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The map label for this gene is sstT [H]

Identifier: 145297016

GI number: 145297016

Start: 3234025

End: 3235278

Strand: Reverse

Name: sstT [H]

Synonym: cgR_2914

Alternate gene names: 145297016

Gene position: 3235278-3234025 (Counterclockwise)

Preceding gene: 145297018

Following gene: 145297015

Centisome position: 97.62

GC content: 55.9

Gene sequence:

>1254_bases
ATGGACATAAAGAGCATGAGCTCGTCGCTGCTGTTCCGAGTGATCGTTGCCATCATCCTCGGAATCATCTGCAGCCTCTT
CTTCCCGGTGTGGCTCGCTGAGATCTTCACCACCTTCAACGGCCTATTCAGCAACTTTCTGGGCTTCTTCATCCCAGTGC
TGATCTTCTCCCTCATCGCCCCCGCCATCGCAGGGCTCGGCCGAGGCGCTGGCAAATGGCTCGGCATTGTTGCAGCAATC
GCCTACGCGTCCACCATCTTCTCCGGTCTGATCGCCTACGGAGCATCCCAAGCGCTCTACCCATGGCTGCTGAAAGACCA
CCAAAGCGTCGCCGAAATCGACCTTGATGCAGGTGCCCTCCAGCCCTACTTCAACATCGAGATGCCACCACCATTTGAAG
TGATGACCGCACTGCTGCTGGCATTCTGCCTCGGCCTGGGCATGGCTGTAGTTAAATCAGACACCCTGTTCAAGGTAACC
CGCGAACTCGAGCGCGTAGTCATGAAGACCATCACCGCCTTTGTCATCCCACTGCTGCCACTCTTCATCTTCGGCATCTT
CCTCGGCATGGGCATGAACGGTGGCCTCCTGGAGATCATGTCCGCATTTGGCAAGGTACTGATCCTCGCTGTCGTGGGTA
CCCTGCTCTTCCTGACTATCCAGTTCATTATCGCTGGTGCAGTATCCAAGAAGAACCCATGGAAACTGTTCAAAAACATG
CTCCCTGCATACTTCACTGCACTGGGCACCTCCTCTTCAGCGGCAACCATCCCAGTGACCTACCAGCAGACCCTCAAAAA
CGACGTTGATGTCAATGTCGCAGGCTTTGTTGTCCCACTGTGCGCCACCATCCACCTAGCTGGATCGATGATGAAAATCG
GCCTCTTCGCCTTCGCGGTCGTCTTCATATACGACATGGAAGTAAACGCTGGCCTCGCCATCGGATTCCTCCTCATGTTG
GGCATCACCATGATCGCTGCACCAGGCGTTCCGGGCGGAGCCATCATGGCGGCAACCGGAATGTTGTCCTCCATGCTCGG
ATTCAACACCGAACAAGTCGCCCTCATGATCGCCGCCTACATCGCGATCGATTCCTTCGGCACCGCAGCAAACGTCACCG
GCGACGGCGCAATCGCAGTCATCGTGAACAAATTCGCCAAGGGCCAGCTGCACACCACTTCCCCAGATGAAATCGAAGAA
GACGACCGCGTTGCCTTCGACATCACTCCATCGGATGTGGAACACCACAAGTAG

Upstream 100 bases:

>100_bases
GCTGTCCTTGTGACCCGTCACTTCCAAGCCGCACACAAAATTCCATCACGCGCTGCCGAGCATTGCTCAGACAGCACCTG
ATTAGAAATAAGGAACAACC

Downstream 100 bases:

>100_bases
AAACCCGCATTTTCTGTAGTTTTTACTGCGGTTTGATCGCACCAGCTCGATGTGGCTGGTGCGATTTTTTCTGTCTTGAG
GGTTCCCGGGCTCTGTGGAA

Product: hypothetical protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: Na(+)/serine-threonine symporter [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDIKSMSSSLLFRVIVAIILGIICSLFFPVWLAEIFTTFNGLFSNFLGFFIPVLIFSLIAPAIAGLGRGAGKWLGIVAAI
AYASTIFSGLIAYGASQALYPWLLKDHQSVAEIDLDAGALQPYFNIEMPPPFEVMTALLLAFCLGLGMAVVKSDTLFKVT
RELERVVMKTITAFVIPLLPLFIFGIFLGMGMNGGLLEIMSAFGKVLILAVVGTLLFLTIQFIIAGAVSKKNPWKLFKNM
LPAYFTALGTSSSAATIPVTYQQTLKNDVDVNVAGFVVPLCATIHLAGSMMKIGLFAFAVVFIYDMEVNAGLAIGFLLML
GITMIAAPGVPGGAIMAATGMLSSMLGFNTEQVALMIAAYIAIDSFGTAANVTGDGAIAVIVNKFAKGQLHTTSPDEIEE
DDRVAFDITPSDVEHHK

Sequences:

>Translated_417_residues
MDIKSMSSSLLFRVIVAIILGIICSLFFPVWLAEIFTTFNGLFSNFLGFFIPVLIFSLIAPAIAGLGRGAGKWLGIVAAI
AYASTIFSGLIAYGASQALYPWLLKDHQSVAEIDLDAGALQPYFNIEMPPPFEVMTALLLAFCLGLGMAVVKSDTLFKVT
RELERVVMKTITAFVIPLLPLFIFGIFLGMGMNGGLLEIMSAFGKVLILAVVGTLLFLTIQFIIAGAVSKKNPWKLFKNM
LPAYFTALGTSSSAATIPVTYQQTLKNDVDVNVAGFVVPLCATIHLAGSMMKIGLFAFAVVFIYDMEVNAGLAIGFLLML
GITMIAAPGVPGGAIMAATGMLSSMLGFNTEQVALMIAAYIAIDSFGTAANVTGDGAIAVIVNKFAKGQLHTTSPDEIEE
DDRVAFDITPSDVEHHK
>Mature_417_residues
MDIKSMSSSLLFRVIVAIILGIICSLFFPVWLAEIFTTFNGLFSNFLGFFIPVLIFSLIAPAIAGLGRGAGKWLGIVAAI
AYASTIFSGLIAYGASQALYPWLLKDHQSVAEIDLDAGALQPYFNIEMPPPFEVMTALLLAFCLGLGMAVVKSDTLFKVT
RELERVVMKTITAFVIPLLPLFIFGIFLGMGMNGGLLEIMSAFGKVLILAVVGTLLFLTIQFIIAGAVSKKNPWKLFKNM
LPAYFTALGTSSSAATIPVTYQQTLKNDVDVNVAGFVVPLCATIHLAGSMMKIGLFAFAVVFIYDMEVNAGLAIGFLLML
GITMIAAPGVPGGAIMAATGMLSSMLGFNTEQVALMIAAYIAIDSFGTAANVTGDGAIAVIVNKFAKGQLHTTSPDEIEE
DDRVAFDITPSDVEHHK

Specific function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=196, Percent_Identity=32.1428571428571, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI40254478, Length=201, Percent_Identity=30.8457711442786, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI66773030, Length=266, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI194239697, Length=166, Percent_Identity=33.7349397590361, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4827012, Length=165, Percent_Identity=29.6969696969697, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI21314632, Length=179, Percent_Identity=26.2569832402235, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI262359914, Length=88, Percent_Identity=40.9090909090909, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71983106, Length=337, Percent_Identity=26.4094955489614, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71983099, Length=337, Percent_Identity=26.4094955489614, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193206654, Length=286, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17541374, Length=186, Percent_Identity=31.7204301075269, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71996953, Length=165, Percent_Identity=29.0909090909091, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193206505, Length=265, Percent_Identity=28.3018867924528, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=177, Percent_Identity=29.9435028248588, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583025, Length=189, Percent_Identity=24.8677248677249, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137668, Length=189, Percent_Identity=24.8677248677249, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583023, Length=189, Percent_Identity=24.8677248677249, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR023025 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44455; Mature: 44455

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure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HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA