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The map label for this gene is ndk [H]

Identifier: 145296337

GI number: 145296337

Start: 2482191

End: 2482601

Strand: Reverse

Name: ndk [H]

Synonym: cgR_2252

Alternate gene names: 145296337

Gene position: 2482601-2482191 (Counterclockwise)

Preceding gene: 145296338

Following gene: 145296333

Centisome position: 74.91

GC content: 55.96

Gene sequence:

>411_bases
ATGACTGAACGTACTCTCATCCTTATCAAGCCAGACGGTGTTACCAACGGACACGTCGGCGAAATCATCGCACGTATTGA
GCGCAAGGGCCTGAAGCTCGCTGCTCTGGATCTGCGTGTTGCAGACCGCGAGACCGCTGAAAAGCACTACGAAGAGCACG
CTGACAAGCCATTCTTCGGTGAGCTCGTTGAATTCATCACCTCTGCACCTCTGATCGCAGGCATCGTCGAAGGCGAGCGT
GCAATCGATGCATGGCGTCAGCTTGCTGGTGGCACCGACCCAGTTGCTAAGGCAACCCCAGGCACCATCCGCGGCGATTT
CGCACTGACTGTTGGAGAGAACGTTGTTCACGGTTCTGATTCCCCAGAGTCCGCTGAGCGCGAGATCTCCATCTGGTTCC
CTAACCTGTAA

Upstream 100 bases:

>100_bases
AGTAGGGGATCATCCAGCGAAGCGGTCGCAGAGGCTGTGAGGAAGCTCTAAGTCGACTTAAGTGCGCGAAGCAGACCACC
ATTAGGTAGAATCACCCAAC

Downstream 100 bases:

>100_bases
TTTTTACGGTTAGAAAAAAATTAACTCCCGACCATTTTCGGCCGGGAGTTTTTTGCTGCCTGATTACTAGAGCAGTGGGT
GCCCACTGGCAATAGAAATG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 136; Mature: 135

Protein sequence:

>136_residues
MTERTLILIKPDGVTNGHVGEIIARIERKGLKLAALDLRVADRETAEKHYEEHADKPFFGELVEFITSAPLIAGIVEGER
AIDAWRQLAGGTDPVAKATPGTIRGDFALTVGENVVHGSDSPESAEREISIWFPNL

Sequences:

>Translated_136_residues
MTERTLILIKPDGVTNGHVGEIIARIERKGLKLAALDLRVADRETAEKHYEEHADKPFFGELVEFITSAPLIAGIVEGER
AIDAWRQLAGGTDPVAKATPGTIRGDFALTVGENVVHGSDSPESAEREISIWFPNL
>Mature_135_residues
TERTLILIKPDGVTNGHVGEIIARIERKGLKLAALDLRVADRETAEKHYEEHADKPFFGELVEFITSAPLIAGIVEGERA
IDAWRQLAGGTDPVAKATPGTIRGDFALTVGENVVHGSDSPESAEREISIWFPNL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=131, Percent_Identity=51.1450381679389, Blast_Score=137, Evalue=2e-33,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=50.381679389313, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=50.381679389313, Blast_Score=136, Evalue=4e-33,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=50.381679389313, Blast_Score=136, Evalue=4e-33,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=50.381679389313, Blast_Score=136, Evalue=4e-33,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=50.381679389313, Blast_Score=136, Evalue=4e-33,
Organism=Homo sapiens, GI38045913, Length=132, Percent_Identity=49.2424242424242, Blast_Score=135, Evalue=8e-33,
Organism=Homo sapiens, GI4557797, Length=132, Percent_Identity=49.2424242424242, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI4826862, Length=131, Percent_Identity=43.5114503816794, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=37.037037037037, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=37.037037037037, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=39.4160583941606, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI30023828, Length=138, Percent_Identity=32.6086956521739, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI4505413, Length=141, Percent_Identity=34.0425531914894, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788866, Length=131, Percent_Identity=45.8015267175573, Blast_Score=115, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17506807, Length=132, Percent_Identity=50, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322783, Length=132, Percent_Identity=51.5151515151515, Blast_Score=144, Evalue=6e-36,
Organism=Drosophila melanogaster, GI45549037, Length=131, Percent_Identity=50.381679389313, Blast_Score=142, Evalue=6e-35,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=34.5588235294118, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 14800; Mature: 14669

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERTLILIKPDGVTNGHVGEIIARIERKGLKLAALDLRVADRETAEKHYEEHADKPFFG
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHCCCCHHH
ELVEFITSAPLIAGIVEGERAIDAWRQLAGGTDPVAKATPGTIRGDFALTVGENVVHGSD
HHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCEEECCCC
SPESAEREISIWFPNL
CCCCCCCEEEEEECCC
>Mature Secondary Structure 
TERTLILIKPDGVTNGHVGEIIARIERKGLKLAALDLRVADRETAEKHYEEHADKPFFG
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHCCCCHHH
ELVEFITSAPLIAGIVEGERAIDAWRQLAGGTDPVAKATPGTIRGDFALTVGENVVHGSD
HHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCEEECCCC
SPESAEREISIWFPNL
CCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]