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The map label for this gene is pkwA [H]

Identifier: 145300186

GI number: 145300186

Start: 3566201

End: 3567169

Strand: Direct

Name: pkwA [H]

Synonym: ASA_3297

Alternate gene names: 145300186

Gene position: 3566201-3567169 (Clockwise)

Preceding gene: 145300183

Following gene: 145300187

Centisome position: 75.84

GC content: 60.58

Gene sequence:

>969_bases
ATGATAAAAAGTGCCATTTATCTCATCGGTATTTGTCTGACACTGACCGGTTGCGAGCAGAGCTCCCGGCCGGGCCAACA
AGTCACACTCGCCAATCAGGGTCTGCTGAGTGCAGACCTTGCCAGCGATGGCAAGCAGGCCATCGTCTCCAGCCTGGGAC
AGGGCACTGTCGTGTGGGATCTGGAACAGGGAAAGGAGCGCTGGCGCTGGCGCCAGTCAGACAATCAGGACAACTTCGTC
ATCGTTACCCGCTTCTCGGCAGACAACAGCCATGCGGTGACCGCCACCCTGGATACCTTCGCCATCTGGCGCCTGCAAGA
TGGTCAGTCCCAAGGCTACTACTCGCTACCTGAATCCAAACTGAGGGACATAGCGCTGTCGGCCAATGGCCGCCAGGTGC
TGATCGGGCGTGAAGATGGCAAGGCGGAGGTGGTCGATACCCAGAGCGGCCGCCGGCTGCAATTTCTCGGCCACACCGAG
CAGGTCAATACGGTGGATCTCTCCGCCAATGGTCGCTACGCCCTCACCGGCGGCAACGACTACAGCGCCTATCTGTGGGA
TACCCGCTCAGGTCAGGTGGTATGGCGTTTCAACCACGCTGGTCGGGTGGTGATGGCAAGGCTCGATCCCCAGGGCCGTT
TCGCCTTCACAGCGGACAGCCGCCAGGCCAGCATCTGGGATCTCAAGACAGGCAAGGAGGTGAGCCGGTTGCAGTTCGCG
CACCGCTTCGAGGTCTACACCAGTGCCCGCTTCGTCAACGACGGCAAATGGCTCATCACGGGTGCCCCCTCCCGCCAGCT
CTCCCTGTGGCAGGTGAGCGATGGCACCCAACTGCAAAGCTGGCTCGTCTCACCCCATCCCAAGGTGAAACCGCCGAGTG
CAGTGGTCTACGGCGTGGCTTTGCGCGACAATAGTCACCTTGTCAGCGCCAGCTCCAGTGGTCTGGCCGAAATCTGGACT
ATCAAGTAA

Upstream 100 bases:

>100_bases
AATACCGCTCTCGGTTCCTTCGTGAAATGAGAGGTTTATCGTGATAAGCGCCTTATACTAACGCCGTGATCGCAGGTAAC
GAAAGCATGAGACAGGAAAA

Downstream 100 bases:

>100_bases
GGACCTAAAGGCCCATGAGTCAGCAACTTAACGATCGCATCGAAACTCTGGAAAGCCGTCTCGCCTTCGCCGAATACACG
GTGGAACAGCTCAACGACGA

Product: WD40 domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MIKSAIYLIGICLTLTGCEQSSRPGQQVTLANQGLLSADLASDGKQAIVSSLGQGTVVWDLEQGKERWRWRQSDNQDNFV
IVTRFSADNSHAVTATLDTFAIWRLQDGQSQGYYSLPESKLRDIALSANGRQVLIGREDGKAEVVDTQSGRRLQFLGHTE
QVNTVDLSANGRYALTGGNDYSAYLWDTRSGQVVWRFNHAGRVVMARLDPQGRFAFTADSRQASIWDLKTGKEVSRLQFA
HRFEVYTSARFVNDGKWLITGAPSRQLSLWQVSDGTQLQSWLVSPHPKVKPPSAVVYGVALRDNSHLVSASSSGLAEIWT
IK

Sequences:

>Translated_322_residues
MIKSAIYLIGICLTLTGCEQSSRPGQQVTLANQGLLSADLASDGKQAIVSSLGQGTVVWDLEQGKERWRWRQSDNQDNFV
IVTRFSADNSHAVTATLDTFAIWRLQDGQSQGYYSLPESKLRDIALSANGRQVLIGREDGKAEVVDTQSGRRLQFLGHTE
QVNTVDLSANGRYALTGGNDYSAYLWDTRSGQVVWRFNHAGRVVMARLDPQGRFAFTADSRQASIWDLKTGKEVSRLQFA
HRFEVYTSARFVNDGKWLITGAPSRQLSLWQVSDGTQLQSWLVSPHPKVKPPSAVVYGVALRDNSHLVSASSSGLAEIWT
IK
>Mature_322_residues
MIKSAIYLIGICLTLTGCEQSSRPGQQVTLANQGLLSADLASDGKQAIVSSLGQGTVVWDLEQGKERWRWRQSDNQDNFV
IVTRFSADNSHAVTATLDTFAIWRLQDGQSQGYYSLPESKLRDIALSANGRQVLIGREDGKAEVVDTQSGRRLQFLGHTE
QVNTVDLSANGRYALTGGNDYSAYLWDTRSGQVVWRFNHAGRVVMARLDPQGRFAFTADSRQASIWDLKTGKEVSRLQFA
HRFEVYTSARFVNDGKWLITGAPSRQLSLWQVSDGTQLQSWLVSPHPKVKPPSAVVYGVALRDNSHLVSASSSGLAEIWT
IK

Specific function: May play a regulatory role during the complex growth cycle and in secondary metabolite production [H]

COG id: COG2319

COG function: function code R; FOG: WD40 repeat

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 WD repeats [H]

Homologues:

Organism=Homo sapiens, GI32189425, Length=242, Percent_Identity=25.2066115702479, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI113865883, Length=139, Percent_Identity=34.5323741007194, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17505895, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17541222, Length=223, Percent_Identity=26.9058295964126, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319675, Length=202, Percent_Identity=25.7425742574257, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020472
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR015943
- InterPro:   IPR001680
- InterPro:   IPR011046
- InterPro:   IPR019782
- InterPro:   IPR019775
- InterPro:   IPR017986
- InterPro:   IPR019781 [H]

Pfam domain/function: PF00069 Pkinase; PF00400 WD40 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 35648; Mature: 35648

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00678 WD_REPEATS_1 ; PS50082 WD_REPEATS_2 ; PS50294 WD_REPEATS_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSAIYLIGICLTLTGCEQSSRPGQQVTLANQGLLSADLASDGKQAIVSSLGQGTVVWD
CCCHHHEEEEEEEEEECCCCCCCCCCEEEEECCCEEEEHHCCCCHHHHHHHCCCCCEEEE
LEQGKERWRWRQSDNQDNFVIVTRFSADNSHAVTATLDTFAIWRLQDGQSQGYYSLPESK
ECCCHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEEEECCCCCCEEECCHHH
LRDIALSANGRQVLIGREDGKAEVVDTQSGRRLQFLGHTEQVNTVDLSANGRYALTGGND
HHEEEEECCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCEEEEECCCCCEEEECCCC
YSAYLWDTRSGQVVWRFNHAGRVVMARLDPQGRFAFTADSRQASIWDLKTGKEVSRLQFA
EEEEEEECCCCEEEEEEECCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCHHHHHHHH
HRFEVYTSARFVNDGKWLITGAPSRQLSLWQVSDGTQLQSWLVSPHPKVKPPSAVVYGVA
HHEEEEEEEEEEECCCEEEECCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCEEEEEEE
LRDNSHLVSASSSGLAEIWTIK
EECCCEEEEECCCCCEEEEEEC
>Mature Secondary Structure
MIKSAIYLIGICLTLTGCEQSSRPGQQVTLANQGLLSADLASDGKQAIVSSLGQGTVVWD
CCCHHHEEEEEEEEEECCCCCCCCCCEEEEECCCEEEEHHCCCCHHHHHHHCCCCCEEEE
LEQGKERWRWRQSDNQDNFVIVTRFSADNSHAVTATLDTFAIWRLQDGQSQGYYSLPESK
ECCCHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEEEECCCCCCEEECCHHH
LRDIALSANGRQVLIGREDGKAEVVDTQSGRRLQFLGHTEQVNTVDLSANGRYALTGGND
HHEEEEECCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCEEEEECCCCCEEEECCCC
YSAYLWDTRSGQVVWRFNHAGRVVMARLDPQGRFAFTADSRQASIWDLKTGKEVSRLQFA
EEEEEEECCCCEEEEEEECCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCHHHHHHHH
HRFEVYTSARFVNDGKWLITGAPSRQLSLWQVSDGTQLQSWLVSPHPKVKPPSAVVYGVA
HHEEEEEEEEEEECCCEEEECCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCEEEEEEE
LRDNSHLVSASSSGLAEIWTIK
EECCCEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631732 [H]