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The map label for this gene is cyaA [H]

Identifier: 146282802

GI number: 146282802

Start: 2686450

End: 2687838

Strand: Direct

Name: cyaA [H]

Synonym: PST_2461

Alternate gene names: 146282802

Gene position: 2686450-2687838 (Clockwise)

Preceding gene: 146282801

Following gene: 146282803

Centisome position: 58.82

GC content: 62.35

Gene sequence:

>1389_bases
ATGACTTCCACCAGGGTTGAGCGCCGCAATGGCCTCGCCACTCGCCCGTTGCGCGAGTACTACTCCCGCGTGCTCGCCTA
TCTGATCTGCGCCGCGACCATTGCCGCTGGTACCTACATCCAGTACTTCTCGATGGACCTGCTGTGGATGGTGCCGTACG
CCCTGCTCTATCCGCACCTGGCCTATCACCTGAGCTACCGCTTCAAGCGCGATCATCCGGAACGCACGGCACAGGTCCTG
CTCTGCCTGGACGCCATGAACGCCGGTGCCGGCATCCTGTTGCTCGGCTTCTCCATCGTACCCAGCCTGATGTTCCTGCT
GACCCTCAGCTTCAGCGCCCTGGTGAGCGGCAGCCTGCGCAACCTGGCCATGGCGCTGCTCTGCGTGGGCATCGGCATCG
GCCTGGCATACCCCGTGGTGAGTCTGCATTACCAGGGCGTCACCCCGCCGCTGGTCTCGCTGGTCAGCATTCTGTTCACA
ACATTCTATGTCTGCGCCACCGCCTATTTCGTTCACCAGCAAGGCGTGCGCCTGGCGCTGGCGCGCAAGGAAATCGAACT
GGAACAGGCCAAGGCCGCGCGCCTGGCCCGCAACCTGGCCAAGTATCTGTCGCCACAGGTCTGGGAATCGATCTTCACCG
GCAAGCGCAGCGTTCGCCTGGAAACCCAGCGCAAGCGGCTGACGGTGTTCTTCTCCGACATCAAGGGCTTCACCGAGCTC
TCCGAAGAGCTGGAAGCAGAAGCCCTGACCGACCTGCTCAACAACTACCTCAATGAAATGTCGAAGATCGCCCTCAAGTA
CGGCGGCACCATCGACAAGTTCGTCGGCGACTGCGTAATGGTGTTCTTCGGCGACCCGTCCAGCCAGGGCGCCAAGAAAG
ACGCGGTGGCGGCCGTTTCCATGGCCATTGCCATGCGCAAGCACATGAAGGTACTGCGCCAGCAATGGCGCGCGCGGGGC
ATCACCCGCCCGCTGGAAATCCGCATGGGCGTCAACACCGGCTACTGCACGGTGGGCAACTTCGGTGCCGACACCCGCAT
GGACTACACCATCATCGGCCGCGAAGTGAACCTGGCCAGCCGCCTGGAAAGCGCGGCCGAGGCCAGCGAGATCCTGGTCT
CTCACGAAACCTATTCGCTGGTAAAGGACGTGATCATGTGCCGCGACAAGGGGCAGATCGCGGTCAAGGGTTTCTCCCGT
CCGGTACAGATCTACCAGGTGGTGGACTTCCGCCGCGACCTGGGCGCGACCAATAGCTTCGTCGAGCACGAGCTGCCAGG
GTTCTCCATGTACCTGGACACCAACGGCGTGCAGAACTTCGACAAGGAGCGGGTAATCCAGGCGCTGCAACAGGCCGCCG
AGAAACTCCGCGACAAGGTCATCCTCTGA

Upstream 100 bases:

>100_bases
GAGCCACCATCATCGATGCCTGGCGCCGATCCCGCCCGGTGGCAGTCTGCAAGGCGCATAGAAAAAGGCGTCGATAAATC
TACCAGGGATCGTACGCATA

Downstream 100 bases:

>100_bases
TTTACTGATTGGCGGGCTGGCAGCGTGCGGTTACCGTGTCCGGTCCGCAGAGCCCGCTTTCGAGATCGCCGATGCTATCG
CTGCGCAACTACCAGCACGA

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTSTRVERRNGLATRPLREYYSRVLAYLICAATIAAGTYIQYFSMDLLWMVPYALLYPHLAYHLSYRFKRDHPERTAQVL
LCLDAMNAGAGILLLGFSIVPSLMFLLTLSFSALVSGSLRNLAMALLCVGIGIGLAYPVVSLHYQGVTPPLVSLVSILFT
TFYVCATAYFVHQQGVRLALARKEIELEQAKAARLARNLAKYLSPQVWESIFTGKRSVRLETQRKRLTVFFSDIKGFTEL
SEELEAEALTDLLNNYLNEMSKIALKYGGTIDKFVGDCVMVFFGDPSSQGAKKDAVAAVSMAIAMRKHMKVLRQQWRARG
ITRPLEIRMGVNTGYCTVGNFGADTRMDYTIIGREVNLASRLESAAEASEILVSHETYSLVKDVIMCRDKGQIAVKGFSR
PVQIYQVVDFRRDLGATNSFVEHELPGFSMYLDTNGVQNFDKERVIQALQQAAEKLRDKVIL

Sequences:

>Translated_462_residues
MTSTRVERRNGLATRPLREYYSRVLAYLICAATIAAGTYIQYFSMDLLWMVPYALLYPHLAYHLSYRFKRDHPERTAQVL
LCLDAMNAGAGILLLGFSIVPSLMFLLTLSFSALVSGSLRNLAMALLCVGIGIGLAYPVVSLHYQGVTPPLVSLVSILFT
TFYVCATAYFVHQQGVRLALARKEIELEQAKAARLARNLAKYLSPQVWESIFTGKRSVRLETQRKRLTVFFSDIKGFTEL
SEELEAEALTDLLNNYLNEMSKIALKYGGTIDKFVGDCVMVFFGDPSSQGAKKDAVAAVSMAIAMRKHMKVLRQQWRARG
ITRPLEIRMGVNTGYCTVGNFGADTRMDYTIIGREVNLASRLESAAEASEILVSHETYSLVKDVIMCRDKGQIAVKGFSR
PVQIYQVVDFRRDLGATNSFVEHELPGFSMYLDTNGVQNFDKERVIQALQQAAEKLRDKVIL
>Mature_461_residues
TSTRVERRNGLATRPLREYYSRVLAYLICAATIAAGTYIQYFSMDLLWMVPYALLYPHLAYHLSYRFKRDHPERTAQVLL
CLDAMNAGAGILLLGFSIVPSLMFLLTLSFSALVSGSLRNLAMALLCVGIGIGLAYPVVSLHYQGVTPPLVSLVSILFTT
FYVCATAYFVHQQGVRLALARKEIELEQAKAARLARNLAKYLSPQVWESIFTGKRSVRLETQRKRLTVFFSDIKGFTELS
EELEAEALTDLLNNYLNEMSKIALKYGGTIDKFVGDCVMVFFGDPSSQGAKKDAVAAVSMAIAMRKHMKVLRQQWRARGI
TRPLEIRMGVNTGYCTVGNFGADTRMDYTIIGREVNLASRLESAAEASEILVSHETYSLVKDVIMCRDKGQIAVKGFSRP
VQIYQVVDFRRDLGATNSFVEHELPGFSMYLDTNGVQNFDKERVIQALQQAAEKLRDKVIL

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI134152694, Length=246, Percent_Identity=28.8617886178862, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI148536830, Length=160, Percent_Identity=27.5, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4504217, Length=203, Percent_Identity=29.064039408867, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI167830411, Length=187, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17534659, Length=217, Percent_Identity=29.4930875576037, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534657, Length=219, Percent_Identity=28.7671232876712, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71989822, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989805, Length=215, Percent_Identity=26.5116279069767, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534649, Length=219, Percent_Identity=28.7671232876712, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534655, Length=219, Percent_Identity=28.310502283105, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585694, Length=303, Percent_Identity=21.1221122112211, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62473752, Length=221, Percent_Identity=25.7918552036199, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137448, Length=221, Percent_Identity=25.7918552036199, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076872, Length=173, Percent_Identity=29.4797687861272, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574512, Length=173, Percent_Identity=29.4797687861272, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI62484477, Length=270, Percent_Identity=24.0740740740741, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62484298, Length=270, Percent_Identity=24.0740740740741, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116008008, Length=270, Percent_Identity=24.0740740740741, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 51748; Mature: 51617

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTRVERRNGLATRPLREYYSRVLAYLICAATIAAGTYIQYFSMDLLWMVPYALLYPHL
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYHLSYRFKRDHPERTAQVLLCLDAMNAGAGILLLGFSIVPSLMFLLTLSFSALVSGSLR
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLAMALLCVGIGIGLAYPVVSLHYQGVTPPLVSLVSILFTTFYVCATAYFVHQQGVRLAL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ARKEIELEQAKAARLARNLAKYLSPQVWESIFTGKRSVRLETQRKRLTVFFSDIKGFTEL
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHH
SEELEAEALTDLLNNYLNEMSKIALKYGGTIDKFVGDCVMVFFGDPSSQGAKKDAVAAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCEEEEEECCCCCCCCHHHHHHHHH
MAIAMRKHMKVLRQQWRARGITRPLEIRMGVNTGYCTVGNFGADTRMDYTIIGREVNLAS
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCCEEEEECCCCCHHH
RLESAAEASEILVSHETYSLVKDVIMCRDKGQIAVKGFSRPVQIYQVVDFRRDLGATNSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCHH
VEHELPGFSMYLDTNGVQNFDKERVIQALQQAAEKLRDKVIL
HHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSTRVERRNGLATRPLREYYSRVLAYLICAATIAAGTYIQYFSMDLLWMVPYALLYPHL
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]