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The map label for this gene is kefC [H]

Identifier: 145300844

GI number: 145300844

Start: 4281552

End: 4283408

Strand: Direct

Name: kefC [H]

Synonym: ASA_3987

Alternate gene names: 145300844

Gene position: 4281552-4283408 (Clockwise)

Preceding gene: 145300843

Following gene: 145300845

Centisome position: 91.05

GC content: 61.5

Gene sequence:

>1857_bases
ATGGGTCACGGATTACTGTTTGATGCGCTTATCTACCTCTCGGCGGCGGTGATCGCCGTGCCGCTGGCCAAACGCTGGGG
GCTGGGCTCTGTGCTTGGCTACCTGCTGGCAGGCATCATCATAGGTCCCTTCCTGCTGGGGCTGGTGGGGGAGCAGAAGG
ATGTGATGCACTTCGCCGAGTTCGGGGTAGTGCTGATGCTGTTTCTGGTCGGGCTGGAGCTGCGCCCTGCCCTCTTGTGG
CAGCTGAAGGGGCCCATACTCGGCACCGGCGGCCTGCAGGTGCTGCTCACCACAGGTGCCCTGACTGGCGTGGCATATCT
CATCGGACTGCCCTGGCAGCAGGGACTGGGCATCGGCCTCATCCTGGCGCTCTCCTCCACTGCCATAGTGTTGCAGAGCC
TGCAGGAGCGCAAACTGATGCAGAGCGAAAGCGGTCGATCCGCCTTTGCGGTGCTGTTGTTTCAGGACATTGCCGTCATT
CCCATACTGGCGATCCTGCCGCTGCTCGCCATAGCACCGGTGGCCAGCAATGGCAGTGCGGAGCTGGCTGGCTGGCAACA
CGGCCTGCTGGTGGTCGCGGCCATCTCCGGCATAGTACTGGGTGGCCACTACCTGATGCGGCCGGTGTTTCGCGCCATCG
CCCAGTCCCACATGCGGGAGATCTTCGTCGCCGCCGCCCTGCTGCTGGTGATCGCCATCGCAGTGCTGATGGAGTCGGTG
GGACTCTCCCCTGCCCTTGGCTCCTTCCTCGCCGGTGTGGTGCTGGCCGACAGCGAATATCGCCACGAGCTGGAGGCGGA
CATAGAGCCGTTCAAGGGCTTGCTGCTCGGCCTCTTCTTCATGTCGGTGGGCGCCGGAATCAACTTCAGCCTGTTTGCCG
AACACCCCTTTCTCATCCCGGCGCTGGTGATCGGCCTGATGGCATTGAAATGGCTGGTGCTGATGGCGCTCGGCTTTGTC
ATTCGTATCTCGCCCAACCAGCGCTGGACCTTCGGGCTGGCGCTGGCACAGGGTGGCGAGTTTGCCTTTGTGCTCTTCTC
GTTTGCCTCCCAGAACAAGGTGCTGCCAGGCGACACCATATCGCTGCTCACCCTGGTGGTGGCCCTCTCCATGGCGCTGA
CGCCGCTCTTGCTGATCCTCAACGATCGGGTGATCCAGCCCTGGTTCGATTACCGTACCCACAGCGATTCGCCGCAGCAC
GAGCAACCTGAATTGGTGGAGCACCCCGTCATCATCGCCGGCTTCGGCCGCTTCGGCCAGATAGTGGGGCGCCTGCTGCA
CGGCCACGGCATAGGCACAACCATACTGGAGCAGGACGCCAGTCAGATAGAGATGCTGCGCAGGTACGGCTATCAGGTGT
TCTACGGCGATGCCAGCCGGCTCGATCTGCTGCATGCCGCCGGCGCCCACAAGGCAAAACTGCTGGTGCTCTCCATCAAT
GACCCGGCCACCTCGCTTGAGGTGATTGAAATGGTGAAGAAACACTTCCCGCACCTTAAGATACTGGCGCGTGCCCAAGA
CAGACCCCATGCTCACGAGATCCTGCGCCACGGCGTGGACAGCGTGCATCGGGAAACCCTGGGTTCCGCCGTGGATCTGG
GGGTGGAAGCGCTGACCCAGCTGGGATTTCGGGCCAACCAGGCCTGGCGGGCGGGACAGACCTTCAAACAACACGACAAC
TGGTTGCTGCGGGAGCAGGCCAATTACTTGGACGACGAACACACCTACATCAACAAGAGCCTGCAATACAGGGACATCCT
TTCCGATCTGTTGCAAGACGATCAGGAAGGACAAGAGCGTATTCACGCTCACAACTGGAACAGCGGTCTGCCCGACAACG
ACAAGGAAGCAATATGA

