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The map label for this gene is dapE [H]

Identifier: 145296724

GI number: 145296724

Start: 2911223

End: 2912596

Strand: Direct

Name: dapE [H]

Synonym: cgR_2629

Alternate gene names: 145296724

Gene position: 2911223-2912596 (Clockwise)

Preceding gene: 145296709

Following gene: 145296725

Centisome position: 87.84

GC content: 58.01

Gene sequence:

>1374_bases
ATGACCCAATTCGAAAACGCGCAAGTACTTAAAGAGAACATCGAAAACCAACGCGAGCAGATCTTTACCCAGTTGAAAGA
AATTGTGTCTTTCAACTCCGTGCACAGCGATCCAAACCTACTGGAGGACTACGCCGGCGCGAAAGAATGGGTAAAAGAAA
CACTGACCAACGCAGGGCTTACCGTCAGCGAATTCGCTGCCGAAGATGGAACCACCAACTTCATCGGCACACGCAAGGGC
TCCGAAGGTGCACCAAAGGTACTGCTGTACAGCCACTTCGACGTTGTCCCATCCGGCCCTTTGGATCTCTGGGACACCAA
TCCTTTTGAACTCACCGAGCGCGACGCTGGCCACGGCACCCGCTGGTACGGCCGCGGCGCCGCTGACTGCAAGGGCAACC
TGGTCATGCACCTCGCAGCACTGCGCGCCGTCGAAGCCAGCGGCGACACCACACTCAACCTCACCTACGTGGTCGAGGGC
TCCGAGGAAATGGGAGGCGGAGCGCTCAGCGCGCTCATCAAGGACAAGCCTGAGCTTTTCGACGCAGATGTCATCTTGAT
TGCAGACAGCGGAAACGCTTCCGTGGGCACCCCAACCTTGACCACTACCCTGCGCGGTGGCGGACAGGTCACCGTCACCG
TGGACACCCTTGAAGGCGCTGTTCACTCCGGCCAGTACGGTGGCGCTGCCCCAGATGCTGTTGCTGCTCTCGTGCGCGTT
CTGGATACTTTGCGCGATGAACACGGACGCACCGTCATCGACGGCGTCAACACCACCGCAAACTGGAAGGGCGAGCCTTA
TGATCCAGAGACTTTCCGCAGCGATGCCGGCATCCTCGACGGTGTAGACATCATGGGCGACGGCGACAACCCAGCAAGCA
TGCTGTGGTCCAGGCCTGCAATCTCCATCACCGGATTCACTTCCACCCCAGTGGCAGAAGCACTCAACGCAGTGCCCGCA
ACGGCGTCCGCCAAGCTAAACCTTCGCGTGCCAGCAGGCCTGGAAGCAAACGATGTGGCCGAGAAGCTGAAGCAACACCT
GATCAACCACACCCCTTGGGGCGCAAAGATCACGGTGGAGATCGATGACATTAACCAACCGTTCTCCACCGATATTACCG
GCCCTGCAATGTCCACCCTGGCGTCCTGCCTGAGCGCTGCGTACGAGGGCAAGGATCTTGTCACCGAAGGCAGCGGCGGA
TCCATTCCACTGTGCACCGAACTGATTGAGGTCAACCCAGAAGCAGAATTGGCACTCTACGGTGTGGAAGAACCCCTCAC
CGTTATCCACTCCGCTAATGAATCTGTTGACCCCAATGAGATTCGCGATATCGCCACCGCAGAAGCATTGTTCCTGCTCA
ACTACACCAAGTAG

Upstream 100 bases:

>100_bases
CGCTGCCCCTCTATGCTGCTCCTAGTTACACCTGCACAAATAGCGGTTTTTCTCACGCATTCTGCATAGAGTCGGGTCGA
CGTATATAAGGTGGAAAGGC

Downstream 100 bases:

>100_bases
ACTTAGAAGCAGGCATTAACACTGCCACCTTTGCAAAATTAACCACCCCCTGATGGGGTGGTTTTTTCATGAGTTGAAAA
AAGTGTCTTGATTCACTTTG

Product: hypothetical protein

Products: NA

Alternate protein names: SDAP desuccinylase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTQFENAQVLKENIENQREQIFTQLKEIVSFNSVHSDPNLLEDYAGAKEWVKETLTNAGLTVSEFAAEDGTTNFIGTRKG
SEGAPKVLLYSHFDVVPSGPLDLWDTNPFELTERDAGHGTRWYGRGAADCKGNLVMHLAALRAVEASGDTTLNLTYVVEG
SEEMGGGALSALIKDKPELFDADVILIADSGNASVGTPTLTTTLRGGGQVTVTVDTLEGAVHSGQYGGAAPDAVAALVRV
LDTLRDEHGRTVIDGVNTTANWKGEPYDPETFRSDAGILDGVDIMGDGDNPASMLWSRPAISITGFTSTPVAEALNAVPA
TASAKLNLRVPAGLEANDVAEKLKQHLINHTPWGAKITVEIDDINQPFSTDITGPAMSTLASCLSAAYEGKDLVTEGSGG
SIPLCTELIEVNPEAELALYGVEEPLTVIHSANESVDPNEIRDIATAEALFLLNYTK

Sequences:

