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The map label for this gene is lysS [H]

Identifier: 145296683

GI number: 145296683

Start: 2860555

End: 2862135

Strand: Reverse

Name: lysS [H]

Synonym: cgR_2588

Alternate gene names: 145296683

Gene position: 2862135-2860555 (Counterclockwise)

Preceding gene: 145296684

Following gene: 145296682

Centisome position: 86.36

GC content: 57.75

Gene sequence:

>1581_bases
GTGACTAATTCCAATCCCACTTCCAAGAACAATTCCGCCGATTTGCCTGAGCAGCTGCGAATTCGTCGCGAAAAGCGCGA
GCGCATTCTGGACAGTGGATTGGACGCCTACCCAGTCGAGGTTGATCGCACCATCTCAATCTCTGACCTGCGCTCCCAAT
TTGTTGTCATTACAGAAGACCTCCAAGAGCGCGAAGAAGGCGTAACCTACCTCGAAGTAGGCGAAGAAACCGACGTTGAG
GTCGCAATCGCTGGCCGCGTCATGTTCGTTCGCAACACCGGCAAGCTCTGCTTCGCATCCATCCAAGAAGGAAACGGCAC
CACCGTCCAAGCAATGCTGTCCCTGGCAGCAGTCGGTGAAGAATCCCTCAAGGCATGGAAAGCCGATGTGGACATGGGCG
ACATCGTCTCCATCCGCGGCAAAGTGATCTCCTCCAAGCGTGGCGAGCTCTCCGTGATGGCTGACTCCTGGCACATGGCC
TCCAAGTCCCTACGCCCACTGCCAGTCGCATTCGCCGACCTCAGTGAAGACACCCGCGTCCGCCACCGCTACACCGACCT
CATCATGCGCGAACAAGCCCGCACCAACGCGCTCACCCGCATCAAGGTCATGCGTGCACTCCGCCACTACCTCGAAGACC
AAGACTTCCTTGAGGTAGAAACCCCTATGCTGCAAACCCTCCACGGTGGCGCAGCTGCACGACCATTCAAAACCCACTCC
AACGCCCTCGATATTGACCTCTACCTGCGCATCGCACCAGAGCTTTACCTCAAGCGTTGCGTTGTCGGTGGCATCGAGCG
CGTCTTCGAAGTCAACCGCAACTTCCGCAACGAAGGCGTCGACTCCTCCCACTCCCCAGAATTCGCCATGCTCGAAACCT
ACGAAGCCTGGGGAACCTACGAAACCGGCGCGAAACTGATCAAGGGTCTCGTCCAATCCGTCGCCCAAGAAGTCTTCGGA
ACCACCCTGGTCACCCTCGCAGACGGCACCGAATACGACCTCGGCGGCGAGTGGAAAGTCATCGAGATGTACCCCTCCCT
CAACGAAGCCCTCGCACGCAAATTCCCAGGACACCCAGAAGTCACCATCGACTCCACCGTCGAAGAACTCCGCGAAATCG
CTAAGGTAATCGGCCTCTCCGTCCCCGAAAACGGCGGCTGGGGACACGGCAAACTCGTCGAAGAAATCTGGGAACTCCTC
TGCGAAGACCAACTCTACGGACCAATCTTTGTCAAAGACTTCCCAGTAGAAACCTCCCCACTGACACGCCAACACCGCAC
CAAGCCAGGCGTCACCGAAAAGTGGGACCTCTACGTCCGCGGATTTGAACTAGCAACCGGATACTCCGAACTCATTGACC
CAGTCATCCAACGCGAACGCTTCGAAGACCAAGCCCGCCTCGCCGCCGACGGAGACGACGAAGCCATGGTCCTCGACGAA
GACTTCCTCACCGCAATGGAACAAGGCATGCCACCAACCTCCGGCAACGGCATGGGAATCGACCGCCTCCTCATGGCCCT
CACTGGCCTCGGAATCCGCGAAACCGTACTCTTCCCAATGGTGAAACCAGAACAAAAGTAG

Upstream 100 bases:

>100_bases
CACGACAACGTCGGCCTACCGCTTGGAATCGGCTTCAAAAACATCGAAGGCTGATCCCGGTTTACCCAGTTCGCATACCT
TTCGACTACCCTAGGAAATC

Downstream 100 bases:

>100_bases
GTTTTCTGTTTGGGTAGGTTAGCTCCAGGACTTTGTGTCCTGGAGTTTTCCTCTTCCAAGGGTTGATCGGGATGGGTTTT
GTAAGGTCGGGTCGGCGTCG

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MTNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITEDLQEREEGVTYLEVGEETDVE
VAIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGEESLKAWKADVDMGDIVSIRGKVISSKRGELSVMADSWHMA
SKSLRPLPVAFADLSEDTRVRHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFKTHS
NALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTYETGAKLIKGLVQSVAQEVFG
TTLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGHPEVTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELL
CEDQLYGPIFVKDFPVETSPLTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDE
DFLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK

Sequences:

>Translated_526_residues
MTNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITEDLQEREEGVTYLEVGEETDVE
VAIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGEESLKAWKADVDMGDIVSIRGKVISSKRGELSVMADSWHMA
SKSLRPLPVAFADLSEDTRVRHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFKTHS
NALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTYETGAKLIKGLVQSVAQEVFG
TTLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGHPEVTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELL
CEDQLYGPIFVKDFPVETSPLTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDE
DFLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK
>Mature_525_residues
TNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITEDLQEREEGVTYLEVGEETDVEV
AIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGEESLKAWKADVDMGDIVSIRGKVISSKRGELSVMADSWHMAS
KSLRPLPVAFADLSEDTRVRHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFKTHSN
ALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTYETGAKLIKGLVQSVAQEVFGT
TLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGHPEVTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELLC
EDQLYGPIFVKDFPVETSPLTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDED
FLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=532, Percent_Identity=37.593984962406, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI194272210, Length=532, Percent_Identity=37.593984962406, Blast_Score=327, Evalue=2e-89,
Organism=Escherichia coli, GI1790571, Length=531, Percent_Identity=38.9830508474576, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1789256, Length=529, Percent_Identity=39.6975425330813, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI87082379, Length=333, Percent_Identity=29.7297297297297, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1788173, Length=178, Percent_Identity=28.0898876404494, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535927, Length=520, Percent_Identity=36.3461538461538, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17535925, Length=520, Percent_Identity=36.3461538461538, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI71994340, Length=519, Percent_Identity=36.8015414258189, Blast_Score=305, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17551876, Length=487, Percent_Identity=23.8193018480493, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI32566633, Length=216, Percent_Identity=26.8518518518519, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320242, Length=475, Percent_Identity=37.6842105263158, Blast_Score=302, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6324256, Length=502, Percent_Identity=27.6892430278884, Blast_Score=160, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24640849, Length=510, Percent_Identity=37.843137254902, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI24640851, Length=502, Percent_Identity=38.0478087649402, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI17136276, Length=484, Percent_Identity=24.1735537190083, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 58950; Mature: 58818

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITED
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCEEEEEHH
LQEREEGVTYLEVGEETDVEVAIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGE
HHHHHCCCEEEEECCCCCEEEEEECEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCH
ESLKAWKADVDMGDIVSIRGKVISSKRGELSVMADSWHMASKSLRPLPVAFADLSEDTRV
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCCCEEECCCCCHHHH
RHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFKTHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCCCCCCCCCCC
NALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTY
CEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHCCCH
ETGAKLIKGLVQSVAQEVFGTTLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGHPE
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCC
VTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELLCEDQLYGPIFVKDFPVETSP
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
LTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDE
CCHHHCCCCCCCCCEEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECH
DFLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHEECCCCCCCC
>Mature Secondary Structure 
TNSNPTSKNNSADLPEQLRIRREKRERILDSGLDAYPVEVDRTISISDLRSQFVVITED
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCEEEEEHH
LQEREEGVTYLEVGEETDVEVAIAGRVMFVRNTGKLCFASIQEGNGTTVQAMLSLAAVGE
HHHHHCCCEEEEECCCCCEEEEEECEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCH
ESLKAWKADVDMGDIVSIRGKVISSKRGELSVMADSWHMASKSLRPLPVAFADLSEDTRV
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCCCEEECCCCCHHHH
RHRYTDLIMREQARTNALTRIKVMRALRHYLEDQDFLEVETPMLQTLHGGAAARPFKTHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCCCCCCCCCCC
NALDIDLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYEAWGTY
CEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHCCCH
ETGAKLIKGLVQSVAQEVFGTTLVTLADGTEYDLGGEWKVIEMYPSLNEALARKFPGHPE
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHCCCCCC
VTIDSTVEELREIAKVIGLSVPENGGWGHGKLVEEIWELLCEDQLYGPIFVKDFPVETSP
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
LTRQHRTKPGVTEKWDLYVRGFELATGYSELIDPVIQRERFEDQARLAADGDDEAMVLDE
CCHHHCCCCCCCCCEEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECH
DFLTAMEQGMPPTSGNGMGIDRLLMALTGLGIRETVLFPMVKPEQK
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA