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The map label for this gene is lysC [H]

Identifier: 145299511

GI number: 145299511

Start: 2755587

End: 2756939

Strand: Direct

Name: lysC [H]

Synonym: ASA_2578

Alternate gene names: 145299511

Gene position: 2755587-2756939 (Clockwise)

Preceding gene: 145299510

Following gene: 145299513

Centisome position: 58.6

GC content: 64.45

Gene sequence:

>1353_bases
ATGAGCCCGATGAATGTCGCCAAGTTTGGCGGAACCAGTGTCGCCAATGCCGCGGCCATGAACAACTGCGCCAATGTGGT
ACTGGCCAATCCGGCAACCCGGGTGGTGGTACTGAGCGCCAGCGCCGGCGTCACCAATCTGCTGGTGGCACTGGCCCAGG
GCGATCTGGACGAGGCAGGCCAGGAGGCACAGCTGGCCAAACTGGCCGAGATCCAGCAGGCCATACTGACGGCACTGGGC
GATCCCGCCGACGTGAGTACCCTGATCCATGCCACCCTCGGCGAGATCCGCACCATGGCCCGCCAGGCCAGTCAGCATAC
GGATGCAGAGCTGGCTGACAGGCTCATCGCCTGTGGCGAGCTGATGTCTACCCGCCTCTTCACCGAGCTGTTGCACCAGC
GTGGTATCAAGGCCCACTGGCAGGATGTGCGCCAGCTGATGCGCACCGACAGCCGCTTTGGCAAGGCGACCGTGGATCTC
GGTGCCACTCGCGGCCTCTGCCAACAGGCGCTGGGGCCCCTGCTCGGCGACAGCCTCATCATCACTCAGGGCTTCATCGG
CTCGGATGCCGATGGCCGCACCACCACGCTTGGTCGCGGCGGCTCCGATTACAGCGCCGCCCTGCTCGCCGAAGCGCTGG
ATGCGGGCAGCATAGAGATCTGGACCGATGTGCCCGGCATCTACACCACGGATCCGCGACTGGTGACACGCGCACGCCCC
ATTCCTGAAATAAGCTTCGTGGAAGCGGCTGAGATGGCTACCTTTGGCGCCAAGGTGCTGCACCCGGCCACCCTGCAACC
TGCGGTGCGCCAGGACATTCCTGTCTTTGTCGGCTCCAGCAAGGATCCCGCCGCCGGCGGCACCTGGATCCGCGCCAGCA
CCAGCACCAACCCGCTGTTTCGCGCCGTGGCATTGCGCCGCCAGCAAGTGCTGGTCACACTGCACAGCCTCAACATGTTC
CACGCCTACGGCTTCCTGGCCGAGGTGTTCGGCATCCTGGCCCGCCACCGCATCTCGGTGGATCTCATCACCACCTCGGA
AGTGAGCGTGTCGCTCACCCTGGATCACACCGGCAGCCAGAGCAACGGCGAGCCCGTGCTCAGCGACAAGGTGCTGGCCG
AGCTGGGTCAGCTGTGCAAGGTGAAGGTGGAAACCGGTCTGGCACTGGTGGCGCTCATCGGCAACCGCATGAGCGAGGCG
GCCGGTGTAGGCAGTCAGGTCTTTGACGCCATTCGCGAGCACAACATCCGCATGATCTGTTATGGCGCCAGTGCCCACAA
TCTCTGCTTCCTGGTCAAGGAAGAAGAAGCGGGCCACATCGTCAACCGCCTCCACCAGGAGCTGCTCGACTGA

Upstream 100 bases:

>100_bases
CTTCTGGCCGGGATAGCTTCTCTCATTCCTGCCATTTTCAGCCTCCTCCTCTCTTTTTGCCCGATGGAACCGGATTTTTA
TATTAAGACAGGAGTAAGCA

Downstream 100 bases:

>100_bases
GCCAGCCAAGGTTTGACACGGCATAAAAGAGGGGCACTCAGGGTGCCCCTCTTGTCGTTGATGCCCATGTCATTGATGCA
GATACCAGCCCCTACCCTAC

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSPMNVAKFGGTSVANAAAMNNCANVVLANPATRVVVLSASAGVTNLLVALAQGDLDEAGQEAQLAKLAEIQQAILTALG
DPADVSTLIHATLGEIRTMARQASQHTDAELADRLIACGELMSTRLFTELLHQRGIKAHWQDVRQLMRTDSRFGKATVDL
GATRGLCQQALGPLLGDSLIITQGFIGSDADGRTTTLGRGGSDYSAALLAEALDAGSIEIWTDVPGIYTTDPRLVTRARP
IPEISFVEAAEMATFGAKVLHPATLQPAVRQDIPVFVGSSKDPAAGGTWIRASTSTNPLFRAVALRRQQVLVTLHSLNMF
HAYGFLAEVFGILARHRISVDLITTSEVSVSLTLDHTGSQSNGEPVLSDKVLAELGQLCKVKVETGLALVALIGNRMSEA
AGVGSQVFDAIREHNIRMICYGASAHNLCFLVKEEEAGHIVNRLHQELLD

Sequences:

>Translated_450_residues
MSPMNVAKFGGTSVANAAAMNNCANVVLANPATRVVVLSASAGVTNLLVALAQGDLDEAGQEAQLAKLAEIQQAILTALG
DPADVSTLIHATLGEIRTMARQASQHTDAELADRLIACGELMSTRLFTELLHQRGIKAHWQDVRQLMRTDSRFGKATVDL
GATRGLCQQALGPLLGDSLIITQGFIGSDADGRTTTLGRGGSDYSAALLAEALDAGSIEIWTDVPGIYTTDPRLVTRARP
IPEISFVEAAEMATFGAKVLHPATLQPAVRQDIPVFVGSSKDPAAGGTWIRASTSTNPLFRAVALRRQQVLVTLHSLNMF
HAYGFLAEVFGILARHRISVDLITTSEVSVSLTLDHTGSQSNGEPVLSDKVLAELGQLCKVKVETGLALVALIGNRMSEA
AGVGSQVFDAIREHNIRMICYGASAHNLCFLVKEEEAGHIVNRLHQELLD
>Mature_449_residues
SPMNVAKFGGTSVANAAAMNNCANVVLANPATRVVVLSASAGVTNLLVALAQGDLDEAGQEAQLAKLAEIQQAILTALGD
PADVSTLIHATLGEIRTMARQASQHTDAELADRLIACGELMSTRLFTELLHQRGIKAHWQDVRQLMRTDSRFGKATVDLG
ATRGLCQQALGPLLGDSLIITQGFIGSDADGRTTTLGRGGSDYSAALLAEALDAGSIEIWTDVPGIYTTDPRLVTRARPI
PEISFVEAAEMATFGAKVLHPATLQPAVRQDIPVFVGSSKDPAAGGTWIRASTSTNPLFRAVALRRQQVLVTLHSLNMFH
AYGFLAEVFGILARHRISVDLITTSEVSVSLTLDHTGSQSNGEPVLSDKVLAELGQLCKVKVETGLALVALIGNRMSEAA
GVGSQVFDAIREHNIRMICYGASAHNLCFLVKEEEAGHIVNRLHQELLD

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=450, Percent_Identity=61.1111111111111, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1786183, Length=468, Percent_Identity=32.9059829059829, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1790376, Length=397, Percent_Identity=29.4710327455919, Blast_Score=135, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6320893, Length=500, Percent_Identity=27.6, Blast_Score=170, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 47825; Mature: 47694

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPMNVAKFGGTSVANAAAMNNCANVVLANPATRVVVLSASAGVTNLLVALAQGDLDEAG
CCCCCCHHCCCCHHHHHHHHHCCCCEEEECCCCEEEEEECCCCHHHHHHHHHCCCHHHCC
QEAQLAKLAEIQQAILTALGDPADVSTLIHATLGEIRTMARQASQHTDAELADRLIACGE
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LMSTRLFTELLHQRGIKAHWQDVRQLMRTDSRFGKATVDLGATRGLCQQALGPLLGDSLI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCEE
ITQGFIGSDADGRTTTLGRGGSDYSAALLAEALDAGSIEIWTDVPGIYTTDPRLVTRARP
EEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEECCCCHHHCCCC
IPEISFVEAAEMATFGAKVLHPATLQPAVRQDIPVFVGSSKDPAAGGTWIRASTSTNPLF
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEECCCCCCCCCCCEEEECCCCCHHH
RAVALRRQQVLVTLHSLNMFHAYGFLAEVFGILARHRISVDLITTSEVSVSLTLDHTGSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEEEECCCCC
SNGEPVLSDKVLAELGQLCKVKVETGLALVALIGNRMSEAAGVGSQVFDAIREHNIRMIC
CCCCCCHHHHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEE
YGASAHNLCFLVKEEEAGHIVNRLHQELLD
ECCCCCCEEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SPMNVAKFGGTSVANAAAMNNCANVVLANPATRVVVLSASAGVTNLLVALAQGDLDEAG
CCCCCHHCCCCHHHHHHHHHCCCCEEEECCCCEEEEEECCCCHHHHHHHHHCCCHHHCC
QEAQLAKLAEIQQAILTALGDPADVSTLIHATLGEIRTMARQASQHTDAELADRLIACGE
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LMSTRLFTELLHQRGIKAHWQDVRQLMRTDSRFGKATVDLGATRGLCQQALGPLLGDSLI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCEE
ITQGFIGSDADGRTTTLGRGGSDYSAALLAEALDAGSIEIWTDVPGIYTTDPRLVTRARP
EEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEECCCCHHHCCCC
IPEISFVEAAEMATFGAKVLHPATLQPAVRQDIPVFVGSSKDPAAGGTWIRASTSTNPLF
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEECCCCCCCCCCCEEEECCCCCHHH
RAVALRRQQVLVTLHSLNMFHAYGFLAEVFGILARHRISVDLITTSEVSVSLTLDHTGSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEEEECCCCC
SNGEPVLSDKVLAELGQLCKVKVETGLALVALIGNRMSEAAGVGSQVFDAIREHNIRMIC
CCCCCCHHHHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEE
YGASAHNLCFLVKEEEAGHIVNRLHQELLD
ECCCCCCEEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]