Click here to switch to the map view.

The map label for this gene is tdh [H]

Identifier: 145296271

GI number: 145296271

Start: 2413714

End: 2414700

Strand: Reverse

Name: tdh [H]

Synonym: cgR_2188

Alternate gene names: 145296271

Gene position: 2414700-2413714 (Counterclockwise)

Preceding gene: 145296272

Following gene: 145296270

Centisome position: 72.86

GC content: 58.36

Gene sequence:

>987_bases
GTGACTGACATCAACATTCAAAAGTGGGTTGGCGGATCCGATTTCGAATACGCCACCGTCGAAGCTCCGCAGCTTAAAGA
AGGGGAACGACTCGTCGAAATGCGAGTTGCGGCAGTGTGCGGCTCTGACCGCCACACCGTCTCTGGGCGTCGCTCAGGCG
CGTGCCCCTCGGTCCTCGGCCATGAAGGCGTGGGAACAATCGTGGCGGGGCCGGGCGTCGATAAGCGTGTAGTTTTTAGC
GTGACTTCGATTTGTGGGGAGTGCACCAACTGCAAGCGCGGGCTGACCGCTAAGTGTGAGCATGTGCTGAAGGTGGGGCA
TGAATCCTACGACGGCGAGTGGGCATTGTCTGGAACGTATGCGTCTCACATCGTGCTTCCTGCAGGGGTTGCGGTTGTTG
AGGTTCCGGAGTCTGTGTCTGATGATGCGGCCTCGATCGCTGGATGTTCCGTGGCGACCGTGATGGCAACGTTGGAAACT
GCTGGTGATATTGCTGGCCGCGACGTGTTTGTCAACGGCCTGGGCATGCTCGGACTGGTTGCTGTTGCAGCAGCTATTTC
CCGTGGTGCTCGCGCAGTTTATGCCTTCGATCCATCGGAAGAACGCATGGCGCAGGCATTGGCTCTTGGCGCTCAGCCAA
TGGGCAAGGGCCAAGAAGTTGAAGTTGCTTTGGAATTCTCCGGAGTAGCAGCGGGCGTGCGCAGTGCCATTGCATCCCTG
GGCATCGGTGGAACCGCAGTGCTGGCAGGAAGTGTTGCACCAGCTGGTGACATCGAGGTCGATCCAGAGTGGATGGTTCG
CGGTTGGCGCACCATTACCGGTGTGCACAACTACGAGCCACGGCACCTGCAAGACGCAGTTGATTTCTTAGCTTCTGTTG
CACTTCCGTGGGACGAGCTGCTCAGCGGCCCGATTTCCTTGGAGGAGCTGCCTCAGGAGTTCGCACAGCCTCACTCAGGC
TTGAGGACTCTGGTCAAGATTAACTAG

Upstream 100 bases:

>100_bases
GTCACCTCACCACCGAGGACTTCCAGAACGAAGGCGCAGACCACATCATCGATTCTGTAGCGATCATCCCAGCGTTGATC
CTCAACTAGGCATAAAACTC

Downstream 100 bases:

>100_bases
TTAAAAAAATCCCCACCTTCAAATCATTGGAGGTGGGGATTTTTGCTACCTAAACAGATTTTAAGCCTGGATCCACCGAT
GTAGTTCGGGTTCCAGCGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTDINIQKWVGGSDFEYATVEAPQLKEGERLVEMRVAAVCGSDRHTVSGRRSGACPSVLGHEGVGTIVAGPGVDKRVVFS
VTSICGECTNCKRGLTAKCEHVLKVGHESYDGEWALSGTYASHIVLPAGVAVVEVPESVSDDAASIAGCSVATVMATLET
AGDIAGRDVFVNGLGMLGLVAVAAAISRGARAVYAFDPSEERMAQALALGAQPMGKGQEVEVALEFSGVAAGVRSAIASL
GIGGTAVLAGSVAPAGDIEVDPEWMVRGWRTITGVHNYEPRHLQDAVDFLASVALPWDELLSGPISLEELPQEFAQPHSG
LRTLVKIN

Sequences:

>Translated_328_residues
MTDINIQKWVGGSDFEYATVEAPQLKEGERLVEMRVAAVCGSDRHTVSGRRSGACPSVLGHEGVGTIVAGPGVDKRVVFS
VTSICGECTNCKRGLTAKCEHVLKVGHESYDGEWALSGTYASHIVLPAGVAVVEVPESVSDDAASIAGCSVATVMATLET
AGDIAGRDVFVNGLGMLGLVAVAAAISRGARAVYAFDPSEERMAQALALGAQPMGKGQEVEVALEFSGVAAGVRSAIASL
GIGGTAVLAGSVAPAGDIEVDPEWMVRGWRTITGVHNYEPRHLQDAVDFLASVALPWDELLSGPISLEELPQEFAQPHSG
LRTLVKIN
>Mature_327_residues
TDINIQKWVGGSDFEYATVEAPQLKEGERLVEMRVAAVCGSDRHTVSGRRSGACPSVLGHEGVGTIVAGPGVDKRVVFSV
TSICGECTNCKRGLTAKCEHVLKVGHESYDGEWALSGTYASHIVLPAGVAVVEVPESVSDDAASIAGCSVATVMATLETA
GDIAGRDVFVNGLGMLGLVAVAAAISRGARAVYAFDPSEERMAQALALGAQPMGKGQEVEVALEFSGVAAGVRSAIASLG
IGGTAVLAGSVAPAGDIEVDPEWMVRGWRTITGVHNYEPRHLQDAVDFLASVALPWDELLSGPISLEELPQEFAQPHSGL
RTLVKIN

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=26.5193370165746, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790045, Length=329, Percent_Identity=26.7477203647416, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=28, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788075, Length=333, Percent_Identity=24.3243243243243, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=332, Percent_Identity=26.2048192771084, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=362, Percent_Identity=27.3480662983425, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 34105; Mature: 33974

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDINIQKWVGGSDFEYATVEAPQLKEGERLVEMRVAAVCGSDRHTVSGRRSGACPSVLG
CCCCCCHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHC
HEGVGTIVAGPGVDKRVVFSVTSICGECTNCKRGLTAKCEHVLKVGHESYDGEWALSGTY
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEECCC
ASHIVLPAGVAVVEVPESVSDDAASIAGCSVATVMATLETAGDIAGRDVFVNGLGMLGLV
HHEEEECCCEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
AVAAAISRGARAVYAFDPSEERMAQALALGAQPMGKGQEVEVALEFSGVAAGVRSAIASL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHHHHHHC
GIGGTAVLAGSVAPAGDIEVDPEWMVRGWRTITGVHNYEPRHLQDAVDFLASVALPWDEL
CCCCHHEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHH
LSGPISLEELPQEFAQPHSGLRTLVKIN
HCCCCCHHHHHHHHHCHHHCCCEEEEEC
>Mature Secondary Structure 
TDINIQKWVGGSDFEYATVEAPQLKEGERLVEMRVAAVCGSDRHTVSGRRSGACPSVLG
CCCCCHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHC
HEGVGTIVAGPGVDKRVVFSVTSICGECTNCKRGLTAKCEHVLKVGHESYDGEWALSGTY
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEECCC
ASHIVLPAGVAVVEVPESVSDDAASIAGCSVATVMATLETAGDIAGRDVFVNGLGMLGLV
HHEEEECCCEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
AVAAAISRGARAVYAFDPSEERMAQALALGAQPMGKGQEVEVALEFSGVAAGVRSAIASL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHHHHHHC
GIGGTAVLAGSVAPAGDIEVDPEWMVRGWRTITGVHNYEPRHLQDAVDFLASVALPWDEL
CCCCHHEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHH
LSGPISLEELPQEFAQPHSGLRTLVKIN
HCCCCCHHHHHHHHHCHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA