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The map label for this gene is yhdH [H]

Identifier: 145296535

GI number: 145296535

Start: 2685722

End: 2686729

Strand: Reverse

Name: yhdH [H]

Synonym: cgR_2444

Alternate gene names: 145296535

Gene position: 2686729-2685722 (Counterclockwise)

Preceding gene: 145296536

Following gene: 145296534

Centisome position: 81.07

GC content: 54.86

Gene sequence:

>1008_bases
TTGTTTTCTGAAGGCCCAATTAACAGCGTTGTTTTAACCCAAGATGAGGATGGAAATTTCTCCACCGCTTATCAGGACAC
TTATTCTGATCCTTCCTTTTTGGGGGAGGGCGATGTTCTCATTGAGGTAGGTTGGTCCAGCCTGAATTACAAGGACGCAA
TGGCCCTTAAGGGAGATAAAGGAGTGGTGCGCACTGTGCCACTGATTCCGGGCATCGATGTGGTGGGCACTGTGATCGAG
AGCGCTGATCCTCGTTTTGGCCGTGGGGATGAAGTGGTGCTGAATGGCGCTGGTTTGGGGGAGAACCGGCATGGAGGTTT
CACGCAGCGACTGAAAGTGCCGTCTGAACCGTTGCTGCATATTCCATTTAACTTCTCCGCGCAGCAGGTGGGTGCGTTGG
GTACTGCAGGTTTCACGGCTGCGCTATCGGTGAATGCTCTGGTCGATCAAGGTATCAAACCGGAGGATGGGGAGATTCTG
GTAACTGGTTCGACTGGTGGTGTGGGTTCGATTGCACTTCACCTGCTGAATAAGTTGGGATATACGACGGTCGCGGTGAC
GGGGCGTCGAGAAGCGCATGCCGAATACCTGACCAGCCTGGGCGCAAGCGACATCATTGATCGCGCGGAGCTTTCTGAAA
AGGGCCGACCGCTGCAGAAGGGGCGTTGGGCGGGTGTAGTGGATTCAGTGGGATCCCACACACTTGTCAATGCGATTGCG
CAGACAAAATGGGGCGGAATTGTCACGGCGTGTGGCATGGCTCAGGGGCCGGATCTGCCGGGAACGGTGTTGCCGTTTAT
TCTTCGTGGCGTGCATTTGGTTGGCATTAACTCTGTCGATGCACCCCGTGAGCTGCGTCGACGTGCGTGGGCGTTGCTGT
CCGAGCATCTTGATACCGCGGTGCTAGATGATATGACCACTGTGATTGATGTCAAGGATGTTGCTCAAGCTGGCGAAGAT
TTGATGGCTGGCAAGCTTCACGGACGTACCGCGGTGCGTGTTCATTAG

Upstream 100 bases:

>100_bases
TTCATTAGATCGGCTATCTTTGATGGAGGGATCCAACACCAAATTCCATGCCCCGGATGGACATTTTTCATTACACTCGG
GGGCTATGAGTCCAACACAT

Downstream 100 bases:

>100_bases
CAGGTCAAGTGCGTAATTGAGGGCTAGACTGGTTAGTACCGGATATTCTTTTTTCTTTAGTTTGTAGGAGTGGAGATAAC
TATGGACAATCCAGTCAACA

Product: hypothetical protein

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MFSEGPINSVVLTQDEDGNFSTAYQDTYSDPSFLGEGDVLIEVGWSSLNYKDAMALKGDKGVVRTVPLIPGIDVVGTVIE
SADPRFGRGDEVVLNGAGLGENRHGGFTQRLKVPSEPLLHIPFNFSAQQVGALGTAGFTAALSVNALVDQGIKPEDGEIL
VTGSTGGVGSIALHLLNKLGYTTVAVTGRREAHAEYLTSLGASDIIDRAELSEKGRPLQKGRWAGVVDSVGSHTLVNAIA
QTKWGGIVTACGMAQGPDLPGTVLPFILRGVHLVGINSVDAPRELRRRAWALLSEHLDTAVLDDMTTVIDVKDVAQAGED
LMAGKLHGRTAVRVH

Sequences:

>Translated_335_residues
MFSEGPINSVVLTQDEDGNFSTAYQDTYSDPSFLGEGDVLIEVGWSSLNYKDAMALKGDKGVVRTVPLIPGIDVVGTVIE
SADPRFGRGDEVVLNGAGLGENRHGGFTQRLKVPSEPLLHIPFNFSAQQVGALGTAGFTAALSVNALVDQGIKPEDGEIL
VTGSTGGVGSIALHLLNKLGYTTVAVTGRREAHAEYLTSLGASDIIDRAELSEKGRPLQKGRWAGVVDSVGSHTLVNAIA
QTKWGGIVTACGMAQGPDLPGTVLPFILRGVHLVGINSVDAPRELRRRAWALLSEHLDTAVLDDMTTVIDVKDVAQAGED
LMAGKLHGRTAVRVH
>Mature_335_residues
MFSEGPINSVVLTQDEDGNFSTAYQDTYSDPSFLGEGDVLIEVGWSSLNYKDAMALKGDKGVVRTVPLIPGIDVVGTVIE
SADPRFGRGDEVVLNGAGLGENRHGGFTQRLKVPSEPLLHIPFNFSAQQVGALGTAGFTAALSVNALVDQGIKPEDGEIL
VTGSTGGVGSIALHLLNKLGYTTVAVTGRREAHAEYLTSLGASDIIDRAELSEKGRPLQKGRWAGVVDSVGSHTLVNAIA
QTKWGGIVTACGMAQGPDLPGTVLPFILRGVHLVGINSVDAPRELRRRAWALLSEHLDTAVLDDMTTVIDVKDVAQAGED
LMAGKLHGRTAVRVH

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789651, Length=325, Percent_Identity=46.7692307692308, Blast_Score=284, Evalue=7e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR014188 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 35321; Mature: 35321

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSEGPINSVVLTQDEDGNFSTAYQDTYSDPSFLGEGDVLIEVGWSSLNYKDAMALKGDK
CCCCCCCCEEEEEECCCCCEECEECCCCCCCCCCCCCCEEEEECCCCCCCCHHEEECCCC
GVVRTVPLIPGIDVVGTVIESADPRFGRGDEVVLNGAGLGENRHGGFTQRLKVPSEPLLH
CCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCEEE
IPFNFSAQQVGALGTAGFTAALSVNALVDQGIKPEDGEILVTGSTGGVGSIALHLLNKLG
ECCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
YTTVAVTGRREAHAEYLTSLGASDIIDRAELSEKGRPLQKGRWAGVVDSVGSHTLVNAIA
CEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHH
QTKWGGIVTACGMAQGPDLPGTVLPFILRGVHLVGINSVDAPRELRRRAWALLSEHLDTA
HHCCCCEEEECCCCCCCCCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
VLDDMTTVIDVKDVAQAGEDLMAGKLHGRTAVRVH
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MFSEGPINSVVLTQDEDGNFSTAYQDTYSDPSFLGEGDVLIEVGWSSLNYKDAMALKGDK
CCCCCCCCEEEEEECCCCCEECEECCCCCCCCCCCCCCEEEEECCCCCCCCHHEEECCCC
GVVRTVPLIPGIDVVGTVIESADPRFGRGDEVVLNGAGLGENRHGGFTQRLKVPSEPLLH
CCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCCEEE
IPFNFSAQQVGALGTAGFTAALSVNALVDQGIKPEDGEILVTGSTGGVGSIALHLLNKLG
ECCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
YTTVAVTGRREAHAEYLTSLGASDIIDRAELSEKGRPLQKGRWAGVVDSVGSHTLVNAIA
CEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHH
QTKWGGIVTACGMAQGPDLPGTVLPFILRGVHLVGINSVDAPRELRRRAWALLSEHLDTA
HHCCCCEEEECCCCCCCCCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
VLDDMTTVIDVKDVAQAGEDLMAGKLHGRTAVRVH
HHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1370469; 9278503 [H]