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The map label for this gene is wzc [H]

Identifier: 146282834

GI number: 146282834

Start: 2718505

End: 2720721

Strand: Direct

Name: wzc [H]

Synonym: PST_2493

Alternate gene names: 146282834

Gene position: 2718505-2720721 (Clockwise)

Preceding gene: 146282833

Following gene: 146282835

Centisome position: 59.52

GC content: 61.98

Gene sequence:

>2217_bases
ATGACAACCATGCCCCGCCCAATCTATGAAACCAAAGAGGACAAGGACATCGACCTGGCCCACCTCTTTGACACCTTCAT
CAACAACCGCATGCTCATTCTTGGCATCACCGGCTTCTTCGCGGCCCTGGGCATCGCCTATGCGCTGCTCGCAACACCGG
TCTATCTCGCCAGCGCGATGATCCAGATCGAACCCAAGAGCGGCTTGCCGAGCCTGACCGACGTGGTCAACAACAACCCG
CCGGTATCGCCGGCACAGACCGAGATCGCGCTGCTCAAGTCGCGCTCGGTGGTGGGTGGCGCGGTCAGCAACCTGAACCT
CGACATCATCATCAAGCCCCACCACTTCCCGATCATCGGCGGCTTCATGGCCCGGCGCTTCGAGCCGACCGAAGAAGGCG
AGCTGGGCTGGTACCCGACCGGCCTCGGCGCTTACGCCTGGGGTGGCGAAGTGCTGAAGGTCACCCAAATGGAAGTACCG
GACAAGGTGCATGGCAAGGAGCTGACGCTGGAAGCCGCCGAGAACAACGGCTTCATCCTGCGCGATGAAGACGGTGAAGT
CGTGGTACAGGGCGTCACCGGCGAGCCGGTAGAGAATGAAGGCTACCGCGTCACCGTGGCCGAGCTGAACGCTCGCCCCG
GCACCACCTTCACCGTGATCAAGAATCGCACCTACAACACCACGGAGAGCTATCAGCAGCGCCTGTCCGCCGCCGAGCGC
GGCAAGCAGTCGGGCATCGTCAACGTGACCCTGGAAGACCCGGATCCGCAACACGCCATCCGCGTGCTGGAGGAAGTAGC
CAACCGCTACGTCGATCAGAACGTTGCCCGTAACGCTGCAGAAGCGACCCAGAGCCTGGAATTCCTCAACGAGCAGGTTC
CGGCCGTACGCCGCAACCTCGAGGCTGCCCAGACCGCGCTGAACAAGTACCAGACCGGCTCCCGCTCGGTGGATATCACC
GCAGAAACCCAGTCGGTGCTCGATCGCATCGTCGACCTGGAAAAGCAGATCTCCGAGCAGAACCTCAAGCGCACCGAGAT
GGAACGTCGCTTCACTCGTCAGCACCCGAACTTCCAGGCACTGATGAACCAGATCAACCAGCTGCAGATGCAGAAGGACC
AGCTGGAGAAGCAGATCGACACCCTGCCGTCGACCCAGCAGGAACTGCTGCGCCTGACCCGCGACGTGGAAGTTTCCTCG
GAAACCTACTCCATGCTGCTGAACAAGACCCAGGAGCTGGACATCATCCGCGCCGGCACCGTGGGTAATGTGCGCATCAT
CGACCACGCCGCGGCAGACCTGGAAAACCCGGTCAAGCCGAACAAGCCGCTGGTCGTCATCGTCGCCACCCTGCTCGGCG
CCCTGCTCGCCACCGCCTTCGTCTATGTGCGTGAAGCACTCAAGCGCGGCGTGGAGAACCCGGAGGACATCGAACGCACC
GGCACCCCGGTCTACGCCTCGATTCCCTTCACCGAGAAGCAGGCCACGCTGGAGAAGCGCCTGGCCAACTTCAAGCGCGA
CAAGAGCACTGCATCCTACCTGCTGACCATCAACGACCCGGCCGACCTCGCCACCGAGGCCATGCGCAGCCTGCGCACCA
GCCTGCACTTCGCGATGATCGAGGCCAAGAACAACGTCCTGATGATCACCGGTCCGAGCCCGGCAGTCGGCAAGTCCTTC
GTCACCACCAACCTGGCCGCCGTTGTCGCTCAGTCCGGCAAGCGTGTACTGCTGATCGACGCCGACATGCGCAAGGGTTA
CCTGCACAAGGTCATGCGTTGCGATGGCGACAAGGGTCTGTCCGATATCCTCTCCGGTCGCATCACCCTGTTCGATGCCA
TCCAGAAGACCCAGCTGAACAACCTGCACGTGATCACCCATGGCCAGTTGCCGCCGAACCCGTCGGAACTGCTGATGCAC
GAGAACTTCTCGCGCTTCGTCAAGGAGATCAGCCACATGTACGACCTGGTGATCTTCGATACCCCGCCGATCCTGGCGGT
CACCGACGCCGCGCTGGTCGGCAGCCAGGCAGGTACCACGCTGATGGTCACCCGCTACGGCCTGAACGGCCTGAAGGAAA
TCGAAGCGGCCAAGCGGCGCCTCGAGCAGAACGGCCTGCTGGTCAAGGGCGTGATCTTCAACGCCGTGGTCCGCAAGGCA
TCCACCTATGGCGAGTACGGCTACTACCAGTACGAATACGCCAGCACCAATAAGTAA

Upstream 100 bases:

>100_bases
CCCTACCGCCAATCCAAACCCGCTTTTGAACATGTCCACAATCTCCTGACGAAATCCGTCGAGAGCTGGCTTCCTTACCT
GAAATGAAGAAGGAACTTCG

Downstream 100 bases:

>100_bases
GTGATTCGCACGGCGGCGGGGTCAACCCCGTCGCCATGCCGAACGCCGCCCCATTTTTTTTCGTATCTGCCCGACACTGA
CCTTGCGAGCGTCAGCGGAC

Product: tyrosine-protein kinase

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 738; Mature: 737

Protein sequence:

>738_residues
MTTMPRPIYETKEDKDIDLAHLFDTFINNRMLILGITGFFAALGIAYALLATPVYLASAMIQIEPKSGLPSLTDVVNNNP
PVSPAQTEIALLKSRSVVGGAVSNLNLDIIIKPHHFPIIGGFMARRFEPTEEGELGWYPTGLGAYAWGGEVLKVTQMEVP
DKVHGKELTLEAAENNGFILRDEDGEVVVQGVTGEPVENEGYRVTVAELNARPGTTFTVIKNRTYNTTESYQQRLSAAER
GKQSGIVNVTLEDPDPQHAIRVLEEVANRYVDQNVARNAAEATQSLEFLNEQVPAVRRNLEAAQTALNKYQTGSRSVDIT
AETQSVLDRIVDLEKQISEQNLKRTEMERRFTRQHPNFQALMNQINQLQMQKDQLEKQIDTLPSTQQELLRLTRDVEVSS
ETYSMLLNKTQELDIIRAGTVGNVRIIDHAAADLENPVKPNKPLVVIVATLLGALLATAFVYVREALKRGVENPEDIERT
GTPVYASIPFTEKQATLEKRLANFKRDKSTASYLLTINDPADLATEAMRSLRTSLHFAMIEAKNNVLMITGPSPAVGKSF
VTTNLAAVVAQSGKRVLLIDADMRKGYLHKVMRCDGDKGLSDILSGRITLFDAIQKTQLNNLHVITHGQLPPNPSELLMH
ENFSRFVKEISHMYDLVIFDTPPILAVTDAALVGSQAGTTLMVTRYGLNGLKEIEAAKRRLEQNGLLVKGVIFNAVVRKA
STYGEYGYYQYEYASTNK

Sequences:

>Translated_738_residues
MTTMPRPIYETKEDKDIDLAHLFDTFINNRMLILGITGFFAALGIAYALLATPVYLASAMIQIEPKSGLPSLTDVVNNNP
PVSPAQTEIALLKSRSVVGGAVSNLNLDIIIKPHHFPIIGGFMARRFEPTEEGELGWYPTGLGAYAWGGEVLKVTQMEVP
DKVHGKELTLEAAENNGFILRDEDGEVVVQGVTGEPVENEGYRVTVAELNARPGTTFTVIKNRTYNTTESYQQRLSAAER
GKQSGIVNVTLEDPDPQHAIRVLEEVANRYVDQNVARNAAEATQSLEFLNEQVPAVRRNLEAAQTALNKYQTGSRSVDIT
AETQSVLDRIVDLEKQISEQNLKRTEMERRFTRQHPNFQALMNQINQLQMQKDQLEKQIDTLPSTQQELLRLTRDVEVSS
ETYSMLLNKTQELDIIRAGTVGNVRIIDHAAADLENPVKPNKPLVVIVATLLGALLATAFVYVREALKRGVENPEDIERT
GTPVYASIPFTEKQATLEKRLANFKRDKSTASYLLTINDPADLATEAMRSLRTSLHFAMIEAKNNVLMITGPSPAVGKSF
VTTNLAAVVAQSGKRVLLIDADMRKGYLHKVMRCDGDKGLSDILSGRITLFDAIQKTQLNNLHVITHGQLPPNPSELLMH
ENFSRFVKEISHMYDLVIFDTPPILAVTDAALVGSQAGTTLMVTRYGLNGLKEIEAAKRRLEQNGLLVKGVIFNAVVRKA
STYGEYGYYQYEYASTNK
>Mature_737_residues
TTMPRPIYETKEDKDIDLAHLFDTFINNRMLILGITGFFAALGIAYALLATPVYLASAMIQIEPKSGLPSLTDVVNNNPP
VSPAQTEIALLKSRSVVGGAVSNLNLDIIIKPHHFPIIGGFMARRFEPTEEGELGWYPTGLGAYAWGGEVLKVTQMEVPD
KVHGKELTLEAAENNGFILRDEDGEVVVQGVTGEPVENEGYRVTVAELNARPGTTFTVIKNRTYNTTESYQQRLSAAERG
KQSGIVNVTLEDPDPQHAIRVLEEVANRYVDQNVARNAAEATQSLEFLNEQVPAVRRNLEAAQTALNKYQTGSRSVDITA
ETQSVLDRIVDLEKQISEQNLKRTEMERRFTRQHPNFQALMNQINQLQMQKDQLEKQIDTLPSTQQELLRLTRDVEVSSE
TYSMLLNKTQELDIIRAGTVGNVRIIDHAAADLENPVKPNKPLVVIVATLLGALLATAFVYVREALKRGVENPEDIERTG
TPVYASIPFTEKQATLEKRLANFKRDKSTASYLLTINDPADLATEAMRSLRTSLHFAMIEAKNNVLMITGPSPAVGKSFV
TTNLAAVVAQSGKRVLLIDADMRKGYLHKVMRCDGDKGLSDILSGRITLFDAIQKTQLNNLHVITHGQLPPNPSELLMHE
NFSRFVKEISHMYDLVIFDTPPILAVTDAALVGSQAGTTLMVTRYGLNGLKEIEAAKRRLEQNGLLVKGVIFNAVVRKAS
TYGEYGYYQYEYASTNK

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=730, Percent_Identity=42.6027397260274, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1787216, Length=734, Percent_Identity=41.008174386921, Blast_Score=557, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 81823; Mature: 81692