Upstream 100 bases:

>100_bases
TCTTATCTGCGGGATCTGCTGGAGGGGCTCTCATGAAACACGGGCAGCTATTTGGCCGACCCCATGAGCCTGACCAGATG
TTTAAACGGAGGGCTGGCTG

Downstream 100 bases:

>100_bases
TTGCCTATTATCCTCTGCTCAAACACCTGCACATGACCCTCGCCATCGTCAGCCTGCTGCTGTTTGTCTATCGCTGGATG
CTTTCTCTCAACGCCAGCCC

Product: glutathione-regulated potassium efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MGHGLLFDALIYLSAAVIAVPLAKRWGLGSVLGYLLAGIIIGPFLLGLVGEQKDVMHFAEFGVVLMLFLVGLELRPALLW
QLKGPILGTGGLQVLLTTGALTGVAYLIGLPWQQGLGIGLILALSSTAIVLQSLQERKLMQSESGRSAFAVLLFQDIAVI
PILAILPLLAIAPVASNGSAELAGWQHGLLVVAAISGIVLGGHYLMRPVFRAIAQSHMREIFVAAALLLVIAIAVLMESV
GLSPALGSFLAGVVLADSEYRHELEADIEPFKGLLLGLFFMSVGAGINFSLFAEHPFLIPALVIGLMALKWLVLMALGFV
IRISPNQRWTFGLALAQGGEFAFVLFSFASQNKVLPGDTISLLTLVVALSMALTPLLLILNDRVIQPWFDYRTHSDSPQH
EQPELVEHPVIIAGFGRFGQIVGRLLHGHGIGTTILEQDASQIEMLRRYGYQVFYGDASRLDLLHAAGAHKAKLLVLSIN
DPATSLEVIEMVKKHFPHLKILARAQDRPHAHEILRHGVDSVHRETLGSAVDLGVEALTQLGFRANQAWRAGQTFKQHDN
WLLREQANYLDDEHTYINKSLQYRDILSDLLQDDQEGQERIHAHNWNSGLPDNDKEAI

Sequences:

>Translated_618_residues
MGHGLLFDALIYLSAAVIAVPLAKRWGLGSVLGYLLAGIIIGPFLLGLVGEQKDVMHFAEFGVVLMLFLVGLELRPALLW
QLKGPILGTGGLQVLLTTGALTGVAYLIGLPWQQGLGIGLILALSSTAIVLQSLQERKLMQSESGRSAFAVLLFQDIAVI
PILAILPLLAIAPVASNGSAELAGWQHGLLVVAAISGIVLGGHYLMRPVFRAIAQSHMREIFVAAALLLVIAIAVLMESV
GLSPALGSFLAGVVLADSEYRHELEADIEPFKGLLLGLFFMSVGAGINFSLFAEHPFLIPALVIGLMALKWLVLMALGFV
IRISPNQRWTFGLALAQGGEFAFVLFSFASQNKVLPGDTISLLTLVVALSMALTPLLLILNDRVIQPWFDYRTHSDSPQH
EQPELVEHPVIIAGFGRFGQIVGRLLHGHGIGTTILEQDASQIEMLRRYGYQVFYGDASRLDLLHAAGAHKAKLLVLSIN
DPATSLEVIEMVKKHFPHLKILARAQDRPHAHEILRHGVDSVHRETLGSAVDLGVEALTQLGFRANQAWRAGQTFKQHDN
WLLREQANYLDDEHTYINKSLQYRDILSDLLQDDQEGQERIHAHNWNSGLPDNDKEAI
>Mature_617_residues
GHGLLFDALIYLSAAVIAVPLAKRWGLGSVLGYLLAGIIIGPFLLGLVGEQKDVMHFAEFGVVLMLFLVGLELRPALLWQ
LKGPILGTGGLQVLLTTGALTGVAYLIGLPWQQGLGIGLILALSSTAIVLQSLQERKLMQSESGRSAFAVLLFQDIAVIP
ILAILPLLAIAPVASNGSAELAGWQHGLLVVAAISGIVLGGHYLMRPVFRAIAQSHMREIFVAAALLLVIAIAVLMESVG
LSPALGSFLAGVVLADSEYRHELEADIEPFKGLLLGLFFMSVGAGINFSLFAEHPFLIPALVIGLMALKWLVLMALGFVI
RISPNQRWTFGLALAQGGEFAFVLFSFASQNKVLPGDTISLLTLVVALSMALTPLLLILNDRVIQPWFDYRTHSDSPQHE
QPELVEHPVIIAGFGRFGQIVGRLLHGHGIGTTILEQDASQIEMLRRYGYQVFYGDASRLDLLHAAGAHKAKLLVLSIND
PATSLEVIEMVKKHFPHLKILARAQDRPHAHEILRHGVDSVHRETLGSAVDLGVEALTQLGFRANQAWRAGQTFKQHDNW
LLREQANYLDDEHTYINKSLQYRDILSDLLQDDQEGQERIHAHNWNSGLPDNDKEAI

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=381, Percent_Identity=28.0839895013123, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI1786232, Length=603, Percent_Identity=46.7661691542289, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1789749, Length=610, Percent_Identity=45.7377049180328, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1786685, Length=514, Percent_Identity=27.6264591439689, Blast_Score=157, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67369; Mature: 67238

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHGLLFDALIYLSAAVIAVPLAKRWGLGSVLGYLLAGIIIGPFLLGLVGEQKDVMHFAE
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FGVVLMLFLVGLELRPALLWQLKGPILGTGGLQVLLTTGALTGVAYLIGLPWQQGLGIGL
HHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCEEEEHHHHHHHHHHHHCCCHHHCCCHHH
ILALSSTAIVLQSLQERKLMQSESGRSAFAVLLFQDIAVIPILAILPLLAIAPVASNGSA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ELAGWQHGLLVVAAISGIVLGGHYLMRPVFRAIAQSHMREIFVAAALLLVIAIAVLMESV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLSPALGSFLAGVVLADSEYRHELEADIEPFKGLLLGLFFMSVGAGINFSLFAEHPFLIP
CCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALVIGLMALKWLVLMALGFVIRISPNQRWTFGLALAQGGEFAFVLFSFASQNKVLPGDTI
HHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCEEEEEEEHHCCCCCCCCCHH
SLLTLVVALSMALTPLLLILNDRVIQPWFDYRTHSDSPQHEQPELVEHPVIIAGFGRFGQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCHHHHCCEEEECCCHHHH
IVGRLLHGHGIGTTILEQDASQIEMLRRYGYQVFYGDASRLDLLHAAGAHKAKLLVLSIN
HHHHHHHCCCCCHHHHHCCHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEEEC
DPATSLEVIEMVKKHFPHLKILARAQDRPHAHEILRHGVDSVHRETLGSAVDLGVEALTQ
CCCHHHHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFRANQAWRAGQTFKQHDNWLLREQANYLDDEHTYINKSLQYRDILSDLLQDDQEGQER
HCCCCCCHHHCCCHHHHHCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHH
IHAHNWNSGLPDNDKEAI
HHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GHGLLFDALIYLSAAVIAVPLAKRWGLGSVLGYLLAGIIIGPFLLGLVGEQKDVMHFAE
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FGVVLMLFLVGLELRPALLWQLKGPILGTGGLQVLLTTGALTGVAYLIGLPWQQGLGIGL
HHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCEEEEHHHHHHHHHHHHCCCHHHCCCHHH
ILALSSTAIVLQSLQERKLMQSESGRSAFAVLLFQDIAVIPILAILPLLAIAPVASNGSA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ELAGWQHGLLVVAAISGIVLGGHYLMRPVFRAIAQSHMREIFVAAALLLVIAIAVLMESV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLSPALGSFLAGVVLADSEYRHELEADIEPFKGLLLGLFFMSVGAGINFSLFAEHPFLIP
CCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALVIGLMALKWLVLMALGFVIRISPNQRWTFGLALAQGGEFAFVLFSFASQNKVLPGDTI
HHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCEEEEEEEHHCCCCCCCCCHH
SLLTLVVALSMALTPLLLILNDRVIQPWFDYRTHSDSPQHEQPELVEHPVIIAGFGRFGQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCHHHHCCEEEECCCHHHH
IVGRLLHGHGIGTTILEQDASQIEMLRRYGYQVFYGDASRLDLLHAAGAHKAKLLVLSIN
HHHHHHHCCCCCHHHHHCCHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEEEC
DPATSLEVIEMVKKHFPHLKILARAQDRPHAHEILRHGVDSVHRETLGSAVDLGVEALTQ
CCCHHHHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGFRANQAWRAGQTFKQHDNWLLREQANYLDDEHTYINKSLQYRDILSDLLQDDQEGQER
HCCCCCCHHHCCCHHHHHCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHH
IHAHNWNSGLPDNDKEAI
HHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA