Click here to switch to the map view.

The map label for this gene is gpo [H]

Identifier: 145299221

GI number: 145299221

Start: 2393117

End: 2393593

Strand: Direct

Name: gpo [H]

Synonym: ASA_2263

Alternate gene names: 145299221

Gene position: 2393117-2393593 (Clockwise)

Preceding gene: 145299218

Following gene: 145299222

Centisome position: 50.89

GC content: 59.54

Gene sequence:

>477_bases
ATGTCTCTGCCCGATCTTCCCCTGCAACGCCTCGATGGTACCGAATTCTCTCTCACCGCCCTGCAAGGTCAGGTCATTCT
GGTGGTCAACGTGGCCAGCCGCTGTGGTTTTACCCCCCAATACACGGGCCTGGAGGCACTCTACCAGCAGCTGGGACCCA
AAGGGCTGGTGATCTTGGGCTTCCCCTGCGATCAGTTCGGCCATCAGGAGCCGGGGGATGCGGACGAAATCGCCCGCTTC
TGCTCGCTGGATTATCCGGTCAGCTTCCCCATCATGGCCAAGTGCGAAGTCAACGGCGAGCACGCCCACCCCTTCTATCG
CTGGCTTAAACAACAAAAACCCGGGCTGCTGGGGCTGGAAAACGTCAAATGGAACTTCACCAAGTTCCTCATCAACCGTG
AGGGTGAGGTGGTGGAGCGCTTCGCCCCCCAGACCAAGCCAGAGAGCCTGCTGGACGAGATAAGCGCACTGCTCTGA

Upstream 100 bases:

>100_bases
GGGAGGCAAACCCGGCACTTGCTGCTTGCCTCGGGATCCCGGGCCCGTTAACGTGCATAACCACTGCCCTGAATGGGCCC
CATCCTCTCTGGAGTGCACC

Downstream 100 bases:

>100_bases
GCCTCGCCAGCAGGTTGATGCGGGACCAGACTCACGCAGCGGCCCGGGCAAGTGACACGGCTGCTGCGTGCAGGCCGCAC
ATCTGCTATATTACGCCCCC

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MSLPDLPLQRLDGTEFSLTALQGQVILVVNVASRCGFTPQYTGLEALYQQLGPKGLVILGFPCDQFGHQEPGDADEIARF
CSLDYPVSFPIMAKCEVNGEHAHPFYRWLKQQKPGLLGLENVKWNFTKFLINREGEVVERFAPQTKPESLLDEISALL

Sequences:

>Translated_158_residues
MSLPDLPLQRLDGTEFSLTALQGQVILVVNVASRCGFTPQYTGLEALYQQLGPKGLVILGFPCDQFGHQEPGDADEIARF
CSLDYPVSFPIMAKCEVNGEHAHPFYRWLKQQKPGLLGLENVKWNFTKFLINREGEVVERFAPQTKPESLLDEISALL
>Mature_157_residues
SLPDLPLQRLDGTEFSLTALQGQVILVVNVASRCGFTPQYTGLEALYQQLGPKGLVILGFPCDQFGHQEPGDADEIARFC
SLDYPVSFPIMAKCEVNGEHAHPFYRWLKQQKPGLLGLENVKWNFTKFLINREGEVVERFAPQTKPESLLDEISALL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=148, Percent_Identity=43.9189189189189, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI90903240, Length=148, Percent_Identity=43.9189189189189, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI15618997, Length=155, Percent_Identity=41.9354838709677, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI192455698, Length=147, Percent_Identity=38.0952380952381, Blast_Score=106, Evalue=7e-24,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=43.8461538461538, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI41406084, Length=170, Percent_Identity=35.8823529411765, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI4557629, Length=168, Percent_Identity=38.0952380952381, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI6006001, Length=168, Percent_Identity=36.9047619047619, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=34.2541436464088, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI33186887, Length=166, Percent_Identity=33.1325301204819, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI41406082, Length=58, Percent_Identity=55.1724137931034, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1788003, Length=161, Percent_Identity=39.1304347826087, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17535473, Length=158, Percent_Identity=39.2405063291139, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17506887, Length=158, Percent_Identity=36.7088607594937, Blast_Score=122, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI193210707, Length=162, Percent_Identity=38.2716049382716, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71993584, Length=151, Percent_Identity=35.7615894039735, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17550320, Length=163, Percent_Identity=31.9018404907975, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193209493, Length=163, Percent_Identity=31.2883435582822, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319721, Length=157, Percent_Identity=54.7770700636943, Blast_Score=187, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6322228, Length=146, Percent_Identity=56.1643835616438, Blast_Score=184, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6322826, Length=147, Percent_Identity=46.2585034013605, Blast_Score=144, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24656767, Length=160, Percent_Identity=43.75, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24656777, Length=160, Percent_Identity=43.75, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24656772, Length=160, Percent_Identity=43.75, Blast_Score=133, Evalue=5e-32,
Organism=Drosophila melanogaster, GI85726443, Length=160, Percent_Identity=34.375, Blast_Score=102, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17694; Mature: 17562

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPDLPLQRLDGTEFSLTALQGQVILVVNVASRCGFTPQYTGLEALYQQLGPKGLVILG
CCCCCCCHHHCCCCCEEEEEECCCEEEEEEEHHHCCCCCCCCCHHHHHHHCCCCCEEEEE
FPCDQFGHQEPGDADEIARFCSLDYPVSFPIMAKCEVNGEHAHPFYRWLKQQKPGLLGLE
CCCHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEECC
NVKWNFTKFLINREGEVVERFAPQTKPESLLDEISALL
CCCCCHHHEEECCCCHHHHHHCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SLPDLPLQRLDGTEFSLTALQGQVILVVNVASRCGFTPQYTGLEALYQQLGPKGLVILG
CCCCCCHHHCCCCCEEEEEECCCEEEEEEEHHHCCCCCCCCCHHHHHHHCCCCCEEEEE
FPCDQFGHQEPGDADEIARFCSLDYPVSFPIMAKCEVNGEHAHPFYRWLKQQKPGLLGLE
CCCHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEECC
NVKWNFTKFLINREGEVVERFAPQTKPESLLDEISALL
CCCCCHHHEEECCCCHHHHHHCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]