Click here to switch to the map view.

The map label for this gene is galK [H]

Identifier: 145299345

GI number: 145299345

Start: 2551125

End: 2552282

Strand: Direct

Name: galK [H]

Synonym: ASA_2392

Alternate gene names: 145299345

Gene position: 2551125-2552282 (Clockwise)

Preceding gene: 145299344

Following gene: 145299350

Centisome position: 54.25

GC content: 58.2

Gene sequence:

>1158_bases
ATGAGTATTGAATCACCACGCAGCATGACTGATACCACGTTTTACACCCAATTCGGTTACCATCCGACCCTCGCCATCCA
AGCGCCAGGTCGCGTCAATCTGATCGGTGAACACACGGATTACAACGACGGTTTTGTACTCCCCTGTGCCATTGACTATC
AGACAGTGATCAGTGCGGCTCCTCGTCAGGACAGCCTGGTGCGAGTCATCGCCGCTGACTACAACAATCAGCAGGATGAG
TTTGATTTGAGCCGTCCCATAGCGTCACGCCCTGAATACTTGTGGGCCAACTATGTACGGGGAGTCATCAAGTATCTGCT
GCTGCGGGGCTGCGAACTGACCGGTGCCGATCTGGTGCTCAGTGGCAATGTCCCGCAGGGCGCTGGCCTGAGCTCCTCCG
CCTCTCTGGAAGTGGCCGTGGGGCAGGTATTTAAGGAGATGAATCACCTCGACATCAGTCAGGCCGATATCGCCCTCAAT
GGGCAACTGGCAGAGAACATGTTCGTCGGCTGCAACTGCGGCATCATGGATCAGTTCATCTCGGCTCTGGGTCAGCAGGA
TCACGCCCTGCTGATCGACTGCCGCAGCCTGAGGACTCGCCCCGTCCGTATTCCGGCTGGCATCGATGTTGTCATCATCA
ACTCCAATGTTCGCCGCGGACTGGTCGACAGTGAATACAATGCCCGCCGGGCACAATGTGAAGAGGCGGCCCGCCATTTT
GGCGTCAAGGCGCTGCGCGATCTGACCATGACGCAGTTTGTCTCCCGAGCCGATGAGCTGGATCCCGTCGTCGCCCGCCG
CGCACGGCATGTCATCTCCGAGAATGAACGGACCCTGGCCGCAGCCGATGCCCTGGCCAATGAAGACATGCTCATGATGG
CAGAGCTGATGGCGCTCTCCCATGCCTCGATGCGGGATGATTTTGCCATTACCGTGCCCGCCATTGATGCCCTGGTCGAC
ATCATCAAGGAGATCATCGGCAGTCGCGGCGGTGTGAGAATGACGGGTGGCGGCTTCGGTGGCTGCGTTGTGGCGCTGGT
GCCACATTCACTGACCTCGATAGTCTGTGAACAGGTCAATGCCCGCTATCCCCAGGTCAGCGGGTTGCAACCCAGCATCT
ATATCAGTAAACCCTCGGCAGGCGCCGGTATCCTCTGA

Upstream 100 bases:

>100_bases
GCTGGCAGAAACGCAGCGTGATCTGACGGCAGAGCAAGCGGCCGAACGACTGCGTGCTGTCAGTGATGTCCATTTTCGTG
AACAGGTTTGAGGTTGAGTT

Downstream 100 bases:

>100_bases
TGTCCCTGACGATGTCGCTATCGGGCACTCTTCGTAGCCATCACGAATAGTGACATCGTCGGGAGAGAACTGACGCCGGT
TTGAACGCGTTGCACCCTAG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSIESPRSMTDTTFYTQFGYHPTLAIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISAAPRQDSLVRVIAADYNNQQDE
FDLSRPIASRPEYLWANYVRGVIKYLLLRGCELTGADLVLSGNVPQGAGLSSSASLEVAVGQVFKEMNHLDISQADIALN
GQLAENMFVGCNCGIMDQFISALGQQDHALLIDCRSLRTRPVRIPAGIDVVIINSNVRRGLVDSEYNARRAQCEEAARHF
GVKALRDLTMTQFVSRADELDPVVARRARHVISENERTLAAADALANEDMLMMAELMALSHASMRDDFAITVPAIDALVD
IIKEIIGSRGGVRMTGGGFGGCVVALVPHSLTSIVCEQVNARYPQVSGLQPSIYISKPSAGAGIL

Sequences:

>Translated_385_residues
MSIESPRSMTDTTFYTQFGYHPTLAIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISAAPRQDSLVRVIAADYNNQQDE
FDLSRPIASRPEYLWANYVRGVIKYLLLRGCELTGADLVLSGNVPQGAGLSSSASLEVAVGQVFKEMNHLDISQADIALN
GQLAENMFVGCNCGIMDQFISALGQQDHALLIDCRSLRTRPVRIPAGIDVVIINSNVRRGLVDSEYNARRAQCEEAARHF
GVKALRDLTMTQFVSRADELDPVVARRARHVISENERTLAAADALANEDMLMMAELMALSHASMRDDFAITVPAIDALVD
IIKEIIGSRGGVRMTGGGFGGCVVALVPHSLTSIVCEQVNARYPQVSGLQPSIYISKPSAGAGIL
>Mature_384_residues
SIESPRSMTDTTFYTQFGYHPTLAIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISAAPRQDSLVRVIAADYNNQQDEF
DLSRPIASRPEYLWANYVRGVIKYLLLRGCELTGADLVLSGNVPQGAGLSSSASLEVAVGQVFKEMNHLDISQADIALNG
QLAENMFVGCNCGIMDQFISALGQQDHALLIDCRSLRTRPVRIPAGIDVVIINSNVRRGLVDSEYNARRAQCEEAARHFG
VKALRDLTMTQFVSRADELDPVVARRARHVISENERTLAAADALANEDMLMMAELMALSHASMRDDFAITVPAIDALVDI
IKEIIGSRGGVRMTGGGFGGCVVALVPHSLTSIVCEQVNARYPQVSGLQPSIYISKPSAGAGIL

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=379, Percent_Identity=43.2717678100264, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI4503897, Length=451, Percent_Identity=29.0465631929047, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI48527957, Length=440, Percent_Identity=29.0909090909091, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1786972, Length=379, Percent_Identity=63.8522427440633, Blast_Score=501, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71989053, Length=431, Percent_Identity=26.2180974477958, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320212, Length=326, Percent_Identity=28.8343558282209, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319494, Length=267, Percent_Identity=30.3370786516854, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24661292, Length=440, Percent_Identity=25.4545454545455, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355577, Length=440, Percent_Identity=25.4545454545455, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24661285, Length=440, Percent_Identity=25.4545454545455, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41756; Mature: 41625

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIESPRSMTDTTFYTQFGYHPTLAIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISAA
CCCCCCCCCCCCEEEEECCCCCEEEEECCCEEEEEECCCCCCCCEEEEEECCHHHHHHCC
PRQDSLVRVIAADYNNQQDEFDLSRPIASRPEYLWANYVRGVIKYLLLRGCELTGADLVL
CCCCCEEEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
SGNVPQGAGLSSSASLEVAVGQVFKEMNHLDISQADIALNGQLAENMFVGCNCGIMDQFI
ECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCHHCCEEEECCCCHHHHHH
SALGQQDHALLIDCRSLRTRPVRIPAGIDVVIINSNVRRGLVDSEYNARRAQCEEAARHF
HHHCCCCCEEEEEEHHCCCCCEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
GVKALRDLTMTQFVSRADELDPVVARRARHVISENERTLAAADALANEDMLMMAELMALS
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHH
HASMRDDFAITVPAIDALVDIIKEIIGSRGGVRMTGGGFGGCVVALVPHSLTSIVCEQVN
HCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHH
ARYPQVSGLQPSIYISKPSAGAGIL
CCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
SIESPRSMTDTTFYTQFGYHPTLAIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISAA
CCCCCCCCCCCEEEEECCCCCEEEEECCCEEEEEECCCCCCCCEEEEEECCHHHHHHCC
PRQDSLVRVIAADYNNQQDEFDLSRPIASRPEYLWANYVRGVIKYLLLRGCELTGADLVL
CCCCCEEEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
SGNVPQGAGLSSSASLEVAVGQVFKEMNHLDISQADIALNGQLAENMFVGCNCGIMDQFI
ECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCHHCCEEEECCCCHHHHHH
SALGQQDHALLIDCRSLRTRPVRIPAGIDVVIINSNVRRGLVDSEYNARRAQCEEAARHF
HHHCCCCCEEEEEEHHCCCCCEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
GVKALRDLTMTQFVSRADELDPVVARRARHVISENERTLAAADALANEDMLMMAELMALS
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHH
HASMRDDFAITVPAIDALVDIIKEIIGSRGGVRMTGGGFGGCVVALVPHSLTSIVCEQVN
HCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHH
ARYPQVSGLQPSIYISKPSAGAGIL
CCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA