, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI64276486, Length=130, Percent_Identity=39.2307692307692, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI24308049, Length=168, Percent_Identity=34.5238095238095, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI7706339, Length=166, Percent_Identity=34.3373493975904, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI5454154, Length=172, Percent_Identity=33.7209302325581, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI22547215, Length=138, Percent_Identity=36.231884057971, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI22547212, Length=138, Percent_Identity=36.231884057971, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7657473, Length=138, Percent_Identity=36.231884057971, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI310110104, Length=153, Percent_Identity=35.9477124183007, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI10863927, Length=163, Percent_Identity=34.3558282208589, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310129267, Length=161, Percent_Identity=32.9192546583851, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310120620, Length=161, Percent_Identity=32.9192546583851, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789763, Length=187, Percent_Identity=62.0320855614973, Blast_Score=236, Evalue=8e-64,
Organism=Escherichia coli, GI1786736, Length=156, Percent_Identity=56.4102564102564, Blast_Score=167, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17532641, Length=165, Percent_Identity=34.5454545454545, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=178, Percent_Identity=37.0786516853933, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=144, Percent_Identity=35.4166666666667, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=35.4166666666667, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=164, Percent_Identity=34.1463414634146, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=148, Percent_Identity=36.4864864864865, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17532643, Length=188, Percent_Identity=31.9148936170213, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=181, Percent_Identity=33.1491712707182, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=132, Percent_Identity=34.8484848484849, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=207, Percent_Identity=32.8502415458937, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17986117, Length=161, Percent_Identity=36.6459627329193, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922376, Length=143, Percent_Identity=32.1678321678322, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922912, Length=158, Percent_Identity=34.8101265822785, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24652460, Length=147, Percent_Identity=31.9727891156463, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24586038, Length=187, Percent_Identity=30.4812834224599, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17647301, Length=149, Percent_Identity=36.241610738255, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45549139, Length=147, Percent_Identity=36.734693877551, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664125, Length=148, Percent_Identity=35.8108108108108, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357783, Length=148, Percent_Identity=35.8108108108108, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 22434; Mature: 22303

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDRPTRWPADRFPQHQETIMLKRIALTACSVLLAGNLLAAENPRVLLTTSLGEIELELE
CCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCEEEEEEE
AEKAPISVENFLGYVDSGFYDGTVFHRVIPGFMIQGGGFGEGLNQKPTKAPIKNEADNGL
CCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCH
HNVRGTVAMARTQNVNSATSQFFINHRDNDFLDHGSRDFGYAVFGKVVRGMEVVDQIAQV
HHHHHHEEEEECCCCCCHHHEEEEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
PTGNRAMMQNVPLTPVKIITAKKL
CCCCHHHHCCCCCCCEEEEEECCC
>Mature Secondary Structure 
PDRPTRWPADRFPQHQETIMLKRIALTACSVLLAGNLLAAENPRVLLTTSLGEIELELE
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCEEEEEEE
AEKAPISVENFLGYVDSGFYDGTVFHRVIPGFMIQGGGFGEGLNQKPTKAPIKNEADNGL
CCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCH
HNVRGTVAMARTQNVNSATSQFFINHRDNDFLDHGSRDFGYAVFGKVVRGMEVVDQIAQV
HHHHHHEEEEECCCCCCHHHEEEEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
PTGNRAMMQNVPLTPVKIITAKKL
CCCCHHHHCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]