Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 145296963

GI number: 145296963

Start: 3181371

End: 3181820

Strand: Reverse

Name: trxA [H]

Synonym: cgR_2862

Alternate gene names: 145296963

Gene position: 3181820-3181371 (Counterclockwise)

Preceding gene: 145296966

Following gene: 145296961

Centisome position: 96.01

GC content: 54.89

Gene sequence:

>450_bases
TTGGCCGGGAATAACTACAGTCCGCTGAAAGTTGGTCTATATACAGACCTTACAAATCTTGAACGGAGATTCTTAATGGC
AACCATCGATGTAACCGAAGACACATTTGAGAGCACAGTTACCGGCGACGGAATTGTCCTCGTAGACGCATGGGCATCCT
GGTGCGGACCTTGCCGCCAGTTCGCCCCAACCTACGAGAAGGTTTCCGAAACCCACACCGACGCAACCTTCGCCAAGCTT
GATACCGAAGCAAACCAGGGCCTGGCTGCAGCACTGCAGATCCAGTCCATCCCAACTCTGATGGTTTTCCGCGACGGCAT
CATGGTCTACCGCGAAGCCGGCACCATGCCAGCTCCTGCACTGGATGATCTGGTCAACCAGGTTAAGGCGCTCGACATGG
ATGACGTTCGTCGCCAGGTCGCAGAGCAGCAGGGTTCTGCAGAGGCATAA

Upstream 100 bases:

>100_bases
CTTCCGATGTGATGAAATCCAGCGGACTCTGAAACGTGTCCAACGTTCAATGTACGATGTGCAGTGAATCAGACGAGCTG
CCGGTCAACGAAGAAAATCC

Downstream 100 bases:

>100_bases
GCTTCCAATTGTGTTTTGGTGAAAACCGCTGAGGAGAACTTCTTCTCGGCGGTTTTTGTCGTTATTGGGAGCTTTGGTTT
TTGGGGGCGCCTGATTTCAC

Product: hypothetical protein

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MAGNNYSPLKVGLYTDLTNLERRFLMATIDVTEDTFESTVTGDGIVLVDAWASWCGPCRQFAPTYEKVSETHTDATFAKL
DTEANQGLAAALQIQSIPTLMVFRDGIMVYREAGTMPAPALDDLVNQVKALDMDDVRRQVAEQQGSAEA

Sequences:

>Translated_149_residues
MAGNNYSPLKVGLYTDLTNLERRFLMATIDVTEDTFESTVTGDGIVLVDAWASWCGPCRQFAPTYEKVSETHTDATFAKL
DTEANQGLAAALQIQSIPTLMVFRDGIMVYREAGTMPAPALDDLVNQVKALDMDDVRRQVAEQQGSAEA
>Mature_148_residues
AGNNYSPLKVGLYTDLTNLERRFLMATIDVTEDTFESTVTGDGIVLVDAWASWCGPCRQFAPTYEKVSETHTDATFAKLD
TEANQGLAAALQIQSIPTLMVFRDGIMVYREAGTMPAPALDDLVNQVKALDMDDVRRQVAEQQGSAEA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=101, Percent_Identity=37.6237623762376, Blast_Score=85, Evalue=2e-18,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=36, Blast_Score=76, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17510299, Length=105, Percent_Identity=36.1904761904762, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=96, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=78, Percent_Identity=42.3076923076923, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=93, Percent_Identity=38.7096774193548, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI18859803, Length=124, Percent_Identity=30.6451612903226, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 16310; Mature: 16178

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGNNYSPLKVGLYTDLTNLERRFLMATIDVTEDTFESTVTGDGIVLVDAWASWCGPCRQ
CCCCCCCCEEEEEECCHHHHHHHHHHEEECCCHHHHHHHCCCCCEEEEECHHHHHHHHHH
FAPTYEKVSETHTDATFAKLDTEANQGLAAALQIQSIPTLMVFRDGIMVYREAGTMPAPA
HCCCHHHHHHHCCCHHHHHHCCCCCCCCEEEEECCCCCEEEEECCCEEEEECCCCCCCCH
LDDLVNQVKALDMDDVRRQVAEQQGSAEA
HHHHHHHHHCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AGNNYSPLKVGLYTDLTNLERRFLMATIDVTEDTFESTVTGDGIVLVDAWASWCGPCRQ
CCCCCCCEEEEEECCHHHHHHHHHHEEECCCHHHHHHHCCCCCEEEEECHHHHHHHHHH
FAPTYEKVSETHTDATFAKLDTEANQGLAAALQIQSIPTLMVFRDGIMVYREAGTMPAPA
HCCCHHHHHHHCCCHHHHHHCCCCCCCCEEEEECCCCCEEEEECCCEEEEECCCCCCCCH
LDDLVNQVKALDMDDVRRQVAEQQGSAEA
HHHHHHHHHCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]