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The map label for this gene is idh [H]

Identifier: 146282650

GI number: 146282650

Start: 2512659

End: 2514887

Strand: Direct

Name: idh [H]

Synonym: PST_2302

Alternate gene names: 146282650

Gene position: 2512659-2514887 (Clockwise)

Preceding gene: 146282648

Following gene: 146282651

Centisome position: 55.01

GC content: 61.46

Gene sequence:

>2229_bases
ATGTCCACCCCTTCGAAGATCATCTATACCTTCACCGACGAAGCTCCAGCCCTGGCAACCTATTCGCTTCTTCCCATTGT
AGAAGCCTTCGCAGCCTCCGCTGACATCTCCGTCGAAACACGCGACATCTCTCTTGCAGGGCGCATCCTTGCGAGCTTCG
CCGATCAGCTGGATGCCGACAAGAAAGTCGAAGATGATCTGGCCAAGCTTGCCGAGCTGACCAACCAGCCCGACGCCAAC
ATCATCAAGCTCCCCAACATCAGCGCCTCCGTTCCACAGCTCAAGGCAGCGATCGCCGAGCTGCAGGCCCTGGGCTACAA
CATCCCCAACTACCCCGAAGACCCGCAGACCGATGCCGAGAAAGACGCGCGCGCGCGTTACAGCAAGGTGCTCGGTAGCG
CCGTGAACCCGGTCCTGCGCGAAGGCAACTCCGACCGCCGCGCGCCGGCCGCCGTGAAAGCCTATGCCCGCAAGCATCCG
CACTCCATGGGTAAGTGGAGCAAGGCATCCCAGTCCCACGCCGATTACATGCGCGGCGGCGACTTCTTCTCCAGCGAACA
GTCGATCACCATGGAAAAAGCCGGTGACGTGCGTATCGAGTTCGTTGGCAAGGATGGCAAGGTCGAGGTCAAGAAGCAGC
TCGCCCTGCAGGAAGGCGAAGTGCTCGATGGCATGTTCATGAGCTGCAAGAAGCTGCGCGCGTTCTTCGAAGACACGCTG
CAGGACTGCAAGGAAACCGGCGTCATGTGGTCCCTGCACGTCAAGGCGACCATGATGAAGATCTCCCACCCGATCGTCTT
CGGCCATGCCGTGAGCGTTTACTACAAGGACGTCTTCGACAAGTACGGCGATCTGTTCAAGGAGCTGGGCGTCAACCCGA
ACAACGGCATCAGCAGCGTCTACGACAAGATCAAGTCCCTGCCCGCCTCGCAGCAGGAAGAAATCCTGCATGACATCCAC
GAGGTCTATAGCCACCGCCCGGAAATGGCGATGGTCGACTCGGTCAAGGGCATCACCAACCTGCACATCCCGAGCGACGT
GATCGTCGACGCCTCGATGCCGGCGATGATTCGCAACTCCGGCCAGATGTGGGGCAAGGATGGCAAGCAGAAGGACACCA
AGGCGGTGATGCCGGAGAGCACCTACGCCCGCATCTACCAGGAAATGATCAACTTCTGCAAAACCAACGGCGCCTTCGAC
CCGGTCACCATGGGCAGCGTGCCAAACGTCGGTCTGATGGCGCAGAAGGCTGAGGAATACGGCTCACACGACAAGACCTT
CGAAATGCACGCCGACGGCACCATGCGCGTCGTACTGGCCGATGGCACCGTACTGATGCAGCACGAAGTCGAGAAAGGCG
ATATCTGGCGTGCCTGCCAGACCAAGGACGCGCCGATCCGCGACTGGGTCAAGCTGGCCGTTACCCGCGCCCGCCAGTCC
AACACCCCAGCCGTGTTCTGGCTGGACCCGGAGCGTGCCCACGACATGCAGCTGCAGAAGAAGGTCGAAACCTATCTGCA
GGAGCACGACCTGAGCGGCCTGGACATTCGCATCATGGGCTACAACGAAGCCATTCGCCTGAGCATGGAGCGCATGATCC
GCGGCAAGGACACCATTTCCGTCACCGGCAACGTGCTGCGCGATTACCTGACCGACCTGTTCCCGATCATGGAGCTGGGC
ACCTCGGCCAAGATGCTGTCCATCGTTCCGCTGATGGCCGGCGGCGGCATGTACGAGACTGGCGCCGGTGGTTCCGCGCC
GAAGCACGTGCAGCAGCTGGTCGAAGAGAACTATCTGCGCTGGGATTCGCTGGGCGAGTTCCTCGCCCTGGCGGTTTCGC
TGGAGGAGACTGGCATCAAGACTGGCAACAGCAAGGCGAAGATCCTCGGCAAGACCTTGGACCAGGCCACTGGCAAGTTG
CTGGACAACAACAAGTCCCCGGCGCGCAAGGTTGGCCAGATCGACAACCGCGGCAGCCACTTCTACCTGGCGCTGTACTG
GGCGCAGGCTCTGGCCGCGCAGGACGAAGATGCCGAGCTGAAGGCTCACTTCACTCCGCTGGCCAAGACCCTGACCGAGC
AGGAAGCGGCCATCGTCGCTGAACTGGCAGCCGTGCAGGGCAAGCCGGTCGACATCGGCGGCTACTACCGCTCCAACCCG
GAGCTGACCAGCAAGGTGATGCGCCCCAGCGCCACCTTCAACGCTGCCCTGGCCGCGCTGAACGCCTGA

Upstream 100 bases:

>100_bases
CGAATCCCCTTCTGGCTCGACTACTAGATGGAGAGTCAGGGCGCCTACCCGGCGCATTCGGGATTCTGTGCACGCCCAGC
AAGAAGAGAGTTAACGCTAA

Downstream 100 bases:

>100_bases
GTCTGCACCTGAGCGTCAATACGAACCCCGGCCTTGCGCCGGGGTTCGTGCTTTCAGCAGCCCAGCTGCTGTTATGATCG
CCTCATTTGCGCAAGGCAGC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MSTPSKIIYTFTDEAPALATYSLLPIVEAFAASADISVETRDISLAGRILASFADQLDADKKVEDDLAKLAELTNQPDAN
IIKLPNISASVPQLKAAIAELQALGYNIPNYPEDPQTDAEKDARARYSKVLGSAVNPVLREGNSDRRAPAAVKAYARKHP
HSMGKWSKASQSHADYMRGGDFFSSEQSITMEKAGDVRIEFVGKDGKVEVKKQLALQEGEVLDGMFMSCKKLRAFFEDTL
QDCKETGVMWSLHVKATMMKISHPIVFGHAVSVYYKDVFDKYGDLFKELGVNPNNGISSVYDKIKSLPASQQEEILHDIH
EVYSHRPEMAMVDSVKGITNLHIPSDVIVDASMPAMIRNSGQMWGKDGKQKDTKAVMPESTYARIYQEMINFCKTNGAFD
PVTMGSVPNVGLMAQKAEEYGSHDKTFEMHADGTMRVVLADGTVLMQHEVEKGDIWRACQTKDAPIRDWVKLAVTRARQS
NTPAVFWLDPERAHDMQLQKKVETYLQEHDLSGLDIRIMGYNEAIRLSMERMIRGKDTISVTGNVLRDYLTDLFPIMELG
TSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENYLRWDSLGEFLALAVSLEETGIKTGNSKAKILGKTLDQATGKL
LDNNKSPARKVGQIDNRGSHFYLALYWAQALAAQDEDAELKAHFTPLAKTLTEQEAAIVAELAAVQGKPVDIGGYYRSNP
ELTSKVMRPSATFNAALAALNA

Sequences:

>Translated_742_residues
MSTPSKIIYTFTDEAPALATYSLLPIVEAFAASADISVETRDISLAGRILASFADQLDADKKVEDDLAKLAELTNQPDAN
IIKLPNISASVPQLKAAIAELQALGYNIPNYPEDPQTDAEKDARARYSKVLGSAVNPVLREGNSDRRAPAAVKAYARKHP
HSMGKWSKASQSHADYMRGGDFFSSEQSITMEKAGDVRIEFVGKDGKVEVKKQLALQEGEVLDGMFMSCKKLRAFFEDTL
QDCKETGVMWSLHVKATMMKISHPIVFGHAVSVYYKDVFDKYGDLFKELGVNPNNGISSVYDKIKSLPASQQEEILHDIH
EVYSHRPEMAMVDSVKGITNLHIPSDVIVDASMPAMIRNSGQMWGKDGKQKDTKAVMPESTYARIYQEMINFCKTNGAFD
PVTMGSVPNVGLMAQKAEEYGSHDKTFEMHADGTMRVVLADGTVLMQHEVEKGDIWRACQTKDAPIRDWVKLAVTRARQS
NTPAVFWLDPERAHDMQLQKKVETYLQEHDLSGLDIRIMGYNEAIRLSMERMIRGKDTISVTGNVLRDYLTDLFPIMELG
TSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENYLRWDSLGEFLALAVSLEETGIKTGNSKAKILGKTLDQATGKL
LDNNKSPARKVGQIDNRGSHFYLALYWAQALAAQDEDAELKAHFTPLAKTLTEQEAAIVAELAAVQGKPVDIGGYYRSNP
ELTSKVMRPSATFNAALAALNA
>Mature_741_residues
STPSKIIYTFTDEAPALATYSLLPIVEAFAASADISVETRDISLAGRILASFADQLDADKKVEDDLAKLAELTNQPDANI
IKLPNISASVPQLKAAIAELQALGYNIPNYPEDPQTDAEKDARARYSKVLGSAVNPVLREGNSDRRAPAAVKAYARKHPH
SMGKWSKASQSHADYMRGGDFFSSEQSITMEKAGDVRIEFVGKDGKVEVKKQLALQEGEVLDGMFMSCKKLRAFFEDTLQ
DCKETGVMWSLHVKATMMKISHPIVFGHAVSVYYKDVFDKYGDLFKELGVNPNNGISSVYDKIKSLPASQQEEILHDIHE
VYSHRPEMAMVDSVKGITNLHIPSDVIVDASMPAMIRNSGQMWGKDGKQKDTKAVMPESTYARIYQEMINFCKTNGAFDP
VTMGSVPNVGLMAQKAEEYGSHDKTFEMHADGTMRVVLADGTVLMQHEVEKGDIWRACQTKDAPIRDWVKLAVTRARQSN
TPAVFWLDPERAHDMQLQKKVETYLQEHDLSGLDIRIMGYNEAIRLSMERMIRGKDTISVTGNVLRDYLTDLFPIMELGT
SAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENYLRWDSLGEFLALAVSLEETGIKTGNSKAKILGKTLDQATGKLL
DNNKSPARKVGQIDNRGSHFYLALYWAQALAAQDEDAELKAHFTPLAKTLTEQEAAIVAELAAVQGKPVDIGGYYRSNPE
LTSKVMRPSATFNAALAALNA

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 81730; Mature: 81599

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPSKIIYTFTDEAPALATYSLLPIVEAFAASADISVETRDISLAGRILASFADQLDAD
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHCCC
KKVEDDLAKLAELTNQPDANIIKLPNISASVPQLKAAIAELQALGYNIPNYPEDPQTDAE
CHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
KDARARYSKVLGSAVNPVLREGNSDRRAPAAVKAYARKHPHSMGKWSKASQSHADYMRGG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
DFFSSEQSITMEKAGDVRIEFVGKDGKVEVKKQLALQEGEVLDGMFMSCKKLRAFFEDTL
CCCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QDCKETGVMWSLHVKATMMKISHPIVFGHAVSVYYKDVFDKYGDLFKELGVNPNNGISSV
HHHHHCCCEEEEEHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YDKIKSLPASQQEEILHDIHEVYSHRPEMAMVDSVKGITNLHIPSDVIVDASMPAMIRNS
HHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCEEECCCCCHHHHCC
GQMWGKDGKQKDTKAVMPESTYARIYQEMINFCKTNGAFDPVTMGSVPNVGLMAQKAEEY
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
GSHDKTFEMHADGTMRVVLADGTVLMQHEVEKGDIWRACQTKDAPIRDWVKLAVTRARQS
CCCCCEEEEECCCEEEEEEECCEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCC
NTPAVFWLDPERAHDMQLQKKVETYLQEHDLSGLDIRIMGYNEAIRLSMERMIRGKDTIS
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEE
VTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENYLR
ECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCC
WDSLGEFLALAVSLEETGIKTGNSKAKILGKTLDQATGKLLDNNKSPARKVGQIDNRGSH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCE
FYLALYWAQALAAQDEDAELKAHFTPLAKTLTEQEAAIVAELAAVQGKPVDIGGYYRSNP
EEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEECCCH
ELTSKVMRPSATFNAALAALNA
HHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
STPSKIIYTFTDEAPALATYSLLPIVEAFAASADISVETRDISLAGRILASFADQLDAD
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHCCC
KKVEDDLAKLAELTNQPDANIIKLPNISASVPQLKAAIAELQALGYNIPNYPEDPQTDAE
CHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
KDARARYSKVLGSAVNPVLREGNSDRRAPAAVKAYARKHPHSMGKWSKASQSHADYMRGG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
DFFSSEQSITMEKAGDVRIEFVGKDGKVEVKKQLALQEGEVLDGMFMSCKKLRAFFEDTL
CCCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QDCKETGVMWSLHVKATMMKISHPIVFGHAVSVYYKDVFDKYGDLFKELGVNPNNGISSV
HHHHHCCCEEEEEHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YDKIKSLPASQQEEILHDIHEVYSHRPEMAMVDSVKGITNLHIPSDVIVDASMPAMIRNS
HHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCEEECCCCCHHHHCC
GQMWGKDGKQKDTKAVMPESTYARIYQEMINFCKTNGAFDPVTMGSVPNVGLMAQKAEEY
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
GSHDKTFEMHADGTMRVVLADGTVLMQHEVEKGDIWRACQTKDAPIRDWVKLAVTRARQS
CCCCCEEEEECCCEEEEEEECCEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCC
NTPAVFWLDPERAHDMQLQKKVETYLQEHDLSGLDIRIMGYNEAIRLSMERMIRGKDTIS
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEE
VTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENYLR
ECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCC
WDSLGEFLALAVSLEETGIKTGNSKAKILGKTLDQATGKLLDNNKSPARKVGQIDNRGSH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCE
FYLALYWAQALAAQDEDAELKAHFTPLAKTLTEQEAAIVAELAAVQGKPVDIGGYYRSNP
EEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEECCCH
ELTSKVMRPSATFNAALAALNA
HHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]