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The map label for this gene is trxA [H]

Identifier: 145297085

GI number: 145297085

Start: 3306189

End: 3306512

Strand: Direct

Name: trxA [H]

Synonym: cgR_2981

Alternate gene names: 145297085

Gene position: 3306189-3306512 (Clockwise)

Preceding gene: 145297084

Following gene: 145297086

Centisome position: 99.76

GC content: 51.23

Gene sequence:

>324_bases
ATGAGCAATGTTGTTGCAGTAACCGAGCAGACCTTCAAGTCCACCGTCATCGATTCCGACAAGCCAGTCATCGTTGACTT
CTGGGCAGAATGGTGTGGCCCCTGCAAGAAGCTCAGCCCCATCATTGAGGAAATCGCAGGCGAGTACGGCGACAAGGCAG
TCGTTGCCAGCGTCGACGTCGATGCCGAGCGTACCTTGGGTGCCATGTTCCAGATTATGTCGATTCCTTCGGTTCTCATT
TTCAAAAATGGTGCAAAAGTCGAGGAATTTGTCGGTCTGCGCCCCAAGAACGAAATTGTGGAAAAACTAGAGAAGCACCT
CTAA

Upstream 100 bases:

>100_bases
GCTTCTCTGGCCTAATTCACAGTTAGCCTTAAACCAAACCATGTACCAATGAATGTCGGGATTCCCTAGGAGTCCCGTCA
TTGTTAATTTAGGAGAAACC

Downstream 100 bases:

>100_bases
CTGGTATTCTTACTGCAGTCACGTGGATGAACTATATCCATTGATAATTTTGAACATGAATGATGGAAGGAGCAGGGTGT
CTAAAGTCCTGAGAGTTGGC

Product: hypothetical protein

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSNVVAVTEQTFKSTVIDSDKPVIVDFWAEWCGPCKKLSPIIEEIAGEYGDKAVVASVDVDAERTLGAMFQIMSIPSVLI
FKNGAKVEEFVGLRPKNEIVEKLEKHL

Sequences:

>Translated_107_residues
MSNVVAVTEQTFKSTVIDSDKPVIVDFWAEWCGPCKKLSPIIEEIAGEYGDKAVVASVDVDAERTLGAMFQIMSIPSVLI
FKNGAKVEEFVGLRPKNEIVEKLEKHL
>Mature_106_residues
SNVVAVTEQTFKSTVIDSDKPVIVDFWAEWCGPCKKLSPIIEEIAGEYGDKAVVASVDVDAERTLGAMFQIMSIPSVLIF
KNGAKVEEFVGLRPKNEIVEKLEKHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=39.3617021276596, Blast_Score=86, Evalue=9e-18,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=33, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=39.4230769230769, Blast_Score=94, Evalue=2e-21,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=44.0860215053763, Blast_Score=87, Evalue=2e-19,
Organism=Escherichia coli, GI87081747, Length=106, Percent_Identity=34.9056603773585, Blast_Score=78, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=95, Percent_Identity=37.8947368421053, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=34.8314606741573, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=72, Percent_Identity=38.8888888888889, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=102, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=105, Percent_Identity=29.5238095238095, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=106, Percent_Identity=34.9056603773585, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=38.0952380952381, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=39.5061728395062, Blast_Score=70, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=37.7551020408163, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=44.8717948717949, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=44.8717948717949, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=35.1063829787234, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639068, Length=88, Percent_Identity=43.1818181818182, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=92, Percent_Identity=34.7826086956522, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21358065, Length=88, Percent_Identity=39.7727272727273, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17530795, Length=73, Percent_Identity=34.2465753424658, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921434, Length=102, Percent_Identity=31.3725490196078, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11826; Mature: 11695

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVVAVTEQTFKSTVIDSDKPVIVDFWAEWCGPCKKLSPIIEEIAGEYGDKAVVASVDV
CCCEEHHHHHHHHHHHCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCC
DAERTLGAMFQIMSIPSVLIFKNGAKVEEFVGLRPKNEIVEKLEKHL
CHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SNVVAVTEQTFKSTVIDSDKPVIVDFWAEWCGPCKKLSPIIEEIAGEYGDKAVVASVDV
CCEEHHHHHHHHHHHCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCC
DAERTLGAMFQIMSIPSVLIFKNGAKVEEFVGLRPKNEIVEKLEKHL
CHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]