Click here to switch to the map view.

The map label for this gene is proA

Identifier: 145296322

GI number: 145296322

Start: 2466051

End: 2467349

Strand: Reverse

Name: proA

Synonym: cgR_2237

Alternate gene names: 145296322

Gene position: 2467349-2466051 (Counterclockwise)

Preceding gene: 145296323

Following gene: 145296321

Centisome position: 74.45

GC content: 57.43

Gene sequence:

>1299_bases
ATGAGTTCAACGACCCTAACCGATGACCAAATTCGTGACAATGAGCGGACCGAAGTTCTAGCTAAAGCAACTGCAGCTAA
AAACATCGTCCCGGATATTGCAGTGTTGGGCACCGGACCGAAGAACGCAATCCTGCGTGCGGCGGCAGATGAACTCGTTG
CACGCAGCGCAGAAATCATCGAAGCCAACGCTTCCGATATTGAAGCGGGTCGCGCAAACGGCATGGAAGAATCCATGATT
GACCGCCTTGCCCTTGATGAATCTCGCATTGAGGGCATCGCTGGCGGTTTGCGCCAAGTTGCTGGCCTGACCGACCCAGT
CGGTGAAGTACTACGCGGACATGTCATGGAAAATGGCATTCAGATGAAGCAGGTCCGCGTACCTTTGGGCGTGATGGGCA
TGGTCTATGAAGCCCGCCCAAACGTCACCGTCGATGCCTTCGGCCTAGCACTAAAGTCCGGCAACGTAGCTTTGCTGCGC
GGTTCCTCCACAGCTGTGCATTCCAACACCAAGCTCGTGGAAATCCTGCAGGACGTTCTCGAGCGTTTCGAGCTGCCACG
CGAAACCGTGCAGCTGCTGCCTTGCCAAACCCGCGGATCCGTCCAAGACTTGATCACTGCCCGCGGCCTCGTTGACGTGG
TCATCCCACGCGGCGGCGCAGGACTAATCAACGCAGTGGTCACCGGCGCGACCGTGCCCACCATTGAAACCGGCACCGGA
AACTGCCACTTCTACATCGACGCCGAAGCCAAGCTTGATCAGGCAATCGCCATGGTCATCAACGGCAAGACCCGTCGCTG
CAGCGTGTGCAACGCTACTGAAACCGCGCTTCTCGACGCCGCCCTCAGCGACTCAGACAAGCTTGCAGTCGTCCAGGCGC
TCCAGGAAGCAGGAGTTACAATTCATGGACGGGTGGCGGAATTGGAAGCATTCGGTGCAACCGACGTGGTGGAAGCAACC
GAAACCGACTGGGATTCTGAGTACCTGTCCTTCGATATCGCTGTCGCTGTGGTTGACGGCGTGGATGGAGCTCTGGCACA
CATCGCTAAGTACAGCACCAAGCACACCGAAGCGATCGCCACCCAAAACATTGAAACCGCTCAGCGCTTTGCAGATCGCG
TCGATGCAGCAGCGGTGATGATAAACGCATCCACCGCCTACACCGATGGGGAGCAGTACGGCATGGGCGCGGAGATCGGC
ATTTCCACCCAGAAACTGCATGCACGTGGACCAATGGCCCTGCCAGAGCTGACCTCCACCAAGTGGATTCTGCAGGGCAC
AGGACAAATTAGGCCTTAA

Upstream 100 bases:

>100_bases
GAGCAGATGGCCACCGAGGTCGATGTGGTGGCAGGCTACTAGGCCTTTTATGGTGTGCTCCGCCACTGTTTCTTCTAAAG
GGTCTGTATAGTGGGCAACC

Downstream 100 bases:

>100_bases
GTTTGAAGTAGTAATCAAGCTCCCCTGTGAGGACTCGTTGTAGTCTTTTATTTAGTTAATAAAAGATTTCATACCAACTT
GTCAGCAGGGGAGCTTTCAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSSTTLTDDQIRDNERTEVLAKATAAKNIVPDIAVLGTGPKNAILRAAADELVARSAEIIEANASDIEAGRANGMEESMI
DRLALDESRIEGIAGGLRQVAGLTDPVGEVLRGHVMENGIQMKQVRVPLGVMGMVYEARPNVTVDAFGLALKSGNVALLR
GSSTAVHSNTKLVEILQDVLERFELPRETVQLLPCQTRGSVQDLITARGLVDVVIPRGGAGLINAVVTGATVPTIETGTG
NCHFYIDAEAKLDQAIAMVINGKTRRCSVCNATETALLDAALSDSDKLAVVQALQEAGVTIHGRVAELEAFGATDVVEAT
ETDWDSEYLSFDIAVAVVDGVDGALAHIAKYSTKHTEAIATQNIETAQRFADRVDAAAVMINASTAYTDGEQYGMGAEIG
ISTQKLHARGPMALPELTSTKWILQGTGQIRP

Sequences:

>Translated_432_residues
MSSTTLTDDQIRDNERTEVLAKATAAKNIVPDIAVLGTGPKNAILRAAADELVARSAEIIEANASDIEAGRANGMEESMI
DRLALDESRIEGIAGGLRQVAGLTDPVGEVLRGHVMENGIQMKQVRVPLGVMGMVYEARPNVTVDAFGLALKSGNVALLR
GSSTAVHSNTKLVEILQDVLERFELPRETVQLLPCQTRGSVQDLITARGLVDVVIPRGGAGLINAVVTGATVPTIETGTG
NCHFYIDAEAKLDQAIAMVINGKTRRCSVCNATETALLDAALSDSDKLAVVQALQEAGVTIHGRVAELEAFGATDVVEAT
ETDWDSEYLSFDIAVAVVDGVDGALAHIAKYSTKHTEAIATQNIETAQRFADRVDAAAVMINASTAYTDGEQYGMGAEIG
ISTQKLHARGPMALPELTSTKWILQGTGQIRP
>Mature_431_residues
SSTTLTDDQIRDNERTEVLAKATAAKNIVPDIAVLGTGPKNAILRAAADELVARSAEIIEANASDIEAGRANGMEESMID
RLALDESRIEGIAGGLRQVAGLTDPVGEVLRGHVMENGIQMKQVRVPLGVMGMVYEARPNVTVDAFGLALKSGNVALLRG
SSTAVHSNTKLVEILQDVLERFELPRETVQLLPCQTRGSVQDLITARGLVDVVIPRGGAGLINAVVTGATVPTIETGTGN
CHFYIDAEAKLDQAIAMVINGKTRRCSVCNATETALLDAALSDSDKLAVVQALQEAGVTIHGRVAELEAFGATDVVEATE
TDWDSEYLSFDIAVAVVDGVDGALAHIAKYSTKHTEAIATQNIETAQRFADRVDAAAVMINASTAYTDGEQYGMGAEIGI
STQKLHARGPMALPELTSTKWILQGTGQIRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=403, Percent_Identity=34.9875930521092, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI62912457, Length=403, Percent_Identity=34.9875930521092, Blast_Score=237, Evalue=2e-62,
Organism=Escherichia coli, GI1786438, Length=409, Percent_Identity=43.7652811735941, Blast_Score=353, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI17569969, Length=405, Percent_Identity=33.8271604938272, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17569967, Length=405, Percent_Identity=33.8271604938272, Blast_Score=231, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=34.4110854503464, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21357643, Length=383, Percent_Identity=33.9425587467363, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_CORGB (A4QG75)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001139143.1
- ProteinModelPortal:   A4QG75
- SMR:   A4QG75
- STRING:   A4QG75
- GeneID:   4991754
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2237
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   HRIEAMA
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45667; Mature: 45536

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTTLTDDQIRDNERTEVLAKATAAKNIVPDIAVLGTGPKNAILRAAADELVARSAEII
CCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHE
EANASDIEAGRANGMEESMIDRLALDESRIEGIAGGLRQVAGLTDPVGEVLRGHVMENGI
ECCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
QMKQVRVPLGVMGMVYEARPNVTVDAFGLALKSGNVALLRGSSTAVHSNTKLVEILQDVL
EEEEEECCHHHHHEEEECCCCCEEEEEEEEEECCCEEEEECCCCEEECCCHHHHHHHHHH
ERFELPRETVQLLPCQTRGSVQDLITARGLVDVVIPRGGAGLINAVVTGATVPTIETGTG
HHHCCCHHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCCEEECCCC
NCHFYIDAEAKLDQAIAMVINGKTRRCSVCNATETALLDAALSDSDKLAVVQALQEAGVT
CEEEEEECCCHHHHHEEEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCE
IHGRVAELEAFGATDVVEATETDWDSEYLSFDIAVAVVDGVDGALAHIAKYSTKHTEAIA
EEEEEEEHHHCCCCHHHHCCCCCCCCHHHEEEEEEEEECCCCHHHHHHHHHCCHHHHHHH
TQNIETAQRFADRVDAAAVMINASTAYTDGEQYGMGAEIGISTQKLHARGPMALPELTST
HCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHCCCCCEECCCHHHHHCCCCCCCCCCCCC
KWILQGTGQIRP
EEEEECCCCCCC
>Mature Secondary Structure 
SSTTLTDDQIRDNERTEVLAKATAAKNIVPDIAVLGTGPKNAILRAAADELVARSAEII
CCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHE
EANASDIEAGRANGMEESMIDRLALDESRIEGIAGGLRQVAGLTDPVGEVLRGHVMENGI
ECCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
QMKQVRVPLGVMGMVYEARPNVTVDAFGLALKSGNVALLRGSSTAVHSNTKLVEILQDVL
EEEEEECCHHHHHEEEECCCCCEEEEEEEEEECCCEEEEECCCCEEECCCHHHHHHHHHH
ERFELPRETVQLLPCQTRGSVQDLITARGLVDVVIPRGGAGLINAVVTGATVPTIETGTG
HHHCCCHHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCCEEECCCC
NCHFYIDAEAKLDQAIAMVINGKTRRCSVCNATETALLDAALSDSDKLAVVQALQEAGVT
CEEEEEECCCHHHHHEEEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCE
IHGRVAELEAFGATDVVEATETDWDSEYLSFDIAVAVVDGVDGALAHIAKYSTKHTEAIA
EEEEEEEHHHCCCCHHHHCCCCCCCCHHHEEEEEEEEECCCCHHHHHHHHHCCHHHHHHH
TQNIETAQRFADRVDAAAVMINASTAYTDGEQYGMGAEIGISTQKLHARGPMALPELTST
HCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHCCCCCEECCCHHHHHCCCCCCCCCCCCC
KWILQGTGQIRP
EEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA