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The map label for this gene is dsbD [H]

Identifier: 145300376

GI number: 145300376

Start: 3790622

End: 3792409

Strand: Direct

Name: dsbD [H]

Synonym: ASA_3501

Alternate gene names: 145300376

Gene position: 3790622-3792409 (Clockwise)

Preceding gene: 145300375

Following gene: 145300377

Centisome position: 80.61

GC content: 64.09

Gene sequence:

>1788_bases
ATGACACTGTCTCGCCTGCTCTCCCCCCTGCTTGTGCTCTTCGCCATGCTGCTGTCCACCCTGAGTGTGACGCCGGTTCA
GGCCAGCAGTGACAGTCTGCTGAGCGCCCTCGGCATCGAGGCCAACGCCCAGCCCAAGTTTCTGAAAGTCGACGACGCCT
TCGCGCTCGAGAGTGAACAGCAAGGCAACCAGCTATTGCTGACCCTGCGCATCGCCGATAACTACTATCTCTACCGCCAC
AGCTTACGCTTCAAGGGCGAGAATCTCACCTTCAACGAACCCGTCTTGCCCGCCGGGGCAGAGCATGAGGATGACTTCTT
CGGCAAGACCTGGGTCTACTACCGGGAGGTGCAGATCCCCGTCACCCTGACCGAGGCGGGCCAGCAGGCCAGCCTCACCG
TCAGCTATCAGGGCTGTACCGACGGCCTCTGCTACCCGCCCACAGACAAGCAGATTGCGGTGCAGCCTGTCGTCGCTAAC
GATACAGATCCGGCCGCCACCGATGACATGACCCGCGCCCCAGCCAGCAGTCAGCAGGATCAACTGGCCGCGGCCCTCGG
CAGCCAGGGCTTCTGGCTCAGCATCGCCGCCTTCTTCGCGCTGGGGCTGGGGCTCGCCTTCACCCCCTGCGTCTTCCCCA
TGTACCCGATCCTGACCGGCATCATAGCCGGGGCGGGTCATAGGCTCTCCACCCGCCGCGCCTTCCTGCTCTCCTTCGTC
TATGTGCAGGGGATGGCGGTGACCTACACCCTGCTCGGGCTGGTGGTGGCGTCGGCGGGCTTGAAATTCCAGGCGGCGCT
GCAGCACCCCTATGTGCTGATCGGGCTCTCCGTCATGTTCGTGCTGCTGGCGCTCTCCATGTTCGGGCTCTACACCCTGC
AACTGCCGAGCAGCCTGCAAACCCGCTTGAGCGGCCTCTCCAACCGCCAGCAGGGAGGCTCTGTACTCGGGGTCAGCATC
ATGGGGATGATCTCGGGCCTGGTCTGCTCCCCCTGCACCACGGCACCGCTCTCCGGCGCCCTGATTTACGTGGCTCAAAG
CGGCGATCTCTGGCTCGGCGGTGCGGCCCTCTATGCCTTGTCGCTGGGCATGGGACCGCCGTTGCTGCTGCTCGGCACCT
CAGGGGGCAAGTTGCTGCCCAGAGCGGGCGCCTGGATGGATGTGATCAAGCAACTCTTTGGTTTTGCGCTGCTTGCGGTG
CCAATCCTACTGTTGTCACGGCTCTGGAGCGACCAGGTCGCCACCCTCGCCTGGCTCGGCTGGGGGCTGCTGCTGTGCGG
CTACCTCTATCACCACAACCAGCATCGCGCCCACTCGGTCGGCAAGAGTCTCGGCGGCTTTGTGCTGTTGCTGGCGATGA
TGAGCCTGGTGGTGGTAGGCAAGGATCTGCTGCTGCCCGTGCCCGGCGTCAAGGCCAGCGCCGAGACCCAGGCGCCCCAA
TTTATCCGCATCAAGACCCTGGATGACCTCAAGACGCAACTCGCCGCCGCCCGCGGCAAACCTGTGCTGCTGGACCTCTA
CGCCGACTGGTGCGTGGCCTGCAAGGAGTTCGAGCACAAGACCTTCAGCGATCCCGCCGTGCGGGCGCGCTTCGATGACA
TCGCACTGCTGCAAGCGGACGTCACCGCCAACGACGATGCCGATGTGGAACTGCTCAACGGCCTGAACGTGCTGGGCCTG
CCGACCCTGATCTTCTTCGACAGTGCCGGCCAGGAACTGAGTGACCAGCGGGTGACCGGCTTTATGGGCCCCACCGAGTT
TTTGGGTCAGCTCGACAAGTTGCGCTGA

