| Definition | Corynebacterium glutamicum R chromosome, complete genome. |
|---|---|
| Accession | NC_009342 |
| Length | 3,314,179 |
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The map label for this gene is trpC [H]
Identifier: 145297022
GI number: 145297022
Start: 3239614
End: 3241038
Strand: Direct
Name: trpC [H]
Synonym: cgR_2919
Alternate gene names: 145297022
Gene position: 3239614-3241038 (Clockwise)
Preceding gene: 145297021
Following gene: 145297023
Centisome position: 97.75
GC content: 57.96
Gene sequence:
>1425_bases ATGACTAGTAATAATCTGCCCACGGTGTTGGAAAGCATCGTCGAGGGTCGTCGCGGACACCTGGAGGAAATTCGCGCTCG CATCGCTCACGTGGATGTAGATGCGCTTCCAAAATCCACCCGTTCTCTGTTTGATTCCCTCAACCAGGGTAGGGGAGGGG CGCGTTTCATCATGGAGTGCAAGTCTGCATCGCCTTCTTTGGGAATGATTCGTGAGCACTACCAGCCGGGTGAAATCGCT CGCGTGTACTCTCGCTACGCCAGCGGCATTTCCGTGCTGTGCGAGCCGGATCGTTTTGGTGGCGATTACGATCACCTCGC TACCGTTGCCGCTACCTCTCATCTTCCGGTGCTGTGCAAAGACTTCATTATTGATCCTGTCCAGGTACACGCGGCGCGTT ACTTTGGTGCTGATGCCATCCTGCTCATGCTCTCTGTGCTTGATGATGAAGAGTACGCAGCACTCGCTGCCGAGGCTGCG CGTTTTGATCTGGATATCCTCACCGAGGTTATTGATGAGGAGGAAGTCGCCCGCGCTATCAAGCTGGGTGCGAAGATCTT TGGCGTCAACCACCGCAACCTGCATGATCTGTCCATTGATTTGGATCGTTCACGTCGCCTGTCCAAGCTCATTCCAGCAG ATGCCGTGCTCGTGTCTGAGTCTGGCGTGCGCGATACCGAAACCGTCCGCCAGCTAGGTGGGCACTCCAATGCATTCCTC GTTGGCTCCCAGCTGACCAGCCAGGAAAACGTCGATCTGGCAGCCCGCGAATTGGTCTACGGCCCCAACAAAGTCTGCGG ACTCACCTCACCAAGTGCAGCACAAACCGCTCGCGCAGCGGGTGCGGTCTACGGCGGGCTCATCTTCGAAGAGGCATCAC CACGCAATGTTTCACGTGAAACATCGCAAAAAATCATCGCCGCAGAGCCCAACCTGCGCTACGTCGCGGTCAGCCGTCGC ACCTCCGGGTACAAGGATTTGCTTGTCGACGGCATCTTCGCCGTACAAATCCACGCCCCACTGCAGGGCAGCGTCGAAGC AGAAAAGGCATTGATCGCCGCCGTTCGTGAAGAGGTTGGACCGCAGGTCCAGGTCTGGCGCGCGATCTCGATGTCCAGCC CCTTGGGGGCTGAAGTGGCAGCTGCGGTGGAGGGTGACGTCGATAAGCTAATTCTTGATGCCCATGAAGGTGGCAGCGGG GAAGTATTCGACTGGGCTACGGTGCCAGCCGCTGTGAAGGCAAAGTCTTTGCTCGCGGGAGGCATCTCTCCGGACAACGC TGCGCAGGCACTCGCTGTGGGCTGCGCAGGTTTGGACATCAACTCTGGCGTGGAATACCCCGCCGGTGCAGGCACGTGGG CTGGGGCGAAAGACGCCGGCGCGCTGCTGAAAATTTTCGCAACCATCTCCACATTCCACTACTAA
Upstream 100 bases:
>100_bases GATGGTGCACAAAAGGCGCTTTCCTTGCTTGCCGACGGCACCACCCAGGCATGGTTGGCCAAGCACGAAGAGATCGATTA CTCAGAAAAGGAGTCTTCCA
Downstream 100 bases:
>100_bases AGGTTTAAATAGGATCATGACTGAAAAAGAAAACTTGGGTGGCTCCACGCTGCTGCCTGCATACTTCGGTGAATTCGGCG GCCAGTTCGTCGCGGAATCC
Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
Products: NA
Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]
Number of amino acids: Translated: 474; Mature: 473
Protein sequence:
>474_residues MTSNNLPTVLESIVEGRRGHLEEIRARIAHVDVDALPKSTRSLFDSLNQGRGGARFIMECKSASPSLGMIREHYQPGEIA RVYSRYASGISVLCEPDRFGGDYDHLATVAATSHLPVLCKDFIIDPVQVHAARYFGADAILLMLSVLDDEEYAALAAEAA RFDLDILTEVIDEEEVARAIKLGAKIFGVNHRNLHDLSIDLDRSRRLSKLIPADAVLVSESGVRDTETVRQLGGHSNAFL VGSQLTSQENVDLAARELVYGPNKVCGLTSPSAAQTARAAGAVYGGLIFEEASPRNVSRETSQKIIAAEPNLRYVAVSRR TSGYKDLLVDGIFAVQIHAPLQGSVEAEKALIAAVREEVGPQVQVWRAISMSSPLGAEVAAAVEGDVDKLILDAHEGGSG EVFDWATVPAAVKAKSLLAGGISPDNAAQALAVGCAGLDINSGVEYPAGAGTWAGAKDAGALLKIFATISTFHY
Sequences:
>Translated_474_residues MTSNNLPTVLESIVEGRRGHLEEIRARIAHVDVDALPKSTRSLFDSLNQGRGGARFIMECKSASPSLGMIREHYQPGEIA RVYSRYASGISVLCEPDRFGGDYDHLATVAATSHLPVLCKDFIIDPVQVHAARYFGADAILLMLSVLDDEEYAALAAEAA RFDLDILTEVIDEEEVARAIKLGAKIFGVNHRNLHDLSIDLDRSRRLSKLIPADAVLVSESGVRDTETVRQLGGHSNAFL VGSQLTSQENVDLAARELVYGPNKVCGLTSPSAAQTARAAGAVYGGLIFEEASPRNVSRETSQKIIAAEPNLRYVAVSRR TSGYKDLLVDGIFAVQIHAPLQGSVEAEKALIAAVREEVGPQVQVWRAISMSSPLGAEVAAAVEGDVDKLILDAHEGGSG EVFDWATVPAAVKAKSLLAGGISPDNAAQALAVGCAGLDINSGVEYPAGAGTWAGAKDAGALLKIFATISTFHY >Mature_473_residues TSNNLPTVLESIVEGRRGHLEEIRARIAHVDVDALPKSTRSLFDSLNQGRGGARFIMECKSASPSLGMIREHYQPGEIAR VYSRYASGISVLCEPDRFGGDYDHLATVAATSHLPVLCKDFIIDPVQVHAARYFGADAILLMLSVLDDEEYAALAAEAAR FDLDILTEVIDEEEVARAIKLGAKIFGVNHRNLHDLSIDLDRSRRLSKLIPADAVLVSESGVRDTETVRQLGGHSNAFLV GSQLTSQENVDLAARELVYGPNKVCGLTSPSAAQTARAAGAVYGGLIFEEASPRNVSRETSQKIIAAEPNLRYVAVSRRT SGYKDLLVDGIFAVQIHAPLQGSVEAEKALIAAVREEVGPQVQVWRAISMSSPLGAEVAAAVEGDVDKLILDAHEGGSGE VFDWATVPAAVKAKSLLAGGISPDNAAQALAVGCAGLDINSGVEYPAGAGTWAGAKDAGALLKIFATISTFHY
Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]
COG id: COG0134
COG function: function code E; Indole-3-glycerol phosphate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the trpF family [H]
Homologues:
Organism=Escherichia coli, GI87081863, Length=473, Percent_Identity=42.2832980972516, Blast_Score=342, Evalue=2e-95, Organism=Saccharomyces cerevisiae, GI6322638, Length=230, Percent_Identity=33.9130434782609, Blast_Score=107, Evalue=4e-24,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013785 - InterPro: IPR013798 - InterPro: IPR001468 - InterPro: IPR001240 - InterPro: IPR011060 [H]
Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]
EC number: =4.1.1.48; =5.3.1.24 [H]
Molecular weight: Translated: 50393; Mature: 50262
Theoretical pI: Translated: 5.03; Mature: 5.03
Prosite motif: PS00614 IGPS
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTSNNLPTVLESIVEGRRGHLEEIRARIAHVDVDALPKSTRSLFDSLNQGRGGARFIMEC CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHCCCCCCEEEEEE KSASPSLGMIREHYQPGEIARVYSRYASGISVLCEPDRFGGDYDHLATVAATSHLPVLCK CCCCCCHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHH DFIIDPVQVHAARYFGADAILLMLSVLDDEEYAALAAEAARFDLDILTEVIDEEEVARAI HHCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHH KLGAKIFGVNHRNLHDLSIDLDRSRRLSKLIPADAVLVSESGVRDTETVRQLGGHSNAFL HHCHHEEECCCCCCEEEEEECCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCEEE VGSQLTSQENVDLAARELVYGPNKVCGLTSPSAAQTARAAGAVYGGLIFEEASPRNVSRE EECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEECCCCCCCCHH TSQKIIAAEPNLRYVAVSRRTSGYKDLLVDGIFAVQIHAPLQGSVEAEKALIAAVREEVG HHCCEEEECCCEEEEEEECCCCCHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHC PQVQVWRAISMSSPLGAEVAAAVEGDVDKLILDAHEGGSGEVFDWATVPAAVKAKSLLAG CCEEEHHHHHCCCCCCCHHHHHHCCCHHHEEEECCCCCCCCEEEEECCCHHHHHHHHHHC GISPDNAAQALAVGCAGLDINSGVEYPAGAGTWAGAKDAGALLKIFATISTFHY CCCCCHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC >Mature Secondary Structure TSNNLPTVLESIVEGRRGHLEEIRARIAHVDVDALPKSTRSLFDSLNQGRGGARFIMEC CCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHCCCCCCEEEEEE KSASPSLGMIREHYQPGEIARVYSRYASGISVLCEPDRFGGDYDHLATVAATSHLPVLCK CCCCCCHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHH DFIIDPVQVHAARYFGADAILLMLSVLDDEEYAALAAEAARFDLDILTEVIDEEEVARAI HHCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHH KLGAKIFGVNHRNLHDLSIDLDRSRRLSKLIPADAVLVSESGVRDTETVRQLGGHSNAFL HHCHHEEECCCCCCEEEEEECCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCEEE VGSQLTSQENVDLAARELVYGPNKVCGLTSPSAAQTARAAGAVYGGLIFEEASPRNVSRE EECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEECCCCCCCCHH TSQKIIAAEPNLRYVAVSRRTSGYKDLLVDGIFAVQIHAPLQGSVEAEKALIAAVREEVG HHCCEEEECCCEEEEEEECCCCCHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHC PQVQVWRAISMSSPLGAEVAAAVEGDVDKLILDAHEGGSGEVFDWATVPAAVKAKSLLAG CCEEEHHHHHCCCCCCCHHHHHHCCCHHHEEEECCCCCCCCEEEEECCCHHHHHHHHHHC GISPDNAAQALAVGCAGLDINSGVEYPAGAGTWAGAKDAGALLKIFATISTFHY CCCCCHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 3808947; 12948626 [H]