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The map label for this gene is cpxR [H]

Identifier: 146282793

GI number: 146282793

Start: 2678380

End: 2679057

Strand: Direct

Name: cpxR [H]

Synonym: PST_2452

Alternate gene names: 146282793

Gene position: 2678380-2679057 (Clockwise)

Preceding gene: 146282792

Following gene: 146282794

Centisome position: 58.64

GC content: 67.11

Gene sequence:

>678_bases
ATGAGCGAATTGCTGCTTATCGATGATGATCAGGAGCTGTGCGAGCTGCTGATCAGCTGGCTCGCACAGGAAGGCTTCGT
CGCCCATGCCTGCCATGACGGGCAGAGCGCGAAGCAGGCGTTGGCGCAGTATCAGCCCGCCGCGGTAGTACTGGATGTGA
TGCTGCCGGACGGCAGCGGCCTTGAACTGCTCAAGCAGCTGCGCAGCGAACATCCGGACCTCCCGGTGTTGATGCTGTCC
GGTCGTGGCGAACCGCTGGACCGCATTCTCGGCCTCGAACTGGGTGCCGACGACTATCTGGCCAAGCCCTGCGACCCACG
CGAACTGACCGCGCGTCTGCGAGCTGTGCTGCGCCGCAGCCAACCGGCAGCCGCGCCCAGCCAGCTCGAACTCGGCGACC
TCAGCTACAGCCCCGCCCGCGGCGTTGCCAGTGTCGGCGGGCATGACGTCAGCCTGACGCTGTCCGAAGGCCGCATCCTT
GAGGCCCTGCTGGCCCAGGCCGGCGAGCCGATCGACAAGCAGGCCCTGGCCCAGCACGCCCTGGGTCGCAAGCTCACGCT
CTACGACCGCAGCCTGGACATGCATGTCAGCAACCTGCGCCGCAAACTGGGCCCGCACGCCGACGGCAGCCCGCGGATCG
TCGCCCTGCGCAGCCGTGGCTATCTCTATTCGGCCTGA

Upstream 100 bases:

>100_bases
GCGGTGGGCGGAGCCGTTGGCGTCACCAGCTTCTTACTGGGCCTGCTGGTGACGCGCGGCCGGCGTCGGCGCCAGTGGCT
CAATTGAGTAACAGGCAAAC

Downstream 100 bases:

>100_bases
TCACGCCCGGCTGATCGTCTTTACCGAGGCTTTACCCTGGGCTGACCGCCCTTGACCTTGCGCTGCGTAGACTGAACTCA
TCCGGTCACCGACCAGCCGC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSELLLIDDDQELCELLISWLAQEGFVAHACHDGQSAKQALAQYQPAAVVLDVMLPDGSGLELLKQLRSEHPDLPVLMLS
GRGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRSQPAAAPSQLELGDLSYSPARGVASVGGHDVSLTLSEGRIL
EALLAQAGEPIDKQALAQHALGRKLTLYDRSLDMHVSNLRRKLGPHADGSPRIVALRSRGYLYSA

Sequences:

>Translated_225_residues
MSELLLIDDDQELCELLISWLAQEGFVAHACHDGQSAKQALAQYQPAAVVLDVMLPDGSGLELLKQLRSEHPDLPVLMLS
GRGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRSQPAAAPSQLELGDLSYSPARGVASVGGHDVSLTLSEGRIL
EALLAQAGEPIDKQALAQHALGRKLTLYDRSLDMHVSNLRRKLGPHADGSPRIVALRSRGYLYSA
>Mature_224_residues
SELLLIDDDQELCELLISWLAQEGFVAHACHDGQSAKQALAQYQPAAVVLDVMLPDGSGLELLKQLRSEHPDLPVLMLSG
RGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRSQPAAAPSQLELGDLSYSPARGVASVGGHDVSLTLSEGRILE
ALLAQAGEPIDKQALAQHALGRKLTLYDRSLDMHVSNLRRKLGPHADGSPRIVALRSRGYLYSA

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=44.7826086956522, Blast_Score=178, Evalue=2e-46,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=35.1111111111111, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=38.1818181818182, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1789809, Length=205, Percent_Identity=37.0731707317073, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.6322869955157, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.9775784753363, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=31.2217194570136, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.8245614035088, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1789402, Length=201, Percent_Identity=32.8358208955224, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786911, Length=204, Percent_Identity=34.3137254901961, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=29.7872340425532, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=32.8888888888889, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787229, Length=208, Percent_Identity=28.3653846153846, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1787375, Length=204, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=30, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790299, Length=129, Percent_Identity=29.4573643410853, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24366; Mature: 24235

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELLLIDDDQELCELLISWLAQEGFVAHACHDGQSAKQALAQYQPAAVVLDVMLPDGSG
CCCEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCC
LELLKQLRSEHPDLPVLMLSGRGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRS
HHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHC
QPAAAPSQLELGDLSYSPARGVASVGGHDVSLTLSEGRILEALLAQAGEPIDKQALAQHA
CCCCCCCCEEECCCCCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHH
LGRKLTLYDRSLDMHVSNLRRKLGPHADGSPRIVALRSRGYLYSA
HCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEECC
>Mature Secondary Structure 
SELLLIDDDQELCELLISWLAQEGFVAHACHDGQSAKQALAQYQPAAVVLDVMLPDGSG
CCEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCC
LELLKQLRSEHPDLPVLMLSGRGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRS
HHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHC
QPAAAPSQLELGDLSYSPARGVASVGGHDVSLTLSEGRILEALLAQAGEPIDKQALAQHA
CCCCCCCCEEECCCCCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHH
LGRKLTLYDRSLDMHVSNLRRKLGPHADGSPRIVALRSRGYLYSA
HCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]