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The map label for this gene is tcrA [H]

Identifier: 145300769

GI number: 145300769

Start: 4194469

End: 4195137

Strand: Direct

Name: tcrA [H]

Synonym: ASA_3909

Alternate gene names: 145300769

Gene position: 4194469-4195137 (Clockwise)

Preceding gene: 145300759

Following gene: 145300770

Centisome position: 89.2

GC content: 64.13

Gene sequence:

>669_bases
ATGAAAATACTGGTGGTGGAAGACAATCCCCAGGTCGCGGAAACCATCATGGATTACCTGGAGCTGGCCGGGCACAGGCT
GGACTGCGCCTATCACGGTCAGGCTGCCCTGCAACTGCTGGCCGAGCAGCGCTTCGACGTCATCATCATGGATGTCATGA
TGCCGCGTCTGGATGGCCTCTCCACGGTTGAGCGGCTGCGGGCCGATGGCATAGCGACTCCAGTGCTGTTTCTCACCGCC
CGCGACAGTCTGGATGACAAGCTGGCGGGCTTTCGGGCCGGTGGCGATGACTATCTGGTCAAGCCGTTCGCCATGGAGGA
ACTGGAAGTGCGGCTGCAGGCGCTGGCCCTGCGTGGCCCCCGCAGCGACATGGGGGCCCTCAGCGTGGGCGAGCTGACGC
TGGATCCCGCCAGTGGCCGCGCCACCCGCGCCGGAGTCGAGCTCAAGCTCGGCAAGATCCCGTTCCAGATCCTCACCCTG
CTGGTGCGCCGCGCCCCCCATCTGGTGAGCCGGCAAGAAGTGCTGGAGACAGTCTGGGGGGATGAAGAGCCAGACTCCGA
TGCCCTGCGCAGCCACATCTATGCCCTGCGCAACGCCCTCGACAAACCCTTCCCTACCCCCATGCTGGAAACCCTCCACG
GTCAGGGCTATCGACTGGTGACATCATGA

Upstream 100 bases:

>100_bases
ACTTCTTCATCAGGGATCCTCGGGGTTACACTGCCACACAGGATGCCTCGTCCAGTGTGAGATGACCGTGAAATATCGGT
CAAAACCAGGAGATCAAAAC

Downstream 100 bases:

>100_bases
TCAAACCCGGAGGCCATGACCCATCCCCATCGGGTGATTCAATGAACCAGCCAGCGGGAGGCCTTGACCAGGCACAGCCG
GATACCCAGGTCAGCCTGCC

Product: two-component system response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKILVVEDNPQVAETIMDYLELAGHRLDCAYHGQAALQLLAEQRFDVIIMDVMMPRLDGLSTVERLRADGIATPVLFLTA
RDSLDDKLAGFRAGGDDYLVKPFAMEELEVRLQALALRGPRSDMGALSVGELTLDPASGRATRAGVELKLGKIPFQILTL
LVRRAPHLVSRQEVLETVWGDEEPDSDALRSHIYALRNALDKPFPTPMLETLHGQGYRLVTS

Sequences:

>Translated_222_residues
MKILVVEDNPQVAETIMDYLELAGHRLDCAYHGQAALQLLAEQRFDVIIMDVMMPRLDGLSTVERLRADGIATPVLFLTA
RDSLDDKLAGFRAGGDDYLVKPFAMEELEVRLQALALRGPRSDMGALSVGELTLDPASGRATRAGVELKLGKIPFQILTL
LVRRAPHLVSRQEVLETVWGDEEPDSDALRSHIYALRNALDKPFPTPMLETLHGQGYRLVTS
>Mature_222_residues
MKILVVEDNPQVAETIMDYLELAGHRLDCAYHGQAALQLLAEQRFDVIIMDVMMPRLDGLSTVERLRADGIATPVLFLTA
RDSLDDKLAGFRAGGDDYLVKPFAMEELEVRLQALALRGPRSDMGALSVGELTLDPASGRATRAGVELKLGKIPFQILTL
LVRRAPHLVSRQEVLETVWGDEEPDSDALRSHIYALRNALDKPFPTPMLETLHGQGYRLVTS

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=35.7466063348416, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=36.8181818181818, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=35.4260089686099, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=32.1266968325792, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=31.5315315315315, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=32.1428571428571, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.0649350649351, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=30.6306306306306, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=32.5892857142857, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=28.0542986425339, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=26.7543859649123, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=28.1385281385281, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788550, Length=127, Percent_Identity=33.0708661417323, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=25.6637168141593, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=32.7433628318584, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=122, Percent_Identity=31.9672131147541, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693140, Length=190, Percent_Identity=27.8947368421053, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=118, Percent_Identity=34.7457627118644, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=30.4347826086957, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=37.2549019607843, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24574; Mature: 24574

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDNPQVAETIMDYLELAGHRLDCAYHGQAALQLLAEQRFDVIIMDVMMPRLDGL
CEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCEEHHHHHHHCCCCH
STVERLRADGIATPVLFLTARDSLDDKLAGFRAGGDDYLVKPFAMEELEVRLQALALRGP
HHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCC
RSDMGALSVGELTLDPASGRATRAGVELKLGKIPFQILTLLVRRAPHLVSRQEVLETVWG
CCCCCCEEECCEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHCC
DEEPDSDALRSHIYALRNALDKPFPTPMLETLHGQGYRLVTS
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECC
>Mature Secondary Structure
MKILVVEDNPQVAETIMDYLELAGHRLDCAYHGQAALQLLAEQRFDVIIMDVMMPRLDGL
CEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCEEHHHHHHHCCCCH
STVERLRADGIATPVLFLTARDSLDDKLAGFRAGGDDYLVKPFAMEELEVRLQALALRGP
HHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCC
RSDMGALSVGELTLDPASGRATRAGVELKLGKIPFQILTLLVRRAPHLVSRQEVLETVWG
CCCCCCEEECCEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHCC
DEEPDSDALRSHIYALRNALDKPFPTPMLETLHGQGYRLVTS
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]