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The map label for this gene is qor [C]

Identifier: 145296993

GI number: 145296993

Start: 3207854

End: 3208867

Strand: Reverse

Name: qor [C]

Synonym: cgR_2892

Alternate gene names: 145296993

Gene position: 3208867-3207854 (Counterclockwise)

Preceding gene: 145296997

Following gene: 145296992

Centisome position: 96.82

GC content: 51.48

Gene sequence:

>1014_bases
ATGAGCGTGCAAATGGATACCCCTGATCCCACGATGTCTGCTGTTGCAATGTTAGATTCCATCCCTTCTGATCAACCAGA
TTTCCTAGTTGATGTAGAAGTAGATCGACCAACTCCCGGACCACATGATCTGCTAGTCCACATTGAGGCGGTCTCAATTA
ACCCTGTTGATACCAAGGTACGCATGCGCGCCGGGAAACAAAAGCACCCAAAGATCCTTGGATTTGATGCTGCAGGTGAA
GTGGTGACAGTTGGATCTCAGGTCACGCTTTTCAATGCTGGTGACAAGGTGTTTTATGCAGGTTCCAACCAGCGCCCAGG
AAGTAATGCGCAGTACCAGGTGGTGGATGAACGGCTGGTAGGGCATGCGCCACAAAGCTTAGAGCCACACGATGCCGCTG
CTCTCCCACTGGTTGCGCTCACGGCATGGGAGGCGCTTTTTGATCGTTTGGGCGTAACTCAGTCTTCCACCGGCACGTTG
CTGGTGTTGGGTGGTTCAGGTGGTGTGCCTTCCGCTCTTATCCAAATTGCCCGAGCTCTTACTGGTCTGAAAGTGGTGGC
AACTGCTTCCCGACCTGAGTCGGCAGAATGGGTGACTAAGCTCGGAGCTCATGAGGTGATTGATCACTCCAAGGATTTGA
GTGAGCAGATCTCCGATGTGGATTTTGTGTTCAGCTCGTGGACTACGGGTCGTGAAGTAGAGCTAGCCACGTTGATGAAG
CCACAGTCCCACCTGGTGCTTATTGATGATCCAGTGGATCCAAACTTGGGTGCTTTCAAACAAAAAGCCATCGCTTTGCA
CTGGGAGTTCATGTTTACCCGCGCTATGTTCAATACCCCTGACATGGGTGAACAAGGCAAAATTCTGAATAAGATCGCCG
ACATGGTTGATCGGGGTCAGTTTCAGGCAGTGACAGCAACTGTGCTGGAGGGTCTCAACGCTGCCAACATCATGGAGGGA
CACCGGCTCGTTGAGCAGGGTAAAACCTCAGGAAAAATCGTTGTGAGGATTTAA

Upstream 100 bases:

>100_bases
GTGCAATTAAAAAGCACGTCAGATACGGCAAACATCTGACCGTGTCCAATGCCATAGAAAACACCGGCATGAAACGTACT
CAAGGGCTAACATCGGGGGC

Downstream 100 bases:

>100_bases
AGAGGATTTGAACAATGCATCATCTACGCTATGACTCACCAATCGGAGAGCTACTCCTGGTCGCAAGTGATCAAGGGCTG
ACCTACGTGGCATTCTCCGA

Product: hypothetical protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSVQMDTPDPTMSAVAMLDSIPSDQPDFLVDVEVDRPTPGPHDLLVHIEAVSINPVDTKVRMRAGKQKHPKILGFDAAGE
VVTVGSQVTLFNAGDKVFYAGSNQRPGSNAQYQVVDERLVGHAPQSLEPHDAAALPLVALTAWEALFDRLGVTQSSTGTL
LVLGGSGGVPSALIQIARALTGLKVVATASRPESAEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMK
PQSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQFQAVTATVLEGLNAANIMEG
HRLVEQGKTSGKIVVRI

Sequences:

>Translated_337_residues
MSVQMDTPDPTMSAVAMLDSIPSDQPDFLVDVEVDRPTPGPHDLLVHIEAVSINPVDTKVRMRAGKQKHPKILGFDAAGE
VVTVGSQVTLFNAGDKVFYAGSNQRPGSNAQYQVVDERLVGHAPQSLEPHDAAALPLVALTAWEALFDRLGVTQSSTGTL
LVLGGSGGVPSALIQIARALTGLKVVATASRPESAEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMK
PQSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQFQAVTATVLEGLNAANIMEG
HRLVEQGKTSGKIVVRI
>Mature_336_residues
SVQMDTPDPTMSAVAMLDSIPSDQPDFLVDVEVDRPTPGPHDLLVHIEAVSINPVDTKVRMRAGKQKHPKILGFDAAGEV
VTVGSQVTLFNAGDKVFYAGSNQRPGSNAQYQVVDERLVGHAPQSLEPHDAAALPLVALTAWEALFDRLGVTQSSTGTLL
VLGGSGGVPSALIQIARALTGLKVVATASRPESAEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMKP
QSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQFQAVTATVLEGLNAANIMEGH
RLVEQGKTSGKIVVRI

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=336, Percent_Identity=29.4642857142857, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI194239674, Length=207, Percent_Identity=33.8164251207729, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI13236495, Length=207, Percent_Identity=33.8164251207729, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI194239676, Length=207, Percent_Identity=33.8164251207729, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1790485, Length=199, Percent_Identity=30.6532663316583, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=188, Percent_Identity=36.7021276595745, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71987554, Length=168, Percent_Identity=30.3571428571429, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36273; Mature: 36142

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQMDTPDPTMSAVAMLDSIPSDQPDFLVDVEVDRPTPGPHDLLVHIEAVSINPVDTKV
CCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCHHH
RMRAGKQKHPKILGFDAAGEVVTVGSQVTLFNAGDKVFYAGSNQRPGSNAQYQVVDERLV
HHHCCCCCCCEEEEECCCCCEEEECCEEEEEECCCEEEECCCCCCCCCCCCEEEEHHHHH
GHAPQSLEPHDAAALPLVALTAWEALFDRLGVTQSSTGTLLVLGGSGGVPSALIQIARAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHH
TGLKVVATASRPESAEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMK
CCEEEEEECCCCCHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEC
PQSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQ
CCCCEEEEECCCCCCCCHHHHHHEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
FQAVTATVLEGLNAANIMEGHRLVEQGKTSGKIVVRI
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
SVQMDTPDPTMSAVAMLDSIPSDQPDFLVDVEVDRPTPGPHDLLVHIEAVSINPVDTKV
CCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCHHH
RMRAGKQKHPKILGFDAAGEVVTVGSQVTLFNAGDKVFYAGSNQRPGSNAQYQVVDERLV
HHHCCCCCCCEEEEECCCCCEEEECCEEEEEECCCEEEECCCCCCCCCCCCEEEEHHHHH
GHAPQSLEPHDAAALPLVALTAWEALFDRLGVTQSSTGTLLVLGGSGGVPSALIQIARAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHH
TGLKVVATASRPESAEWVTKLGAHEVIDHSKDLSEQISDVDFVFSSWTTGREVELATLMK
CCEEEEEECCCCCHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEC
PQSHLVLIDDPVDPNLGAFKQKAIALHWEFMFTRAMFNTPDMGEQGKILNKIADMVDRGQ
CCCCEEEEECCCCCCCCHHHHHHEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
FQAVTATVLEGLNAANIMEGHRLVEQGKTSGKIVVRI
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA