The gene/protein map for NC_012581 is currently unavailable.
Definition Corynebacterium glutamicum R chromosome, complete genome.
Accession NC_009342
Length 3,314,179

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The map label for this gene is serS

Identifier: 145296881

GI number: 145296881

Start: 3087836

End: 3089104

Strand: Reverse

Name: serS

Synonym: cgR_2781

Alternate gene names: 145296881

Gene position: 3089104-3087836 (Counterclockwise)

Preceding gene: 145296885

Following gene: 145296880

Centisome position: 93.21

GC content: 56.34

Gene sequence:

>1269_bases
ATGATCGATCTGAAATTCCTCCGTGATAACCCGGACGTTGTTCGTGCCTCCCAGATCACTCGCGGCGAAGACCCCGCGCT
TGTGGACGAACTGATTAGTGCTGATGAATCTCGTCGCGAAGCAATCAAAGCTGCCGACGATCTGCGCGCTGAGCAGAAGG
CTTTTGGAAAGAAGATCGGACAGGCCTCTCCGGAGGACCGCCCTGCACTTCTGGAGGGTTCCAACGAGCTTAAGGCCAAG
GTGAAGGATGCTGAGGCTGCACAGGAAGCTGCAGAGGCGAAAGTCAATGAGCTGCAGATGAAGCTCTCCAACGTGGTATC
CGGCGCGCCTGCGGGTGGCGAAGATGATTTCGTCGTCCTGGAGACCATCGGCGAGCCTCGCACCTTTGATTTCGAGCCAA
AGGATCACCTGGAGCTTGGTGAATCCCTCGGACTTATCGATATGAAGCGTGGCACCAAGGTTTCCGGTGCACGTTTCTAC
TACCTCACCGGTGACGGCGCAATGCTGCAGTTGGGCATGCTCATGTTGGCTGCTCAGAAGGCGCGCGAAGCCGGATTTAG
CATGATGATCCCTCCAGTTTTGGTGCGCCCTGAAATCATGGCGGGCACTGGATTCTTGGGTGATCACTCCGAGGAGATCT
ACTACCTCGAACGCGATGACATGTACTTGGTGGGTACCTCTGAGGTGGCTCTTGCGGGTTACCACAAGGACGAAATCATT
GATCTCAACGAAGGCCCAGTGAAGTACGCCGGTTGGAGCTCCTGCTTCCGCCGTGAGGCTGGTTCCTACGGCAAGGACAC
CCGAGGCATTTTGCGTGTGCACCAGTTCGACAAGGTTGAGATGTTTGTCTACTGCAAGCCTGAAGATGCTGAAGATGTAC
ACCAGCAGCTGCTCGGCATGGAGAAAGAAATGCTCGCAGCCATCGAGGTTCCTTACCGCGTCATCGACGTTGCCGGTGGA
GACTTGGGTGCATCTGCTGCCCGCAAGTTCGACACCGAGGCATGGGTGCCAACCCAGGACACCTACCGTGAACTCACCTC
GACCTCTAACTGCACCACTTTCCAGGCTCGTCGCCTGCAGACCCGTTACCGCGATGAAAACGGCAAGCCACAGATCGCCG
CAACCCTGAACGGTACGTTGGCTACCACTCGTTGGCTTGTCGCGATTCTGGAGAACAACCAGCAGGCAGACGGATCTGTT
GTTGTTCCTGAGGCGCTTCGTCCATTCGTGGGCAAAGACGTGCTCAAGCCAGTGAAACAAGCCGGTTAA

Upstream 100 bases:

>100_bases
GTGACTGAAGCGGGACAGGAGCGCCTAGTAAAAAGCAAGGCTGGAAAACAGATAAGCCCTAAGTGCCCACATGTCTACCG
ATCACGGTAGATTGTTCTTT

Downstream 100 bases:

>100_bases
TTCAGCGGAAAGCTTGTGGTCGACATGGTCAAAAGGTTTGGCTTTTTCGTAGAGGATTCCCTGCCTAAGGTTCCGCTGCA
TCCCGAAGAGTCACGGGAGA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MIDLKFLRDNPDVVRASQITRGEDPALVDELISADESRREAIKAADDLRAEQKAFGKKIGQASPEDRPALLEGSNELKAK
VKDAEAAQEAAEAKVNELQMKLSNVVSGAPAGGEDDFVVLETIGEPRTFDFEPKDHLELGESLGLIDMKRGTKVSGARFY
YLTGDGAMLQLGMLMLAAQKAREAGFSMMIPPVLVRPEIMAGTGFLGDHSEEIYYLERDDMYLVGTSEVALAGYHKDEII
DLNEGPVKYAGWSSCFRREAGSYGKDTRGILRVHQFDKVEMFVYCKPEDAEDVHQQLLGMEKEMLAAIEVPYRVIDVAGG
DLGASAARKFDTEAWVPTQDTYRELTSTSNCTTFQARRLQTRYRDENGKPQIAATLNGTLATTRWLVAILENNQQADGSV
VVPEALRPFVGKDVLKPVKQAG

Sequences:

>Translated_422_residues
MIDLKFLRDNPDVVRASQITRGEDPALVDELISADESRREAIKAADDLRAEQKAFGKKIGQASPEDRPALLEGSNELKAK
VKDAEAAQEAAEAKVNELQMKLSNVVSGAPAGGEDDFVVLETIGEPRTFDFEPKDHLELGESLGLIDMKRGTKVSGARFY
YLTGDGAMLQLGMLMLAAQKAREAGFSMMIPPVLVRPEIMAGTGFLGDHSEEIYYLERDDMYLVGTSEVALAGYHKDEII
DLNEGPVKYAGWSSCFRREAGSYGKDTRGILRVHQFDKVEMFVYCKPEDAEDVHQQLLGMEKEMLAAIEVPYRVIDVAGG
DLGASAARKFDTEAWVPTQDTYRELTSTSNCTTFQARRLQTRYRDENGKPQIAATLNGTLATTRWLVAILENNQQADGSV
VVPEALRPFVGKDVLKPVKQAG
>Mature_422_residues
MIDLKFLRDNPDVVRASQITRGEDPALVDELISADESRREAIKAADDLRAEQKAFGKKIGQASPEDRPALLEGSNELKAK
VKDAEAAQEAAEAKVNELQMKLSNVVSGAPAGGEDDFVVLETIGEPRTFDFEPKDHLELGESLGLIDMKRGTKVSGARFY
YLTGDGAMLQLGMLMLAAQKAREAGFSMMIPPVLVRPEIMAGTGFLGDHSEEIYYLERDDMYLVGTSEVALAGYHKDEII
DLNEGPVKYAGWSSCFRREAGSYGKDTRGILRVHQFDKVEMFVYCKPEDAEDVHQQLLGMEKEMLAAIEVPYRVIDVAGG
DLGASAARKFDTEAWVPTQDTYRELTSTSNCTTFQARRLQTRYRDENGKPQIAATLNGTLATTRWLVAILENNQQADGSV
VVPEALRPFVGKDVLKPVKQAG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI225579074, Length=322, Percent_Identity=40.6832298136646, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI8923421, Length=322, Percent_Identity=40.6832298136646, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI16306548, Length=461, Percent_Identity=31.236442516269, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=37.5586854460094, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17539260, Length=458, Percent_Identity=34.4978165938865, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17542084, Length=322, Percent_Identity=33.8509316770186, Blast_Score=158, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321799, Length=403, Percent_Identity=33.9950372208437, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6320226, Length=436, Percent_Identity=32.3394495412844, Blast_Score=223, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24581334, Length=466, Percent_Identity=32.4034334763949, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI17737985, Length=280, Percent_Identity=36.0714285714286, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_CORGL (Q8NLP6)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927156
- RefSeq:   NP_602083.2
- RefSeq:   YP_227132.2
- ProteinModelPortal:   Q8NLP6
- SMR:   Q8NLP6
- World-2DPAGE:   0001:Q8NLP6
- PRIDE:   Q8NLP6
- GeneID:   1020836
- GeneID:   3342619
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg3201
- KEGG:   cgl:NCgl2793
- HOGENOM:   HBG629391
- OMA:   NLRYRDP
- PhylomeDB:   Q8NLP6
- ProtClustDB:   PRK05431
- BioCyc:   CGLU196627:CG3201-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46472; Mature: 46472

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50862 AA_TRNA_LIGASE_II; PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 273-273 BINDING 280-280 BINDING 379-379

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MIDLKFLRDNPDVVRASQITRGEDPALVDELISADESRREAIKAADDLRAEQKAFGKKIG
CCEEEEECCCCCEEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QASPEDRPALLEGSNELKAKVKDAEAAQEAAEAKVNELQMKLSNVVSGAPAGGEDDFVVL
CCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
ETIGEPRTFDFEPKDHLELGESLGLIDMKRGTKVSGARFYYLTGDGAMLQLGMLMLAAQK
EECCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
AREAGFSMMIPPVLVRPEIMAGTGFLGDHSEEIYYLERDDMYLVGTSEVALAGYHKDEII
HHHCCCEEECCCHHCCCCCEECCCCCCCCCCEEEEEECCCEEEEECCCEEEEECCCCCEE
DLNEGPVKYAGWSSCFRREAGSYGKDTRGILRVHQFDKVEMFVYCKPEDAEDVHQQLLGM
ECCCCCCEECCHHHHHHHHCCCCCCCCHHHHEEEECCCEEEEEEECCCCHHHHHHHHHCC
EKEMLAAIEVPYRVIDVAGGDLGASAARKFDTEAWVPTQDTYRELTSTSNCTTFQARRLQ
HHHHHHHHHCCEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
TRYRDENGKPQIAATLNGTLATTRWLVAILENNQQADGSVVVPEALRPFVGKDVLKPVKQ
HHHCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCEECHHHHHHHCCHHHHHHHHH
AG
CC
>Mature Secondary Structure
MIDLKFLRDNPDVVRASQITRGEDPALVDELISADESRREAIKAADDLRAEQKAFGKKIG
CCEEEEECCCCCEEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QASPEDRPALLEGSNELKAKVKDAEAAQEAAEAKVNELQMKLSNVVSGAPAGGEDDFVVL
CCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
ETIGEPRTFDFEPKDHLELGESLGLIDMKRGTKVSGARFYYLTGDGAMLQLGMLMLAAQK
EECCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
AREAGFSMMIPPVLVRPEIMAGTGFLGDHSEEIYYLERDDMYLVGTSEVALAGYHKDEII
HHHCCCEEECCCHHCCCCCEECCCCCCCCCCEEEEEECCCEEEEECCCEEEEECCCCCEE
DLNEGPVKYAGWSSCFRREAGSYGKDTRGILRVHQFDKVEMFVYCKPEDAEDVHQQLLGM
ECCCCCCEECCHHHHHHHHCCCCCCCCHHHHEEEECCCEEEEEEECCCCHHHHHHHHHCC
EKEMLAAIEVPYRVIDVAGGDLGASAARKFDTEAWVPTQDTYRELTSTSNCTTFQARRLQ
HHHHHHHHHCCEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
TRYRDENGKPQIAATLNGTLATTRWLVAILENNQQADGSVVVPEALRPFVGKDVLKPVKQ
HHHCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCEECHHHHHHHCCHHHHHHHHH
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626