>Translated_457_residues
MTQFENAQVLKENIENQREQIFTQLKEIVSFNSVHSDPNLLEDYAGAKEWVKETLTNAGLTVSEFAAEDGTTNFIGTRKG
SEGAPKVLLYSHFDVVPSGPLDLWDTNPFELTERDAGHGTRWYGRGAADCKGNLVMHLAALRAVEASGDTTLNLTYVVEG
SEEMGGGALSALIKDKPELFDADVILIADSGNASVGTPTLTTTLRGGGQVTVTVDTLEGAVHSGQYGGAAPDAVAALVRV
LDTLRDEHGRTVIDGVNTTANWKGEPYDPETFRSDAGILDGVDIMGDGDNPASMLWSRPAISITGFTSTPVAEALNAVPA
TASAKLNLRVPAGLEANDVAEKLKQHLINHTPWGAKITVEIDDINQPFSTDITGPAMSTLASCLSAAYEGKDLVTEGSGG
SIPLCTELIEVNPEAELALYGVEEPLTVIHSANESVDPNEIRDIATAEALFLLNYTK
>Mature_456_residues
TQFENAQVLKENIENQREQIFTQLKEIVSFNSVHSDPNLLEDYAGAKEWVKETLTNAGLTVSEFAAEDGTTNFIGTRKGS
EGAPKVLLYSHFDVVPSGPLDLWDTNPFELTERDAGHGTRWYGRGAADCKGNLVMHLAALRAVEASGDTTLNLTYVVEGS
EEMGGGALSALIKDKPELFDADVILIADSGNASVGTPTLTTTLRGGGQVTVTVDTLEGAVHSGQYGGAAPDAVAALVRVL
DTLRDEHGRTVIDGVNTTANWKGEPYDPETFRSDAGILDGVDIMGDGDNPASMLWSRPAISITGFTSTPVAEALNAVPAT
ASAKLNLRVPAGLEANDVAEKLKQHLINHTPWGAKITVEIDDINQPFSTDITGPAMSTLASCLSAAYEGKDLVTEGSGGS
IPLCTELIEVNPEAELALYGVEEPLTVIHSANESVDPNEIRDIATAEALFLLNYTK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; fifth step. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI271398239, Length=347, Percent_Identity=27.3775216138329, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI21071039, Length=277, Percent_Identity=29.2418772563177, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1788816, Length=190, Percent_Identity=31.0526315789474, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17563146, Length=258, Percent_Identity=31.0077519379845, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193211059, Length=350, Percent_Identity=27.7142857142857, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321159, Length=360, Percent_Identity=26.3888888888889, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319758, Length=420, Percent_Identity=25, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585880, Length=452, Percent_Identity=25.2212389380531, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 48525; Mature: 48394

Theoretical pI: Translated: 4.14; Mature: 4.14

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQFENAQVLKENIENQREQIFTQLKEIVSFNSVHSDPNLLEDYAGAKEWVKETLTNAGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCC
TVSEFAAEDGTTNFIGTRKGSEGAPKVLLYSHFDVVPSGPLDLWDTNPFELTERDAGHGT
CHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCC
RWYGRGAADCKGNLVMHLAALRAVEASGDTTLNLTYVVEGSEEMGGGALSALIKDKPELF
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHCCHHHHHHHCCCCCCC
DADVILIADSGNASVGTPTLTTTLRGGGQVTVTVDTLEGAVHSGQYGGAAPDAVAALVRV
CCCEEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHCCCCCCCCHHHHHHHHHH
LDTLRDEHGRTVIDGVNTTANWKGEPYDPETFRSDAGILDGVDIMGDGDNPASMLWSRPA
HHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCEEEECCCCCHHHHHCCCCC
ISITGFTSTPVAEALNAVPATASAKLNLRVPAGLEANDVAEKLKQHLINHTPWGAKITVE
EEEECCCCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
IDDINQPFSTDITGPAMSTLASCLSAAYEGKDLVTEGSGGSIPLCTELIEVNPEAELALY
EECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCEEEEE
GVEEPLTVIHSANESVDPNEIRDIATAEALFLLNYTK
ECCCCHHHHCCCCCCCCHHHHHHHHHHEEEEEEEECC
>Mature Secondary Structure 
TQFENAQVLKENIENQREQIFTQLKEIVSFNSVHSDPNLLEDYAGAKEWVKETLTNAGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCC
TVSEFAAEDGTTNFIGTRKGSEGAPKVLLYSHFDVVPSGPLDLWDTNPFELTERDAGHGT
CHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCC
RWYGRGAADCKGNLVMHLAALRAVEASGDTTLNLTYVVEGSEEMGGGALSALIKDKPELF
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHCCHHHHHHHCCCCCCC
DADVILIADSGNASVGTPTLTTTLRGGGQVTVTVDTLEGAVHSGQYGGAAPDAVAALVRV
CCCEEEEECCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHCCCCCCCCHHHHHHHHHH
LDTLRDEHGRTVIDGVNTTANWKGEPYDPETFRSDAGILDGVDIMGDGDNPASMLWSRPA
HHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCEEEECCCCCHHHHHCCCCC
ISITGFTSTPVAEALNAVPATASAKLNLRVPAGLEANDVAEKLKQHLINHTPWGAKITVE
EEEECCCCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
IDDINQPFSTDITGPAMSTLASCLSAAYEGKDLVTEGSGGSIPLCTELIEVNPEAELALY
EECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCEEEEE
GVEEPLTVIHSANESVDPNEIRDIATAEALFLLNYTK
ECCCCHHHHCCCCCCCCHHHHHHHHHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]