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The map label for this gene is patB [H]

Identifier: 145296264

GI number: 145296264

Start: 2406302

End: 2407408

Strand: Direct

Name: patB [H]

Synonym: cgR_2181

Alternate gene names: 145296264

Gene position: 2406302-2407408 (Clockwise)

Preceding gene: 145296259

Following gene: 145296265

Centisome position: 72.61

GC content: 51.13

Gene sequence:

>1107_bases
ATGCGATTTCCTGAACTCGAAGAATTGAAGAATCGCCGGACCTTGAAATGGACCCGGTTTCCAGAAGACGTGCTTCCTTT
GTGGGTTGCGGAAAGTGATTTTGGCACCTGCCCGCCGTTGAAGGAAGCAATGGCAGATGCCGTTGAGCGCGAGGTTTTCG
GATACCCACCAGATGCTACTGGGTTGAATGATGCGTTGGCTGGATTCTACGAGCGTCGCTATGGGTTTGGCCCAAAGCCG
GAGAGTGTTTTCGCCATTCCGGATGTGGTTCGTGGCCTGAAGCTTGCCATTGAGCATTTCACTAAGCCTGGTTCGGCGAT
CATTGTGCCGTTGCCTGCATACCCTCCTTTCATCGAGTTGCCTAAGGTGACTGGTCGTCAGGCGATCTACATTGATGCGC
ATGAGTACGATCTGAAGGAGATTGAAAAGGCCTTCGCTGACGGTGCTGGATCGCTGTTGTTCTGTAATCCTCACAACCCA
CTGGGCACGGTCTTTTCTGAAGAGTACATCCGTGAACTCACCGATATTGCAGCTAAATACGATGCCCGCATCATCGTCGA
TGAGATCCACGCTCCCCTGGTTTTTGAAGGTACCCATGTGGTTGCTGCTGGTGTTTCTAAGAACGCTGCAAACACTTGCA
TCACCATCACTGCAACTTCAAAGGCATGGAACACAGCTGGTTTGAAGTGTGCTCAGATCTTCTTCACCAATGAAGCTGAT
GTAAAGGCATGGAAGAACCTATCGGATATTACTCGTGACGGTGTGTCCATCCTTGGATTGATCGCTGCGGAGACGGTGTA
CAACGAGGGCGAAGAATTCCTTGATGAGTCAATTCAGATTCTCAAGGACAACCGTGACTTTGCGGCTGCTGAACTGGAAA
AGCTTGGCGTGAAGGTCTACGCACCGGACTCTACTTATTTGATGTGGCTGGACTTCGCTGGCACCAAGATTGAAGAGGCG
CCTTCTAAAATTCTTCGTGAGGAGGGTAAGGTCATGCTGAATGATGGCGCAGCTTTTGGTGGTTTCACCACCTGCGCTCG
TCTTAATTTTGCGTGTTCCAGAGAGACCCTTGAGGAGGGGCTGCGCCGTATCGCCAGCGTGTTGTAA

Upstream 100 bases:

>100_bases
CAAGAAGTGCGACGGCTAACAGGGCTGGGATTGTCCTCAACTTCACTTCGGGCTCCTTCTTAGTAATAGGTTCGTAGAAA
AGTTTACTAGCCTAGAGAGT

Downstream 100 bases:

>100_bases
ATAATGAGTAAAAAGTCTGTCCTGATTACTTCTTTGATGCTGTTTTCCATGTTCTTTGGAGCTGGAAACCTCATCTTCCC
GCCGATGCTTGGATTGTCGG

Product: hypothetical protein

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MRFPELEELKNRRTLKWTRFPEDVLPLWVAESDFGTCPPLKEAMADAVEREVFGYPPDATGLNDALAGFYERRYGFGPKP
ESVFAIPDVVRGLKLAIEHFTKPGSAIIVPLPAYPPFIELPKVTGRQAIYIDAHEYDLKEIEKAFADGAGSLLFCNPHNP
LGTVFSEEYIRELTDIAAKYDARIIVDEIHAPLVFEGTHVVAAGVSKNAANTCITITATSKAWNTAGLKCAQIFFTNEAD
VKAWKNLSDITRDGVSILGLIAAETVYNEGEEFLDESIQILKDNRDFAAAELEKLGVKVYAPDSTYLMWLDFAGTKIEEA
PSKILREEGKVMLNDGAAFGGFTTCARLNFACSRETLEEGLRRIASVL

Sequences:

>Translated_368_residues
MRFPELEELKNRRTLKWTRFPEDVLPLWVAESDFGTCPPLKEAMADAVEREVFGYPPDATGLNDALAGFYERRYGFGPKP
ESVFAIPDVVRGLKLAIEHFTKPGSAIIVPLPAYPPFIELPKVTGRQAIYIDAHEYDLKEIEKAFADGAGSLLFCNPHNP
LGTVFSEEYIRELTDIAAKYDARIIVDEIHAPLVFEGTHVVAAGVSKNAANTCITITATSKAWNTAGLKCAQIFFTNEAD
VKAWKNLSDITRDGVSILGLIAAETVYNEGEEFLDESIQILKDNRDFAAAELEKLGVKVYAPDSTYLMWLDFAGTKIEEA
PSKILREEGKVMLNDGAAFGGFTTCARLNFACSRETLEEGLRRIASVL
>Mature_368_residues
MRFPELEELKNRRTLKWTRFPEDVLPLWVAESDFGTCPPLKEAMADAVEREVFGYPPDATGLNDALAGFYERRYGFGPKP
ESVFAIPDVVRGLKLAIEHFTKPGSAIIVPLPAYPPFIELPKVTGRQAIYIDAHEYDLKEIEKAFADGAGSLLFCNPHNP
LGTVFSEEYIRELTDIAAKYDARIIVDEIHAPLVFEGTHVVAAGVSKNAANTCITITATSKAWNTAGLKCAQIFFTNEAD
VKAWKNLSDITRDGVSILGLIAAETVYNEGEEFLDESIQILKDNRDFAAAELEKLGVKVYAPDSTYLMWLDFAGTKIEEA
PSKILREEGKVMLNDGAAFGGFTTCARLNFACSRETLEEGLRRIASVL

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=312, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787909, Length=367, Percent_Identity=28.8828337874659, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788722, Length=367, Percent_Identity=22.8882833787466, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=364, Percent_Identity=26.3736263736264, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 40681; Mature: 40681

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFPELEELKNRRTLKWTRFPEDVLPLWVAESDFGTCPPLKEAMADAVEREVFGYPPDAT
CCCCCHHHHHCCCCEEEECCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
GLNDALAGFYERRYGFGPKPESVFAIPDVVRGLKLAIEHFTKPGSAIIVPLPAYPPFIEL
CHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEC
PKVTGRQAIYIDAHEYDLKEIEKAFADGAGSLLFCNPHNPLGTVFSEEYIRELTDIAAKY
CCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHC
DARIIVDEIHAPLVFEGTHVVAAGVSKNAANTCITITATSKAWNTAGLKCAQIFFTNEAD
CCEEEEECCCCCEEECCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCH
VKAWKNLSDITRDGVSILGLIAAETVYNEGEEFLDESIQILKDNRDFAAAELEKLGVKVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCEEEE
APDSTYLMWLDFAGTKIEEAPSKILREEGKVMLNDGAAFGGFTTCARLNFACSRETLEEG
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LRRIASVL
HHHHHHHC
>Mature Secondary Structure
MRFPELEELKNRRTLKWTRFPEDVLPLWVAESDFGTCPPLKEAMADAVEREVFGYPPDAT
CCCCCHHHHHCCCCEEEECCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
GLNDALAGFYERRYGFGPKPESVFAIPDVVRGLKLAIEHFTKPGSAIIVPLPAYPPFIEL
CHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEC
PKVTGRQAIYIDAHEYDLKEIEKAFADGAGSLLFCNPHNPLGTVFSEEYIRELTDIAAKY
CCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHC
DARIIVDEIHAPLVFEGTHVVAAGVSKNAANTCITITATSKAWNTAGLKCAQIFFTNEAD
CCEEEEECCCCCEEECCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCH
VKAWKNLSDITRDGVSILGLIAAETVYNEGEEFLDESIQILKDNRDFAAAELEKLGVKVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCEEEE
APDSTYLMWLDFAGTKIEEAPSKILREEGKVMLNDGAAFGGFTTCARLNFACSRETLEEG
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LRRIASVL
HHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]