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The map label for this gene is ydgK [H]

Identifier: 145296742

GI number: 145296742

Start: 2927672

End: 2928868

Strand: Reverse

Name: ydgK [H]

Synonym: cgR_2646

Alternate gene names: 145296742

Gene position: 2928868-2927672 (Counterclockwise)

Preceding gene: 145296744

Following gene: 145296737

Centisome position: 88.37

GC content: 52.21

Gene sequence:

>1197_bases
ATGCAGAAAAAACAACAGCTGAGCACCGCCCTGATTATGGGATTGGCATTATTGTCAGCCAGCTCCGCGCTAGCGACCGA
TATGTATTTGCCGGCAATGCCTGGTATTGCGGAAGATTTGGGGACAACTGCACCGATGGTGCAGTTAACTCTTTCTTCCT
TTATGGCTGGAATGGCGATTGGCCAATTGATCATTGGTCCTTTGTCGGATCAATTGGGAAGGAAAGGCCTGCTCGTTGCA
GGTGCGGTGGCTGCGCTGGTCGCTAGTGTGGTGTGTGCGCTGGCGCCGTCGATAAGCGTATTAGTGATCGCACGCCTGGT
GCAGGGGCTTGGCGGCGGTGCGTGCGTGGTGATTGCGCGCGCGATCGTGCCAGACCTTGAACGCGGACAAAAGGCTGCGC
ACGCCTTTGCACTGCTGATGATTATTCAGGGAATTGCTCCCGTGGTAGCTCCGCTCATTGGTGGTGTGCTGGTCGGGCCT
TTCGGCTGGCGGGGAATTTTCTGGGCACTTGCACTGGTGAATTTTGCGCAGCTGCTTGTTGCTTTGCTGCAGATTAAGGA
GTCGAAGCCAGTTGAAGAGCGTACCGCAGCAGGACTTGGCGGAATGCTGTCCAACTATGTTTTTGTGCTGAAGAATCCTC
AATTTTTGGCATATGTATTCACATTGGGGCTGTCTTTTGGGGCGATGTTCTCCTACATTTCGGCGTCGCCGTTCGTGCTG
CAGAATCAAATGGGCATTCCAGTACTGCTGTATTCCATTATTTTCGGAGTGAATGCTTTTGGTTTGATTGTGGGCGGAAT
GATCAATAGGCGACTTCTGCAGCGGATTCATCCACACCGCATCATGCAAACTGTGCTGGCCAGTTTTACTGTGCTGTGTG
CGCTTTTGCTGATTGAAGTGCTGTTTATTAATTGGATACCGCTGTTCCTGTTGCTGCTGTTTCTTATCGTTTCCCATATT
CCGATGGTTATGGCTAACGCGACAGCTCTGGGAACTGAAGCTGTGCGAAGCAGGGCGGGATCGGGTTCTGCAATTTTGGG
ATTTGTGCAGTTCTCGATGGGTGCGTTGGTGAGTTCACTGGTCGGATTGGGTTCTGATAAGGCTGTGACCATGGGATTTG
CGATGACTGGTTGTGCTTTGCTGGCGTGTGGATGTGCGTACTTGGCGGGTCGAAAAGGTATCCCGGAAATGAGGTAG

Upstream 100 bases:

>100_bases
TTTTAAGTATTGGTGCTATCTTCCGGTGCTGATGGTACCTGAATGAAAATTTCTAATTAAAAATACCCCCAAATCTTCGA
TATAGATACATGAGACAGTG

Downstream 100 bases:

>100_bases
CTGCTGGAGCCGTTTTAAGGGCTTTGAGGCGCCGGATGGGTACATGTGTGGGATTGGTGATTTGAGGCCCTTAAACGGCA
ATCTAGGGGTGTGACTTTTG

Product: hypothetical protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAIGQLIIGPLSDQLGRKGLLVA
GAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIARAIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGP
FGWRGIFWALALVNFAQLLVALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
QNQMGIPVLLYSIIFGVNAFGLIVGGMINRRLLQRIHPHRIMQTVLASFTVLCALLLIEVLFINWIPLFLLLLFLIVSHI
PMVMANATALGTEAVRSRAGSGSAILGFVQFSMGALVSSLVGLGSDKAVTMGFAMTGCALLACGCAYLAGRKGIPEMR

Sequences:

>Translated_398_residues
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAIGQLIIGPLSDQLGRKGLLVA
GAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIARAIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGP
FGWRGIFWALALVNFAQLLVALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
QNQMGIPVLLYSIIFGVNAFGLIVGGMINRRLLQRIHPHRIMQTVLASFTVLCALLLIEVLFINWIPLFLLLLFLIVSHI
PMVMANATALGTEAVRSRAGSGSAILGFVQFSMGALVSSLVGLGSDKAVTMGFAMTGCALLACGCAYLAGRKGIPEMR
>Mature_398_residues
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAIGQLIIGPLSDQLGRKGLLVA
GAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIARAIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGP
FGWRGIFWALALVNFAQLLVALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
QNQMGIPVLLYSIIFGVNAFGLIVGGMINRRLLQRIHPHRIMQTVLASFTVLCALLLIEVLFINWIPLFLLLLFLIVSHI
PMVMANATALGTEAVRSRAGSGSAILGFVQFSMGALVSSLVGLGSDKAVTMGFAMTGCALLACGCAYLAGRKGIPEMR

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=386, Percent_Identity=31.3471502590674, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1790146, Length=233, Percent_Identity=33.4763948497854, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI48994889, Length=281, Percent_Identity=32.3843416370107, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082312, Length=361, Percent_Identity=26.0387811634349, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787065, Length=281, Percent_Identity=26.6903914590747, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790794, Length=232, Percent_Identity=26.7241379310345, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789042, Length=171, Percent_Identity=26.9005847953216, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=183, Percent_Identity=30.6010928961749, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319480, Length=271, Percent_Identity=23.9852398523985, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319657, Length=146, Percent_Identity=26.7123287671233, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41614; Mature: 41614

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHH
GQLIIGPLSDQLGRKGLLVAGAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIAR
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGPFGWRGIFWALALVNFAQLLV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHC
QNQMGIPVLLYSIIFGVNAFGLIVGGMINRRLLQRIHPHRIMQTVLASFTVLCALLLIEV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LFINWIPLFLLLLFLIVSHIPMVMANATALGTEAVRSRAGSGSAILGFVQFSMGALVSSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VGLGSDKAVTMGFAMTGCALLACGCAYLAGRKGIPEMR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQKKQQLSTALIMGLALLSASSALATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHH
GQLIIGPLSDQLGRKGLLVAGAVAALVASVVCALAPSISVLVIARLVQGLGGGACVVIAR
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIVPDLERGQKAAHAFALLMIIQGIAPVVAPLIGGVLVGPFGWRGIFWALALVNFAQLLV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ALLQIKESKPVEERTAAGLGGMLSNYVFVLKNPQFLAYVFTLGLSFGAMFSYISASPFVL
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHC
QNQMGIPVLLYSIIFGVNAFGLIVGGMINRRLLQRIHPHRIMQTVLASFTVLCALLLIEV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LFINWIPLFLLLLFLIVSHIPMVMANATALGTEAVRSRAGSGSAILGFVQFSMGALVSSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VGLGSDKAVTMGFAMTGCALLACGCAYLAGRKGIPEMR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]