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTMPRPIYETKEDKDIDLAHLFDTFINNRMLILGITGFFAALGIAYALLATPVYLASAM
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHEE
IQIEPKSGLPSLTDVVNNNPPVSPAQTEIALLKSRSVVGGAVSNLNLDIIIKPHHFPIIG
EEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHCCHHCCCCEEEEECCCCCCCHH
GFMARRFEPTEEGELGWYPTGLGAYAWGGEVLKVTQMEVPDKVHGKELTLEAAENNGFIL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCEEE
RDEDGEVVVQGVTGEPVENEGYRVTVAELNARPGTTFTVIKNRTYNTTESYQQRLSAAER
ECCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHC
GKQSGIVNVTLEDPDPQHAIRVLEEVANRYVDQNVARNAAEATQSLEFLNEQVPAVRRNL
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAAQTALNKYQTGSRSVDITAETQSVLDRIVDLEKQISEQNLKRTEMERRFTRQHPNFQA
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LMNQINQLQMQKDQLEKQIDTLPSTQQELLRLTRDVEVSSETYSMLLNKTQELDIIRAGT
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCHHHCEEEEECC
VGNVRIIDHAAADLENPVKPNKPLVVIVATLLGALLATAFVYVREALKRGVENPEDIERT
CCCEEEEECHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
GTPVYASIPFTEKQATLEKRLANFKRDKSTASYLLTINDPADLATEAMRSLRTSLHFAMI
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHEEEE
EAKNNVLMITGPSPAVGKSFVTTNLAAVVAQSGKRVLLIDADMRKGYLHKVMRCDGDKGL
EECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCH
SDILSGRITLFDAIQKTQLNNLHVITHGQLPPNPSELLMHENFSRFVKEISHMYDLVIFD
HHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEC
TPPILAVTDAALVGSQAGTTLMVTRYGLNGLKEIEAAKRRLEQNGLLVKGVIFNAVVRKA
CCCCEEEECHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
STYGEYGYYQYEYASTNK
HCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
TTMPRPIYETKEDKDIDLAHLFDTFINNRMLILGITGFFAALGIAYALLATPVYLASAM
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHEE
IQIEPKSGLPSLTDVVNNNPPVSPAQTEIALLKSRSVVGGAVSNLNLDIIIKPHHFPIIG
EEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCHHCCHHCCCCEEEEECCCCCCCHH
GFMARRFEPTEEGELGWYPTGLGAYAWGGEVLKVTQMEVPDKVHGKELTLEAAENNGFIL
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCEEE
RDEDGEVVVQGVTGEPVENEGYRVTVAELNARPGTTFTVIKNRTYNTTESYQQRLSAAER
ECCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHC
GKQSGIVNVTLEDPDPQHAIRVLEEVANRYVDQNVARNAAEATQSLEFLNEQVPAVRRNL
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAAQTALNKYQTGSRSVDITAETQSVLDRIVDLEKQISEQNLKRTEMERRFTRQHPNFQA
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LMNQINQLQMQKDQLEKQIDTLPSTQQELLRLTRDVEVSSETYSMLLNKTQELDIIRAGT
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCHHHCEEEEECC
VGNVRIIDHAAADLENPVKPNKPLVVIVATLLGALLATAFVYVREALKRGVENPEDIERT
CCCEEEEECHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
GTPVYASIPFTEKQATLEKRLANFKRDKSTASYLLTINDPADLATEAMRSLRTSLHFAMI
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHEEEE
EAKNNVLMITGPSPAVGKSFVTTNLAAVVAQSGKRVLLIDADMRKGYLHKVMRCDGDKGL
EECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCH
SDILSGRITLFDAIQKTQLNNLHVITHGQLPPNPSELLMHENFSRFVKEISHMYDLVIFD
HHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEC
TPPILAVTDAALVGSQAGTTLMVTRYGLNGLKEIEAAKRRLEQNGLLVKGVIFNAVVRKA
CCCCEEEECHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
STYGEYGYYQYEYASTNK
HCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]