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The map label for this gene is nhaP [H]

Identifier: 145300773

GI number: 145300773

Start: 4201544

End: 4202821

Strand: Direct

Name: nhaP [H]

Synonym: ASA_3913

Alternate gene names: 145300773

Gene position: 4201544-4202821 (Clockwise)

Preceding gene: 145300770

Following gene: 145300774

Centisome position: 89.35

GC content: 59.31

Gene sequence:

>1278_bases
ATGAGCGTCTACTACACACTCTGCTTTTTGGCAGCGTTGGCGATCCTGATCGCCTTTGCCAACCAGTATGTCGTGAAGAT
CCAGACCACCATCGCCATCACTGCCGGATCCATGCTGATCTCCGCCCTGATGGTGCTGTTTGGCAAACTGGGTTGGTTCA
ACCTTGAGCCCCTGGCCATCGAAACCATGAAGAGCATCGACTTCCAGAATTTCCTGCTGAAGGGGATCCTGGGCTTCCTG
CTGTTCGCTGGCGGCATTGGCATCAACCTCAAGGCCTTGCGCAGCCAGAAGTGGGAAATCACCATACTGGCGATCTTCTC
CACCCTGCTCTCCACCTTCCTGATCGGTTACGGCTTCTGGTTCATCGCCAAGCTGCTGGGCTGGGAAGTACCGCTGGTCT
ATTGCCTGCTGTTCGGGGCCCTGATCACCCCCACCGACCCCATTGCCGTGCTGGCCATCGTCAAGAAGATGCAGGCGCCC
CCCCAGATCGCCATTCAAATTGAAGGGGAATCCCTGTTCAACGACGGTACCGGTCTGGTGATATTCGCCACCATATTTGC
CGTGGCGTTTGGCGGCGTTGAACCGACCTTCGGCAGCGTCGCCGGTCTGTTCCTGCACGAGGCCCTCGGTGGCATCTTGT
TCGGCGCCGTGCTGGGCCTCATCGCCCACGTGATGATCAGTGCCACCGACGATGGCTCCCTGGAGCTGCTGCTGACCCTT
TGCATACCGACTGCCGGCTTTGCCCTCGCCAATATGATGGGTGTCTCCGGTGCCCTGGCCATGGTGGTCACCGGCATCAT
GATCGGCAACTGGACCCGTCACTCCGGCTTCTCCGAGCAGAGCAGCCACTATCTGGATCACTTCTGGGAGTTGATGGACC
AGTTCCTCAACGCGCTCTTGTTCCTGCTGATCGGTCTGGCACTGGTGCTGCTGGATCTCGCCTGGCGTGACTGGATCCTG
CTGGTTATCGCGGTACCGCTCTGCCTGGCGGCGCGCTTCATCAGCGTCTCTGTCCCCTTCATGGCCTTCCGCCGTTTTCG
CACCTACAACCGCTTCACCATCCGCATCCTTACCTGGGGCGGCTTGCGTGGCGGTCTGGCCATGGCCATGGCGCTGGCAC
TGCCTTCCGGTGTCATGATGATACCCGAGCACAACGTCGATCTGCGTCAGGTCATACTGGTGATGACCTACTCTGTGGTG
ATGTTCTCCATCGTGGTGCAGGGCATGACCATTACACCCATGATCACCGCCGCCAAGAAGGCCAGCGGCGACTACTGA

Upstream 100 bases:

>100_bases
ACTCATAAATAGGTAATGAGTAACATGTGACCCCAGAGTACCCTATGCCGGTCCTCAGCGAAGGATACGTGCTTGCTGTT
TACTAACGAGAAAAATAACC

Downstream 100 bases:

>100_bases
GTCACCGTCTGACAGTGATTGACCTGCTGAAAAAGGGCTCCCGACGGGAGCCCTTTTTATCTCGGAGAACACGACAAAAA
CGGATCTGGTACAAAATCAC

Product: Na(+)/H(+) antiporter NhaP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSVYYTLCFLAALAILIAFANQYVVKIQTTIAITAGSMLISALMVLFGKLGWFNLEPLAIETMKSIDFQNFLLKGILGFL
LFAGGIGINLKALRSQKWEITILAIFSTLLSTFLIGYGFWFIAKLLGWEVPLVYCLLFGALITPTDPIAVLAIVKKMQAP
PQIAIQIEGESLFNDGTGLVIFATIFAVAFGGVEPTFGSVAGLFLHEALGGILFGAVLGLIAHVMISATDDGSLELLLTL
CIPTAGFALANMMGVSGALAMVVTGIMIGNWTRHSGFSEQSSHYLDHFWELMDQFLNALLFLLIGLALVLLDLAWRDWIL
LVIAVPLCLAARFISVSVPFMAFRRFRTYNRFTIRILTWGGLRGGLAMAMALALPSGVMMIPEHNVDLRQVILVMTYSVV
MFSIVVQGMTITPMITAAKKASGDY

Sequences:

>Translated_425_residues
MSVYYTLCFLAALAILIAFANQYVVKIQTTIAITAGSMLISALMVLFGKLGWFNLEPLAIETMKSIDFQNFLLKGILGFL
LFAGGIGINLKALRSQKWEITILAIFSTLLSTFLIGYGFWFIAKLLGWEVPLVYCLLFGALITPTDPIAVLAIVKKMQAP
PQIAIQIEGESLFNDGTGLVIFATIFAVAFGGVEPTFGSVAGLFLHEALGGILFGAVLGLIAHVMISATDDGSLELLLTL
CIPTAGFALANMMGVSGALAMVVTGIMIGNWTRHSGFSEQSSHYLDHFWELMDQFLNALLFLLIGLALVLLDLAWRDWIL
LVIAVPLCLAARFISVSVPFMAFRRFRTYNRFTIRILTWGGLRGGLAMAMALALPSGVMMIPEHNVDLRQVILVMTYSVV
MFSIVVQGMTITPMITAAKKASGDY
>Mature_424_residues
SVYYTLCFLAALAILIAFANQYVVKIQTTIAITAGSMLISALMVLFGKLGWFNLEPLAIETMKSIDFQNFLLKGILGFLL
FAGGIGINLKALRSQKWEITILAIFSTLLSTFLIGYGFWFIAKLLGWEVPLVYCLLFGALITPTDPIAVLAIVKKMQAPP
QIAIQIEGESLFNDGTGLVIFATIFAVAFGGVEPTFGSVAGLFLHEALGGILFGAVLGLIAHVMISATDDGSLELLLTLC
IPTAGFALANMMGVSGALAMVVTGIMIGNWTRHSGFSEQSSHYLDHFWELMDQFLNALLFLLIGLALVLLDLAWRDWILL
VIAVPLCLAARFISVSVPFMAFRRFRTYNRFTIRILTWGGLRGGLAMAMALALPSGVMMIPEHNVDLRQVILVMTYSVVM
FSIVVQGMTITPMITAAKKASGDY

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=325, Percent_Identity=26.7692307692308, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI15529998, Length=323, Percent_Identity=25.6965944272446, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI294997330, Length=356, Percent_Identity=26.685393258427, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI5454070, Length=356, Percent_Identity=26.685393258427, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI110227626, Length=356, Percent_Identity=26.685393258427, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI41872703, Length=437, Percent_Identity=24.4851258581236, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI14211919, Length=355, Percent_Identity=26.4788732394366, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI194239733, Length=314, Percent_Identity=26.1146496815287, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI27777632, Length=335, Percent_Identity=24.7761194029851, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI27734935, Length=355, Percent_Identity=23.0985915492958, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790501, Length=317, Percent_Identity=26.813880126183, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71999819, Length=399, Percent_Identity=24.5614035087719, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71999817, Length=399, Percent_Identity=24.5614035087719, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71999821, Length=399, Percent_Identity=24.5614035087719, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71990924, Length=366, Percent_Identity=25.1366120218579, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71990932, Length=346, Percent_Identity=25.4335260115607, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71980847, Length=346, Percent_Identity=25.4335260115607, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71987537, Length=389, Percent_Identity=25.9640102827763, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71987535, Length=389, Percent_Identity=25.9640102827763, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25150332, Length=335, Percent_Identity=24.1791044776119, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71993590, Length=405, Percent_Identity=23.7037037037037, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71993582, Length=405, Percent_Identity=23.7037037037037, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25147678, Length=295, Percent_Identity=25.0847457627119, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71992107, Length=245, Percent_Identity=25.3061224489796, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71992101, Length=245, Percent_Identity=25.3061224489796, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=344, Percent_Identity=25.8720930232558, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510740, Length=327, Percent_Identity=25.6880733944954, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585580, Length=327, Percent_Identity=25.6880733944954, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585578, Length=327, Percent_Identity=25.6880733944954, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221510734, Length=327, Percent_Identity=25.6880733944954, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221510738, Length=327, Percent_Identity=25.6880733944954, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221510736, Length=327, Percent_Identity=25.6880733944954, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221510732, Length=327, Percent_Identity=25.6880733944954, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI221473212, Length=350, Percent_Identity=27.7142857142857, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281364513, Length=350, Percent_Identity=27.7142857142857, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221473215, Length=350, Percent_Identity=27.7142857142857, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221473222, Length=350, Percent_Identity=27.7142857142857, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281360447, Length=359, Percent_Identity=24.5125348189415, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46233; Mature: 46102

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVYYTLCFLAALAILIAFANQYVVKIQTTIAITAGSMLISALMVLFGKLGWFNLEPLAI
CCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHH
ETMKSIDFQNFLLKGILGFLLFAGGIGINLKALRSQKWEITILAIFSTLLSTFLIGYGFW
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
FIAKLLGWEVPLVYCLLFGALITPTDPIAVLAIVKKMQAPPQIAIQIEGESLFNDGTGLV
HHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHCCCCCCHH
IFATIFAVAFGGVEPTFGSVAGLFLHEALGGILFGAVLGLIAHVMISATDDGSLELLLTL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
CIPTAGFALANMMGVSGALAMVVTGIMIGNWTRHSGFSEQSSHYLDHFWELMDQFLNALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLLIGLALVLLDLAWRDWILLVIAVPLCLAARFISVSVPFMAFRRFRTYNRFTIRILTWG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEEEEC
GLRGGLAMAMALALPSGVMMIPEHNVDLRQVILVMTYSVVMFSIVVQGMTITPMITAAKK
CCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHH
ASGDY
CCCCC
>Mature Secondary Structure 
SVYYTLCFLAALAILIAFANQYVVKIQTTIAITAGSMLISALMVLFGKLGWFNLEPLAI
CHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHH
ETMKSIDFQNFLLKGILGFLLFAGGIGINLKALRSQKWEITILAIFSTLLSTFLIGYGFW
HHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
FIAKLLGWEVPLVYCLLFGALITPTDPIAVLAIVKKMQAPPQIAIQIEGESLFNDGTGLV
HHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHCCCCCCHH
IFATIFAVAFGGVEPTFGSVAGLFLHEALGGILFGAVLGLIAHVMISATDDGSLELLLTL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
CIPTAGFALANMMGVSGALAMVVTGIMIGNWTRHSGFSEQSSHYLDHFWELMDQFLNALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLLIGLALVLLDLAWRDWILLVIAVPLCLAARFISVSVPFMAFRRFRTYNRFTIRILTWG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEEEEC
GLRGGLAMAMALALPSGVMMIPEHNVDLRQVILVMTYSVVMFSIVVQGMTITPMITAAKK
CCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHH
ASGDY
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]