Click here to switch to the map view.

The map label for this gene is glpA [H]

Identifier: 145299274

GI number: 145299274

Start: 2456656

End: 2458350

Strand: Direct

Name: glpA [H]

Synonym: ASA_2318

Alternate gene names: 145299274

Gene position: 2456656-2458350 (Clockwise)

Preceding gene: 145299273

Following gene: 145299275

Centisome position: 52.24

GC content: 63.01

Gene sequence:

>1695_bases
ATGAAAAGAATAACCACACAAGTCGTCATCATAGGGGGTGGCGCAACCGGAGCCGGCATCATGCGCGATTGCGCACTGCG
CGGCATCGACTGCATCCTGCTGGAGCGCGATGACATCGCCGCCGGCACCACGGGCCGCAACCACGGTTTGCTCCACTCTG
GCGCCCGCTATGCGGTGACGGATCCGGAATCCGCCCGCGAGTGCATTCAGGAAAACCGCATCCTCAAGCGGATCGCCAGC
CACTGCGTCGAGGACACGGGCGGTCTCTTCGTCACCCTGCCGGAAGATGACATCAATTTTCAAAAAACCTTTATGGATGC
CTGCGCCCTGGCGGGTATAGATACACGCCAGCTGGATCCGGCCGATGCGCTGCGCCTCGAGCCCAACGTCAACCCGGCCC
TGATAGGGGCTATTCAAGTACCGGACGGCACTGTGGATCCTTTCCGCCTCGCCGCCGCCAACGTACTGGATGCCAAGGAA
CACGGCGCGCGCATTTTCACCCACAGCAAGGTGCTGGGGCTGCTGCGCAATCAGGACAGAGTCTATGGCGTCAAGGCCAT
CAACACCCGCACCGGTGAAGCCTTCGAAGTGGAGGCCCAGGAGGTGGTGAACGCTGCCGGGATCTGGGGCCAACAGATCT
GCGAGTACGCCGATCTCGGCATCCGCATGTTCCCGGCCAAGGGTTCGTTGCTCATCATGGATTACCGCATCAACCAGATG
GTGCTCAACCGCGCTCGCAAACCTGCGGATGCGGACATACTGGTGCCTGGCGATACCATCTCCCTCATCGGCACCACTTC
AAGCCGCATCGACTATCACAAGATTGATCAGCTCACCGTGGATCCGGACGAGGTGGAGGTGCTGCTGCGTGAGGGGATCA
AGCTCGCCCCCATCATGGCCCGCACCCGTCTGCTGCGCGCCTACGCCGGGGTTCGCCCCCTGGTGGCGGTGGATGGCGAC
GAGACCGGCCGCAACATCAGCCGCGGCATAGTGCTGCTGGATCATGCCGAGCGCGATGGGCTACAGGGCTTCAATACCAT
CACCGGCGGCAAGCTGATGACCTACCGGCTGATGGCCGAGTGGGCCACCGACCTTATCGCCAGGAAGATAGGCAACACCA
AGCCGTGCCGCACCGCCGAACTCAGCCTGCCCGGCTCGCGGGATCCGGAGAAAGTGTCCGCCCCCGGTCTGTCGGCCCCG
GCAGAAGGCTCGGCCCAGTATCGCCACGGCGAGCGGGTCATCGCCTTCTTTCGTGACAACCCCAAGGCCAACGCCCTCAT
CTGCGAATGCGAGATGGTGACAGCCGGCGAAATCGAATACGCCCTGCGGGAGCTCGACGTGGACAACCTGGTGGATCTGC
GCCGCCGCACGCGCCTCGGCATGGGCCCCTGTCAGGGAGAGCTGTGCGCCTACCGGGCCGCCGGTCTGATGCAGGAGTAT
GGCAAGGCCGATGGCCGCGAAGCCTGTGTCATGTTGCGCCAGTTCCTGGAAGAACGTTACAAGGGTACCCGCCCCGTGCT
GTGGGGCGATGCCCTGCGGGAAGCGGAGTTTACCTACTGGATTTATGAAGGGCTGTTTGGTCTGGGAGAGTGGACTGCGC
CCCATCTGGTGGCCGAGCCCCCCTTTCCCCTCGACCCTGTGACCAGGACAGAGGATCACAGCCAGGCCACATTGACTCAA
GGAGTGCAGTCATGA

Upstream 100 bases:

