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The map label for this gene is adh [H]

Identifier: 145296792

GI number: 145296792

Start: 2983188

End: 2984225

Strand: Reverse

Name: adh [H]

Synonym: cgR_2695

Alternate gene names: 145296792

Gene position: 2984225-2983188 (Counterclockwise)

Preceding gene: 145296793

Following gene: 145296791

Centisome position: 90.04

GC content: 55.49

Gene sequence:

>1038_bases
ATGACCACTGCTGCACCCCAAGAATTTACTGCTGCTGTTGTTGAAAAATTCGGTCATGAGGTGACCGTGAAGGATATTGA
CCTTCCAAAGCCAGGACCAAACCAGGCATTGGTGAAGGTACTCACCTCCGGCATCTGCCACACCGACCTCCACGCCTTGG
AGGGCGATTGGCCAGTAAAGCCGGAACCACCATTCGTACCAGGACACGAAGGTGTAGGTGAAGTTGTTGAGCTCGGACCA
GGTGAACACGATGTGAAGGTCGGCGATATTGTCGGCAATGCATGGCTCTGGTCAGCGTGTGGCACCTGCGAATACTGCAT
CACCGGCAGGGAAACTCAGTGCAACGAAGCTGAGTATGGTGGCTACACCCAAAATGGATCCTTCGGCCAGTACATGCTGG
TGGATACCCGTTACGCCGCTCGCATCCCAGACGGCGTGGACTACCTCGAAGCAGCACCAATTCTGTGTGCAGGCGTGACT
GTCTACAAGGCACTCAAAGTCTCTGAAACCCGCCCGGGCCAATTCATGGTGATCTCCGGTGTCGGCGGACTTGGCCACAT
CGCAGTCCAATACGCAGCGGCGATGGGCATGCGTGTCATTGCGGTAGATATTGCCGATGACAAGCTGGAACTTGCCCGTA
AGCACGGTGCGGAATTTACCGTGAATGCTCGCAATGAAGATCCAGGCGAAGCTGTACAGAAGTACACCAACGGTGGCGCA
CACGGCGTGCTTGTGACTGCAGTTCACGAGGCAGCATTCGGCCAGGCGCTGGATATGGCTCGACGTGCAGGAACGATTGT
GTTCAACGGCCTGCCACCGGGAGAGTTCCCAGCATCCGTGTTCAACATCGTATTCAAGGGCCTGACCATCCGTGGATCCC
TCGTGGGAACCCGCCAAGACTTGGCCGAAGCGCTCGATTTCTTTGCACGCGGACTAATCAAGCCAACCGTGAGTGAGTGT
TCCCTCGATGAGGTCAATGATGTTCTTGACCGCATGCGAAACGGCAAGATTGATGGTCGTGTGGCAATTCGCTACTAA

Upstream 100 bases:

>100_bases
TTGCAAGGATTGTAATTTGAACCACACATTGACTGGTGTGAAATTACATTTGCCAGAAGAGCAATTTGCCAAGTAATCCA
AGCGAGAAGGAGTGAGTTTT

Downstream 100 bases:

>100_bases
CCGTTGGTTTGAAAACTGCAGTGAAGCTACCTTGAGGCGGTTGCTTTACGGCGGTTCGGCTGAAAATTGTGACGAAATTT
GGCTGAGCTTTCGTCGCTTT

Product: Zn-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTTAAPQEFTAAVVEKFGHEVTVKDIDLPKPGPNQALVKVLTSGICHTDLHALEGDWPVKPEPPFVPGHEGVGEVVELGP
GEHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYGGYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVT
VYKALKVSETRPGQFMVISGVGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDPGEAVQKYTNGGA
HGVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQDLAEALDFFARGLIKPTVSEC
SLDEVNDVLDRMRNGKIDGRVAIRY

Sequences:

>Translated_345_residues
MTTAAPQEFTAAVVEKFGHEVTVKDIDLPKPGPNQALVKVLTSGICHTDLHALEGDWPVKPEPPFVPGHEGVGEVVELGP
GEHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYGGYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVT
VYKALKVSETRPGQFMVISGVGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDPGEAVQKYTNGGA
HGVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQDLAEALDFFARGLIKPTVSEC
SLDEVNDVLDRMRNGKIDGRVAIRY
>Mature_344_residues
TTAAPQEFTAAVVEKFGHEVTVKDIDLPKPGPNQALVKVLTSGICHTDLHALEGDWPVKPEPPFVPGHEGVGEVVELGPG
EHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYGGYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVTV
YKALKVSETRPGQFMVISGVGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDPGEAVQKYTNGGAH
GVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQDLAEALDFFARGLIKPTVSECS
LDEVNDVLDRMRNGKIDGRVAIRY

Specific function: Active with primary alcohols, including methanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=360, Percent_Identity=27.5, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI34577061, Length=360, Percent_Identity=28.0555555555556, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=27.2222222222222, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=24.4565217391304, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4501939, Length=368, Percent_Identity=24.4565217391304, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI262073058, Length=333, Percent_Identity=27.027027027027, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71743840, Length=333, Percent_Identity=27.027027027027, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71565152, Length=366, Percent_Identity=24.0437158469945, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI71565154, Length=363, Percent_Identity=22.8650137741047, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156627571, Length=280, Percent_Identity=26.0714285714286, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI22538446, Length=317, Percent_Identity=25.5520504731861, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI22538444, Length=317, Percent_Identity=25.5520504731861, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI194239674, Length=346, Percent_Identity=22.5433526011561, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI13236495, Length=346, Percent_Identity=22.5433526011561, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=43.952802359882, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1786518, Length=330, Percent_Identity=33.6363636363636, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI87082401, Length=337, Percent_Identity=29.080118694362, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=30.5637982195846, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788073, Length=264, Percent_Identity=29.5454545454545, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI226510992, Length=296, Percent_Identity=31.0810810810811, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082125, Length=341, Percent_Identity=27.2727272727273, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788075, Length=309, Percent_Identity=29.7734627831715, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790718, Length=308, Percent_Identity=27.5974025974026, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=307, Percent_Identity=27.6872964169381, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=30.5405405405405, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788407, Length=191, Percent_Identity=29.8429319371728, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790485, Length=304, Percent_Identity=28.6184210526316, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=38.7755102040816, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71988145, Length=347, Percent_Identity=35.4466858789625, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17562582, Length=350, Percent_Identity=38.8571428571429, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17562876, Length=215, Percent_Identity=30.6976744186047, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=218, Percent_Identity=30.2752293577982, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17507255, Length=247, Percent_Identity=26.7206477732794, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=378, Percent_Identity=24.0740740740741, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=345, Percent_Identity=45.2173913043478, Blast_Score=294, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6323961, Length=341, Percent_Identity=45.7478005865103, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6319621, Length=342, Percent_Identity=45.0292397660819, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6324486, Length=323, Percent_Identity=47.3684210526316, Blast_Score=281, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6319949, Length=330, Percent_Identity=29.6969696969697, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323980, Length=327, Percent_Identity=27.82874617737, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319520, Length=313, Percent_Identity=25.5591054313099, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=374, Percent_Identity=25.1336898395722, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322619, Length=330, Percent_Identity=26.969696969697, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=329, Percent_Identity=26.4437689969605, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=215, Percent_Identity=27.906976744186, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=23.8605898123324, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137530, Length=296, Percent_Identity=26.0135135135135, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=216, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36887; Mature: 36756

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAAPQEFTAAVVEKFGHEVTVKDIDLPKPGPNQALVKVLTSGICHTDLHALEGDWPVK
CCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCC
PEPPFVPGHEGVGEVVELGPGEHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYG
CCCCCCCCCCCCCHHHCCCCCCCCEEEHHEECCCHHHHCCCCEEEEECCCCCCCCCCCCC
GYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVTVYKALKVSETRPGQFMVISG
CCCCCCCCCEEEEEECHHHHCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCCEEEEEC
VGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDPGEAVQKYTNGGA
CCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCC
HGVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQD
CEEEEEEHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCHHH
LAEALDFFARGLIKPTVSECSLDEVNDVLDRMRNGKIDGRVAIRY
HHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
TTAAPQEFTAAVVEKFGHEVTVKDIDLPKPGPNQALVKVLTSGICHTDLHALEGDWPVK
CCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCC
PEPPFVPGHEGVGEVVELGPGEHDVKVGDIVGNAWLWSACGTCEYCITGRETQCNEAEYG
CCCCCCCCCCCCCHHHCCCCCCCCEEEHHEECCCHHHHCCCCEEEEECCCCCCCCCCCCC
GYTQNGSFGQYMLVDTRYAARIPDGVDYLEAAPILCAGVTVYKALKVSETRPGQFMVISG
CCCCCCCCCEEEEEECHHHHCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCCEEEEEC
VGGLGHIAVQYAAAMGMRVIAVDIADDKLELARKHGAEFTVNARNEDPGEAVQKYTNGGA
CCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCC
HGVLVTAVHEAAFGQALDMARRAGTIVFNGLPPGEFPASVFNIVFKGLTIRGSLVGTRQD
CEEEEEEHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCHHH
LAEALDFFARGLIKPTVSECSLDEVNDVLDRMRNGKIDGRVAIRY
HHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8049268 [H]