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The map label for this gene is lysA [H]

Identifier: 145300547

GI number: 145300547

Start: 3965585

End: 3966835

Strand: Direct

Name: lysA [H]

Synonym: ASA_3679

Alternate gene names: 145300547

Gene position: 3965585-3966835 (Clockwise)

Preceding gene: 145300545

Following gene: 145300548

Centisome position: 84.33

GC content: 62.67

Gene sequence:

>1251_bases
TTGGATCACTTTAACTACGATGCCGACGGCCAGCTTCAGGCCGAGCAAACCTCGCTGCAACACCTTGCCGAGCAGTACGG
CACCCCGCTGTACGTATACTCCCGTGCGACCCTGGAGCGCCACTGGCATGCCTTCGATCAGGCAGCGGGCGATATTCCCC
ATCTGATCTGCTATGCGGTCAAGGCCAACTCCAATCTGGCGCTGCTCAACCTGCTGGCCCGCCTGGGCTCGGGTTTTGAC
ATCGTCTCCGGCGGCGAGTTGTCGCGGGTGCTGGCGGCGGGCGGTGATCCGGCCAAGGTGGTTTTCTCCGGCGTGGCCAA
GAGCGAAGCCGAGATGCGGCTGGCGCTGGATAAAGAGATCCTCTGTTTCAACCTGGAGTCGGAAGCCGAACTGGAGCGTC
TGAACCGGGTGGCGGGCAGCATGGGCAAGAAGGCCCGGGTCTCGGTGCGGGTCAATCCGGATATCGATGCCGGCACTCAC
CCTTATATCTCCACCGGCCTCAAGCAGAACAAATTTGGCATCCCCATCGAGCAGGCGCCTGCCATCTATCGCAAGGCGGC
GGCCATGGCCAACATAGAGATCAAGGGGGTGGATTGCCATATCGGTTCCCAGCTGACTGAACTCAACCCCTTCATGGAGG
CGGCCGACAAGCTGCTGCGCCTGATCGACACCCTGGCGGCGGAAGGTATTCACATCCATCACCTGGACGTGGGCGGCGGC
CTCGGGGTCAACTATGGTGCCGAGCAGCCACCTCATCCCACCGAGTATGCCGAGGCGCTCAAGCAGAAGCTGGCGGGTAG
GGATCTGACCCTGCTGTTCGAACCGGGCCGTGCCATCGTTGCCAACGCCGGTGTGCTGCTGACCCGGGTGGAGTACCTGA
AGCCGGGTGAAACCCGCAACTTCGCCCTGATCGATGCCGGCATGAACGACCTGCTGCGTCCCTCTCTCTACGGCGCCTGG
ATGAACATCATAGAGGTGGACAGCCGCACGGCCCATGAGAAGGCGCTGTATGACGTGGTCGGCCCGGTCTGCGAGACGGG
TGACTTCCTCGGCAAGGAGCGCACCCTGGCTATCGCCGAGGGCTCCCTGCTGGCGGTACGCTCCGCCGGTGCCTATGGCT
TTACCATGTCATCCAACTACAACACCCGTCCGCGTGCGGCCGAGGTGCTGGTGGATGGCACCCAATCCTTCCTCATCAGA
GAGCGCGAGCAGTTGGCCGATCTCTGGCGTGGTGAGCATCTACTGCCCTGA

Upstream 100 bases:

>100_bases
AGCAGCCCCAGACCGAGAGTACACCGCAAGCACAGACGCCTGCGACCGTCGAAGCTGCCCCAGAGGCCGCGCCGCAATAA
TTTAGGAAGGAACCGCCCCC

Downstream 100 bases:

>100_bases
ACACAGGAAGGCACCACGGCGACTGGATTTTCCAGACGAGTCTCTGTGTGCGTTGAACGCGCGAGCAGTTGACCGATTGC
CGGTGTTGCGAGCATTGACG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MDHFNYDADGQLQAEQTSLQHLAEQYGTPLYVYSRATLERHWHAFDQAAGDIPHLICYAVKANSNLALLNLLARLGSGFD
IVSGGELSRVLAAGGDPAKVVFSGVAKSEAEMRLALDKEILCFNLESEAELERLNRVAGSMGKKARVSVRVNPDIDAGTH
PYISTGLKQNKFGIPIEQAPAIYRKAAAMANIEIKGVDCHIGSQLTELNPFMEAADKLLRLIDTLAAEGIHIHHLDVGGG
LGVNYGAEQPPHPTEYAEALKQKLAGRDLTLLFEPGRAIVANAGVLLTRVEYLKPGETRNFALIDAGMNDLLRPSLYGAW
MNIIEVDSRTAHEKALYDVVGPVCETGDFLGKERTLAIAEGSLLAVRSAGAYGFTMSSNYNTRPRAAEVLVDGTQSFLIR
EREQLADLWRGEHLLP

Sequences:

>Translated_416_residues
MDHFNYDADGQLQAEQTSLQHLAEQYGTPLYVYSRATLERHWHAFDQAAGDIPHLICYAVKANSNLALLNLLARLGSGFD
IVSGGELSRVLAAGGDPAKVVFSGVAKSEAEMRLALDKEILCFNLESEAELERLNRVAGSMGKKARVSVRVNPDIDAGTH
PYISTGLKQNKFGIPIEQAPAIYRKAAAMANIEIKGVDCHIGSQLTELNPFMEAADKLLRLIDTLAAEGIHIHHLDVGGG
LGVNYGAEQPPHPTEYAEALKQKLAGRDLTLLFEPGRAIVANAGVLLTRVEYLKPGETRNFALIDAGMNDLLRPSLYGAW
MNIIEVDSRTAHEKALYDVVGPVCETGDFLGKERTLAIAEGSLLAVRSAGAYGFTMSSNYNTRPRAAEVLVDGTQSFLIR
EREQLADLWRGEHLLP
>Mature_416_residues
MDHFNYDADGQLQAEQTSLQHLAEQYGTPLYVYSRATLERHWHAFDQAAGDIPHLICYAVKANSNLALLNLLARLGSGFD
IVSGGELSRVLAAGGDPAKVVFSGVAKSEAEMRLALDKEILCFNLESEAELERLNRVAGSMGKKARVSVRVNPDIDAGTH
PYISTGLKQNKFGIPIEQAPAIYRKAAAMANIEIKGVDCHIGSQLTELNPFMEAADKLLRLIDTLAAEGIHIHHLDVGGG
LGVNYGAEQPPHPTEYAEALKQKLAGRDLTLLFEPGRAIVANAGVLLTRVEYLKPGETRNFALIDAGMNDLLRPSLYGAW
MNIIEVDSRTAHEKALYDVVGPVCETGDFLGKERTLAIAEGSLLAVRSAGAYGFTMSSNYNTRPRAAEVLVDGTQSFLIR
EREQLADLWRGEHLLP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=239, Percent_Identity=26.7782426778243, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789203, Length=428, Percent_Identity=32.7102803738318, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1789307, Length=318, Percent_Identity=25.4716981132075, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562780, Length=345, Percent_Identity=23.4782608695652, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=387, Percent_Identity=24.5478036175711, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24586474, Length=386, Percent_Identity=23.8341968911917, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24586472, Length=339, Percent_Identity=24.7787610619469, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45299; Mature: 45299

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFNYDADGQLQAEQTSLQHLAEQYGTPLYVYSRATLERHWHAFDQAAGDIPHLICYAV
CCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEE
KANSNLALLNLLARLGSGFDIVSGGELSRVLAAGGDPAKVVFSGVAKSEAEMRLALDKEI
ECCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCEE
LCFNLESEAELERLNRVAGSMGKKARVSVRVNPDIDAGTHPYISTGLKQNKFGIPIEQAP
EEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHCH
AIYRKAAAMANIEIKGVDCHIGSQLTELNPFMEAADKLLRLIDTLAAEGIHIHHLDVGGG
HHHHHHHHHEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
LGVNYGAEQPPHPTEYAEALKQKLAGRDLTLLFEPGRAIVANAGVLLTRVEYLKPGETRN
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHCCCCCCCC
FALIDAGMNDLLRPSLYGAWMNIIEVDSRTAHEKALYDVVGPVCETGDFLGKERTLAIAE
EEEEECCHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEC
GSLLAVRSAGAYGFTMSSNYNTRPRAAEVLVDGTQSFLIREREQLADLWRGEHLLP
CCEEEEECCCCEEEEECCCCCCCCCHHHEEECCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDHFNYDADGQLQAEQTSLQHLAEQYGTPLYVYSRATLERHWHAFDQAAGDIPHLICYAV
CCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEE
KANSNLALLNLLARLGSGFDIVSGGELSRVLAAGGDPAKVVFSGVAKSEAEMRLALDKEI
ECCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCEE
LCFNLESEAELERLNRVAGSMGKKARVSVRVNPDIDAGTHPYISTGLKQNKFGIPIEQAP
EEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHCH
AIYRKAAAMANIEIKGVDCHIGSQLTELNPFMEAADKLLRLIDTLAAEGIHIHHLDVGGG
HHHHHHHHHEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
LGVNYGAEQPPHPTEYAEALKQKLAGRDLTLLFEPGRAIVANAGVLLTRVEYLKPGETRN
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHCCCCCCCC
FALIDAGMNDLLRPSLYGAWMNIIEVDSRTAHEKALYDVVGPVCETGDFLGKERTLAIAE
EEEEECCHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEC
GSLLAVRSAGAYGFTMSSNYNTRPRAAEVLVDGTQSFLIREREQLADLWRGEHLLP
CCEEEEECCCCEEEEECCCCCCCCCHHHEEECCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]