>100_bases
ATTTATGCGCGTTTACGAACATTAATTTGGCCCATATCAAACATTTCATCCCATGAGTAAGGGACACTGTTCCCATCTGG
AAGAGATGAGACGGGCAAGA

Downstream 100 bases:

>100_bases
AATTTGACAGTATCGTGATAGGTGGCGGCATGGCGGGTCTCTCGGCGGCGCTGCGCCTCGCCGAAGCGGGTCAGAAGACG
CTGCTGATGGCCTCTGGCCA

Product: sn-glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MKRITTQVVIIGGGATGAGIMRDCALRGIDCILLERDDIAAGTTGRNHGLLHSGARYAVTDPESARECIQENRILKRIAS
HCVEDTGGLFVTLPEDDINFQKTFMDACALAGIDTRQLDPADALRLEPNVNPALIGAIQVPDGTVDPFRLAAANVLDAKE
HGARIFTHSKVLGLLRNQDRVYGVKAINTRTGEAFEVEAQEVVNAAGIWGQQICEYADLGIRMFPAKGSLLIMDYRINQM
VLNRARKPADADILVPGDTISLIGTTSSRIDYHKIDQLTVDPDEVEVLLREGIKLAPIMARTRLLRAYAGVRPLVAVDGD
ETGRNISRGIVLLDHAERDGLQGFNTITGGKLMTYRLMAEWATDLIARKIGNTKPCRTAELSLPGSRDPEKVSAPGLSAP
AEGSAQYRHGERVIAFFRDNPKANALICECEMVTAGEIEYALRELDVDNLVDLRRRTRLGMGPCQGELCAYRAAGLMQEY
GKADGREACVMLRQFLEERYKGTRPVLWGDALREAEFTYWIYEGLFGLGEWTAPHLVAEPPFPLDPVTRTEDHSQATLTQ
GVQS

Sequences:

>Translated_564_residues
MKRITTQVVIIGGGATGAGIMRDCALRGIDCILLERDDIAAGTTGRNHGLLHSGARYAVTDPESARECIQENRILKRIAS
HCVEDTGGLFVTLPEDDINFQKTFMDACALAGIDTRQLDPADALRLEPNVNPALIGAIQVPDGTVDPFRLAAANVLDAKE
HGARIFTHSKVLGLLRNQDRVYGVKAINTRTGEAFEVEAQEVVNAAGIWGQQICEYADLGIRMFPAKGSLLIMDYRINQM
VLNRARKPADADILVPGDTISLIGTTSSRIDYHKIDQLTVDPDEVEVLLREGIKLAPIMARTRLLRAYAGVRPLVAVDGD
ETGRNISRGIVLLDHAERDGLQGFNTITGGKLMTYRLMAEWATDLIARKIGNTKPCRTAELSLPGSRDPEKVSAPGLSAP
AEGSAQYRHGERVIAFFRDNPKANALICECEMVTAGEIEYALRELDVDNLVDLRRRTRLGMGPCQGELCAYRAAGLMQEY
GKADGREACVMLRQFLEERYKGTRPVLWGDALREAEFTYWIYEGLFGLGEWTAPHLVAEPPFPLDPVTRTEDHSQATLTQ
GVQS
>Mature_564_residues
MKRITTQVVIIGGGATGAGIMRDCALRGIDCILLERDDIAAGTTGRNHGLLHSGARYAVTDPESARECIQENRILKRIAS
HCVEDTGGLFVTLPEDDINFQKTFMDACALAGIDTRQLDPADALRLEPNVNPALIGAIQVPDGTVDPFRLAAANVLDAKE
HGARIFTHSKVLGLLRNQDRVYGVKAINTRTGEAFEVEAQEVVNAAGIWGQQICEYADLGIRMFPAKGSLLIMDYRINQM
VLNRARKPADADILVPGDTISLIGTTSSRIDYHKIDQLTVDPDEVEVLLREGIKLAPIMARTRLLRAYAGVRPLVAVDGD
ETGRNISRGIVLLDHAERDGLQGFNTITGGKLMTYRLMAEWATDLIARKIGNTKPCRTAELSLPGSRDPEKVSAPGLSAP
AEGSAQYRHGERVIAFFRDNPKANALICECEMVTAGEIEYALRELDVDNLVDLRRRTRLGMGPCQGELCAYRAAGLMQEY
GKADGREACVMLRQFLEERYKGTRPVLWGDALREAEFTYWIYEGLFGLGEWTAPHLVAEPPFPLDPVTRTEDHSQATLTQ
GVQS

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=505, Percent_Identity=27.1287128712871, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI285002231, Length=505, Percent_Identity=27.1287128712871, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI197927446, Length=287, Percent_Identity=25.0871080139373, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI21361378, Length=287, Percent_Identity=25.0871080139373, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788574, Length=510, Percent_Identity=67.0588235294118, Blast_Score=697, Evalue=0.0,
Organism=Escherichia coli, GI2367226, Length=378, Percent_Identity=26.4550264550265, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17509253, Length=419, Percent_Identity=27.4463007159904, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI115534726, Length=403, Percent_Identity=24.317617866005, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161077125, Length=401, Percent_Identity=29.426433915212, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653942, Length=401, Percent_Identity=29.426433915212, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653944, Length=401, Percent_Identity=29.426433915212, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20130025, Length=401, Percent_Identity=29.426433915212, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20130091, Length=235, Percent_Identity=29.7872340425532, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24586295, Length=406, Percent_Identity=24.1379310344828, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 61879; Mature: 61879

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRITTQVVIIGGGATGAGIMRDCALRGIDCILLERDDIAAGTTGRNHGLLHSGARYAVT
CCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEECCCEEEEC
DPESARECIQENRILKRIASHCVEDTGGLFVTLPEDDINFQKTFMDACALAGIDTRQLDP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCC
ADALRLEPNVNPALIGAIQVPDGTVDPFRLAAANVLDAKEHGARIFTHSKVLGLLRNQDR
CCCEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCE
VYGVKAINTRTGEAFEVEAQEVVNAAGIWGQQICEYADLGIRMFPAKGSLLIMDYRINQM
EEEEEEECCCCCCEEEECHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCEEEEEEHHHHH
VLNRARKPADADILVPGDTISLIGTTSSRIDYHKIDQLTVDPDEVEVLLREGIKLAPIMA
HHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHCCEEECCHHHHHHHHHCCCCCCHHHH
RTRLLRAYAGVRPLVAVDGDETGRNISRGIVLLDHAERDGLQGFNTITGGKLMTYRLMAE
HHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
WATDLIARKIGNTKPCRTAELSLPGSRDPEKVSAPGLSAPAEGSAQYRHGERVIAFFRDN
HHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
PKANALICECEMVTAGEIEYALRELDVDNLVDLRRRTRLGMGPCQGELCAYRAAGLMQEY
CCCCEEEEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
GKADGREACVMLRQFLEERYKGTRPVLWGDALREAEFTYWIYEGLFGLGEWTAPHLVAEP
CCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHCHHEEEEHHHHHCCCCCCCCCEECCC
PFPLDPVTRTEDHSQATLTQGVQS
CCCCCCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MKRITTQVVIIGGGATGAGIMRDCALRGIDCILLERDDIAAGTTGRNHGLLHSGARYAVT
CCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEECCCEEEEC
DPESARECIQENRILKRIASHCVEDTGGLFVTLPEDDINFQKTFMDACALAGIDTRQLDP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCC
ADALRLEPNVNPALIGAIQVPDGTVDPFRLAAANVLDAKEHGARIFTHSKVLGLLRNQDR
CCCEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCE
VYGVKAINTRTGEAFEVEAQEVVNAAGIWGQQICEYADLGIRMFPAKGSLLIMDYRINQM
EEEEEEECCCCCCEEEECHHHHHHHHCCCHHHHHHHHCCCEEEECCCCCEEEEEEHHHHH
VLNRARKPADADILVPGDTISLIGTTSSRIDYHKIDQLTVDPDEVEVLLREGIKLAPIMA
HHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHCCEEECCHHHHHHHHHCCCCCCHHHH
RTRLLRAYAGVRPLVAVDGDETGRNISRGIVLLDHAERDGLQGFNTITGGKLMTYRLMAE
HHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
WATDLIARKIGNTKPCRTAELSLPGSRDPEKVSAPGLSAPAEGSAQYRHGERVIAFFRDN
HHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
PKANALICECEMVTAGEIEYALRELDVDNLVDLRRRTRLGMGPCQGELCAYRAAGLMQEY
CCCCEEEEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
GKADGREACVMLRQFLEERYKGTRPVLWGDALREAEFTYWIYEGLFGLGEWTAPHLVAEP
CCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHCHHEEEEHHHHHCCCCCCCCCEECCC
PFPLDPVTRTEDHSQATLTQGVQS
CCCCCCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]