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The map label for this gene is add [H]

Identifier: 145300971

GI number: 145300971

Start: 4417102

End: 4418103

Strand: Direct

Name: add [H]

Synonym: ASA_4124

Alternate gene names: 145300971

Gene position: 4417102-4418103 (Clockwise)

Preceding gene: 145300970

Following gene: 145300976

Centisome position: 93.93

GC content: 62.87

Gene sequence:

>1002_bases
ATGATTGACAGATCTCTCCCCTTGACCGACCTGCACCGCCATCTGGACGGTAATATCCGCGCGCAGACCATCCTCGAGCT
GGGCCGTCAGCACAATATCCAGTTGCCAGCCTTTGAGCTGGAAGCACTTCGCCCCCACGTGCAGATCGTCGAGAATGAGC
CGAGTCTGGTCGCCTTCCTGAAGAAACTGGACTGGGGCGTGGCCGTGCTGGCTGATTACGATGCCTGCCGCCGTGTTGCC
TACGAGAACGTGGAGGATCTGCTGCGTGCCGGTATCGACTATGCCGAGCTGCGCTTCAGTCCCGCCTACATGGCCATGAC
CCACAAACTGCATCCACAAGGTGTGGTGGAAGCCATCATTGACGGCGTTGCAGTTGGCAGCCGCGACTTTGGCATCAAGA
CCAACCTCATCGGCATCATGAGCCGCACCTTCGGCACCGAACAGTGCCGCAAGGAGCTGGACGCCTGTCTGGCCCATCGC
GACAAACTGGTTGCCGTCGATCTGGCCGGTGACGAACTGGGCTTCCCGGGCGAGCTGTTCACCGAGCATTTTCGCAAGGT
CCGTGATGCGGGCATGCGCGTCACAGTACACGCAGGCGAAGCGGCGGGCCCCGAAAGCATGTGGCAAGCCATTCGCGATC
TCGGCGCCGAGCGCATCGGCCACGGCGTCAAGGCGATTGCGGATCCTGCCCTGATGGCTTATCTGGCGGAGCACCGCATC
GGCATCGAATCCTGCCTCACCTCCAACCTGCAGACCACCACGGTCACGAATCTGACCGAGCACCCAATCCGCCAGTTCCT
GGCTGCCGGTGTGCTGGTCTGCCTCAACACGGACGATCCGGCGGTCGAAGGCATAGACCTGCCCCACGAATATGAGGTGG
CCGCCCCGGCCGCCGGCATGACGGCGAGCGAGATCCGCACCGCCCAGCAAAACGGTCTGACCCTCGCTTTCCTGAGCGAT
GGCGAGAAAGCCGAGCTGAGCGCCCGCGCCGCCCGCCGCTAA

Upstream 100 bases:

>100_bases
CTGACCAATAAGACCCCGTTTGATTTCAAACGGGGTATCTTTTTTGAAAGCCCTGCCTAGAATGGCAGGCTTTCAAACCC
GACTCGAAGAAGGCGCCATC

Downstream 100 bases:

>100_bases
ACCTTGAACCGTTTGCTTACCCCATAAAAAAACCGCCGAAAGGCGGTTTTTTATCTTCAGTGCAGGGCTGCCTGTTCAGA
TCACCCGGGAGAACTGCTGC

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase 1 [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIDRSLPLTDLHRHLDGNIRAQTILELGRQHNIQLPAFELEALRPHVQIVENEPSLVAFLKKLDWGVAVLADYDACRRVA
YENVEDLLRAGIDYAELRFSPAYMAMTHKLHPQGVVEAIIDGVAVGSRDFGIKTNLIGIMSRTFGTEQCRKELDACLAHR
DKLVAVDLAGDELGFPGELFTEHFRKVRDAGMRVTVHAGEAAGPESMWQAIRDLGAERIGHGVKAIADPALMAYLAEHRI
GIESCLTSNLQTTTVTNLTEHPIRQFLAAGVLVCLNTDDPAVEGIDLPHEYEVAAPAAGMTASEIRTAQQNGLTLAFLSD
GEKAELSARAARR

Sequences:

>Translated_333_residues
MIDRSLPLTDLHRHLDGNIRAQTILELGRQHNIQLPAFELEALRPHVQIVENEPSLVAFLKKLDWGVAVLADYDACRRVA
YENVEDLLRAGIDYAELRFSPAYMAMTHKLHPQGVVEAIIDGVAVGSRDFGIKTNLIGIMSRTFGTEQCRKELDACLAHR
DKLVAVDLAGDELGFPGELFTEHFRKVRDAGMRVTVHAGEAAGPESMWQAIRDLGAERIGHGVKAIADPALMAYLAEHRI
GIESCLTSNLQTTTVTNLTEHPIRQFLAAGVLVCLNTDDPAVEGIDLPHEYEVAAPAAGMTASEIRTAQQNGLTLAFLSD
GEKAELSARAARR
>Mature_333_residues
MIDRSLPLTDLHRHLDGNIRAQTILELGRQHNIQLPAFELEALRPHVQIVENEPSLVAFLKKLDWGVAVLADYDACRRVA
YENVEDLLRAGIDYAELRFSPAYMAMTHKLHPQGVVEAIIDGVAVGSRDFGIKTNLIGIMSRTFGTEQCRKELDACLAHR
DKLVAVDLAGDELGFPGELFTEHFRKVRDAGMRVTVHAGEAAGPESMWQAIRDLGAERIGHGVKAIADPALMAYLAEHRI
GIESCLTSNLQTTTVTNLTEHPIRQFLAAGVLVCLNTDDPAVEGIDLPHEYEVAAPAAGMTASEIRTAQQNGLTLAFLSD
GEKAELSARAARR

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=336, Percent_Identity=32.7380952380952, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1787910, Length=333, Percent_Identity=66.6666666666667, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI32565969, Length=339, Percent_Identity=30.3834808259587, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17538512, Length=339, Percent_Identity=30.3834808259587, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI115537133, Length=323, Percent_Identity=24.1486068111455, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324188, Length=285, Percent_Identity=24.5614035087719, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24645260, Length=336, Percent_Identity=22.9166666666667, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 36456; Mature: 36456

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRSLPLTDLHRHLDGNIRAQTILELGRQHNIQLPAFELEALRPHVQIVENEPSLVAFL
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCCHHHHHH
KKLDWGVAVLADYDACRRVAYENVEDLLRAGIDYAELRFSPAYMAMTHKLHPQGVVEAII
HHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCHHHHHHHHH
DGVAVGSRDFGIKTNLIGIMSRTFGTEQCRKELDACLAHRDKLVAVDLAGDELGFPGELF
HHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
TEHFRKVRDAGMRVTVHAGEAAGPESMWQAIRDLGAERIGHGVKAIADPALMAYLAEHRI
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GIESCLTSNLQTTTVTNLTEHPIRQFLAAGVLVCLNTDDPAVEGIDLPHEYEVAAPAAGM
CHHHHHCCCCCCEEECCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
TASEIRTAQQNGLTLAFLSDGEKAELSARAARR
CHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCC
>Mature Secondary Structure
MIDRSLPLTDLHRHLDGNIRAQTILELGRQHNIQLPAFELEALRPHVQIVENEPSLVAFL
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCCHHHHHH
KKLDWGVAVLADYDACRRVAYENVEDLLRAGIDYAELRFSPAYMAMTHKLHPQGVVEAII
HHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCHHHHHHHHH
DGVAVGSRDFGIKTNLIGIMSRTFGTEQCRKELDACLAHRDKLVAVDLAGDELGFPGELF
HHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
TEHFRKVRDAGMRVTVHAGEAAGPESMWQAIRDLGAERIGHGVKAIADPALMAYLAEHRI
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GIESCLTSNLQTTTVTNLTEHPIRQFLAAGVLVCLNTDDPAVEGIDLPHEYEVAAPAAGM
CHHHHHCCCCCCEEECCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
TASEIRTAQQNGLTLAFLSDGEKAELSARAARR
CHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]