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The map label for this gene is purC

Identifier: 145296591

GI number: 145296591

Start: 2760794

End: 2761687

Strand: Reverse

Name: purC

Synonym: cgR_2499

Alternate gene names: 145296591

Gene position: 2761687-2760794 (Counterclockwise)

Preceding gene: 145296592

Following gene: 145296590

Centisome position: 83.33

GC content: 53.13

Gene sequence:

>894_bases
ATGCGTCCTGAACTCTCCCAGTACAAGCACCTGTCGGCAGGCAAGGTCCGTGAGATCTACGAGATCGACGACAAGCACAT
CCTCATGGTGGCTTCCGATCGTATCTCTGCATACGATTTCATCCTCGATACCGAAATTCCAGACAAGGGTCGAGTGCTCA
CTGCGATGAGCCAGTTCTTCTTCGACACCATCGATTTTCCTAATCACCTTGCGGGTCCAGCTGATGATCCACGTATCCCA
GAAGAAGTTTTGGGACGCGCAATGGTGTGCAAGAAGCTCAACATGCTTCCTTTTGAATGCGTGGTTCGTGGATACCTCAC
TGGCTCTGGACTTGTTGAATACAAGCAAACCAGCTCCGTGTGTGGCGTTGAGCTCCCAGAAGGCCTCGTTGAATCCTCGC
AGCTGCCTGAGCCAATCTTTACCCCAGCCACCAAGGCTGACATCGGCGACCACGACATTAACGTCTCCTTTGACGTTGTT
GAAGAACGTCTCGGCGAAGCTCGTGCGAACCAATTGCGCGATGCCTCTATTGCTATTTACAAGGCTGCTGCTGAGATCGC
CCGTGAACGTGGCGTCATCCTTGCCGACACCAAATTTGAATTTGGTATCGATGAAGACGGCACCCTCGTCCTTGGAGATG
AAGTCCTTACCCCAGATTCCTCCCGCTACTGGCCTTTGGAAGGCTATGAAGCAGGATCTGTGCAACCAAGCTTTGATAAG
CAATTCGTGCGCAACTGGCTCACCGGCCCTAAATCTGGCTGGGACAAGGATTCCGGCTTGGAGCCACCAGCTCTGCCAGG
TTCCGTTGTTGAGGCAACCCGCGAGCGCTACATCGAGGCCTACGAGCTGATTTCTGGTCAGAAGTTCTGCCAGTGGATTG
GTTCTTGCGTCTAA

Upstream 100 bases:

>100_bases
GGTGAAACCGGTAGTGAAACCAGCGGTGAATCCGGTAGTGAAACCAGCGGTGAACGCTAAAATTTTCCGAACACACCCGA
GGGGTCTAGACTTGCCTATC

Downstream 100 bases:

>100_bases
GCTGCTTGATTTTCCCTAAACCCCGGATTCTTAAATGAATCCGGGTTTTTCAGTTTCGGGGTGCAAATCAGAATGTCGCC
AATGGCGAACACACGAGCGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRPELSQYKHLSAGKVREIYEIDDKHILMVASDRISAYDFILDTEIPDKGRVLTAMSQFFFDTIDFPNHLAGPADDPRIP
EEVLGRAMVCKKLNMLPFECVVRGYLTGSGLVEYKQTSSVCGVELPEGLVESSQLPEPIFTPATKADIGDHDINVSFDVV
EERLGEARANQLRDASIAIYKAAAEIARERGVILADTKFEFGIDEDGTLVLGDEVLTPDSSRYWPLEGYEAGSVQPSFDK
QFVRNWLTGPKSGWDKDSGLEPPALPGSVVEATRERYIEAYELISGQKFCQWIGSCV

Sequences:

>Translated_297_residues
MRPELSQYKHLSAGKVREIYEIDDKHILMVASDRISAYDFILDTEIPDKGRVLTAMSQFFFDTIDFPNHLAGPADDPRIP
EEVLGRAMVCKKLNMLPFECVVRGYLTGSGLVEYKQTSSVCGVELPEGLVESSQLPEPIFTPATKADIGDHDINVSFDVV
EERLGEARANQLRDASIAIYKAAAEIARERGVILADTKFEFGIDEDGTLVLGDEVLTPDSSRYWPLEGYEAGSVQPSFDK
QFVRNWLTGPKSGWDKDSGLEPPALPGSVVEATRERYIEAYELISGQKFCQWIGSCV
>Mature_297_residues
MRPELSQYKHLSAGKVREIYEIDDKHILMVASDRISAYDFILDTEIPDKGRVLTAMSQFFFDTIDFPNHLAGPADDPRIP
EEVLGRAMVCKKLNMLPFECVVRGYLTGSGLVEYKQTSSVCGVELPEGLVESSQLPEPIFTPATKADIGDHDINVSFDVV
EERLGEARANQLRDASIAIYKAAAEIARERGVILADTKFEFGIDEDGTLVLGDEVLTPDSSRYWPLEGYEAGSVQPSFDK
QFVRNWLTGPKSGWDKDSGLEPPALPGSVVEATRERYIEAYELISGQKFCQWIGSCV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=297, Percent_Identity=42.7609427609428, Blast_Score=250, Evalue=2e-67,
Organism=Drosophila melanogaster, GI18860083, Length=242, Percent_Identity=24.3801652892562, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583917, Length=222, Percent_Identity=23.4234234234234, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_CORGB (A4QGZ4)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001139412.1
- ProteinModelPortal:   A4QGZ4
- SMR:   A4QGZ4
- STRING:   A4QGZ4
- GeneID:   4994289
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2499
- eggNOG:   COG0152
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- ProtClustDB:   PRK13961
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 33005; Mature: 33005

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPELSQYKHLSAGKVREIYEIDDKHILMVASDRISAYDFILDTEIPDKGRVLTAMSQFF
CCCCHHHHHCCCCCCHHHHEECCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHH
FDTIDFPNHLAGPADDPRIPEEVLGRAMVCKKLNMLPFECVVRGYLTGSGLVEYKQTSSV
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEHHCCCC
CGVELPEGLVESSQLPEPIFTPATKADIGDHDINVSFDVVEERLGEARANQLRDASIAIY
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KAAAEIARERGVILADTKFEFGIDEDGTLVLGDEVLTPDSSRYWPLEGYEAGSVQPSFDK
HHHHHHHHHCCEEEEECCEEECCCCCCCEEECCEEECCCCCCCCCCCCCCCCCCCCCHHH
QFVRNWLTGPKSGWDKDSGLEPPALPGSVVEATRERYIEAYELISGQKFCQWIGSCV
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRPELSQYKHLSAGKVREIYEIDDKHILMVASDRISAYDFILDTEIPDKGRVLTAMSQFF
CCCCHHHHHCCCCCCHHHHEECCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHH
FDTIDFPNHLAGPADDPRIPEEVLGRAMVCKKLNMLPFECVVRGYLTGSGLVEYKQTSSV
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEHHCCCC
CGVELPEGLVESSQLPEPIFTPATKADIGDHDINVSFDVVEERLGEARANQLRDASIAIY
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KAAAEIARERGVILADTKFEFGIDEDGTLVLGDEVLTPDSSRYWPLEGYEAGSVQPSFDK
HHHHHHHHHCCEEEEECCEEECCCCCCCEEECCEEECCCCCCCCCCCCCCCCCCCCCHHH
QFVRNWLTGPKSGWDKDSGLEPPALPGSVVEATRERYIEAYELISGQKFCQWIGSCV
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA