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The map label for this gene is mrpD [H]

Identifier: 145296729

GI number: 145296729

Start: 2917428

End: 2919128

Strand: Direct

Name: mrpD [H]

Synonym: cgR_2634

Alternate gene names: 145296729

Gene position: 2917428-2919128 (Clockwise)

Preceding gene: 145296728

Following gene: 145296730

Centisome position: 88.03

GC content: 56.03

Gene sequence:

>1701_bases
ATGACTAGTTTGTACGAAACTCTCGTCCCGTTGATCCCTTATATGGTCCCGCTGCCCATCATTTTGCCTGCGGTTGCGGC
GGCGCTGGCATTGATTTTGTCGAAATATCTGACAGCGCAGCGCACCATTACTTTGTCTGTTTTGGCGTTCCTCATTGGTC
TTAACGCCACCATGCTGTACGTGGTGGATCGCGAAGGCATTCAGACTTTGCAGTTGGGTGGCTGGGATGCCCCGATCGGA
ATCACCCTGGTGGCCGACCGACTGTCTGTTTCCATGCTGACGGTTAGTTCCATCGTGCTATTTTCTGTCATGTGGTACGC
GATCAGCCAGGGTATTCGCGACGGCGGCAAGGACGAACCTGTTGCGGTGTTCCTGCCTACTTACCTGCTGCTCTCGATGG
GAGTGAACCTGGCGTTCCTCGCTGGCGACCTGTTTAACCTCTACGTTGGTTTCGAAGTGCTGCTGGTGGCGTCATACGTG
CTGCTCACCTTGGGTGCATCGCCGGCACGTGTACGTTCCGGCGTGGGTTACGTGATGGTGTCCATGGCGTCATCGATGGT
GTTCCTGTTTGGACTCGCCATGGTTTACGCCTCAGTGGGCACGTTGAACATGGCTCACATTGGCCTACGTATGGAAGAAG
TTCCCTCCGGAACTCGCTCCGCGATCTTCGCAGTGTTGCTCGTGGCATTCGGTATTAAAGCTGCAGTGTTCCCCCTAGAT
TCCTGGCTGCCGGACTCCTACCCCACCGCGCCATCGCTGGTCACCGCGGTGTTCGCAGGTCTGTTGACCAAGGTGGGTGT
GTATTCCATCATTCGAGCACGCTCGATTATTTTCACCGATGGATCCCTTGACACCATGCTGATGTGGGTGGCACTCGCCA
CCATGCTCATTGGTATTTTGGGCGCGATGGCGCAAAACGATATCAAACGTTTGTTGTCATTTACTCTGGTCAGCCACATC
GGTTACATGATCTTCGGCGTGGCCCTTGGGTCTGCGCAGGGTTTGTCTGGTGCGATCTTCTACGCAATCCACCACATTCT
GGTTCAGACTTCCCTGTTCCTGGTGGTCGGTCTAATCGAACGCCAAGCCGGATCCTCCTCGCTGCGCCGCCTTGGATCCC
TAGCATATATCTCCCCACTTCTTGCGATTTTGTACTTCATCCCCGCTATCAACCTGGGTGGTATCCCACCGTTCTCCGGC
TTTCTGGGCAAGGTCATGCTCATCCAAGCCGGCGCCGAGGATGGCAGCTGGCTGGCATGGGTACTTATCGCAGGCGCCGT
TGTCACCTCACTGCTCACCTTGTACACCATGGTTCTGGTATGGTCCAAGGCTTTCTGGCGCGACCGTAAAGACGCCCCCG
ATGGAGCAATCGCACTAGCAAGACCTGCACCTTTGGTAGATGTCCAAGACGAAGTCGCCGTTAAAGACCGCGATGATGTC
GGACGGATGCCTTGGGGCATGGTCTTCTCCACTGCTCTCCTGGTTTCAGCATCTCTTGCTGTATCCGTGCTCGCAGGACC
ACTGTCATCCATCACCGGTCGCGCCGCCGAATCCGCACAAGATGTCAACATCTACCGCACCGCAGTACTCGGCCCCAACT
ACCTCGACCCATCACGCACACTCGAGATGGAGCGTTACGACGCCAACCGCGATGACATCAACCACCGCGTAGACGCCAAT
GGAACGGAGGAACAACCATGA

Upstream 100 bases:

>100_bases
GACCACGATGCATCTGACGACCCAGAAACTGGTCGCATGACCTCAGACGGCGACGATTTTGGACCCGAGTCCTTCGAAGC
ACCACTGAAGGGAGATAAGG

Downstream 100 bases:

>100_bases
TCAGTGGATTCAAACGTCGCTTCCACCCCTTCTTCATCATCGGTCTCACCCTCATGTGGGTCATGCTCATGGCAGAATTC
AGCTGGGCAAACTTCGTCGG

Product: putative monovalent cation/H+ antiporter subunit D

Products: H2; oxidized ferredoxin [C]

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MTSLYETLVPLIPYMVPLPIILPAVAAALALILSKYLTAQRTITLSVLAFLIGLNATMLYVVDREGIQTLQLGGWDAPIG
ITLVADRLSVSMLTVSSIVLFSVMWYAISQGIRDGGKDEPVAVFLPTYLLLSMGVNLAFLAGDLFNLYVGFEVLLVASYV
LLTLGASPARVRSGVGYVMVSMASSMVFLFGLAMVYASVGTLNMAHIGLRMEEVPSGTRSAIFAVLLVAFGIKAAVFPLD
SWLPDSYPTAPSLVTAVFAGLLTKVGVYSIIRARSIIFTDGSLDTMLMWVALATMLIGILGAMAQNDIKRLLSFTLVSHI
GYMIFGVALGSAQGLSGAIFYAIHHILVQTSLFLVVGLIERQAGSSSLRRLGSLAYISPLLAILYFIPAINLGGIPPFSG
FLGKVMLIQAGAEDGSWLAWVLIAGAVVTSLLTLYTMVLVWSKAFWRDRKDAPDGAIALARPAPLVDVQDEVAVKDRDDV
GRMPWGMVFSTALLVSASLAVSVLAGPLSSITGRAAESAQDVNIYRTAVLGPNYLDPSRTLEMERYDANRDDINHRVDAN
GTEEQP

Sequences:

>Translated_566_residues
MTSLYETLVPLIPYMVPLPIILPAVAAALALILSKYLTAQRTITLSVLAFLIGLNATMLYVVDREGIQTLQLGGWDAPIG
ITLVADRLSVSMLTVSSIVLFSVMWYAISQGIRDGGKDEPVAVFLPTYLLLSMGVNLAFLAGDLFNLYVGFEVLLVASYV
LLTLGASPARVRSGVGYVMVSMASSMVFLFGLAMVYASVGTLNMAHIGLRMEEVPSGTRSAIFAVLLVAFGIKAAVFPLD
SWLPDSYPTAPSLVTAVFAGLLTKVGVYSIIRARSIIFTDGSLDTMLMWVALATMLIGILGAMAQNDIKRLLSFTLVSHI
GYMIFGVALGSAQGLSGAIFYAIHHILVQTSLFLVVGLIERQAGSSSLRRLGSLAYISPLLAILYFIPAINLGGIPPFSG
FLGKVMLIQAGAEDGSWLAWVLIAGAVVTSLLTLYTMVLVWSKAFWRDRKDAPDGAIALARPAPLVDVQDEVAVKDRDDV
GRMPWGMVFSTALLVSASLAVSVLAGPLSSITGRAAESAQDVNIYRTAVLGPNYLDPSRTLEMERYDANRDDINHRVDAN
GTEEQP
>Mature_565_residues
TSLYETLVPLIPYMVPLPIILPAVAAALALILSKYLTAQRTITLSVLAFLIGLNATMLYVVDREGIQTLQLGGWDAPIGI
TLVADRLSVSMLTVSSIVLFSVMWYAISQGIRDGGKDEPVAVFLPTYLLLSMGVNLAFLAGDLFNLYVGFEVLLVASYVL
LTLGASPARVRSGVGYVMVSMASSMVFLFGLAMVYASVGTLNMAHIGLRMEEVPSGTRSAIFAVLLVAFGIKAAVFPLDS
WLPDSYPTAPSLVTAVFAGLLTKVGVYSIIRARSIIFTDGSLDTMLMWVALATMLIGILGAMAQNDIKRLLSFTLVSHIG
YMIFGVALGSAQGLSGAIFYAIHHILVQTSLFLVVGLIERQAGSSSLRRLGSLAYISPLLAILYFIPAINLGGIPPFSGF
LGKVMLIQAGAEDGSWLAWVLIAGAVVTSLLTLYTMVLVWSKAFWRDRKDAPDGAIALARPAPLVDVQDEVAVKDRDDVG
RMPWGMVFSTALLVSASLAVSVLAGPLSSITGRAAESAQDVNIYRTAVLGPNYLDPSRTLEMERYDANRDDINHRVDANG
TEEQP

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=298, Percent_Identity=22.8187919463087, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI251831117, Length=406, Percent_Identity=21.4285714285714, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1788827, Length=340, Percent_Identity=27.3529411764706, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788829, Length=324, Percent_Identity=29.6296296296296, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788613, Length=286, Percent_Identity=29.3706293706294, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788831, Length=395, Percent_Identity=25.5696202531646, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788614, Length=372, Percent_Identity=28.494623655914, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI145693160, Length=361, Percent_Identity=27.1468144044321, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI2367154, Length=320, Percent_Identity=24.0625, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 60598; Mature: 60467

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLYETLVPLIPYMVPLPIILPAVAAALALILSKYLTAQRTITLSVLAFLIGLNATMLY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VVDREGIQTLQLGGWDAPIGITLVADRLSVSMLTVSSIVLFSVMWYAISQGIRDGGKDEP
EEECCCCCEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VAVFLPTYLLLSMGVNLAFLAGDLFNLYVGFEVLLVASYVLLTLGASPARVRSGVGYVMV
EEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHH
SMASSMVFLFGLAMVYASVGTLNMAHIGLRMEEVPSGTRSAIFAVLLVAFGIKAAVFPLD
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCH
SWLPDSYPTAPSLVTAVFAGLLTKVGVYSIIRARSIIFTDGSLDTMLMWVALATMLIGIL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHH
GAMAQNDIKRLLSFTLVSHIGYMIFGVALGSAQGLSGAIFYAIHHILVQTSLFLVVGLIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RQAGSSSLRRLGSLAYISPLLAILYFIPAINLGGIPPFSGFLGKVMLIQAGAEDGSWLAW
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEECCCCCCHHHH
VLIAGAVVTSLLTLYTMVLVWSKAFWRDRKDAPDGAIALARPAPLVDVQDEVAVKDRDDV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHCCCCCCCC
GRMPWGMVFSTALLVSASLAVSVLAGPLSSITGRAAESAQDVNIYRTAVLGPNYLDPSRT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHEEEEECCCCCCCCHHH
LEMERYDANRDDINHRVDANGTEEQP
EEHHHCCCCCHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSLYETLVPLIPYMVPLPIILPAVAAALALILSKYLTAQRTITLSVLAFLIGLNATMLY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
VVDREGIQTLQLGGWDAPIGITLVADRLSVSMLTVSSIVLFSVMWYAISQGIRDGGKDEP
EEECCCCCEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VAVFLPTYLLLSMGVNLAFLAGDLFNLYVGFEVLLVASYVLLTLGASPARVRSGVGYVMV
EEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHH
SMASSMVFLFGLAMVYASVGTLNMAHIGLRMEEVPSGTRSAIFAVLLVAFGIKAAVFPLD
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCH
SWLPDSYPTAPSLVTAVFAGLLTKVGVYSIIRARSIIFTDGSLDTMLMWVALATMLIGIL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHH
GAMAQNDIKRLLSFTLVSHIGYMIFGVALGSAQGLSGAIFYAIHHILVQTSLFLVVGLIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RQAGSSSLRRLGSLAYISPLLAILYFIPAINLGGIPPFSGFLGKVMLIQAGAEDGSWLAW
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEECCCCCCHHHH
VLIAGAVVTSLLTLYTMVLVWSKAFWRDRKDAPDGAIALARPAPLVDVQDEVAVKDRDDV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHCCCCCCCC
GRMPWGMVFSTALLVSASLAVSVLAGPLSSITGRAAESAQDVNIYRTAVLGPNYLDPSRT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHEEEEECCCCCCCCHHH
LEMERYDANRDDINHRVDANGTEEQP
EEHHHCCCCCHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton; reduced ferredoxin [C]

Specific reaction: Proton + reduced ferredoxin = H2 + oxidized ferredoxin [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]