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The map label for this gene is pheA [H]

Identifier: 145300136

GI number: 145300136

Start: 3503407

End: 3504579

Strand: Direct

Name: pheA [H]

Synonym: ASA_3238

Alternate gene names: 145300136

Gene position: 3503407-3504579 (Clockwise)

Preceding gene: 145300114

Following gene: 145300139

Centisome position: 74.5

GC content: 61.38

Gene sequence:

>1173_bases
ATGGCTACGCTCGACGAGATCAGACAAGACATCACCCGGTTGGATCAGGAGCTGCTTGCCCTGCTGGCCAAGCGCAAGAC
TCTCAGTATCGAGGTCGCCCGTGCCAAGCAGGCCAATCCCCGTCCCATTCGCGATACCCAGCGCGAGCAGGACTTGCTGG
TCGCCCTGATCCAGCAGGGCCGGCTGCTGGGGCTGGATGCCCAGTACATCACCCGCATCTACCACACCATCATCGAAGAT
TCGGTGCTCTCCCAGCAGGCTTATCTGCAGAGCCTGATCAACCCGGAGCAGCAGGAGCCCATGACCAGCGTCGCCTATCT
GGGCCCGCACGGCTCTTACTCCAGCCTGGCGGCCCGCAAGTATCTGGCCCGCTACAAGGATCAGGTGATAGAGGTGAATT
GCCAGAACTTCCGCGAGGTGCTGGATGCGGTGGAGTCAGGGCGCGCTGCCTTTGGCGTCTTGCCCATCGAGAACACCAGC
TCGGGCTCCATCAACGAGGTGTACGATGTGATGCAGCACACCAGCCTCTCCATCGTCGGTGAGCTGACCTACCCCATAGA
GCACTGCATCCTCACCGCAGTGCCGACCGAGCTGGGTCGCATCAAAACCTTCTATGCCCACCCTCAGGTGTTCCAGCAGT
GCTCCCACTACCTGAGCAAGCTGGAAGGGGCGCGCCACGAGATCTGCGATTCTTCTTCCAGCGCCATGATGAAGGTGAAA
GAGCTGGCCAGCCCCGATGCCGCCGCCATCGGCAGCGCAGCCGGCGGTGAGCTCTATGGCCTGAACGTGCTGGCCGAACA
GCTCGCCAACCAGAAGGAGAACTACAGCCGCTTCATCGTAGTGGCGCGCAAGCCCATCGACGTAGCGCCGCAAATTCCGG
CCAAGACCACCCTCATCATGTCCACCTCCCAGAAACCGGGTTCCCTGGTGGAAGCGCTGCTGGTGCTGCGCAACAACGAG
ATCAACATGACCAAGCTCGAATCCCGGCCGGTACAGGGCAACCCCTGGGAAGAGATGTTCTATCTGGATGTGTCCGCCAA
CCTGCAGACGCCGGCCATGCAAGCCGCATTGATCGAGCTGACCAAGCTCACCCGCTACATCAAGGTGCTCGGCTGCTACC
CGAGCGAAGACGTCAAGCCGACCACAGTGCCGCCGGTCCTGATGGGCAACTGA

Upstream 100 bases:

>100_bases
CTGTCGTCGCGTGAACAGCAACCAAAGACGAATCGAGCCTCCCCTAGTGGAGGCTTTTTTTTGCAGCTACAACAATCGAT
TACTTGGATAGGGAACAATC

Downstream 100 bases:

>100_bases
CCGTAACTGCAAACAAAAAAGGCGAACATTATGTTCGCCTTTTTTGTTTTTACCTCAGCTCGGCACGCCGTCAGAACTGA
CCCGCCATCAACTGGTTGAT

Product: chorismate mutase/prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MATLDEIRQDITRLDQELLALLAKRKTLSIEVARAKQANPRPIRDTQREQDLLVALIQQGRLLGLDAQYITRIYHTIIED
SVLSQQAYLQSLINPEQQEPMTSVAYLGPHGSYSSLAARKYLARYKDQVIEVNCQNFREVLDAVESGRAAFGVLPIENTS
SGSINEVYDVMQHTSLSIVGELTYPIEHCILTAVPTELGRIKTFYAHPQVFQQCSHYLSKLEGARHEICDSSSSAMMKVK
ELASPDAAAIGSAAGGELYGLNVLAEQLANQKENYSRFIVVARKPIDVAPQIPAKTTLIMSTSQKPGSLVEALLVLRNNE
INMTKLESRPVQGNPWEEMFYLDVSANLQTPAMQAALIELTKLTRYIKVLGCYPSEDVKPTTVPPVLMGN

Sequences:

>Translated_390_residues
MATLDEIRQDITRLDQELLALLAKRKTLSIEVARAKQANPRPIRDTQREQDLLVALIQQGRLLGLDAQYITRIYHTIIED
SVLSQQAYLQSLINPEQQEPMTSVAYLGPHGSYSSLAARKYLARYKDQVIEVNCQNFREVLDAVESGRAAFGVLPIENTS
SGSINEVYDVMQHTSLSIVGELTYPIEHCILTAVPTELGRIKTFYAHPQVFQQCSHYLSKLEGARHEICDSSSSAMMKVK
ELASPDAAAIGSAAGGELYGLNVLAEQLANQKENYSRFIVVARKPIDVAPQIPAKTTLIMSTSQKPGSLVEALLVLRNNE
INMTKLESRPVQGNPWEEMFYLDVSANLQTPAMQAALIELTKLTRYIKVLGCYPSEDVKPTTVPPVLMGN
>Mature_389_residues
ATLDEIRQDITRLDQELLALLAKRKTLSIEVARAKQANPRPIRDTQREQDLLVALIQQGRLLGLDAQYITRIYHTIIEDS
VLSQQAYLQSLINPEQQEPMTSVAYLGPHGSYSSLAARKYLARYKDQVIEVNCQNFREVLDAVESGRAAFGVLPIENTSS
GSINEVYDVMQHTSLSIVGELTYPIEHCILTAVPTELGRIKTFYAHPQVFQQCSHYLSKLEGARHEICDSSSSAMMKVKE
LASPDAAAIGSAAGGELYGLNVLAEQLANQKENYSRFIVVARKPIDVAPQIPAKTTLIMSTSQKPGSLVEALLVLRNNEI
NMTKLESRPVQGNPWEEMFYLDVSANLQTPAMQAALIELTKLTRYIKVLGCYPSEDVKPTTVPPVLMGN

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=377, Percent_Identity=56.2334217506631, Blast_Score=438, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6324013, Length=320, Percent_Identity=21.25, Blast_Score=80, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010952
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 43259; Mature: 43128

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLDEIRQDITRLDQELLALLAKRKTLSIEVARAKQANPRPIRDTQREQDLLVALIQQG
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCC
RLLGLDAQYITRIYHTIIEDSVLSQQAYLQSLINPEQQEPMTSVAYLGPHGSYSSLAARK
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCHHHHHHHH
YLARYKDQVIEVNCQNFREVLDAVESGRAAFGVLPIENTSSGSINEVYDVMQHTSLSIVG
HHHHHHHHEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHEEE
ELTYPIEHCILTAVPTELGRIKTFYAHPQVFQQCSHYLSKLEGARHEICDSSSSAMMKVK
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
ELASPDAAAIGSAAGGELYGLNVLAEQLANQKENYSRFIVVARKPIDVAPQIPAKTTLIM
HHCCCCHHHHCCCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCEEEEE
STSQKPGSLVEALLVLRNNEINMTKLESRPVQGNPWEEMFYLDVSANLQTPAMQAALIEL
ECCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
TKLTRYIKVLGCYPSEDVKPTTVPPVLMGN
HHHHHHHHHHCCCCCCCCCCCCCCCEECCC
>Mature Secondary Structure 
ATLDEIRQDITRLDQELLALLAKRKTLSIEVARAKQANPRPIRDTQREQDLLVALIQQG
CCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCC
RLLGLDAQYITRIYHTIIEDSVLSQQAYLQSLINPEQQEPMTSVAYLGPHGSYSSLAARK
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCHHHHHHHH
YLARYKDQVIEVNCQNFREVLDAVESGRAAFGVLPIENTSSGSINEVYDVMQHTSLSIVG
HHHHHHHHEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHEEE
ELTYPIEHCILTAVPTELGRIKTFYAHPQVFQQCSHYLSKLEGARHEICDSSSSAMMKVK
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
ELASPDAAAIGSAAGGELYGLNVLAEQLANQKENYSRFIVVARKPIDVAPQIPAKTTLIM
HHCCCCHHHHCCCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCEEEEE
STSQKPGSLVEALLVLRNNEINMTKLESRPVQGNPWEEMFYLDVSANLQTPAMQAALIEL
ECCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
TKLTRYIKVLGCYPSEDVKPTTVPPVLMGN
HHHHHHHHHHCCCCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]