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The map label for this gene is nupC [H]

Identifier: 145300613

GI number: 145300613

Start: 4037683

End: 4038888

Strand: Direct

Name: nupC [H]

Synonym: ASA_3745

Alternate gene names: 145300613

Gene position: 4037683-4038888 (Clockwise)

Preceding gene: 145300610

Following gene: 145300618

Centisome position: 85.86

GC content: 56.05

Gene sequence:

>1206_bases
ATGGAATACGTTCACTTTATACTCGGACTCGTCATGGTCCTTGCTCTCGCTTTGCTGGCCAACCGCCACAACTGGAAACA
GATCAAATTGCGTTATATTGGCCAACTGCTGGTGGTCGAACTGGCGCTGGCCTGGTTCATGCTGAACTCCGAAGTGGGCC
TGGCCGTGGTGGGTGGCTTTGCCGCCGGCTTCACCAAGCTGATGGAGTTTGCCAAACAGGGGACCGATTTTGTATTCGGT
GGTCTGGTCAACGAAGGGGCCTTCTCCTTCTTCCTGATGGTACTGATGCCCATCGTCTTCATCTCTGTACTGATCGGCAT
TCTGCAGTACATCCGTCTGCTGCCCATCGTCATCCGTGGCATAGGGACAGTGCTGGCCAAGGTGAACGGCATGGGCAAGC
TGGAATCATTCAACGCCATCAGCTCCATGATCGTCGGCCAGTCCGAGAACTTCATCGCGCTCAAGAACACACTGCCGCAC
CTGAATGAAAAGCAGATGTACACCCTGGCGGCGACTGCCATGTCCACCGTTTCCATGTCCATCGTCGGCGCCTACATGCA
GTTGATAGAGCCGCGCTACGTGGTGGCCGCGCTGGTGCTCAACATGTTCAGTACCTTCATCGTGCTGTCGCTGATCAACC
CGTACGAGCCGGATAACTCGGTCACCGATCTGAAAGCCATCGCCGAAGGCGACGAGCACCACACACCGAAGAAAGAGAAC
TTCTTCGAGATGCTGGGCGAGTACATCATGGCCGGTTTCACCGTGGCCGTGATAGTGGGTGCCATGCTGGTCGGCTTCAT
CGCTCTGATCGCCCTGGTCAACTACCTGTTCGAAGTAGCGTTTGGCGTCAACTTCCAGTACGTCATGGGTTACATTTTCT
ACCCAATCGCCTGGATCCTGGGTATCCCCAGTGGTGAGGCCCTGCAAGCCGGCTCCATCATGGCGACCAAACTGGTGACC
AACGAATTCGTGGCCATGATGGATCTGGGCAAGATTGCTGCCGAGCTCTCCCCGCGTACCATCGGCATCCTCTCCATCTT
CATGGTGTCGTTCGCCAACTTCAGCTCCATCGGTATCATCGCCGGTGCTGTGAAGGCACTGAACGAAGAGAAGGGCAACA
TGGTCTCCCGCTTCGGTCTGAAGCTGGTGTACGGTTCTACTCTGGTGAGCCTGCTCTCCGCCGTGATTGCCGGTGTGATG
ATCTAG

Upstream 100 bases:

>100_bases
ATATTTTTACCGCAGATTGTGATGGCTATCTGATTTTTAAATATGCATATGTCTATGATGGCGCCCATCAAATATAACAA
TTCACTCAGGTGCTACAGGT

Downstream 100 bases:

>100_bases
TCACACCTCGCCATCACCACGACAAACCCCTGCCTTGGCAGGGGTTTGTTTTTTTCAGGGGTGGGCAAATGCGTCCCCAT
GTTCGCAGACATGCCGTGCC

Product: nucleoside permease

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: Nucleoside-transport system protein nupC [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MEYVHFILGLVMVLALALLANRHNWKQIKLRYIGQLLVVELALAWFMLNSEVGLAVVGGFAAGFTKLMEFAKQGTDFVFG
GLVNEGAFSFFLMVLMPIVFISVLIGILQYIRLLPIVIRGIGTVLAKVNGMGKLESFNAISSMIVGQSENFIALKNTLPH
LNEKQMYTLAATAMSTVSMSIVGAYMQLIEPRYVVAALVLNMFSTFIVLSLINPYEPDNSVTDLKAIAEGDEHHTPKKEN
FFEMLGEYIMAGFTVAVIVGAMLVGFIALIALVNYLFEVAFGVNFQYVMGYIFYPIAWILGIPSGEALQAGSIMATKLVT
NEFVAMMDLGKIAAELSPRTIGILSIFMVSFANFSSIGIIAGAVKALNEEKGNMVSRFGLKLVYGSTLVSLLSAVIAGVM
I

Sequences:

>Translated_401_residues
MEYVHFILGLVMVLALALLANRHNWKQIKLRYIGQLLVVELALAWFMLNSEVGLAVVGGFAAGFTKLMEFAKQGTDFVFG
GLVNEGAFSFFLMVLMPIVFISVLIGILQYIRLLPIVIRGIGTVLAKVNGMGKLESFNAISSMIVGQSENFIALKNTLPH
LNEKQMYTLAATAMSTVSMSIVGAYMQLIEPRYVVAALVLNMFSTFIVLSLINPYEPDNSVTDLKAIAEGDEHHTPKKEN
FFEMLGEYIMAGFTVAVIVGAMLVGFIALIALVNYLFEVAFGVNFQYVMGYIFYPIAWILGIPSGEALQAGSIMATKLVT
NEFVAMMDLGKIAAELSPRTIGILSIFMVSFANFSSIGIIAGAVKALNEEKGNMVSRFGLKLVYGSTLVSLLSAVIAGVM
I
>Mature_401_residues
MEYVHFILGLVMVLALALLANRHNWKQIKLRYIGQLLVVELALAWFMLNSEVGLAVVGGFAAGFTKLMEFAKQGTDFVFG
GLVNEGAFSFFLMVLMPIVFISVLIGILQYIRLLPIVIRGIGTVLAKVNGMGKLESFNAISSMIVGQSENFIALKNTLPH
LNEKQMYTLAATAMSTVSMSIVGAYMQLIEPRYVVAALVLNMFSTFIVLSLINPYEPDNSVTDLKAIAEGDEHHTPKKEN
FFEMLGEYIMAGFTVAVIVGAMLVGFIALIALVNYLFEVAFGVNFQYVMGYIFYPIAWILGIPSGEALQAGSIMATKLVT
NEFVAMMDLGKIAAELSPRTIGILSIFMVSFANFSSIGIIAGAVKALNEEKGNMVSRFGLKLVYGSTLVSLLSAVIAGVM
I

Specific function: Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force [H]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=414, Percent_Identity=22.9468599033816, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI11545853, Length=359, Percent_Identity=22.8412256267409, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI227116277, Length=414, Percent_Identity=21.0144927536232, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1788737, Length=403, Percent_Identity=65.2605459057072, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1788485, Length=419, Percent_Identity=30.5489260143198, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788488, Length=420, Percent_Identity=30.2380952380952, Blast_Score=167, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17560276, Length=398, Percent_Identity=23.6180904522613, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71991794, Length=395, Percent_Identity=23.0379746835443, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45552517, Length=392, Percent_Identity=24.234693877551, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI19921868, Length=392, Percent_Identity=24.234693877551, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45552519, Length=392, Percent_Identity=24.234693877551, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI281360430, Length=405, Percent_Identity=22.2222222222222, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 43602; Mature: 43602

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYVHFILGLVMVLALALLANRHNWKQIKLRYIGQLLVVELALAWFMLNSEVGLAVVGGF
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AAGFTKLMEFAKQGTDFVFGGLVNEGAFSFFLMVLMPIVFISVLIGILQYIRLLPIVIRG
HHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGTVLAKVNGMGKLESFNAISSMIVGQSENFIALKNTLPHLNEKQMYTLAATAMSTVSMS
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
IVGAYMQLIEPRYVVAALVLNMFSTFIVLSLINPYEPDNSVTDLKAIAEGDEHHTPKKEN
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHH
FFEMLGEYIMAGFTVAVIVGAMLVGFIALIALVNYLFEVAFGVNFQYVMGYIFYPIAWIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
GIPSGEALQAGSIMATKLVTNEFVAMMDLGKIAAELSPRTIGILSIFMVSFANFSSIGII
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHH
AGAVKALNEEKGNMVSRFGLKLVYGSTLVSLLSAVIAGVMI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEYVHFILGLVMVLALALLANRHNWKQIKLRYIGQLLVVELALAWFMLNSEVGLAVVGGF
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AAGFTKLMEFAKQGTDFVFGGLVNEGAFSFFLMVLMPIVFISVLIGILQYIRLLPIVIRG
HHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGTVLAKVNGMGKLESFNAISSMIVGQSENFIALKNTLPHLNEKQMYTLAATAMSTVSMS
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
IVGAYMQLIEPRYVVAALVLNMFSTFIVLSLINPYEPDNSVTDLKAIAEGDEHHTPKKEN
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHH
FFEMLGEYIMAGFTVAVIVGAMLVGFIALIALVNYLFEVAFGVNFQYVMGYIFYPIAWIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
GIPSGEALQAGSIMATKLVTNEFVAMMDLGKIAAELSPRTIGILSIFMVSFANFSSIGII
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHH
AGAVKALNEEKGNMVSRFGLKLVYGSTLVSLLSAVIAGVMI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]