Upstream 100 bases:

>100_bases
GTATCCTCAACCATCACCCCTATGAGGTGCCGGAGATCCTGGCACTCCCGACAAGCCAGGGCCATCAGCCCTATCTCGAC
TGGTTAACACAGGAAACCTC

Downstream 100 bases:

>100_bases
AGGCCATTGGCCCGGAGTTAACTGCTCCGGGCCATACCCGCGGCTAGCTACTGATTTTTCTGACAATCCCTTGTATATGA
TCGGCAGCGTGGCAGAATTT

Product: thiol:disulfide interchange protein DsbD

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MTLSRLLSPLLVLFAMLLSTLSVTPVQASSDSLLSALGIEANAQPKFLKVDDAFALESEQQGNQLLLTLRIADNYYLYRH
SLRFKGENLTFNEPVLPAGAEHEDDFFGKTWVYYREVQIPVTLTEAGQQASLTVSYQGCTDGLCYPPTDKQIAVQPVVAN
DTDPAATDDMTRAPASSQQDQLAAALGSQGFWLSIAAFFALGLGLAFTPCVFPMYPILTGIIAGAGHRLSTRRAFLLSFV
YVQGMAVTYTLLGLVVASAGLKFQAALQHPYVLIGLSVMFVLLALSMFGLYTLQLPSSLQTRLSGLSNRQQGGSVLGVSI
MGMISGLVCSPCTTAPLSGALIYVAQSGDLWLGGAALYALSLGMGPPLLLLGTSGGKLLPRAGAWMDVIKQLFGFALLAV
PILLLSRLWSDQVATLAWLGWGLLLCGYLYHHNQHRAHSVGKSLGGFVLLLAMMSLVVVGKDLLLPVPGVKASAETQAPQ
FIRIKTLDDLKTQLAAARGKPVLLDLYADWCVACKEFEHKTFSDPAVRARFDDIALLQADVTANDDADVELLNGLNVLGL
PTLIFFDSAGQELSDQRVTGFMGPTEFLGQLDKLR

Sequences:

>Translated_595_residues
MTLSRLLSPLLVLFAMLLSTLSVTPVQASSDSLLSALGIEANAQPKFLKVDDAFALESEQQGNQLLLTLRIADNYYLYRH
SLRFKGENLTFNEPVLPAGAEHEDDFFGKTWVYYREVQIPVTLTEAGQQASLTVSYQGCTDGLCYPPTDKQIAVQPVVAN
DTDPAATDDMTRAPASSQQDQLAAALGSQGFWLSIAAFFALGLGLAFTPCVFPMYPILTGIIAGAGHRLSTRRAFLLSFV
YVQGMAVTYTLLGLVVASAGLKFQAALQHPYVLIGLSVMFVLLALSMFGLYTLQLPSSLQTRLSGLSNRQQGGSVLGVSI
MGMISGLVCSPCTTAPLSGALIYVAQSGDLWLGGAALYALSLGMGPPLLLLGTSGGKLLPRAGAWMDVIKQLFGFALLAV
PILLLSRLWSDQVATLAWLGWGLLLCGYLYHHNQHRAHSVGKSLGGFVLLLAMMSLVVVGKDLLLPVPGVKASAETQAPQ
FIRIKTLDDLKTQLAAARGKPVLLDLYADWCVACKEFEHKTFSDPAVRARFDDIALLQADVTANDDADVELLNGLNVLGL
PTLIFFDSAGQELSDQRVTGFMGPTEFLGQLDKLR
>Mature_594_residues
TLSRLLSPLLVLFAMLLSTLSVTPVQASSDSLLSALGIEANAQPKFLKVDDAFALESEQQGNQLLLTLRIADNYYLYRHS
LRFKGENLTFNEPVLPAGAEHEDDFFGKTWVYYREVQIPVTLTEAGQQASLTVSYQGCTDGLCYPPTDKQIAVQPVVAND
TDPAATDDMTRAPASSQQDQLAAALGSQGFWLSIAAFFALGLGLAFTPCVFPMYPILTGIIAGAGHRLSTRRAFLLSFVY
VQGMAVTYTLLGLVVASAGLKFQAALQHPYVLIGLSVMFVLLALSMFGLYTLQLPSSLQTRLSGLSNRQQGGSVLGVSIM
GMISGLVCSPCTTAPLSGALIYVAQSGDLWLGGAALYALSLGMGPPLLLLGTSGGKLLPRAGAWMDVIKQLFGFALLAVP
ILLLSRLWSDQVATLAWLGWGLLLCGYLYHHNQHRAHSVGKSLGGFVLLLAMMSLVVVGKDLLLPVPGVKASAETQAPQF
IRIKTLDDLKTQLAAARGKPVLLDLYADWCVACKEFEHKTFSDPAVRARFDDIALLQADVTANDDADVELLNGLNVLGLP
TLIFFDSAGQELSDQRVTGFMGPTEFLGQLDKLR

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm, thereby maintaining the

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=565, Percent_Identity=50.4424778761062, Blast_Score=533, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 63927; Mature: 63796

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSRLLSPLLVLFAMLLSTLSVTPVQASSDSLLSALGIEANAQPKFLKVDDAFALESEQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCC
QGNQLLLTLRIADNYYLYRHSLRFKGENLTFNEPVLPAGAEHEDDFFGKTWVYYREVQIP
CCCEEEEEEEEECCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEE
VTLTEAGQQASLTVSYQGCTDGLCYPPTDKQIAVQPVVANDTDPAATDDMTRAPASSQQD
EEEECCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHH
QLAAALGSQGFWLSIAAFFALGLGLAFTPCVFPMYPILTGIIAGAGHRLSTRRAFLLSFV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
YVQGMAVTYTLLGLVVASAGLKFQAALQHPYVLIGLSVMFVLLALSMFGLYTLQLPSSLQ
HHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCHHHH
TRLSGLSNRQQGGSVLGVSIMGMISGLVCSPCTTAPLSGALIYVAQSGDLWLGGAALYAL
HHHHHCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEECHHHHHHH
SLGMGPPLLLLGTSGGKLLPRAGAWMDVIKQLFGFALLAVPILLLSRLWSDQVATLAWLG
HCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WGLLLCGYLYHHNQHRAHSVGKSLGGFVLLLAMMSLVVVGKDLLLPVPGVKASAETQAPQ
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCC
FIRIKTLDDLKTQLAAARGKPVLLDLYADWCVACKEFEHKTFSDPAVRARFDDIALLQAD
EEEEEEHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEC
VTANDDADVELLNGLNVLGLPTLIFFDSAGQELSDQRVTGFMGPTEFLGQLDKLR
CCCCCCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TLSRLLSPLLVLFAMLLSTLSVTPVQASSDSLLSALGIEANAQPKFLKVDDAFALESEQ
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCC
QGNQLLLTLRIADNYYLYRHSLRFKGENLTFNEPVLPAGAEHEDDFFGKTWVYYREVQIP
CCCEEEEEEEEECCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEE
VTLTEAGQQASLTVSYQGCTDGLCYPPTDKQIAVQPVVANDTDPAATDDMTRAPASSQQD
EEEECCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHH
QLAAALGSQGFWLSIAAFFALGLGLAFTPCVFPMYPILTGIIAGAGHRLSTRRAFLLSFV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
YVQGMAVTYTLLGLVVASAGLKFQAALQHPYVLIGLSVMFVLLALSMFGLYTLQLPSSLQ
HHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCHHHH
TRLSGLSNRQQGGSVLGVSIMGMISGLVCSPCTTAPLSGALIYVAQSGDLWLGGAALYAL
HHHHHCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEECHHHHHHH
SLGMGPPLLLLGTSGGKLLPRAGAWMDVIKQLFGFALLAVPILLLSRLWSDQVATLAWLG
HCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WGLLLCGYLYHHNQHRAHSVGKSLGGFVLLLAMMSLVVVGKDLLLPVPGVKASAETQAPQ
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCC
FIRIKTLDDLKTQLAAARGKPVLLDLYADWCVACKEFEHKTFSDPAVRARFDDIALLQAD
EEEEEEHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEC
VTANDDADVELLNGLNVLGLPTLIFFDSAGQELSDQRVTGFMGPTEFLGQLDKLR
CCCCCCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]